158,087 results match your criteria antitumor


Adoptive T-cell immunotherapy in digestive tract malignancies: Current challenges and future perspectives.

Cancer Treat Rev 2021 Sep 4;100:102288. Epub 2021 Sep 4.

Department of Biomedical Sciences and Human Oncology, University of Bari "Aldo Moro", 70124 Bari, Italy.

Multiple systemic treatments are currently available for advanced cancers of the digestive tract, but none of them is curative. Adoptive T-cell immunotherapy refers to the extraction, modification and re-infusion of autologous or allogenic T lymphocytes for therapeutic purposes. A number of clinical trials have investigated either non-engineered T cells (i. Read More

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September 2021

Harnessing features of adaptive NK cells to generate iPSC-derived NK cells for enhanced immunotherapy.

Cell Stem Cell 2021 Sep 9. Epub 2021 Sep 9.

University of Minnesota, Department of Medicine, Minneapolis, MN 55455, USA. Electronic address:

Select subsets of immune effector cells have the greatest propensity to mediate antitumor responses. However, procuring these subsets is challenging, and cell-based immunotherapy is hampered by limited effector-cell persistence and lack of on-demand availability. To address these limitations, we generated a triple-gene-edited induced pluripotent stem cell (iPSC). Read More

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September 2021

Synergistic PIM kinase and proteasome inhibition as a therapeutic strategy for MYC-overexpressing triple-negative breast cancer.

Cell Chem Biol 2021 Sep 8. Epub 2021 Sep 8.

Department of Pharmacology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA; Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL 60611, USA. Electronic address:

Triple-negative breast cancer (TNBC) is the breast cancer subtype with the poorest clinical outcome. The PIM family of kinases has emerged as a factor that is both overexpressed in TNBC and associated with poor outcomes. Preclinical data suggest that TNBC with an elevated MYC expression is sensitive to PIM inhibition. Read More

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September 2021

Selenium inhibits growth of trastuzumab-resistant human breast cancer cells via downregulation of Akt and beclin-1.

PLoS One 2021 15;16(9):e0257298. Epub 2021 Sep 15.

Department of Surgery, Ewha Womans University College of Medicine, Seoul, South Korea.

The response rate to treatment with trastuzumab (Tz), a recombinant humanized anti-HER2 monoclonal antibody, is only 12-34% despite demonstrated effectiveness on improving the survival of patients with HER2-positive breast cancers. Selenium has an antitumor effect against cancer cells and can play a cytoprotective role on normal cells. This study investigated the effect of selenium on HER2-positive breast cancer cells and the mechanism in relation to the response of the cells to Tz. Read More

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September 2021

TIPE2 is a checkpoint of natural killer cell maturation and antitumor immunity.

Sci Adv 2021 Sep 15;7(38):eabi6515. Epub 2021 Sep 15.

Hefei National Laboratory for Physical Sciences at Microscale, The CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Basic Medical Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230027, China.

[Figure: see text]. Read More

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September 2021

Redirecting iNKT Cell Antitumor Immunity with α-GalCer/CD1d-scFv Fusion Proteins.

Methods Mol Biol 2021 ;2388:175-180

Translational Tumor Immunology Group, Ludwig Cancer Research, University of Lausanne, Epalinges, Switzerland.

Invariant natural killer T (iNKT) cells display important properties that could bridge the innate and adaptive immunity, and they have been shown to play key roles in cancer immunotherapy. However, administration of iNKT cell agonist αGalCer fails to induce sustained antitumor immunity due to the rapid anergy induction after an initial strong activation. To this end, we have designed a recombinant CD1d protein that is fused to an anti-TAA scFv, which is able to recruit iNKT cells to the tumor site and induce tumor regression. Read More

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January 2021

Expansion of Human iNKT Cells Ex Vivo.

Methods Mol Biol 2021 ;2388:123-129

Shanghai Public Health Clinical Center Affiliated to Fudan University, Shanghai, China.

