92 results match your criteria antioxidative capabilities

Characterization of Oxygenated Heterocyclic Compounds and in vitro Antioxidant Activity of Pomelo Essential Oil.

Drug Des Devel Ther 2021 2;15:937-947. Epub 2021 Mar 2.

College of Horticulture and Landscape Architecture, Southwest University, Chongqing, People's Republic of China.

Purpose: Citrus essential oils are widely used for aromatherapy and the alternative treatment of chronic diseases. Beyond the aroma substances, they are known to contain bioactive nonvolatile components; however, little knowledge has been gained about nonvolatiles in the essential oil of pomelo ( Osbeck), the largest citrus fruit. The purpose of this study was to analyze the nonvolatile oxygenated heterocyclic compounds (OHCs) of pomelo essential oils and evaluate their in vitro antioxidant activities for further development. Read More

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Perfluorooctanoic acid-induced liver injury is potentially associated with gut microbiota dysbiosis.

Chemosphere 2021 Mar 18;266:129004. Epub 2020 Nov 18.

State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, 214122, PR China; School of Food Science and Technology, Jiangnan University, Wuxi, 214122, PR China; National Engineering Research Center for Functional Food, Jiangnan University, Wuxi, 214122, PR China; Beijing Innovation Centre of Food Nutrition and Human Health, Beijing Technology and Business University (BTBU), Beijing, 100048, PR China.

Perfluorooctanoic acid (PFOA), an environmental pollutant, is widely engaged in industrial products and tends to accumulate in the liver. Emerging evidence has suggested that the gut microbiome is a pivotal player in maintaining animal health and can potentially altered by xenobiotic. However, few studies explored whether PFOA-induced liver injury is associated with gut microbiota dysbiosis. Read More

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Chemical composition, nutritional profile and antioxidant properties of the cultivated mushroom .

R Soc Open Sci 2020 Sep 2;7(9):200900. Epub 2020 Sep 2.

Faculty of Medicine, Department of Pharmacology, Toxicology and Clinical Pharmacology, University of Novi Sad, Hajduk Veljkova 3, 21000, Novi Sad, Serbia.

This study investigated the chemical and nutritional profile and antioxidative properties of cultivated . Proximate analysis revealed that is rich in carbohydrates, dietary fibres and proteins, and could also be a valuable source of phenolics. Additionally, fat content is low, consisting mainly of polyunsaturated and omega-3 fatty acids. Read More

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September 2020

Immunomodulatory and Antioxidative potentials of adipose-derived Mesenchymal stem cells isolated from breast versus abdominal tissue: a comparative study.

Cell Regen 2020 Oct 6;9(1):18. Epub 2020 Oct 6.

Stem Cell Research Group, Centre of Excellence for Medical Research, National Research Centre, Cairo, Egypt.

Background: Adipose-derived stem cells (ASCs) are considered ideal candidates for both research and cellular therapy due to ease of access, large yield, feasibility, and efficacy in preclinical and clinical studies. Unlike the subcutaneous abdominal fat depot, breast ASCs features are still not well recognized, limiting their possible therapeutic use. ASCs were found to exert immunomodulatory and antioxidative activities for maintaining homeostasis and functionality of diseased/damaged tissues. Read More

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October 2020

Discovery and Characterization of Novel Naphthalimide Analogs as Potent Multitargeted Directed Ligands against Alzheimer's Disease.

Drug Dev Res 2020 Jun 16. Epub 2020 Jun 16.

Department of Discovery and Biomedical Sciences, University of South Carolina, Columbia, South Carolina, USA.

Current therapeutic drugs for Alzheimer's disease (AD) can only offer limited symptomatic benefits and do not halt disease progression. Multitargeted directed ligands (MTDLs) have been considered to be a feasible way to treat AD due to the multiple neuropathological processes in AD. Previous studies proposed that compounds containing two aromatic groups connected by a carbon chain should act as effective amyloid β (Aβ) aggregation inhibitors although the optimal length of the carbon chain has not been explored. Read More

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Neuroprotective Effects of Emodin against Ischemia/Reperfusion Injury through Activating ERK-1/2 Signaling Pathway.

