9,242 results match your criteria antioxidative enzymes

A rice transcription factor, OsMADS57, positively regulates high salinity tolerance in transgenic Arabidopsis thaliana and Oryza sativa plants.

Physiol Plant 2021 Jul 20. Epub 2021 Jul 20.

Zhejiang Key Lab of Crop Germplasm, Department of Agronomy, College of Agriculture and Biotechnology, Zhejiang University, Hangzhou, China.

MADS-box transcription factors (TFs) play indispensable roles in various aspects of plant growth, development as well as in response to environmental stresses. Several MADS-box genes have been reported to be involved in the salt tolerance in different plant species. However, the role of the transcription factor OsMADS57 under salinity stress is still unknown. Read More

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White rice ethanol extract is qualitatively, but not quantitatively, equivalent to that of brown rice as an antioxidant source.

Biosci Biotechnol Biochem 2021 Jul 19. Epub 2021 Jul 19.

Graduate School of Environmental and Life Science, Okayama University, Okayama 700-8530, Japan.

The purpose of this study is to compare the potentials to exhibit biologically-active antioxidant actions between white rice (WR) and brown rice (BR) in in vitro assays and a cellular model. The Trolox equivalent (TE) per 1 mg ethanol extract of WR for the 1,1-diphenyl-2-picrylhydrazyl assay was slightly higher than that of BR, whereas the TE per 1 g whole WR was much lower than that for BR. This tendency was very comparable to those for the oxygen radical absorbance capacity and total polyphenol content. Read More

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Changes in Human Erythrocyte Exposed to Organophosphate Flame Retardants: Tris(2-chloroethyl) Phosphate and Tris(1-chloro-2-propyl) Phosphate.

Bożena Bukowska

Materials (Basel) 2021 Jul 1;14(13). Epub 2021 Jul 1.

Department of Biophysics of Environmental Pollution, Faculty of Biology and Environmental Protection, University of Lodz, Pomorska Str. 141/143, 90-236 Lodz, Poland.

Tris(2-chloroethyl) phosphate (TCEP) and tris(1-chloro-2-propyl) phosphate (TCPP) are the main representatives of organophosphate flame retardants (OPFRs). The exposure of humans to OPFRs present in air, water, and food leads to their occurrence in the circulation. Thus far, no report has been published about the influence of these retardants on non-nucleated cells like mature erythrocytes. Read More

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[Role and mechanism of low-dose lipopolysaccharide-treated human periodontal ligament stem cells on the expression of macrophage pro-inflammatory factors].

Zhonghua Kou Qiang Yi Xue Za Zhi 2021 Jul;56(7):672-678

Department of Periodontology, School of Stomatology, The Fourth Military Medical University & State Key Laboratory of Military Stomatology & National Clinical Research Center for Oral Diseases & Shaanxi Engineering Research Center for Dental Materials and Advanced Manufacture, Xi'an 710032, China.

To investigate the effect of low dose lipopolysaccharide (LPS)-treated human periodontal ligament stem cells (HPDLSC) on the expression of macrophage pro-inflammatory factors and the mechanism involved. The primary HPDLSCs were obtained from healthy third molar periodontal ligament tissue. Phosphate buffer saline (PBS), 100 μg/L or 10 mg/L of LPS were used to treat HPDLSCs for 48 h, and their conditioned media were respectively co-cultured with THP-1-derived macrophages for 48 h. Read More

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Photoinactivation of the oxygen-evolving complex regulates the photosynthetic strategy of the seagrass Zostera marina.

J Photochem Photobiol B 2021 Jul 14;222:112259. Epub 2021 Jul 14.

Ocean School, Yantai University, Yantai 264005, PR China.

Zostera marina, a widespread seagrass, evolved from a freshwater ancestor of terrestrial monocots and successfully transitioned into a completely submerged seagrass. We found that its oxygen-evolving complex (OEC) was partially inactivated in response to light exposure, as evidenced by both the increment of the relative variable fluorescence at the K-step and the downregulation of the OEC genes and proteins. This photosynthetic regulation was further addressed at both proteome and physiology levels by an in vivo study. Read More

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Self-cascade MoS nanozymes for efficient intracellular antioxidation and hepatic fibrosis therapy.

Nanoscale 2021 Jul 15. Epub 2021 Jul 15.

State Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection, School for Radiological and Interdisciplinary Sciences (RAD-X), Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Soochow University, Suzhou 215123, China. and Institute of Quantitative Biology, College of Life Sciences, Zhejiang University, Hangzhou 310058, China and Department of Chemistry, Columbia University, New York, NY 10027, USA.