Invariant natural killer T (iNKT) cells are credited with antitumor activity by preclinical studies and clinical trials. Efficient expansion of iNKT cells ex vivo is essential for their translational usage. The culturing procedure described here provides an optimized method for ex vivo expansion of iNKT cells using recombinant human IL-15 (rhIL-15) and recombinant human IL-12 (rhIL-12), which results in cell products with enhanced cytokine secretion and cytotoxicity while maintaining the purity and viability of iNKT cells. Read More

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January 2021

Recent Advances on Bioactive Ingredients of Morchella esculenta.

Appl Biochem Biotechnol 2021 Sep 15. Epub 2021 Sep 15.

Engineering Research Center of Bio-Process, School of Food and Biological Engineering, Hefei University of Technology, Hefei, 230009, Anhui, China.

Morchella esculenta (M. esculenta) is a delicious edible mushroom prized for its special flavor and strong health promoting abilities. Several bioactive ingredients including polysaccharides, polyphenolic compounds, proteins, and protein hydrolysates all contribute to the biological activities of M. Read More

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September 2021

hydrogen nanogenerator for bimodal imaging guided synergistic photothermal/hydrogen therapies.

Nanoscale 2021 Sep 15. Epub 2021 Sep 15.

Department of Chemistry, College of Chemistry and Materials Science, Jinan University, Guangzhou 510632, China.

Multifunctional nanoagents integrating multiple therapeutic and imaging functions hold promise in the field of non-invasive and precise tumor therapies. However, the complex preparation process and uncertain drug metabolism of nanoagents loaded with various therapeutic agents or imaging agents greatly hinder its clinical applications. Developing simple and effective nanoagents that integrate multiple therapeutic and imaging functions remain a huge challenge. Read More

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September 2021

Enzyme-responsive micellar JQ1 induces enhanced BET protein inhibition and immunotherapy of malignant tumors.

Biomater Sci 2021 Sep 15. Epub 2021 Sep 15.

Biomedical Polymers Laboratory, College of Chemistry, Chemical Engineering and Materials Science, and State Key Laboratory of Radiation Medicine and Protection, Soochow University, Suzhou 215123, China.

Bromodomain and extra-terminal (BET) proteins are attractive targets for treating various malignancies including melanoma. The inhibition of BET bromodomains, with JQ1, is found to downregulate the expression of both c-MYC oncoprotein and programmed cell death ligand 1 (PD-L1), which play a crucial role in tumor growth and the immunosuppressive tumor microenvironment, respectively. The BET bromodomain inhibitors like JQ1 though exhibiting high selectivity and affinity show usually low bioavailability and efficacy due to fast clearance and inferior uptake by tumor cells. Read More

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September 2021

Downregulation of miR-487a-3p suppresses the progression of non-small cell lung cancer via targeting Smad7.

Drug Dev Res 2021 Sep 15. Epub 2021 Sep 15.

Department of Thoracic Surgery, Ningbo Zhenhai People's Hospital, Ningbo, Zhejiang, China.

Non-small cell lung cancer (NSCLC) is the most prevalent type of lung cancer; however, the treatment efficacy of advanced NSCLC remains poor. MicroRNAs (miRNAs) are closely associated with the pathogenesis of lung cancer, while the detailed function of miR-487a-3p in NSCLC remains unclear. Bioinformatic analysis was performed to identify differentially expressed miRNAs (DEmiRNAs) between NSCLC and normal tissues. Read More

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September 2021

Tireless surveillance by exhausted T cells.

Authors:
Michael L Dustin

J Clin Invest 2021 Sep;131(18)

T cell exhaustion is an evocative concept that results in attenuated function in the face of chronic antigen exposure and is critical to avoid immunopathology. However, tumors often exploit this dampened T cell function to escape the antitumor immune response. In this issue of the JCI, You et al. Read More

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September 2021

3D Printing of Black Bioceramic Scaffolds with Micro/Nanostructure for Bone Tumor-Induced Tissue Therapy.

Adv Healthc Mater 2021 Sep 15:e2101181. Epub 2021 Sep 15.

