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Georgian Med News 2021 Mar(312):100-104

3European University, Tbilisi, Georgia.

Depression is linked to systemic inflammation. There is an association between blood cell count and/or hematological inflammatory markers with depression symptoms. Oxytocin reduces the activity of brain regions that produce anxiety and might involve in the rehabilitation of depressive-like behavior. Read More

Georgian Med News 2021 Mar(312):61-67

1Bogomolets National Medical University, Kyiv; Ukraine.

Functional dyspepsia - postprandial distress-syndrome (FD-PDS) is one of the most common reasons for seeking medical attention of general practitioners, internists and gastroenterologists worldwide. Standard approaches to the treatment of patients with postprandial distress syndrome are only effective in small amount of cases. Aim of the study - comparative assessment of the effectiveness of combined eradication and prokinetic therapy and eradication therapy only in the treatment of FD-PDS by studying their effect on the clinical manifestations of the disease, patients' psychological status and quality of life. Read More

Health Place 2021 May 5;69:102572. Epub 2021 May 5.

Centre for Healthy Community, School of Public Health, University of Alberta, Alberta, Canada.

In-situ methodologies, including go-along and photo-elicited interviews, are ideal for harnessing people's lived experiences of place and their meanings for health and health equity. Their immersive nature means that the COVID-19 pandemic has impacted their use. Physical distancing measures combined to anxiety over the sharing of physical space have created ethical and practical challenges to the conduct of in-person in-situ methodologies. Read More

Gen Hosp Psychiatry 2021 Apr 29;71:76-81. Epub 2021 Apr 29.

Department of Medicine, Weill Cornell Medicine, New York, NY; Division of Hospital Medicine, Ascension Saint Thomas Hospital West, Nashville, TN.

Introduction: Use of virtual reality (VR) in healthcare has expanded in recent years. The challenges faced by patients with prolonged COVID-19-related hospitalizations - social isolation, disability, neurologic sequelae, adjustment-related anxiety, depression, and stress - may be mitigated by the novel use of VR as one modality of a comprehensive rehabilitation plan. This descriptive study aimed to understand patient satisfaction and perceived benefit of virtual reality on a COVID-19 recovery unit, as well as the logistical and operational feasibility of providing VR content for patients and staff. Read More

Int J Pediatr Otorhinolaryngol 2021 Apr 28;146:110741. Epub 2021 Apr 28.

Department of Otolaryngology, Medical College of Wisconsin, Milwaukee, WI, USA; Division of Pediatric Otolaryngology, Children's Wisconsin, Milwaukee, WI, USA.

Objectives: To investigate and identify the concerns and opinions expressed in both parental and provider posts on social media about ankyloglossia.

Methods: In this study, posts on Twitter between 1/1/2008 and 12/31/2018 were collected using search terms and hashtags specific to pediatric ankyloglossia. The search terms included a primary phrase to indicate ankyloglossia along with a pediatric identifier. Read More

Psychiatry Res 2021 Apr 24;301:113959. Epub 2021 Apr 24.

Department of Epidemiology and Environmental Health, School of Public Health and Health Professions, University at Buffalo, The State University of New York, Buffalo, NY, USA. Electronic address:

During the COVID-19 pandemic, social distancing measures often result in individual isolation, which can lead to adverse mental outcomes. We collected online questionnaires from 3,952 US adults to examine the impact of "shelter-in-place" guidelines on mental health, and to explore potential disparities and modifiable factors. Self-reported anxiety, depression, and PTSD symptoms were associated with more restrictive quarantine. Read More

Soc Sci Med 2021 Apr 28;279:113963. Epub 2021 Apr 28.

Murrow College of Communication, 208 Goertzen Hall, PO BOX 642530, Pullman, WA, 99164, USA. Electronic address:

Rationale: On March 11, 2020, actor Tom Hanks announced via social media that he had been diagnosed with COVID-19. Previous research has found celebrity illness disclosures to influence behavior, but during the uncertainty of a pandemic, the effects of such a disclosure were unclear.

Objective: To test the proposed Celebrity Illness Disclosure Effects (CIDE) model, demonstrating how an illness disclosure, communicated through mediated and interpersonal channels, may shape willingness to engage in prevention behaviors. Read More

Addict Behav 2021 Apr 27;120:106963. Epub 2021 Apr 27.

National Center for PTSD, VA Connecticut Healthcare System, West Haven, CT, USA; Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA; Department of Social and Behavioral Sciences, Yale School of Public Health, New Haven, CT.