Cascade biocatalytic reactions involving multiple antioxidative enzymes are necessary in living cells to regulate cellular metabolism and redox homeostasis. Substantial efforts have been made to construct cascade reactions through engineered enzyme mimics to improve intracellular metabolic flux, especially under pathophysiological conditions. Here, we show that MoS2 nanozymes exhibit activities of four major cellular cascade antioxidant enzymes, including superoxide dismutase, catalase, peroxidase, and glutathione peroxidase. Read More

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Exogenous melatonin-mediated regulation of K /Na transport, H -ATPase activity and enzymatic antioxidative defence operate through endogenous hydrogen sulphide signalling in NaCl-stressed tomato seedling roots.

Plant Biol (Stuttg) 2021 Jul 15. Epub 2021 Jul 15.

Department of Biology, Faculty of Science and Humanities, Quwayiyah, Shaqra University, Shaqra, Saudi Arabia.

Melatonin (Mel) and hydrogen sulphide (H S) have emerged as potential regulators of plant metabolism during abiotic stress. Presence of excess NaCl in the soil is one of the main causes of reduced crop productivity worldwide. The present investigation examines the role of exogenous Mel and endogenous H S in tomato seedlings grown under NaCl stress. Read More

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Soil applied glycine betaine with Arbuscular mycorrhizal fungi reduces chromium uptake and ameliorates chromium toxicity by suppressing the oxidative stress in three genetically different Sorghum (Sorghum bicolor L.) cultivars.

Praveen Kumar

BMC Plant Biol 2021 Jul 14;21(1):336. Epub 2021 Jul 14.

Department of Biochemistry, College of Basic Sciences and Humanities, Chaudhary Charan Singh Haryana Agricultural University, Hisar, Haryana, 125004, India.

Background: Chromium is the most toxic pollutant that negatively affects a plant's metabolic activities and yield. It reduces plant growth by influencing the antioxidant defence system's activities. In the present study, a completely randomized block design experiment with three plants/pot in three replication was conducted on three varieties of sorghum viz. Read More

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Antioxidant Therapy and Antioxidant-Related Bionanomaterials in Diabetic Wound Healing.

Front Bioeng Biotechnol 2021 24;9:707479. Epub 2021 Jun 24.

Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Ulcers are a lower-extremity complication of diabetes with high recurrence rates. Oxidative stress has been identified as a key factor in impaired diabetic wound healing. Hyperglycemia induces an accumulation of intracellular reactive oxygen species (ROS) and advanced glycation end products, activation of intracellular metabolic pathways, such as the polyol pathway, and PKC signaling leading to suppression of antioxidant enzymes and compounds. Read More

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Assessment of ozone toxicity on cotton (Gossypium hirsutum L.) cultivars: Its defensive system and intraspecific sensitivity.

Plant Physiol Biochem 2021 Jul 1;166:912-927. Epub 2021 Jul 1.

School of Environment and Sustainable Development, Central University of Gujarat-Gandhinagar, Gujarat, India. Electronic address:

Anthropogenic activities help the ozone formation at the troposphere which causes toxic effects on plants and humans. Ozone is a highly reactive gas that enters in plants through stomata and initiates the overproduction of ROS which causes oxidative stress in plants that lead to the destruction of membranal lipids, proteins, impaired the production of sugars and other metabolites and ultimately damage the cell. Presented study was conducted to assess the ozone toxicity on the biomass accumulation of cotton (Gossypium hirsutum L. Read More

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The growth of plants and indigenous bacterial community were significantly affected by cadmium contamination in soil-plant system.

AMB Express 2021 Jul 10;11(1):103. Epub 2021 Jul 10.

School of Life Sciences, Hunan University of Science and Technology, Xiangtan, 411201, People's Republic of China.

Concentrations of heavy metals continue to increase in soil environments as a result of both anthropogenic activities and natural processes. Cadmium (Cd) is one of the most toxic heavy metals and poses health risks to both humans and the ecosystem. Herein, we explore the impacts of Cd on a soil-plant system composed of oilseed rapes (Brassica napus and Brassica juncea) and bacteria. Read More

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Putative abrogation impacts of Ajwa seeds on oxidative damage, liver dysfunction and associated complications in rats exposed to carbon tetrachloride.

Mol Biol Rep 2021 Jul 9. Epub 2021 Jul 9.