State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050, P. R. China.

It is common to improve the relevant performance in the field of energy storage materials or catalytic materials by regulating the number of defects. However, there are few studies on the biomaterials containing defects for tissue engineering. Herein, a new type of defect-rich scaffolds, black akermanite (B-AKT) bioceramic scaffolds with micro/nanostructure, the thickness of which is from 0. Read More

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September 2021

Phase I/II study of biweekly nab-paclitaxel in patients with platinum-pretreated non-small cell lung cancer: NJLCG1402.

Thorac Cancer 2021 Sep 14. Epub 2021 Sep 14.

Department of Palliative Medicine, Tohoku University School of Medicine, Sendai, Japan.

Background: NJLCG1402 was a phase I/II trial investigating biweekly nanoparticle albumin-bound paclitaxel (nab-PTX) in patients with advanced non-small cell lung cancer (NSCLC).

Methods: The study included patients aged ≥20 years with previously treated NSCLC. Nab-PTX (100-150 mg/m ) was administered biweekly in a 28-day cycle. Read More

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September 2021

Magnetic systems for cancer immunotherapy.

Acta Pharm Sin B 2021 Aug 30;11(8):2172-2196. Epub 2021 Apr 30.

Department of Chemical & Biological Engineering, University of Colorado, Boulder, CO 80303, USA.

Immunotherapy is a rapidly developing area of cancer treatment due to its higher specificity and potential for greater efficacy than traditional therapies. Immune cell modulation through the administration of drugs, proteins, and cells can enhance antitumoral responses through pathways that may be otherwise inhibited in the presence of immunosuppressive tumors. Magnetic systems offer several advantages for improving the performance of immunotherapies, including increased spatiotemporal control over transport, release, and dosing of immunomodulatory drugs within the body, resulting in reduced off-target effects and improved efficacy. Read More

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PRMT5 disruption drives antitumor immunity in cervical cancer by reprogramming T cell-mediated response and regulating PD-L1 expression.

Theranostics 2021 28;11(18):9162-9176. Epub 2021 Aug 28.

Shanghai Institute of Immunology, Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.

: Protein arginine methyltransferase 5 (PRMT5) is an oncogene that promotes tumor cell proliferation, invasion and metastasis. However, the underlying mechanisms by which PRMT5 contributes to the progression of cervical cancer and especially the tumor microenvironment remain poorly understood. : PRMT5 expression level was analyzed by Q-PCR, western blot, immunohistochemistry, and TCGA database. Read More

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Synthesis of precision antibody conjugates using proximity-induced chemistry.

Theranostics 2021 27;11(18):9107-9117. Epub 2021 Aug 27.

Department of Chemistry, Rice University, 6100 Main Street, Houston, Texas, 77005, USA.

Therapeutic antibody conjugates allow for the specific delivery of cytotoxic agents or immune cells to tumors, thus enhancing the antitumor activity of these agents and minimizing adverse systemic effects. Most current antibody conjugates are prepared by nonspecific modification of antibody cysteine or lysine residues, inevitably resulting in the generation of heterogeneous conjugates with limited therapeutic efficacies. Traditional strategies to prepare homogeneous antibody conjugates require antibody engineering or chemical/enzymatic treatments, processes that often affect antibody folding and stability, as well as yield and cost. Read More

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PLK1 Inhibition Induces Immunogenic Cell Death and Enhances Immunity against NSCLC.

Int J Med Sci 2021 19;18(15):3516-3525. Epub 2021 Aug 19.

Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, P. R. China.

PLK1 inhibitors were shown, and to possess inhibitory activities against non-small cell lung cancer (NSCLC), and such inhibition has been proven by clinical trials. However, it remains unclear whether and how the immune microenvironment is associated with the action. In this study, we found that inhibiting PLK1 could alter the tumor immune microenvironment by increasing DC maturation, and enriching T cells infiltration. Read More

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The combination therapy with EpCAM/CD3 BsAb and MUC-1/CD3 BsAb elicited antitumor immunity by T-cell adoptive immunotherapy in lung cancer.