More than half of U.S. states legalized medical or recreational sale and possession of cannabis since the prevalence of cannabis use was last estimated among U. Read More

Body Image 2021 May 5;38:251-261. Epub 2021 May 5.

Department of Psychology, York University, 4700 Keele St, Toronto, ON, M3J 1P3, Canada. Electronic address:

The current experiment investigated the impact of attaching self-disclaimer captions (i.e., captions about whether photos had been edited) to thin-ideal Instagram photos on young women's body image and mood. Read More

Complement Ther Med 2021 May 5:102725. Epub 2021 May 5.

Pediatrics Department of the University of São Paulo, Av. Dr Enéas Carvalho Aguiar No. 647, Cerqueira Cesar, São Paulo, CEP: 05403-901, Brazil. Electronic address:

Background: Pain is a disagreeable and distressing feeling that affects human beings in multi-dimensional ways. A number of non-pharmacological interventions have had varying degrees of success in treating cancer-related pain, such as breathing and relaxation techniques, and music therapy, which have been identified as beneficial therapies for alleviating pain and anxiety.

Objective: Identify the therapeutic effects of music interventions in psychological and physiological terms and on the quality of life of children undergoing cancer treatment. Read More

Behav Brain Res 2021 May 5:113346. Epub 2021 May 5.

University of Bath, Department of Psychology, United Kingdom.

In everyday life, information from multiple senses is integrated for a holistic understanding of emotion. Despite evidence of atypical multisensory perception in populations with socio-emotional difficulties (e.g. Read More

Behav Brain Res 2021 May 5:113341. Epub 2021 May 5.

Instituto de Fisiología Humana, Instituto de Investigaciones en Ciencias de la Salud (INICSA), CONICET and Facultad de Ciencias Médicas, Universidad Nacional de Córdoba, Santa Rosa 1085, X5000ESU, Córdoba, Argentina; Functional Pharmacology, Department of Neuroscience, Uppsala University, BMC, Husargatan 3, Box 593, SE-751 24, Uppsala, Sweden.

Ghrelin (Ghrl) is an orexigenic peptide with potential roles in the modulation of anxiety- and depressive-like symptoms induced by bilateral olfactory bulbectomy (OB) in rodents. In the present work, we assessed whether intrahippocampal Ghrl could reverse OB-induced depressive-like and amnesic effects by regulating molecular mechanisms related to neuroplasticity. Adult female albino Swiss mice were divided into sham and OB groups, and infused with saline (S) or Ghrl 0. Read More

Int J Pharm 2021 May 5:120670. Epub 2021 May 5.

Riphah Institute of Pharmaceutical Sciences, Riphah International University, Islamabad, Pakistan. Electronic address:

The present study aims to develop curcumin-loaded nanostructured lipid carriers (CUR-NLCs) and investigate their neuroprotective effects in lipopolysaccharide (LPS)-induced depression and anxiety model. Nanotemplate engineering technique was used to prepare CUR-NLCs with Compritol 888 ATO and oleic acid as solid and liquid lipid, respectively. Poloxamer 188, Tween 80 and Span 80 were used as stabilizing agents for solid-liquid lipid core. Read More

Sleep 2021 May 8. Epub 2021 May 8.

Department of Mental Health, Norwegian University of Science and Technology, Trondheim, Norway.

Study Objectives: Digital Cognitive Behavioural Therapy for Insomnia (dCBT-I) is an effective treatment for insomnia. However, less is known about mediators of its benefits. The aim of the present study was to test if intraindividual variability in sleep (IIV) was reduced with dCBT-I, and whether any identified reduction was a mediator of dCBT-I on insomnia severity and psychological distress. Read More

J Gerontol B Psychol Sci Soc Sci 2021 May 8. Epub 2021 May 8.

Yale School of Public Health.

Objectives: During the COVID-19 pandemic, stigmatization of older persons has increased in traditional and social media. It was unknown whether this negative messaging could be detrimental to the mental health of older individuals, and whether the relatively uncommon positive messaging about older individuals could benefit their mental health.

Method: To address these gaps, we designed age-stereotype interventions based on actual news stories that appeared during the pandemic, and divided them into negative and positive versions of what we term personified (i. Read More

Eur Arch Otorhinolaryngol 2021 May 8. Epub 2021 May 8.

ENT Department, University Hospital of Modena, Via del Pozzo 71, 44125, Modena, Italy.

