290,530 results match your criteria anxiety


Dynamic interaction between hippocampus, orbitofrontal cortex, and subthalamic nucleus during goal conflict in the stop signal task in rats.

Neurosci Res 2022 Jun 29. Epub 2022 Jun 29.

Dept. Psychology, University of Otago, Dunedin, New Zealand. Electronic address:

Action stopping depends on at least two (fast, slow) frontal circuits depending on the urgency of execution of the 'go' response. Human EEG suggests a third (even slower, limbic) circuit that activates frontal areas at frequencies typical of 'hippocampal theta'. Here we test in male rats whether stop-go conflict engages the hippocampus and so may send theta-modulated information via the frontal cortex to the subthalamic nucleus. Read More

View Article and Full-Text PDF

Characteristics of Patients Selected for Surgical Treatment of Spinal Meningioma.

World Neurosurg 2022 Jun 29. Epub 2022 Jun 29.

Department of Neurosurgery, Westchester Medical Center, New York Medical College, Valhalla, NY.

Background: Spinal meningiomas are benign extra-axial tumors that can present with neurological deficits. Treatment partly depends on the degree of disability as there is no agreed-upon patient selection algorithm at present. We aimed to elucidate general patient selection patterns in patients undergoing surgery for spinal meningioma. Read More

View Article and Full-Text PDF

Emergency department utilization by patients with bipolar disorder: a national population-based study.

J Affect Disord 2022 Jun 29. Epub 2022 Jun 29.

Department of Psychiatry, Meharry Medical College, Nashville, TN, USA.

Background: There is a scarcity of national United States (US) data on emergency department (ED) utilization of patients with bipolar disorder (BD). This study aims to determine the most common reasons for ED visits of patients with BD, and baseline characteristics of patients who present due to BD.

Methods: We obtained data from the Nationwide Emergency Department Sample (NEDS), the largest all-payer ED database in the US. Read More

View Article and Full-Text PDF

Serum metabolomics study of anxiety disorder patients based on LC-MS.

Clin Chim Acta 2022 Jun 29. Epub 2022 Jun 29.

School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, China, 102488. Electronic address:

Background: In the current environment of increasing social pressure, anxiety disorder has become a kind of health problem that needs to be solved urgently. However, the pathological mechanism of anxiety is still unclear, the classification of clinical diagnosis and symptoms is complex, and there is still a lack of biomarkers that can be identified and judged METHODS: This study used LC-MS and non-targeted metabolomics to analyze the clinically collected plasma of 18 samples from anxiety disorder patients and 31 samples from healthy people to screen differential metabolites and perform subsequent metabolic pathway analysis. Binary Logistic regression was used to construct the anxiety disorder diagnosis prediction model and evaluate the prediction efficacy RESULTS: The results showed that 22 metabolites were disturbed in the plasma of anxiety patients compared with healthy people. Read More

View Article and Full-Text PDF

The effect of Ketamine on delta-range coupling between prefrontal cortex and hippocampus supported by respiratory rhythmic input from the olfactory bulb.

Brain Res 2022 Jun 29:147996. Epub 2022 Jun 29.

Dept Psychiatry at BIDMC, Harvard Medical School, USA. Electronic address:

Respiratory rhythm plays an important role in cognitive functions in rodents, as well as in humans. Respiratory related oscillation (RRO), generated in the olfactory bulb (OB), is an extrinsic rhythm imposed on brain networks. In rats, RRO can couple with intrinsic brain oscillations at theta frequency during sniffing and in the delta range outside of such episodes. Read More

View Article and Full-Text PDF

Hormone contraceptive use in young women: Altered mood states, neuroendocrine and inflammatory biomarkers.

Horm Behav 2022 Jun 29;144:105229. Epub 2022 Jun 29.

Department of Neuroscience, Carleton University, 1125 Colonel By Drive, Ottawa, Ontario K1S 5B6, Canada; University of Ottawa Institute of Mental Health Research, 1145 Carling Avenue, K1Z 7K4 Ottawa, Ontario, Canada.

Oral contraceptives are used by millions of women worldwide, yet there are questions regarding the psychological and biological consequences of these medications. Considering that sex steroid hormones can regulate neuroendocrine and behavioral responses to stress, the current study examined mood and stress symptomatologies, as well as circulating levels of cortisol and inflammatory biomarkers among young women (N = 388), of whom, 47.0 % (n = 182) were using a form of hormonal contraception. Read More

View Article and Full-Text PDF

Psychological distress is independently related to new coronary events at 8 years' follow-up in elderly primary care patients with hypertension.