Int J Med Sci 2021 31;18(15):3380-3388. Epub 2021 Jul 31.

Shenzhen key laboratory of stem cell research and clinical transformation, Guangdong Engineering Technology Research Center of Stem cell and Cell therapy, Translational Medicine Collaborative Innovation Center, The Second Clinical Medical College (Shenzhen People's Hospital), Jinan University, Shenzhen 518020, China.

Lung cancer remains a global challenge due to high morbidity and mortality rates and poor response to treatment, and there are still no effective strategies to solve it. The bispecific antibody (BsAb) is a novel antibody, which can target two different antigens and mediate specific killing effects by selectively redirecting effector cells to the target cells. In this study, we combined two BsAbs to achieve a dual-target therapy strategy of EpCAM and MUC-1 with high affinity and specificity. Read More

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A CLDN18.2-Targeting Bispecific T Cell Co-Stimulatory Activator for Cancer Immunotherapy.

Cancer Manag Res 2021 7;13:6977-6987. Epub 2021 Sep 7.

Sheng Yushou Center of Cell Biology and Immunology, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, 200240, People's Republic of China.

Background: Co-stimulatory receptor agonist antibodies have shown promising antitumor efficacy in preclinical models. However, their clinical development lags due to systemic or local adverse effects of non-specific T cell activation. Utilization of a bispecific antibody format to reduce off-tumor immune activation is a focus of co-stimulatory receptor agonist antibody design. Read More

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September 2021

[Gut Microbiota and Tumor Immune Microenvironment].

Gan To Kagaku Ryoho 2021 Sep;48(9):1103-1108

Dept. of Clinical Immuno-Oncology, Clinical Research Institute of Clinical Pharmacology and Therapeutics, Showa University.

Gut microbiota plays a major role in the cancer microenvironment associated with immune checkpoint blockade. Recent developments in gut microbiota research have benefited from technological innovations by next-generation sequencers, and the research has exploded. Therefore, we considered gut microbiota from the viewpoint of antitumor and adverse events of immune checkpoint inhibitors. Read More

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September 2021

[Association between Immunotherapy with Immune Checkpoint Inhibitors(Anti-PD-1 Antibodies)and Intestinal Microbiota].

Gan To Kagaku Ryoho 2021 Sep;48(9):1096-1099

Dept. of Chest Surgery, Fukushima Medical University.

Immune checkpoint inhibitors(ICIs)are playing an increasingly important role in the treatment of cancer. In the field of lung cancer, ICIs are widely administered from primary therapy to maintenance therapy after chemoradiation for non-small cell lung cancer. However, excluding tumor proportion score(TPS)for PD-L1, no other biomarker has been reported to be clinically useful. Read More

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September 2021

Lurbinectedin versus pegylated liposomal doxorubicin or topotecan in patients with platinum-resistant ovarian cancer: A multicenter, randomized, controlled, open-label phase 3 study (CORAIL).

Gynecol Oncol 2021 Sep 11. Epub 2021 Sep 11.

Fondazione IRCCS - Istituto Nazionale dei Tumori, Milano, and Fondazione Policlinico Gemelli IRCCS, Rome, Italy.

Objective: The randomized phase 3 CORAIL trial evaluated whether lurbinectedin improved progression-free survival (PFS) compared to pegylated liposomal doxorubicin (PLD) or topotecan in patients with platinum-resistant ovarian cancer.

Methods: Patients were randomly assigned (1:1) to lurbinectedin 3.2 mg/m 1-h i. Read More

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September 2021

New insights into neuropeptides regulation of immune system and hemopoiesis: effects on hematologic malignancies.

Curr Med Chem 2021 Sep 14. Epub 2021 Sep 14.

Department of Chemical, Biological, Pharmaceutical and Environmental Chemistry, University of Messina. Italy.