Objective: Through years, interest in quality of life (QoL) among patients affected by vestibular schwannoma (VS) has increased. The expansion of the indications for endoscopic ear surgery allowed the development of the transcanal transpromontorial surgery (TTS) for VS removal. The objective of the present study was to assess QoL in a cohort of VS patients operated on by translabyrinthine (TL), retrosigmoid (RS) and TTS approach. Read More

Support Care Cancer 2021 May 8. Epub 2021 May 8.

Unit of Survivorship & Inequality in Cancer, Danish Cancer Society Research Centre, Danish Cancer Society, Copenhagen, Denmark.

Purpose: Pancreatic cancer (PC) has high morbidity and mortality and is stressful for patients and their partners. We investigated the psychological symptom burden in partners of PC patients.

Methods: We followed 5774 partners of PC patients diagnosed from 2000 to 2016 up for first redeemed prescriptions of antidepressants or hospital admission, anxiolytics, and hypnotics as proxies for clinical depression, anxiety, and insomnia and compared them with 59,099 partners of cancer-free spouses. Read More

J Clin Psychol 2021 May 8. Epub 2021 May 8.

Anxiety Treatment and Research Clinic, St. Joseph's Healthcare, Hamilton, Ontario, Canada.

Background: Individuals with hoarding report stressful and traumatic life events at an elevated rate compared with those with obsessive-compulsive disorder and healthy controls, but have not been compared with other clinical groups. This study compared rates of traumatic life events between those with clinically significant hoarding, anxiety disorders, or posttraumatic stress disorder (PTSD), hypothesizing that rates would be higher in the hoarding and PTSD groups than the anxiety group.

Methods: Rates of traumatic and stressful events were compared across groups. Read More

J Gerontol B Psychol Sci Soc Sci 2021 May 8. Epub 2021 May 8.

Department of Occupational Therapy, The Stanley Steyer School of Health Professions, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 69978, Israel.

Objectives: The COVID-19 pandemic is an ongoing stressor that may have detrimental effects on mental health. Theoretical and empirical literature implies that individuals who are characterized by catastrophic appraisals of somatic cues, a tendency known as anxiety sensitivity, as well as by older subjective age, might be particularly vulnerable to depression and anxiety during the pandemic. Furthermore, subjective age might moderate the relations between anxiety sensitivity with depression and anxiety symptoms. Read More

Schizophr Bull 2021 May 8. Epub 2021 May 8.

Department of Psychology, Northwestern University, Evanston, IL.

Individuals diagnosed with psychotic disorders exhibit abnormalities in the perception of expressive behaviors, which are linked to symptoms and visual information processing domains. Specifically, literature suggests these groups have difficulties perceiving gestures that accompany speech. While our understanding of gesture perception in psychotic disorders is growing, gesture perception abnormalities and clues about potential causes and consequences among individuals meeting criteria for a clinical high-risk (CHR) syndrome is limited. Read More

Chirurgia (Bucur) 2021 Mar-Apr;116(2 Suppl):73-83

The rate of contralateral prophylactic mastectomy (CPM) increased within the recent years. The main reasons are: genetic testing, availability of breast reconstruction, more often use of preoperative breast MRI, improvement of postoperative aesthetic results and reimbursement of breast reconstruction. The purpose of this study was to analyze the indication of CPM, it's evolution and the surgical techniques used for this type of surgery. Read More

J Dermatol 2021 May 7. Epub 2021 May 7.

Department of Biochemistry, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Tokyo, Japan.

Acne vulgaris, a chronic inflammatory skin disease, has been associated with not only sebaceous gland dysfunction but also various endogenous and exogenous stresses. Since sebaceous glands are under neuroendocrine control, including the hypothalamic-pituitary-adrenal axis and neuro-autocrine mechanisms, it remains unclear how psychological stress relates to the pathogenesis of acne. In this study, we investigated the relationship between psychological stress and catecholamine in acne lesions from 18 patients with mild or moderate acne. Read More

Perspect Psychiatr Care 2021 May 7. Epub 2021 May 7.

Department of Nursing, Faculty of Health Sciences, Bandırma Onyedi Eylül Üniversity, Bandırma, Balıkesir, Turkey.

Purpose: This study was carried out with the aim of determining the correlation between the levels of anxiety experienced by students and their sleep quality during the coronavirus disease 2019 (COVID-19) pandemic.

Design And Methods: This descriptive and correlational type study' sample population was 283 students. The personal information form, state-trait anxiety inventory, Verran and Snyder-Halpern sleep scale were used in data collection. Read More

Br J Clin Psychol 2021 May 7. Epub 2021 May 7.