Biological Applications Department, Nuclear Research Center, Egyptian Atomic Energy Authority, Abu-Zaabal, 13759, Egypt.

Background: Industrial toxicants such as Carbon tetrachloride (CCl) are known to disrupt the oxidative-antioxidative balance, which generates excessive amounts of free radicals leading to chronic or acute liver damage. Natural antioxidants, including Ajwa, play an important role in protecting against hepatotoxicity.

Methods And Results: This study investigated the prophylactic impacts of ajwa seeds aqueous extract (ASE) against hepatic oxidative injury in rats induced by CCl. Read More

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Herbicides Tolerance in a Strain Is Associated With Metabolic Plasticity of Antioxidative Enzymes Regardless of Selection.

Front Microbiol 2021 22;12:673211. Epub 2021 Jun 22.

Laboratory of Environmental Microbiology, Biological and Health Sciences Sector, Department of Structural and Molecular Biology and Genetics, State University of Ponta Grossa, Ponta Grossa, Brazil.

Agriculture uses many food production chains, and herbicides participate in this process by eliminating weeds through different biochemical strategies. However, herbicides can affect non-target organisms such as bacteria, which can suffer damage if there is no efficient control of reactive oxygen species. It is not clear, according to the literature, whether the efficiency of this control needs to be selected by the presence of xenobiotics. Read More

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Sex differences in oxidative stress level and antioxidative enzymes expression and activity in obese pre-diabetic elderly rats treated with metformin or liraglutide.

Croat Med J 2021 Jun;62(3):215-226

Ines Drenjančević, Institute and Department of Physiology and Immunology, Faculty of Medicine University Josip Juraj Strossmayer of Osijek, J. Huttlera 4, 31 000 Osijek, Croatia,

Aim: To determine the effects of metformin or liraglutide on oxidative stress level and antioxidative enzymes gene expression and activity in the blood and vessels of pre-diabetic obese elderly Sprague-Dawley (SD) rats of both sexes.

Methods: Male and female SD rats were assigned to the following groups: a) control group (fed with standard rodent chow); b) high-fat and high-carbohydrate diet (HSHFD) group fed with HSHFD from 20-65 weeks of age; c) HSHFD+metformin treatment (50 mg/kg/d s.c. Read More

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Current Perspectives on the Beneficial Effects of Soybean Isoflavones and Their Metabolites for Humans.

Il-Sup Kim

Antioxidants (Basel) 2021 Jun 30;10(7). Epub 2021 Jun 30.

Advanced Bio-Resource Research Center, Kyungpook National University, Daegu 41566, Korea.

Soybeans are rich in proteins and lipids and have become a staple part of the human diet. Besides their nutritional excellence, they have also been shown to contain various functional components, including isoflavones, and have consequently received increasing attention as a functional food item. Isoflavones are structurally similar to 17-β-estradiol and bind to estrogen receptors (ERα and ERβ). Read More

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Isookanin Inhibits PGE-Mediated Angiogenesis by Inducing Cell Arrest through Inhibiting the Phosphorylation of ERK1/2 and CREB in HMEC-1 Cells.

Int J Mol Sci 2021 Jun 16;22(12). Epub 2021 Jun 16.

Biospectrum Life Science Institute, Yongin 16827, Korea.

Inflammation is increasingly recognized as a critical mediator of angiogenesis, and unregulated angiogenic responses often involve human diseases. The importance of regulating angiogenesis in inflammatory diseases has been demonstrated through some successful cases of anti-angiogenesis therapies in related diseases, including arthritis, but it has been reported that some synthetic types of antiangiogenic drugs have potential side effects. In recent years, the importance of finding alternative strategies for regulating angiogenesis has begun to attract the attention of researchers. Read More

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Anakinra Activates Superoxide Dismutase 2 to Mitigate Inflammasome Activity.

Int J Mol Sci 2021 Jun 18;22(12). Epub 2021 Jun 18.

Department of Medicine and Surgery, University of Perugia, 06132 Perugia, Italy.

Inflammasomes are powerful cytosolic sensors of environmental stressors and are critical for triggering interleukin-1 (IL-1)-mediated inflammatory responses. However, dysregulation of inflammasome activation may lead to pathological conditions, and the identification of negative regulators for therapeutic purposes is increasingly being recognized. Anakinra, the recombinant form of the IL-1 receptor antagonist, proved effective by preventing the binding of IL-1 to its receptor, IL-1R1, thus restoring autophagy and dampening NLR family pyrin domain containing 3 (NLRP3) activity. Read More

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Clozapine Worsens Glucose Intolerance, Nonalcoholic Fatty Liver Disease, Kidney Damage, and Retinal Injury and Increases Renal Reactive Oxygen Species Production and Chromium Loss in Obese Mice.

