Mater Sci Eng C Mater Biol Appl 2021 Jul 21;126:112107. Epub 2021 Apr 21.
State key laboratory for manufacturing, systems engineering, Xi'an Jiaotong University, Xi'an 710000, China; Frontier Institute of Science and Technology, Xi'an Jiaotong University, Xi'an 710000, China; National and Local Joint Engineering Research Center of Biodiagnosis and Biotherapy, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710000, China; Instrument Analysis Center, Xi'an Jiaotong University, Xi'an 710054, China. Electronic address:
The design and development of one-component temperature-sensitive bioactive hydrogel with multifunctional properties for protecting skin against light injury remain a challenge. Herein, we report a bioactive multifunctional poly(salicylic acid)-F127-poly(salicylic acid) copolymer hydrogel (FPSa) with one-component for potential skin protection applications. The FPSa hydrogel possesses the thermosensitivity (23 °C), injectability, self-healing ability, ultraviolet shielding (shielding the wavelength between 280 and 370 nm), and antioxidation activity (above 70%), and also showed the good cytocompatibility (cell survival rate >90% and hemolysis rate less than 5%) and biodegradability (90% weight loss at 3 days). Read More