J Psychosom Res 2022 Jun 25;160:110980. Epub 2022 Jun 25.

Department of Medical and Clinical Psychology, Tilburg University, the Netherlands.

Objective: Occurrence of psychological distress in hypertensive patients could have a negative synergistic effect on future cardiovascular events (CVEs). The aim of this study was to determine the association between anxiety or depressive symptoms in elderly hypertensive primary care patients and the development of new CVEs and all-cause mortality.

Methods: A prospective cohort study was conducted in five Dutch general practices between June 2010 and January 2012. Read More

View Article and Full-Text PDF

The interplay between parental care and OPRM1 in reward responsiveness.

Psychoneuroendocrinology 2022 Jun 21;143:105845. Epub 2022 Jun 21.

College of Life Science, Northwest University, Xi'an 710069, China; College of Medicine, Northwest University, Xi'an 710069, China; Shaanxi Key Laboratory for Animal Conservation, Northwest University, Xi'an 710069, China; Institute of Population and Health, Northwest University, Xi'an 710069, China; Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, Northwest University, Xi'an 710069, China. Electronic address:

The Reinforcement Sensitivity Theory (RST) explains a variety of reward-motivated behaviors as the result of the activation of biologically-based systems. Inspired by the influences of parental bonding and opioid peptide on reward system, we investigated the contributions of parental bonding and mu-opioid receptor gene (OPRM1) towards motivation systems (i.e. Read More

View Article and Full-Text PDF

Do social support and community engagement act as mechanisms in the association between neighbourhood income inequality and the mental health of mothers in Calgary, Canada? A mediation analysis.

Health Place 2022 Jun 29;76:102851. Epub 2022 Jun 29.

School of Public Health, University of Alberta, Edmonton, 3-300 Edmonton Clinic Health Academy, 11405-87 Avenue NW, Edmonton, Alberta, T6G 1C9, Canada.

Purpose: According to the social determinants of health framework, income inequality is a potential risk factor for adverse mental health. However, few studies have explored the mechanisms suspected to mediate this relationship. The current study addresses this gap through a mediation analysis to determine if social support and community engagement act as mediators linking neighbourhood income inequality to maternal anxiety and depressive symptoms within a cohort of new mothers living in the City of Calgary, Canada. Read More

View Article and Full-Text PDF

Psychometric evaluation of the pregnancy-related anxiety questionnaire-revised 2 for Chinese pregnant women.

Midwifery 2022 Jun 25;112:103411. Epub 2022 Jun 25.

Nell Hodgson Woodruff School of Nursing, Emory University, Atlanta, GA 30322, United States.

Introduction: Pregnancy related anxiety (PrA) is a unique type of anxiety during pregnancy. PrA can affect both maternal and infant health, as well as pregnancy outcomes. The purpose of this study was to culturally translate the Pregnancy-Related Anxiety Questionnaire-Revised 2 (PRAQ-R2) into Chinese and evaluate its psychometric properties in Chinese women during pregnancy irrespective of parity. Read More

View Article and Full-Text PDF

Sleep disturbances and behavior in Smith-Magenis syndrome.

Res Dev Disabil 2022 Jun 29;128:104286. Epub 2022 Jun 29.

Department of Speech, Language and Hearing Sciences, São Paulo State University (UNESP), Marilia, SP, Brazil. Electronic address:

Background: The Smith-Magenis syndrome (SMS) shows a collection of neurodevelopmental problems including mild to moderate intellectual disability, change-related anxiety, impulsivity, speech delay, Attention-Deficit/Hyperactivity Disorder (ADH) and sleep disturbances. Sleep disorders, when present, have been treated in several populations with consecutive improvements in cognitive and behavioral aspects.

Aims: To better understand the existing relationships between sleep disturbances and behavioral problems in SMS syndrome this study describes the sleep and behavior problems in the SMS and explores the possible relation between both. Read More

View Article and Full-Text PDF

Stakeholder views on mindfulness for youth at risk for psychosis.

Int J Ment Health Nurs 2022 Jul 2. Epub 2022 Jul 2.

School of Psychology, Deakin University, Geelong, Victoria, Australia.

Interventions incorporating mindfulness for youth identified to be at risk for psychosis show promise for symptom management yet to be addressed by other approaches. Important questions remain as to how to safely and effectively implement these interventions with this cohort. The aim of this research was to collaboratively identify with stakeholders of such interventions, namely youth at risk for psychosis, and practitioners with experience working with youth at risk for psychosis - attitudes towards mindfulness and potential intervention adaptations to ensure the safety, uptake, and effectiveness of mindfulness interventions used with youth at risk for psychosis. Read More

View Article and Full-Text PDF

Psychological complications in patients with acromegaly: relationships with sex, arthropathy, and quality of life.