Int J Mol Sci 2021 Jun 22;22(13). Epub 2021 Jun 22.

Department of Veterinary Medicine, College of Veterinary Medicine, National Pingtung University of Science and Technology, 1 Shuefu Road, Neipu, Pingtung 912301, Taiwan.

Clozapine is widely employed in the treatment of schizophrenia. Compared with that of atypical first-generation antipsychotics, atypical second-generation antipsychotics such as clozapine have less severe side effects and may positively affect obesity and blood glucose level. However, no systematic study of clozapine's adverse metabolic effects-such as changes in kidney and liver function, body weight, glucose and triglyceride levels, and retinopathy-was conducted. Read More

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A New Geniposidic Acid Derivative Exerts Antiaging Effects through Antioxidative Stress and Autophagy Induction.

Antioxidants (Basel) 2021 Jun 21;10(6). Epub 2021 Jun 21.

College of Pharmaceutical Sciences, Zhejiang University, Yu Hang Tang Road 866, Hangzhou 310058, China.

Two compounds that can prolong the replicative lifespan of yeast, geniposidic acid (Compound ) and geniposide (Compound ), were isolated from Ellis. Compared with Compound , Compound was different at C11 and showed better bioactivity. On this basis, seven new geniposidic derivatives (-) were synthesized. Read More

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A Comparative Study of Antioxidative Activity of Saliva in Children and Young Teenagers with and without Gingivitis.

Medicina (Kaunas) 2021 Jun 3;57(6). Epub 2021 Jun 3.

Department of Orthodontics and Dentofacial Orthopedics, University Hospital, LMU Munich, 80336 Munich, Germany.

: The aim of this study was to compare the values of total antioxidant capacity (TAC), catalase (CAT) and glutathione peroxidase (GPX) in the saliva of children and young teenagers with and without gingivitis. : A total of 120 children and young teenagers of the mean age of 12.2 participated in the research. Read More

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Amelioration of Chlorpyrifos-Induced Toxicity in L. by Combination of 24-Epibrassinolide and Plant-Growth-Promoting Rhizobacteria.

Biomolecules 2021 Jun 12;11(6). Epub 2021 Jun 12.

Department of Botanical and Environmental Sciences, Guru Nanak Dev University, Amritsar 143005, India.

Pervasive use of chlorpyrifos (CP), an organophosphorus pesticide, has been proven to be fatal for plant growth, especially at higher concentrations. CP poisoning leads to growth inhibition, chlorosis, browning of roots and lipid and protein degradation, along with membrane dysfunction and nuclear damage. Plants form a linking bridge between the underground and above-ground communities to escape from the unfavourable conditions. Read More

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Ameliorative Potential of Hydroethanolic Leaf Extract of on d-Galactose-Induced Testicular Injury.

Molecules 2021 Jun 5;26(11). Epub 2021 Jun 5.

Department of Biochemistry, Faculty of Natural and Agricultural Science, Mafikeng Campus, North West University, Mmabatho 2735, South Africa.

Background: There is an increasing need for botanicals to be used as an alternative and complementary medicine in the management of male infertility. Male infertility has been a major health/social challenge to people all over the world. This study, therefore, investigated the ameliorative potential of hydroethanolic leaf extract of (HELEPN) against d-galactose-induced testicular injury. Read More

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Metal ion homeostasis with emphasis on zinc and copper: Potential crucial link to explain the non-classical antioxidative properties of vitamin D and melatonin.

Life Sci 2021 Sep 28;281:119770. Epub 2021 Jun 28.

Laboratorio de Farmacología Experimental Básica y Traslacional, Área de Farmacología, Departamento de Patología, Facultad de Ciencias Médicas, Universidad Nacional de Cuyo, Mendoza, Argentina; Instituto de Medicina y Biología Experimental de Cuyo, Consejo Nacional de Investigación Científica y Tecnológica (IMBECU-CONICET), Argentina. Electronic address:

Metal ion homeostasis is an essential physiological mechanism necessary for achieving an adequate balance of these ions' concentrations in the different cellular compartments. This fact is of great importance because both an excess and a deficiency of cellular metal ion levels are usually equally harmful due to the exacerbated increase in oxidative stress that may occur in both cases. Metal ion homeostasis ensures an equilibrium among multiple functions associated with the body's antioxidative defense network controlled by metallic micronutrients such as zinc and copper, some of the central regulators of redox processes. Read More

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September 2021

Structural insight into the unique conformation of cystathionine β-synthase from .