Int J Mol Sci 2020 Apr 21;21(8). Epub 2020 Apr 21.

Center for Neurotrauma and Neuroregeneration, Taipei Medical University, 250 Wu-Hsing Street, Taipei 11031, Taiwan.

Background: Stroke is one of the leading causes of death and disability worldwide and places a heavy burden on the economy in our society. Current treatments, such as the use of thrombolytic agents, are often limited by a narrow therapeutic time window. However, the regeneration of the brain after damage is still active days, even weeks, after stroke occurs, which might provide a second window for treatment. Read More

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Microbial inoculation in rice regulates antioxidative reactions and defense related genes to mitigate drought stress.

Sci Rep 2020 03 16;10(1):4818. Epub 2020 Mar 16.

Department of Mycology and Plant Pathology, Institute of Agricultural Sciences, Banaras Hindu University, Varanasi, 21005, India.

Microbial inoculation in drought challenged rice triggered multipronged steps at enzymatic, non-enzymatic and gene expression level. These multifarious modulations in plants were related to stress tolerance mechanisms. Drought suppressed growth of rice plants but inoculation with Trichoderma, Pseudomonas and their combination minimized the impact of watering regime. Read More

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In vitro study of the antioxidative and antiproliferative capabilities of 16-fermented soymilk.

Food Sci Nutr 2020 Jan 11;8(1):48-57. Epub 2019 Dec 11.

School of food science and technology Dalian Polytechnic University Dalian China.

In this study, soymilk was fermented with 16. The contents of aglycone isoflavones, saponins, total phenolic, and free amino acid in the fermented soymilk, and the protection for the HepG cells against 2,2'-azobis(2-amidinopropane) dihydrochloride (ABAP) damage and the antiproliferative effects of the fermented soymilk on the HT-29 cells and Caco-2 cells were studied. The results showed that the levels of total phenolic, aglycone isoflavones, and free amino acids in the 16-fermented soymilk were enhanced. Read More

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January 2020

Sodium Chloride Induced Stress Responses of Antioxidative Activities in Leaves and Roots of Pistachio Rootstock.

Biomolecules 2020 01 26;10(2). Epub 2020 Jan 26.

Department of Horticultural Sciences, University of Tabriz, Tabriz 51666, Iran.

Salinity substantially affects plant growth and crop productivity worldwide. Plants adopt several biochemical mechanisms including regulation of antioxidant biosynthesis to protect themselves against the toxic effects induced by the stress. One-year-old pistachio rootstock exhibiting different degrees of salinity tolerance were subjected to sodium chloride induced stress to identify genetic diversity among cultivated pistachio rootstock for their antioxidant responses, and to determine the correlation of these enzymes to salinity stress. Read More

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January 2020

Extracellular vesicles from endothelial progenitor cells prevent steroid-induced osteoporosis by suppressing the ferroptotic pathway in mouse osteoblasts based on bioinformatics evidence.

Sci Rep 2019 11 6;9(1):16130. Epub 2019 Nov 6.

Department of Orthopaedics, Anhui Provincial Hospital, Anhui Medical University, Lujiang Road No. 17, 230001, Hefei, China.

Abnormal antioxidative capabilities were observed in the pathogenesis of steroid-induced osteoporosis (SIOP). Ferroptosis is a recently discovered type of cell death that is characterized by the overproduction of ROS in response to GPX4 and system X downregulation, which is mediated by an Fe fenton reaction. However, investigations focusing on the relationship between ferroptosis and steroid-induced bone disease remain limited. Read More

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November 2019

Antioxidative capacity is highly associated with the storage property of tuberous roots in different sweetpotato cultivars.

