82,380 results match your criteria anxiolytic


Overview of the Neuroprotective Effects of the MAO-Inhibiting Antidepressant Phenelzine.

Cell Mol Neurobiol 2021 Apr 10. Epub 2021 Apr 10.

Department of Psychiatry (Neurochemical Research Unit), University of Alberta, 12-105B Clinical Sciences Building, Edmonton, AB, T6G 2G3, Canada.

Phenelzine (PLZ) is a monoamine oxidase (MAO)-inhibiting antidepressant with anxiolytic properties. This multifaceted drug has a number of pharmacological and neurochemical effects in addition to inhibition of MAO, and findings on these effects have contributed to a body of evidence indicating that PLZ also has neuroprotective/neurorescue properties. These attributes are reviewed in this paper and include catabolism to the active metabolite β-phenylethylidenehydrazine (PEH) and effects of PLZ and PEH on the GABA-glutamate balance in brain, sequestration of reactive aldehydes, and inhibition of primary amine oxidase. Read More

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Putative anxiolytic-like behavioral effects of acute paracetamol in adult zebrafish.

Behav Brain Res 2021 Apr 7:113293. Epub 2021 Apr 7.

Bioscience Institute, University of Passo Fundo (UPF), Passo Fundo, RS, Brazil; Laboratory of Cell and Molecular Biology and Neurobiology, Moscow Institute of Physics and Technology, Moscow, Russia; The International Zebrafish Neuroscience Research Consortium (ZNRC), Slidell, LA, USA. Electronic address:

Typically triggered by stress, anxiety disorders are most common and widespread mental illnesses. The zebrafish (Danio rerio) is rapidly becoming an important aquatic model species in stress research and central nervous system (CNS) drug screening. Paracetamol is currently the most prescribed medication for pain and fever, and is among the most commonly used drugs globally. Read More

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Disruption of model-based decision making by silencing of serotonin neurons in the dorsal raphe nucleus.

Curr Biol 2021 Mar 31. Epub 2021 Mar 31.

Department of Neuropharmacology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, N15 W7 Kita-ku, Sapporo 060-8638, Japan.

Adapting to changing environmental conditions requires a prospective inference of future actions and their consequences, a strategy also known as model-based decision making. In stable environments, extensive experience of actions and their consequences leads to a shift from a model-based to a model-free strategy, whereby behavioral selection is primarily governed by retrospective experiences of positive and negative outcomes. Human and animal studies, where subjects are required to speculate about implicit information and adjust behavioral responses over multiple sessions, point to a role for the central serotonergic system in model-based decision making. Read More

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Diet supplements of banana fruit pulp mitigates repeated noise stress induced behavioral deficits and oxidative stress.

Pak J Pharm Sci 2020 Sep;33(5(Supplementary)):2293-2300

Department of Chemistry, Federal Urdu University of Arts, Science and Technology, Karachi, Pakistan.

The current study was designed to determine the outcome of banana fruit pulp (BFP) on repeated noise stress exposure (NSE)-induced behavioral deficits and oxidative stress in male mice. BFP (600mg/kg b.w) was administered orally once daily for 2 weeks prior exposure to noise stress. Read More

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September 2020

Eugenol and liposome-based nanocarriers loaded with eugenol protect against anxiolytic disorder via down regulation of neurokinin-1 receptors in mice.

Pak J Pharm Sci 2020 Sep;33(5(Supplementary)):2275-2284

HEJ Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi.

Anxiety disorder is a psychiatric disorder characterized by extreme fear or worry. It is highly prevalent worldwide which affects daily life and is also an enormous health burden. Neurokinin 1 receptor (NK1R) is a G protein coupled receptor, expressed in both central and peripheral nervous system, involved in affective behaviors. Read More

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September 2020

Ameliorative effects of the aqueous extract of Khaya anthotheca (Welw.) C.DC (Meliaceae) in vanadium induced anxiety, memory loss and pathologies in the brain and ovary of mice.