Several neurotransmitters and neuropeptides were reported to join to or to cooperate with different cells of the immune system, bone marrow, and peripheral cells and numerous data support that neuroactive molecules might control immune system activity and hemopoiesis operating on lymphoid organs, and the primary hematopoietic unit, the hematopoietic niche. Furthermore, many compounds seem to be able to take part to the leukemogenesis and lymphomagenesis process, and in the onset of multiple myeloma. In this review, we will assess the possibility that neurotransmitters and neuropeptides may have a role in the onset of haematological neoplasms, may affect the response to treatment or may represent a useful starting point for a new therapeutic approach. Read More

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September 2021

Toosendanin Shows Potent Efficacy Against Human Ovarian Cancer through Caspase-Dependent Mitochondrial Apoptotic Pathway.

Am J Chin Med 2021 Sep 11:1-16. Epub 2021 Sep 11.

Department of Traditional Chinese and Western Medicine, Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou, Henan, P. R. China.

Toosendanin (TSN) is a triterpenoid extracted from the bark or fruits of Sieb et Zucc, which is a traditional Chinese medicine and mainly grows in China and India. TSN has been verified to possess antitumor activities on various human cancers, whereas the effects of TSN on ovarian cancer (OC) has not been reported yet. Here, TSN was shown to significantly inhibit proliferation of SKOV3 and OVCAR3 cell lines in a dose- and time-dependent manner. Read More

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September 2021

The intratumoural microbiota in cancer: new insights from inside.

Biochim Biophys Acta Rev Cancer 2021 Sep 11:188626. Epub 2021 Sep 11.

Department of Gastroenterology and Hepatology, General Hospital, Tianjin Medical University, Tianjin Institute of Digestive Diseases, Tianjin Key Laboratory of Digestive Diseases, Tianjin, China. Electronic address:

The human body harbors a vast array of microbiota that modulates host pathophysiological processes and modifies the risk of diseases including cancer. With the advent of metagenomic sequencing studies, the intratumoural microbiota has been found as a component of the tumor microenvironment, imperceptibly affecting the tumor progression and response to current antitumor treatments. The underlying carcinogenic mechanisms of intratumoural microbiota, mainly including inducing DNA damages, activating oncogenic signaling pathways and suppressing the immune response, differ significantly in varied organs and are not fully understood. Read More

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September 2021

Novel sulfonamide-chalcone hybrid stimulates inflammation, angiogenesis and upregulates vascular endothelial growth factor (VEGF) in vivo.

Microvasc Res 2021 Sep 11:104253. Epub 2021 Sep 11.

Laboratory of Radiobiology and Mutagenesis, Department of Genetics, Institute of Biological Sciences, Universidade Federal de Goiás, Goiânia, Brazil. Electronic address:

Chalcones and sulfonamides are well-known chemical groups associated with several biological activities such as antibiotic, anti-inflammatory, and antitumor activities. Over the past few decades, a series of sulfonamide-chalcone hybrids have been synthesized and assessed to develop compounds with interesting biological properties for application in disease therapy. In the present study, a new sulfonamide-chalcone hybrid μ - (2,5-dichloro-N-{4-[(3E)-4-(3-nitrophenyl) buta-1,3-dien-2-yl] phenyl} benzene sulfonamide), or simply CL185, was synthesized, and its angiogenic activity was assessed using the chick embryo chorioallantoic membrane (CAM) assay at different concentrations (12. Read More

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September 2021

Selenite induced breast cancer MCF7 cells apoptosis through endoplasmic reticulum stress and oxidative stress pathway.

Chem Biol Interact 2021 Sep 11:109651. Epub 2021 Sep 11.

Department of Nutrition, School of Public Health, Xuzhou Medical University, China. Electronic address:

Selenium is an essential trace element for human, and has anti-tumor effects. In this study, we investigated the anti-tumor activity of sodium selenite (NaSeO) and explored its possible mechanisms involved in a breast cancer cell line. We found that NaSeO could inhibit the cell viability of MCF7 cells, yet with minimal damage to human umbilical vein endothelial cells (HUVECs). Read More

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September 2021