Comput Struct Biotechnol J 2021 6;19:3542-3555. Epub 2021 Jun 6.

Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), Bizkaia Technology Park, Building 801A, 48160 Derio, Spain.

Cysteine plays a major role in the redox homeostasis and antioxidative defense mechanisms of many parasites of the phylum Apicomplexa. Of relevance to human health is , the causative agent of toxoplasmosis. A major route of cysteine biosynthesis in this parasite is the reverse transsulfuration pathway involving two key enzymes cystathionine β-synthase (CBS) and cystathionine γ-lyase (CGL). Read More

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Tolerance mechanisms in maize identified through phenotyping and transcriptome analysis in response to water deficit stress.

Physiol Mol Biol Plants 2021 Jun 6;27(6):1377-1394. Epub 2021 Jun 6.

Indian Council of Agricultural Research, New Delhi, India.

Water deficit is a key limiting factor for maize ( L.) productivity. Elucidating the molecular regulatory networks of stress tolerance is crucial for genetic enhancement of drought tolerance. Read More

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PopW enhances drought stress tolerance of alfalfa via activating antioxidative enzymes, endogenous hormones, drought related genes and inhibiting senescence genes.

Gürkan Demirkol

Plant Physiol Biochem 2021 Jun 20;166:540-548. Epub 2021 Jun 20.

Faculty of Agriculture, Department of Field Crops, Ordu University, 52200, Ordu, Turkey. Electronic address:

Alfalfa (Medicago sativa L.) has the advantages of high yield and nutritional value as a perennial forage. However, one of the drawbacks of alfalfa is its susceptibility to drought conditions, which is a global problem in agriculture. Read More

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Effect of drought on photosynthesis, total antioxidant capacity, bioactive component accumulation, and the transcriptome of Atractylodes lancea.

BMC Plant Biol 2021 Jun 25;21(1):293. Epub 2021 Jun 25.

School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, 210000, China.

Background: Atractylodes lancea (Thunb.) DC, a medicinal herb belonging to the Asteraceae family, often faces severe drought stress during its growth. Until now, there has been no research on the effect of drought stress on the quality formation of A. Read More

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Regulation of Postharvest Tomato Fruit Ripening by Endogenous Salicylic Acid.

Front Plant Sci 2021 7;12:663943. Epub 2021 Jun 7.

Division of Plant Physiology, ICAR - Indian Agricultural Research Institute, New Delhi, India.

Exogenous application of salicylic acid (SA) has been known for delaying ripening in many fruit and vegetables. But the function of endogenous SA in relation to postharvest fruit performance is still unexplored. To understand the role of endogenous SA in postharvest fruit ripening of tomato, 33 tomato lines were examined for their endogenous SA content, membrane stability index (MSI), and shelf life (SL) at turning and red stages of tomato fruit ripening. Read More

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Dietary Inorganic Nitrate Protects Hepatic Ischemia-Reperfusion Injury Through NRF2-Mediated Antioxidative Stress.

Front Pharmacol 2021 7;12:634115. Epub 2021 Jun 7.

Salivary Gland Disease Center and Beijing Key Laboratory of Tooth Regeneration and Function Reconstruction, Beijing Laboratory of Oral Health, Capital Medical University School of Stomatology, Beijing, China.

Hepatic ischemia-reperfusion injury (HIRI) is of common occurrence during liver surgery and liver transplantation and may cause hepatic impairment, resulting in acute liver dysfunction. Nitrate plays an important physiological regulatory role in the human body. Whether dietary nitrate could prevent HIRI is, however, unknown. Read More

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Root morphology ion absorption and antioxidative defense system of two Chinese cabbage cultivars (Brassica rapa L.) reveal the different adaptation mechanisms to salt and alkali stress.

Protoplasma 2021 Jun 18. Epub 2021 Jun 18.

College of Horticulture Science and Engineering, Shandong Agricultural University, Tai'an 271018, People's Republic of China.

Salt stress and alkali stress are major factors that affect the growth and production of Chinese cabbage. To explore their tolerant mechanism to salt and alkali stress, three salinity levels (0, 50, 100 mmol/L NaCl) and three different pH levels (pH6.5, pH7. Read More

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