J Ethnopharmacol 2021 Apr 5:114099. Epub 2021 Apr 5.

Department of Veterinary Anatomy, Faculty of Veterinary Medicine, University of Ibadan, Ibadan 20001, Nigeria. Electronic address:

Ethnopharmacological Relevance: Ethnobotanical enquiries have revealed that Khaya anthotheca (Welw.) C.DC (Meliaceae) has anxiolytic properties and is used to alleviate vaginal dryness in postmenopausal women in Cameroon. Read More

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Risk estimation of SUDEP during COVID-19 pandemic era in a tertiary referral center.

Epilepsy Res 2021 Mar 24;173:106625. Epub 2021 Mar 24.

Department of Neurology, Kasr Al-Ainy Faculty of Medicine, Cairo University, Cairo, Egypt.

Objective: No data exist regarding the impact of the lockdown due to the COVID-19 pandemic on the risk factors of sudden unexpected death in epilepsy (SUDEP). This study aimed to stratify risk factors of SUDEP in relation to COVID-19 lockdown, among patients with epilepsy (PWE) in Cairo University epilepsy unit (CUEU). Therefore, we can detect risk factors and mitigate such factors in the second wave of the virus. Read More

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Interactions between the nitrergic and the endocannabinoid system in rats exposed to the elevated T maze.

Acta Neuropsychiatr 2021 Apr 5:1-14. Epub 2021 Apr 5.

Department of Pharmacology, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.

Objective: the aim of this study was to test the hypothesis that synthesis of nitric oxide (NO) and activation of CB1 receptors have opposite effects in a behavioural animal model of panic and anxiety.

Methods: to test the hypothesis male Wistar rats were exposed to the elevated T maze (ETM) model under the following treatments: L-Arginine (L-Arg) was administered before treatment withWIN55,212-2, a CB1 receptor agonist ; AM251, a CB1 antagonist, was administered before treatment with L-Arg. All treatments were by intraperitoneal route. Read More

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COVID-19 quarantine and depression in patients with congenital heart disease.

Am J Cardiovasc Dis 2021 15;11(1):80-86. Epub 2021 Feb 15.

Research Unit, Complejo Hospitalario Universitario Insular-Materno Infantil Las Palmas de Gran Canaria 35016, Spain.

COVID-19 outbreak has brought tremendous psychological pressure to the general population, especially to those with associated cardiovascular disease. An online Patient Health Questionnaire (PHQ-9) survey on consecutive congenital heart disease (CHD) patients, was carried out to determine depression during the Spanish coronavirus disease (COVID-19) quarantine. Two-hundred forty-two out of 407 (59%) CHD patients answered the survey, 123 (51%) had mild defects, 88 (36%) moderate and 31 (13%) great defects, most of them between 18 and 24 years old and 51% were male. Read More

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February 2021

Editorial: Pharmacotherapy of Anxiety Disorders: Promises and Pitfalls.

Front Psychiatry 2021 18;12:662963. Epub 2021 Mar 18.

Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, United States.

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Evaluating cannabidiol (CBD) expectancy effects on acute stress and anxiety in healthy adults: a randomized crossover study.

Psychopharmacology (Berl) 2021 Apr 4. Epub 2021 Apr 4.

Department of Psychology and Neuroscience, Dalhousie University, Life Sciences Centre, 1355 Oxford Street, PO Box 15000, Halifax, Nova Scotia, B3H 4R2, Canada.

Rationale: Cannabidiol (CBD) has been reported to attenuate stress and anxiety, but little is known about the extent to which such effects result from pharmacological versus expectancy factors.

Objectives: We evaluated whether CBD expectancy alone could influence stress, anxiety, and mood, and the extent to which beliefs regarding CBD effects predicted these responses.

Methods: In this randomized crossover study, 43 health adults (23 women) attended two experimental laboratory sessions, where they self-administered CBD-free hempseed oil sublingually. Read More

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Reply to Abdulzahra.

J Perianesth Nurs 2021 04;36(2):107

Department of Anesthesiology, Mahabad Imam Khomeini Hospital, Urmia University of Medical Science, Mahabad, Iran.