Sci Rep 2019 07 31;9(1):11141. Epub 2019 Jul 31.

School of Food and Biological Engineering, Hefei University of Technology, Hefei, Anhui, 230009, P.R. China.

The activities and gene expression of antioxidative enzymes and the ROS content were analyzed in two typical storage-tolerant cultivars (Xushu 32 and Shangshu 19) and another two storage-sensitive cultivars (Yanshu 25 and Sushu 16) to explore the association between the storage capacity of sweetpotato (Ipomoea batatas (L.) Lam) and ROS scavenging capability. The storage roots of the storage-tolerant cultivars maintained higher activities and expression levels of antioxidative enzymes, including ascorbate peroxidase (APX), peroxidase (POD), catalase (CAT), and superoxide dismutase (SOD); lower activity and expression of lipoxygenase (LOX); and lower accumulation of ROS metabolites compared with the storage-sensitive cultivars. Read More

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Ameliorative impact of cold-pressed Rosmarinus officinalis oil against liver toxicity and genotoxic effects in streptozotocin-induced diabetic rats and their offspring.

J Food Biochem 2019 07 20;43(7):e12905. Epub 2019 May 20.

Deanship of Scientific Research, Umm Al-Qura University, Makkah, Kingdom of Saudi Arabia.

Diabetes mellitus (DM) is a chronic, lifelong condition threatening human health. Rosmarinus officinalis oil (RO) could have a future role in DM therapy. This study evaluated the composition and antioxidative potential of RO. Read More

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Baicalin ameliorates lipopolysaccharide-induced acute lung injury in mice by suppressing oxidative stress and inflammation via the activation of the Nrf2-mediated HO-1 signaling pathway.

Naunyn Schmiedebergs Arch Pharmacol 2019 11 4;392(11):1421-1433. Epub 2019 Jul 4.

Intensive Care Unit (ICU), Jining No.1 People's Hospital, No.6, Health Road, Jining City, 272011, Shandong Province, People's Republic of China.

This research aims to investigate the ameliorative potential of baicalin on lipopolysaccharide-induced acute lung injury by the suppression of oxidative stress and inflammation via the activation of the nuclear erythroid factor 2 (Nrf2)-mediated heme oxygenase-1 (HO-1) signaling pathway. Specific pathogen-free male mice, weighing between 25 and 30 g, were divided into the following four groups of 10 mice each: the control group, LPS group, LPS + baicalin group, and baicalin group. Bronchoalveolar lavage fluid (BALF), blood, and tissue were collected on the 16th day and used for hematological (total leukocyte, macrophage, neutrophil, and lymphocyte counts in both blood and BALF, biochemical (antioxidant enzymes, MDA, Nrf2, and HO-1), and histological analyses. Read More

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November 2019

Facile and scalable fabrication of self-assembled Cu architecture with superior antioxidative properties and improved sinterability as a conductive ink for flexible electronics.

Nanotechnology 2019 Aug 17;30(35):355601. Epub 2019 May 17.

The Shenzhen International Innovation Institute of Advanced Electronic Materials, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, People's Republic of China. College of Materials Science and Engineering, Shenzhen University, Shenzhen 518055, People's Republic of China.

The inherent susceptibility to oxidation and poor sinterability significantly limit the practical application of Cu-based conductive inks. Most methodologies employed for the inks like organic polymer coatings and inorganic metal deposition are generally ineffective. Herein, we report the design of a novel hierarchical Cu architecture to simultaneously improve the antioxidative and sinterability via a self-passivation mechanism and loose interior structures. Read More

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The neuroprotective effect of vitamin E on waterpipe tobacco smoking-induced memory impairment: The antioxidative role.

Life Sci 2019 Apr 26;222:46-52. Epub 2019 Feb 26.

Department of Medical Laboratory Sciences, Jordan University of Science and Technology, Jordan.