Endocrine 2022 Jul 2. Epub 2022 Jul 2.

Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy.

Purpose: Current treatment of acromegaly restores a normal life expectancy in most cases. So, the study of persistent complications affecting patients' quality of life (QoL) is of paramount importance, especially motor disability and depression. In a large cohort of acromegalic patients we aimed at establishing the prevalence of depression, to look for clinical and sociodemographic factors associated with it, and to investigate the respective roles (and interactions) of depression and arthropathy in influencing QoL. Read More

View Article and Full-Text PDF

Apparent autistic traits in transgender people: a prospective study of the impact of gender-affirming hormonal treatment.

J Endocrinol Invest 2022 Jul 2. Epub 2022 Jul 2.

Andrology, Women's Endocrinology and Gender Incongruence Unit, Careggi University Hospital, Florence University Hospital, Florence, Italy.

Purpose: We evaluated differences in Autism Spectrum Quotient (AQ) scores between a sample of hormone-naïve transgender and cisgender people and the impact of gender-affirming hormonal treatment (GAHT) on AQ scores across time. Furthermore, we assessed alexithymia and social anxiety as possible mediators of changes in AQ scores.

Methods: A cross-sectional comparison between cisgender and transgender people before GAHT and a prospective study on the effects of GAHT over time were performed. Read More

View Article and Full-Text PDF

Exposure and Response Prevention in Virtual Reality for Patients with Contamination-Related Obsessive-Compulsive Disorder: a Case Series.

Psychiatr Q 2022 Jul 2. Epub 2022 Jul 2.

Department of Psychiatry and Psychotherapy, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246, Hamburg, Germany.

Exposure therapy in virtual reality is successful in treating anxiety disorders. Studies on exposure and response prevention in virtual reality (VERP) in obsessive-compulsive disorder (OCD) are rare, and it is unclear whether distress associated with other emotions than anxiety (e.g. Read More

View Article and Full-Text PDF

Less stress, better success: a scoping review on the effects of anxiety on anesthetic and analgesic consumption.

J Anesth 2022 Jul 2. Epub 2022 Jul 2.

Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School, 75 Francis St, L1,, Boston, MA, 02115, United States of America.

Preoperative anxiety has an incidence of 11-80% in patients undergoing surgical or interventional procedures. Understanding the role of preoperative anxiety on intraoperative anesthetic requirements and postoperative analgesic consumption would allow personalized anesthesia care. Over- or under-anesthetizing patients can lead to complications such as postoperative cognitive dysfunction in elderly patients, or procedural discomfort, respectively. Read More

View Article and Full-Text PDF

Heterogeneity in Mental Health Change During the COVID-19 Pandemic in Germany: The Role of Social Factors.

Stress Health 2022 Jul 2. Epub 2022 Jul 2.

Department of Psychology, Saarland University, Campus A2 4, 66123, Saarbrücken, Germany.

The COVID-19 pandemic constitutes a prolonged global crisis, but its effects on mental health seem inconsistent. This inconsistency highlights the importance of considering the differential impact of the pandemic on individuals. There is some evidence that mental health trajectories are heterogeneous and that both sociodemographic and personal characteristics are associated with higher risk for mental health issues. Read More

View Article and Full-Text PDF

Understanding interpersonal guilt: Associations with attachment, altruism, and personality pathology.

Scand J Psychol 2022 Jul 1. Epub 2022 Jul 1.

Department of Psychiatry, University of British Columbia, Vancouver, Canada.

The aim of this article is to empirically investigate the relationships among interpersonal guilt, as conceived within control-mastery theory (CMT), and attachment, altruism, and personality pathology in an English-speaking sample. An online sample of 393 participants was recruited to complete the Interpersonal Guilt Rating Scale self-report version-15 (IGRS-15s), together with other empirically validated measures for the assessment of attachment, altruism, and personality pathology. On the basis of previous studies conducted in Italian-speaking samples, we hypothesized that survivor guilt, separation/disloyalty guilt, and omnipotent responsibility guilt would be associated with attachment anxiety and avoidance, altruism, and personality pathology; self-hate was hypothesized to be associated only with attachment anxiety and avoidance and personality pathology. Read More

View Article and Full-Text PDF

Adverse childhood experiences in patients with severe health anxiety: No evidence for an increased frequency compared to patients with obsessive-compulsive disorder.