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Reasons for Discontinuation of Acute Postoperative Pain Ketamine Infusions: A Retrospective Case-Control Study.

Pain Pract 2021 Apr 3. Epub 2021 Apr 3.

Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Jacksonville, FL, USA.

Purpose: The purpose of the study was to investigate factors associated with early discontinuation of low-dose ketamine infusions due to adverse drug events (ADEs).

Methods: A retrospective, matched case-control study of surgical patients who received low-dose ketamine infusions for postoperative pain over 6 years was conducted. Forty-seven study patients, who required early discontinuation of their infusion due to ADEs, were included and matched 1:1 with 47 controls, who did not experience ADEs, for a total of 94 patients. Read More

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The Neural Network of Neuropeptide S (NPS): Implications in Food Intake and Gastrointestinal Functions.

Pharmaceuticals (Basel) 2021 Mar 26;14(4). Epub 2021 Mar 26.

School of Pharmacy, University of Camerino, via Madonna delle Carceri, 9, 62032 Camerino, Italy.

The Neuropeptide S (NPS), a 20 amino acids peptide, is recognized as the endogenous ligand of a previously orphan G protein-coupled receptor, now termed NPS receptor (NPSR). The limited distribution of the NPS-expressing neurons in few regions of the brainstem is in contrast with the extensive expression of NPSR in the rodent central nervous system, suggesting the involvement of this receptor in several brain functions. In particular, NPS promotes locomotor activity, behavioral arousal, wakefulness, and unexpectedly, at the same time, it exerts anxiolytic-like properties. Read More

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The Effect of Vasopressin Antagonists on Maternal-Separation-Induced Ultrasonic Vocalization and Stress-Hormone Level Increase during the Early Postnatal Period.

Brain Sci 2021 Mar 30;11(4). Epub 2021 Mar 30.

Institute of Experimental Medicine, 1085 Budapest, Hungary.

In adults, vasopressin exerts an anxiogenic effect, but less is known about the perinatal period. As a sign of distress, rat pups emit ultrasonic vocalizations when they are separated from their mothers, known as maternal separation-induced ultrasonic vocalization (MS-USV). Previously, reduced MS-USV was reported in 7-8-day-old genetically vasopressin-deficient Brattleboro rats. Read More

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An Insight into the Anxiolytic and Antidepressant-Like Proprieties of L. and Their Association with Its Antioxidant Activity.

Life (Basel) 2021 Mar 5;11(3). Epub 2021 Mar 5.

Laboratory of Biotechnology, Environment, Agrifood, and Health, University of Sidi Mohamed Ben Abdellah, FSDM-Fez 30050, Morocco.

Depression and anxiety are widespread illnesses whose consequences on patients' social and professional lives are becoming ever more dangerous and severe. The study's objective is to explore the antidepressant-like and anxiolytic activity of the polyphenolic extract of L. as well as its antioxidant power as they were recently associated. Read More

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Anxiolytic and Antidepressant-Like Effects of Aqueous Extract in the Scopolamine Rat Model.

Plants (Basel) 2021 Mar 29;10(4). Epub 2021 Mar 29.

Department of Biology, Alexandru Ioan Cuza University of Iasi, Bd. Carol I, No. 11, 700506 Iasi, Romania.

is a plant widely used in traditional medicine in Morocco for the treatment of varied health challenges. However, to the best of our knowledge, there is no scientific study justifying the traditional use of extract as an anxiolytic and antidepressant agent. Moreover, data regarding the polyphenolic fraction is limited. Read More

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Essential Oils: Pharmaceutical Applications and Encapsulation Strategies into Lipid-Based Delivery Systems.

Pharmaceutics 2021 Mar 3;13(3). Epub 2021 Mar 3.

Laboratory of Drug Delivery Technology, Department of Drug and Health Sciences, University of Catania, Viale A. Doria 6, 95125 Catania, Italy.