Aims: Tobacco smoking is associated with a vast range of adverse health effects, including diminished cognitive and anti-oxidative capabilities. Conversely, vitamin E (VitE) is known to enhance data acquisition and retention and hippocampal oxidative defense. No studies, however, examined the protective effect of VitE with tobacco administration. Read More

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Separate and combined effects of glyphosate and copper on growth and antioxidative enzymes in Salvinia natans (L.) All.

Sci Total Environ 2019 Mar 15;655:1448-1456. Epub 2018 Nov 15.

The National Field Station of Lake Ecosystem of Liangzi Lake, College of Life Science, Wuhan University, Wuhan 430072, China. Electronic address:

The coexistence of glyphosate and copper is widely found in bodies of water and terrestrial ecosystems due to widespread application of herbicides and heavy metal. However, their joint ecotoxicological risks in aquatic environments remain unknown. The experiment investigated the individual and combined effects of glyphosate and copper on the growth and physiological response in Salvinia natans (L. Read More

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[Research advances on preventive and therapeutic effects of hydrogen on cardiovascular and cerebrovascular diseases and underlying mechanisms].

Sheng Li Xue Bao 2018 Oct;70(5):557-564

Key Laboratory of Atherosclerosis in Colleges and Universities of Shandong Province, Institute of Atherosclerosis of Taishan Medical University, Taishan Institute for Hydrogen Biomedical Research, Taian 271000, China.

For a long time, hydrogen (H) has been considered as a physiological inert gas. However, recent studies have demonstrated that molecular H exerts significant therapeutic effects on various disease models due to its antioxidative, anti-inflammatory and anti-apoptotic capabilities, which have also been well confirmed in many clinical trials. Cardiovascular and cerebrovascular diseases (CCVDs) are the leading cause of death in the world, constituting a serious threat to human life and public health. Read More

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October 2018

Versatile Hyperbranched Poly(β-hydrazide ester) Macromers as Injectable Antioxidative Hydrogels.

ACS Appl Mater Interfaces 2018 Nov 12;10(46):39494-39504. Epub 2018 Nov 12.

Charles Institute of Dermatology, School of Medicine , University College Dublin , Belfield, Dublin 4 , Ireland.

Synthetic reactive oxygen species (ROS)-responsive biomaterials have emerged as a useful platform for regulating critical aspects of ROS-induced pathologies and can improve such hostile microenvironments. Here, we report a series of new hyperbranched poly(β-hydrazide ester) macromers (HB-PBHEs) with disulfide moieties synthesized via an "A2 + B4" Michael addition approach. The three-dimensional structure of HB-PBHEs with multiacrylate end groups endows the macromers with rapid gelation capabilities to form (1) injectable hydrogels via cross-linking with thiolated hyaluronic acid and (2) robust UV-cross-linked hydrogels. Read More

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November 2018

Characteristics of Biologically Active Compounds in Cornelian Cherry Meads.

Molecules 2018 Aug 14;23(8). Epub 2018 Aug 14.

Arboretum and Institute of Physiography in Bolestraszyce, 37-700 Przemyśl, Poland.

In this study, we investigated the effect of Cornelian cherry cultivars differing in fruit color ("Yantaryi"-yellow fruits, "Koralovyi"-coral fruits, "Podolski"-red fruits) on physicochemical characteristics, antioxidative properties, and contents of iridoids and polyphenols in meads with the addition of juices made of their fruits. "" type meads (1:2 honey to water volume) were manufactured from multifloral honey, to which Cornelian cherry fruit juice was added before fermentation. Concentrations of individual iridoids and polyphenols were determined using HPLC analysis with a thermostat refractometric detector, model RID-10A. Read More

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Ultrastructural alterations in the retinal pigment epithelium and photoreceptors of a Stargardt patient and three Stargardt mouse models: indication for the central role of RPE melanin in oxidative stress.

PeerJ 2018 19;6:e5215. Epub 2018 Jul 19.

Division of Experimental Vitreoretinal Surgery, Centre for Ophthalmology, University of Tuebingen, Tuebingen, Germany.