Dartmouth College, Hanover, New Hampshire, USA.

Objectives: Using two intensive longitudinal data sets with different timescales (90 minutes, daily), we examined emotion network density, a metric of emotional inflexibility, as a predictor of clinical-level anxiety and depression.

Design: Mobile-based intensive longitudinal assessments.

Methods: 119 participants (61 anxious and depressed, 58 healthy controls) completed ecological momentary assessment (EMA) to rate a variety of negative (NE) and positive emotions (PE) 9 times per day for 8 days using a mobile phone application. Read More

Fam Cancer 2021 May 8. Epub 2021 May 8.

Department of Clinical Genetics, Royal North Shore Hospital, Sydney, NSW, Australia.

Women with neurofibromatosis type 1 (NF1) have an increased risk of developing early breast cancer with a poorer prognosis compared to the general population. Therefore, international management guidelines recommend regular screening in women with NF1 starting from 30 to 35 years. As the psychological impacts of breast cancer screening in other high-risk populations cannot be extended to women with NF1, due to increased incidence of cognitive and mental health issues, the psychological harms of breast screening in women with NF1 are unknown. Read More

J Behav Med 2021 May 7. Epub 2021 May 7.

Moffitt Cancer Center, Tampa, FL, 33612, USA.

MBSR(BC) is known to have a positive impact on psychological and physical symptoms among breast cancer survivors (BCS). The cognitive mechanisms of "how" MBSR(BC) works was addressed in a recent study that found that there was strong consistent evidence that reduced emotional reactivity is a mediator and moderate consistent evidence that mindfulness, rumination, and worry were mediators. The purpose of this study, as part of a larger R01 trial, was to test whether positive effects achieved from the MBSR(BC) program were mediated through changes in increased mindfulness, decreased fear of breast cancer recurrence, and perceived stress. Read More

Hum Reprod 2021 May 8. Epub 2021 May 8.

The University of Adelaide, Discipline of Obstetrics & Gynaecology, Adelaide, South Australia, Australia.

Study Question: Are reproductive, metabolic or psychological health profiles of women with clinically diagnosed polycystic ovary syndrome (PCOS) different from those with undiagnosed PCOS?

Summary Answer: Obtaining a clinical diagnosis of PCOS is strongly linked to the experience of fertility problems, but not clinical depression or poor metabolic health, although these were highly prevalent in women with PCOS irrespective of when they were diagnosed.

What Is Known Already: PCOS is an endocrine disorder that is relative common, but heterogeneous in presentation. This may impact on the pathways to diagnosis and timely treatment. Read More

Mol Psychiatry 2021 May 7. Epub 2021 May 7.

Department of Developmental Neuropsychology, School of Psychology, Third Military Medical University (Army Medical University), Chongqing, PR China.

Astrocytes are integral components of synaptic transmission, and their dysfunction leads to neuropsychiatric disorders such as anxiety and depression. Liver X receptor β (LXRβ) is expressed in astrocytes, and LXRβ global knockout mice shows impaired synaptic formation. In order to define the role of LXRβ in astrocytes, we used a conditional Cre-loxP system to specifically remove LXRβ from astrocytes. Read More

Mol Psychiatry 2021 May 7. Epub 2021 May 7.

Centre for Interdisciplinary Research in Biology (CIRB), CNRS UMR 7241, INSERM U1050, Labex MemoLife, PSL Research University, Collège de France, Paris, France.

The OTX2 homeoprotein transcription factor is expressed in the dopaminergic neurons of the ventral tegmental area, which projects to limbic structures controlling complex behaviors. OTX2 is also produced in choroid plexus epithelium, from which it is secreted into cerebrospinal fluid and transferred to limbic structure parvalbumin interneurons. Previously, adult male mice subjected to early-life stress were found susceptible to anxiety-like behaviors, with accompanying OTX2 expression changes in ventral tegmental area or choroid plexus. Read More

Sci Rep 2021 May 7;11(1):9763. Epub 2021 May 7.

Department of Healthcare Administration, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Japan.

Providing elderly mental healthcare in Myanmar is challenging due to the growing elderly population and limited health resources. To understand common mental health problems among Myanmar elderly, this study explored the prevalence and risk factors of anxiety and depression among the elderly in the Nay Pyi Taw Union Territory, Myanmar. A cross-sectional study was conducted among 655 elderly by face-to-face interviews with a pretested questionnaire. Read More