Essential oils are being studied for more than 60 years, but a growing interest has emerged in the recent decades due to a desire for a rediscovery of natural remedies. Essential oils are known for millennia and, already in prehistoric times, they were used for medicinal and ritual purposes due to their therapeutic properties. Using a variety of methods refined over the centuries, essential oils are extracted from plant raw materials: the choice of the extraction method is decisive, since it determines the type, quantity, and stereochemical structure of the essential oil molecules. Read More

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Quali-Quantitative Characterization of Volatile and Non-Volatile Compounds in (Aubl.) Marchand Resin by GC-MS Validated Method, GC-FID and HPLC-HRMS.

Molecules 2021 Mar 7;26(5). Epub 2021 Mar 7.

Department of Molecular Biotechnology and Health Sciences, University of Torino, Via Pietro Giuria 5, 10125 Torino, Italy.

(Aubl.) Marchand (PH) trees are endemic to the tropical region of South America, mostly Brazil. Antibacterial, antinociceptive, anti-inflammatory, anxiolytic, antidepressant and anti-hyperlipidemic/anti-hypercholesterolemic effects were reported for its resinous exudate resin (PHR). Read More

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Pharmacological characterisation of anticonvulsant effects elicited by erythrartine.

J Pharm Pharmacol 2021 Mar;73(1):93-97

Department of Biotechnology, University of Ribeirão Preto, Ribeirão Preto, SP, Brazil.

Objectives: The erythrinan alkaloids erythravine and 11α-hydroxy-erythravine from Erythrina verna (Vell.) have been extensively investigated for their anxiolytic and anticonvulsant effects. Both are structurally similar to the erythrartine that also exhibit anxiolytic effects, but there is no report on its anticonvulsant potential. Read More

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Time-trends in cocaine, hallucinogen, amphetamine, and sedative/anxiolytic/hypnotic use disorder hospitalizations in rheumatic diseases: a national time-trends study.

Clin Rheumatol 2021 Mar 30. Epub 2021 Mar 30.

Medicine Service, VA Medical Center, 700 19th St S, Birmingham, Alabama, 35233, United States.

Musculoskeletal diseases (MSDs) are common in the general population, frequently associated with pain, functional limitation, and reduction in quality of life. Similarly, drug/substance use disorders are common in the general population. Recently, opioid drug use disorder has gained a lot of attention as a public health problem. Read More

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Experience and prospects for the use of off-label drugs in oncology.

Exp Oncol 2021 03;43(1):1-5

National University of Pharmacy, Kharkiv 61002, Ukraine.

According to the World Health Organization, half of all drugs available on the global pharmaceutical market are sometimes used for indications that are not included in the instruction for use. This method of therapy has the term "off-label use" which means the use "out of instruction". Today, off-label drugs are also prescribed for cancer treatment. Read More

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Prevalence of depression and anxiety in people with inflammatory bowel disease and associated healthcare use: population-based cohort study.

Evid Based Ment Health 2021 Mar 30. Epub 2021 Mar 30.

Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK.

Background: Inflammatory bowel disease (IBD) has a significant impact on quality of life for many people.

Objective: To assess the prevalence of common mental health conditions in IBD and the combined impact of IBD and mental health conditions on healthcare use and time off work.

Methods: A UK population-based primary care database (Royal College of General Practitioners Research and Surveillance Centre) was used to identify adults with IBD (n=19 011) (Crohn's disease (CD) or ulcerative colitis (UC)), and matched controls (n=76 044). Read More

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Testosterone works through androgen receptors to modulate neuronal response to anxiogenic stimuli.

Neurosci Lett 2021 Mar 27;753:135852. Epub 2021 Mar 27.

Psychology Department, 293 Farm Lane, Giltner Room 108, East Lansing, MI 48824, United States; Neuroscience Program, 293 Farm Lane, Giltner Room 108, East Lansing, MI 48824, United States.