Background: Stargardt disease (SD) is characterized by the accumulation of the age-pigment lipofuscin in the retinal pigment epithelium (RPE) and subsequent neuroretinal degeneration. The disease leads to vision loss early in life. Here, we investigate age-dependent ultrastructural changes in three SD mouse models: albino and pigmented and mice. Read More

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Implications of Antioxidant Systems in Inflammatory Bowel Disease.

Biomed Res Int 2018 9;2018:1290179. Epub 2018 May 9.

College of Bioscience and Biotechnology and College of Animal Science and Technology, Hunan Agricultural University, Changsha, Hunan 410128, China.

The global incidence of inflammatory bowel disease (IBD), a group of chronic gastrointestinal disorders, has been rising. The preponderance of evidence demonstrates that oxidative stress (OS) performs a critical function in the onset of IBD and the manner of its development. The purpose of this review is to outline the generation of reactive oxygen species and antioxidant defense mechanisms in the gastrointestinal tract and the role played by OS in marking the onset and development of IBD. Read More

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October 2018

Comparative analysis of root transcriptome profiles between drought-tolerant and susceptible wheat genotypes in response to water stress.

Plant Sci 2018 Jul 1;272:276-293. Epub 2018 May 1.

Crop Research Institute, Shandong Academy of Agricultural Sciences, Jinan 250100, China. Electronic address:

Water deficit is one of the major factors limiting crop productivity worldwide. Plant roots play a key role in uptaking water, perceiving and transducing of water deficit signals to shoot. Although the mechanisms of drought-tolerance have been reported recently, the transcriptional regulatory network of wheat root response to water stress has not been fully understood. Read More

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Cerium oxide nanoparticles with antioxidant capabilities and gadolinium integration for MRI contrast enhancement.

Sci Rep 2018 05 3;8(1):6999. Epub 2018 May 3.

Division of Molecular Surface Physics and Nanoscience, Department of Physics, Chemistry and Biology (IFM), Linköping University, SE-581 83, Linköping, Sweden.

The chelating gadolinium-complex is routinely used as magnetic resonance imaging (MRI) -contrast enhancer. However, several safety issues have recently been reported by FDA and PRAC. There is an urgent need for the next generation of safer MRI-contrast enhancers, with improved local contrast and targeting capabilities. Read More

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Reduced fecundity and cellular changes in Acheta domesticus after multigenerational exposure to graphene oxide nanoparticles in food.

Sci Total Environ 2018 Sep 24;635:947-955. Epub 2018 Apr 24.

Department of Animal Physiology and Ecotoxicology, University of Silesia in Katowice, Bankowa 9, PL 40-007 Katowice, Poland.

Despite the fact that the demand for graphene and its derivatives in commercial applications is still growing, many aspects of its toxicity and biocompatibility are still poorly understood. Graphene oxide, which is released into the environment (air, soil and water) as so-called nanowaste or nanopollution, is able to penetrate living organisms. It is highly probable that, due to its specific nature, it can migrate along food chains thereby causing negative consequences. Read More

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September 2018

Elucidating the Impact of CHO Cell Culture Media on Tryptophan Oxidation of a Monoclonal Antibody Through Gene Expression Analyses.

Biotechnol J 2018 Oct 17;13(10):e1700254. Epub 2018 Apr 17.

Bioprocess Research and Development, Eli Lilly and Company, Indianapolis 46285, IN, USA.

Oxidation of monoclonal antibodies (mAb) is a common chemical modification with potential impact on a therapeutic protein's activity and immunogenicity. In a previous study, it was found that tryptophan oxidation (Trp-ox) levels of two mAb produced in Chinese hamster ovary (CHO) cells were significantly lowered by modifying cell culture medium/feed. In this study, transcriptome analysis by RNA-Seq is applied to further elucidate the underlying mechanism of those changes in lowering the Trp-ox levels. Read More

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October 2018

36H: A Novel Potent Inhibitor for Antimelanogenesis.

