Immunity 2021 May 5. Epub 2021 May 5.
Division of Gastroenterology, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA; Program in Immunology, Harvard Medical School, Longwood Avenue, Boston, MA, USA. Electronic address:
Two sets of innate immune proteins detect pathogens. Pattern recognition receptors (PRRs) bind microbial products, whereas guard proteins detect virulence factor activities by the surveillance of homeostatic processes within cells. While PRRs are well known for their roles in many types of infections, the role of guard proteins in most infectious contexts remains less understood. Read More