Scand J Psychol 2022 Jul 1. Epub 2022 Jul 1.

Research Clinic for Functional Disorders, Aarhus University Hospital, Aarhus, Denmark.

Theoretical models of health anxiety emphasize adverse childhood experiences in the development of the disorder, but few studies examine such events in patients with severe health anxiety and the results are difficult to compare across studies. The present study examined adult retrospective reports of illness-related and traumatic childhood experiences in 31 patients with severe health anxiety, 32 non-clinical control participants, and a clinical control group of 33 patients with obsessive-compulsive disorder. No evidence of an increased frequency of adverse childhood experiences in patients with severe health anxiety was found. Read More

View Article and Full-Text PDF

Effect of intermittent access to alcohol mixed in energy drink during adolescence on alcohol self-administration, anxiety, and memory during adulthood in rats.

Alcohol Clin Exp Res 2022 Jul 1. Epub 2022 Jul 1.

Oakland University, Dept. of Psychology, Rochester, MI, USA.

Background: Mixing alcohol with caffeinated energy drinks is a common practice among young people. Consumption of alcohol mixed in energy drink is associated with increased risk of binge drinking and alcohol dependence. The purpose of this study was to determine if voluntary intermittent access to alcohol mixed in energy drink in adolescent rats alters adult self-administration of alcohol, anxiety and memory. Read More

View Article and Full-Text PDF

Associations between comorbidities and annual incidence plus frequency of asthma exacerbation hospitalisation during the past year: data from CARN study.

BMC Pulm Med 2022 Jul 1;22(1):261. Epub 2022 Jul 1.

Department of Respiration, Hainan General Hospital, Haikou, China.

Purpose: While asthma comorbidities are associated with higher health care utilisation, lower quality of life and poorer asthma control, the impact of asthma comorbidities on hospitalisation for asthma exacerbation (H-AX) remains less recognised. We aim to analyse the impact of asthma comorbidities on H-AX.

Methods: Based on a national survey on asthma control and disease perception (CARN 2015 study), we analysed the impact of comorbidities on annual incidence and frequency of H-AX in China. Read More

View Article and Full-Text PDF

Disaster response among hospital nurses dispatched to evacuation centers after the Great East Japan Earthquake: a thematic analysis.

BMC Health Serv Res 2022 Jul 1;22(1):848. Epub 2022 Jul 1.

Department of Radiation Health Management, Fukushima Medical University School of Medicine, Fukushima, Japan.

Background: Disaster relief operations involve a variety of components of healthcare efforts. The post-disaster recovery is a key component of hospital preparedness. This study aimed to investigate the role of hospital nurses in the disaster area and their challenges during the relief efforts after the Great East Japan Earthquake in 2011. Read More

View Article and Full-Text PDF

Hybrid Delivery of Mindfulness Meditation and Perceived Stress in Pediatric Resident Physicians: A Randomized Clinical Trial of In-Person and Digital Mindfulness Meditation.

J Clin Psychol Med Settings 2022 Jul 1. Epub 2022 Jul 1.

Department of Psychiatry & Biobehavioral Sciences, David Geffen School of Medicine at UCLA, 760 Westwood Plaza, Semel 48-241, Los Angeles, CA, 90024-1759, USA.

Physicians are experiencing epidemic levels of work-related stress and burnout. Determine efficacy of mindfulness meditation delivered as a hybrid (in-person and digital) format to reduce perceived stress in pediatric residents. Pediatric residents (n = 66) were block randomized to a hybrid Mindful Awareness Practices (MAPs) intervention, comprised of one in-person 60-min session and 6-week access to a digitally delivered MAPs curriculum (n = 27) or wait-list control (n = 39). Read More

View Article and Full-Text PDF

Familiarity modulates both intra- and interspecific yawn contagion in red-capped mangabeys.

Sci Rep 2022 Jul 1;12(1):11138. Epub 2022 Jul 1.

Department of Biology, University of Pisa, Via A. Volta 6, 56126, Pisa, Italy.

Yawn contagion (YC) is, compared to spontaneous yawning, an evolutionary recent phenomenon probably linked to behavioral synchronization in highly social species that is more likely when it involves familiar subjects. Here, we investigate for the first time in monkeys which factors modulate intra- and interspecific YC. Through an experimental approach, we exposed 17 red-capped mangabeys to video stimuli (Yawn vs Control) depicting familiar/unfamiliar red-capped mangabeys and humans, and unfamiliar hamadryas. Read More

View Article and Full-Text PDF

Impact of COVID-19 emergency on the psychological well-being of susceptible individuals.