Oxid Med Cell Longev 2018 4;2018:6354972. Epub 2018 Feb 4.

Graduate Institute of Biomedical Engineering, National Chung Hsing University, Taichung 402, Taiwan.

-Hydroxycinnamoylphenalkylamides (36H) exhibited both antioxidation and antityrosinase abilities. The compound was studied for its antioxidative properties, using a 1,1-diphenyl-2-picrylhydrazul- (DPPH-) scavenging test, a ferric ion-reducing antioxidant power assay (FRAP) assessment, and a metal-chelating power assay. The results showed that 36H had antioxidative capabilities in the DPPH-scavenging and ferric-reducing power examinations but the chelating power assay did not demonstrate antioxidative capability. Read More

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September 2018

Methods to Assess the Antioxidative Properties of Probiotics.

Probiotics Antimicrob Proteins 2018 09;10(3):589-599

Southern Federal University, Rostov-on-Don, Russia.

Probiotics prove useful in correcting and preventing numerous health conditions, including those having severe impact on society, e.g., obesity and cancer. Read More

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September 2018

Antioxidant Potential of Selected Korean Edible Plant Extracts.

Biomed Res Int 2017 6;2017:7695605. Epub 2017 Nov 6.

School of Food Science and Biotechnology, Kyungpook National University, Daegu 41566, Republic of Korea.

This study aimed to evaluate the antioxidant activity of various plant extracts. A total of 94 kinds of edible plant extracts obtained from the Korea Plant Extract Bank were screened for cytotoxicity, following which the total phenolic content of 24 shortlisted extracts was determined. Of these, extracts from three plants, namely, (CC) leaf, (CJ) fruit, and (VD) leaf, were examined for antioxidant capabilities by measuring radical scavenging activity, ferric reducing/antioxidant power, and lipid peroxidation inhibitory activity. Read More

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Effect of elevated CO concentration and temperature on antioxidant capabilities of multiple generations of Bemisia tabaci MEAM1 (Hemiptera: Aleyrodidae).

J Insect Physiol 2017 11 19;103:91-97. Epub 2017 Oct 19.

Key Laboratory of Integrated Pest Management on the Loess Plateaus of Ministry of Agriculture, Northwest A&F University, Yangling, Shaanxi 712100, China.

A rise in atmospheric carbon dioxide concentration ([CO]) and a warming climate are two of the most conspicuous characteristics of global climate change in this century. However, studies addressing the combined impact of rising [CO] and temperature on herbivore insect physiology are still limited. In this study we investigated the combined effects of elevated [CO] and temperature on major antioxidative enzymes, including superoxide dismutase (SOD), catalase (CAT), peroxidases (POD) and detoxification enzymes of glutathione-S-transferases (GST) and acetylcholinesterase (AChE) in three consecutive generations of Bemisia tabaci Middle East-Asia Minor 1 (MEAM1, commonly known as B biotype) adults. Read More

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November 2017

Protective effect of Dendrobium officinale polysaccharides on HO-induced injury in H9c2 cardiomyocytes.

Biomed Pharmacother 2017 Oct 16;94:72-78. Epub 2017 Aug 16.

Key Laboratory on Luminescence and Real-Time Analytical Chemistry (Southwest University), Ministry of Education, College of Pharmaceutical Sciences, Southwest University, Chongqing 400716, China; Chongqing Key Laboratory of Biomedical Analysis, Chongqing Science & Technology Commission, College of Chemistry and Chemical Engineering, Southwest University, Chongqing 400716, China. Electronic address:

The preliminary studies have shown that Dendrobium officinale possessed therapeutic effects on hypertension and atherosclerosis. Studies also reported that Dendrobium officinale polysaccharides showed antioxidant capabilities. However, little is known about its effects on myocardial cells under oxidative stress. Read More

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October 2017