Testosterone (T) exerts anxiolytic effects through functional androgen receptors (ARs) in rodents. T treatment of castrated mice reduces anxiety-like behavior in wild-type (WT) males, but not males with a spontaneous mutation that renders AR dysfunctional (testicular feminization mutation, Tfm). Using Cre-LoxP technology we created males carrying induced dysfunctional AR allele (induced TFM; iTfm) to determine the brain regions responsible for T-induced anxiolysis. Read More

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Development of superabsorbent hydrogel based on Gum Arabic for enhanced removal of anxiolytic drug from water.

J Environ Manage 2021 Mar 27;288:112455. Epub 2021 Mar 27.

Laboratório de Tecnologia e Desenvolvimento de Compósitos e Materiais Poliméricos (LaCoPol), Universidade Federal de Pelotas (UFPel), Campus Capão do Leão S/n, 96010-900, Pelotas, RS, Brazil. Electronic address:

The growing consumption of anxiolytic drugs like diazepam (DZP) has aggravated the problem of persistent organic pollutants in water. Due to its characteristics, the removal of DZP from water and wastewater is a challenging task. As an effort to deals with this issue, in this study, we report the development of a hydrogel based on Gum Arabic (GA) grafted with poly(acrylic acid) (GA-g-PAAc) to be used in the adsorptive removal of DZP from water. Read More

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The association between generalized anxiety disorder and resting-state prefrontal cortex oxygenation is modified by self-reported physical activity: results from The Irish Longitudinal Study on Ageing.

J Gerontol A Biol Sci Med Sci 2021 Mar 29. Epub 2021 Mar 29.

The Irish Longitudinal Study on Ageing, Trinity College Dublin, Ireland.

Individuals with anxiety disorders exhibit lower intrinsic functional connectivity between prefrontal cortical areas and subcortical regions. The prefrontal cortex (PFC) is sensitive to the acute and chronic effects of physical activity (PA), while the anxiolytic effects of PA are well known. The current study examined the association of generalised anxiety disorder (GAD), and its interaction with PA, with resting-state left PFC oxygenation. Read More

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Involvement of GABAergic and nitrergic systems in the anxiolytic and hypnotic effects of : its interaction with anxiolytic-hypnotics.

Drug Metab Pers Ther 2020 Dec 29. Epub 2020 Dec 29.

Department of Pharmacology, Therapeutics and Toxicology, Faculty of Basic Medical Sciences, College of Medicine, University of Lagos, Lagos, Lagos State, Nigeria.

Objectives: Concurrent use of herbs with drugs have become a major healthcare problem. Herb-drug interactions could lead to therapeutic failure or toxicity. Hence, this study seeks to evaluate the impact of combining rhizome (CL) with selected anxiolytic and hypnotic drugs. Read More

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December 2020

Prospects for the Use of Cannabinoids in Psychiatric Disorders.

Front Psychiatry 2021 12;12:620073. Epub 2021 Mar 12.

Laboratory of Palliative Medicine, Department of Social Medicine and Public Health, Medical University of Warsaw, Warsaw, Poland.

Increasing evidence suggests an essential role of the endocannabinoid system in modulating cognitive abilities, mood, stress, and sleep. The psychoactive effects of cannabis are described as euphoric, calming, anxiolytic, and sleep-inducing and positively affect the mood, but can also adversely affect therapy. The responses to cannabinoid medications depend on the patient's endocannabinoid system activity, the proportion of phytocannabinoids, the terpenoid composition, and the dose used. Read More

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Transgenic mice with an R342X mutation in Phf6 display clinical features of Börjeson-Forssman-Lehmann Syndrome (BFLS).

Hum Mol Genet 2021 Mar 26. Epub 2021 Mar 26.

Regenerative Medicine Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada, K1H 8L6.

The PHF6 mutation c.1024C > T; p.R342X, is a recurrent cause of Börjeson-Forssman-Lehmann Syndrome (BFLS), a neurodevelopmental disorder characterized by moderate-severe intellectual disability, truncal obesity, gynecomastia, hypogonadism, long tapering fingers, and large ears (MIM#301900). Read More

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