Sci Rep 2022 Jul 1;12(1):11152. Epub 2022 Jul 1.

Department of Public Health, Section of Occupational Medicine, University of Naples Federico II, Naples, Italy.

The current pandemic has exerted an unprecedented psychological impact on the world population, and its effects on mental health are a growing concern. The present study aims to evaluate psychological well-being (PWB) during the COVID-19 crisis in university workers with one or more diseases likely to increase the risk of severe outcomes in the event of SARS-CoV-2 infection, defined as susceptible. 210 susceptible employees of an Italian University (aged 25-71 years) were recruited during the COVID-19 second wave (October-December 2020). Read More

View Article and Full-Text PDF

Mapping Research Domain Criteria using a transdiagnostic mini-RDoC assessment in mental disorders: a confirmatory factor analysis.

Eur Arch Psychiatry Clin Neurosci 2022 Jul 1. Epub 2022 Jul 1.

Social and Preventive Medicine, Department of Sports and Health Sciences, University of Potsdam, Am Neuen Palais 10, 14469, Potsdam, Germany.

This study aimed to build on the relationship of well-established self-report and behavioral assessments to the latent constructs positive (PVS) and negative valence systems (NVS), cognitive systems (CS), and social processes (SP) of the Research Domain Criteria (RDoC) framework in a large transnosological population which cuts across DSM/ICD-10 disorder criteria categories. One thousand four hundred and thirty one participants (42.1% suffering from anxiety/fear-related, 18. Read More

View Article and Full-Text PDF

The relationship between osteoporosis and depression.

Sci Rep 2022 Jul 1;12(1):11177. Epub 2022 Jul 1.

Nutrition Research Center, Department of Public Health, School of Health, Shiraz University of Medical Sciences, Shiraz, Iran.

Osteoporosis is the most common metabolic bone disease. The complications of osteoporosis have influence on people's lives and lead to anxiety and depression. The aim of this study was to determine the relationship between osteoporosis and depression among Iranian patients. Read More

View Article and Full-Text PDF

The impact of the COVID-19 pandemic on well-being of seniors attending online programs at University of the Third Age: a follow-up study.

Psychogeriatrics 2022 Jul 1. Epub 2022 Jul 1.

Division of Geriatrics, Department of Internal Medicine, Faculty of Medicine, Ege University, Izmir, Turkey.

Background: Reports on psychological effects of quarantine during past outbreaks and pandemics showed that quarantined people were more likely to experience psychological problems than those who were not. It was also shown that there was an increase in anxiety, depression, and stress in all age groups during the COVID-19 pandemic. So, we investigated emotional states and quality of life as components of general well-being in older participants of University of the Third Age (U3A) attending online programs during the second year of the pandemic, and compared them with the pre-pandemic COVID-19 period. Read More

View Article and Full-Text PDF

Childhood Adversity among Adults with Chronic Pain: Prevalence and Association with Pain-Related Outcomes.

Clin J Pain 2022 Jul 1. Epub 2022 Jul 1.

Mary Free Bed Rehabilitation Hospital, 235 Wealthy St. SE, Grand Rapids, MI 49503.

Objectives: Adverse childhood experiences (ACEs) have been linked to the development and impact of chronic pain in adulthood. The goal of this study was to investigate the prevalence of ACEs in a treatment-seeking sample of adults with chronic pain and the relationship between number and type(s) of ACEs and pain-related outcomes.

Methods: Adults (N=1794) presenting for treatment at a multidisciplinary pain management center completed self-report measures of childhood adversity, pain, functioning, emotional distress, and adjustment to pain. Read More

View Article and Full-Text PDF

Feedback of aggregate patient-reported outcomes (PROs) data to clinicians and hospital end users: findings from an Australian codesign workshop process.

BMJ Open 2022 Jul 1;12(7):e055999. Epub 2022 Jul 1.

Public Health: Stroke Division, Florey Institute of Neuroscience and Mental Health-Austin Campus, Heidelberg, Victoria, Australia

Objectives: Patient-reported outcomes (PROs) are increasingly used to measure the patient's perspective of their outcomes following healthcare interventions. The aim of this study was to determine the preferred formats for reporting service-level PROs data to clinicians, researchers and managers to support greater utility of these data to improve healthcare and patient outcomes.

Setting: Healthcare professionals receiving PRO data feedback at the health service level. Read More

View Article and Full-Text PDF