4,381 results match your criteria antioxidant hepatoprotective


[Metabolic mechanism of Prunella vulgaris in treatment of ethanol-induced oxidative stress in rats based on metabonomics].

Zhongguo Zhong Yao Za Zhi 2021 Apr;46(7):1813-1821

Key Laboratory for Quality Evaluation of Bulk Herbs of Hunan Province, Hunan University of Chinese Medicine Changsha 410208, China.

Prunella vulgaris(PV) is an edible and traditional medicinal herb which has a wide range application in fighting inflammation and oxidative stress, and protecting liver. Now it has been used to treat various types of liver diseases and has significant clinical efficacy. This study aims to investigate the effects of PV on ethanol-induced oxidative stress injury in rats and its metabolic mechanism. Read More

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Chrysin Improves Glucose and Lipid Metabolism Disorders by Regulating the AMPK/PI3K/AKT Signaling Pathway in Insulin-Resistant HepG2 Cells and HFD/STZ-Induced C57BL/6J Mice.

J Agric Food Chem 2021 May 12. Epub 2021 May 12.

The State Key Laboratory of Bioreactor Engineering, College of Bioengineering, East China University of Science and Technology, No.130 Meilong Road, Xuhui District, Shanghai 200237, People's Republic of China.

Natural products with minor side effects have been reported to be an effective adjuvant therapy for glucose and lipid metabolism disorders. Chrysin, a flavone, has a wide range of physiological effects, such as antioxidant, anti-inflammatory, anti-diabetes, anti-hyperlipidemia, and hepatoprotective. This study was designed to explore the effects and mechanism of chrysin on metabolic syndrome using insulin-resistant HepG2 cells and HFD/STZ-induced C57BL/6J mice. Read More

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Modulation of Liver P-Glycoprotien Expression May Contribute to Gossypin Protection against Methotrexate-Induced Hepatotoxicity.

Indian J Pharmacol 2021 Jan-Feb;53(1):25-30

Department of Histology, Faculty of Medicine, Minia University, Minya, Egypt.

Objectives: Methotrexate (MTX) is a broadly used anticancer. Its major side effect is hepatotoxicity. Gossypin is a flavonoid has a hepatoprotective effect as well as antitumor property. Read More

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Zingiber roseum Rosc. rhizome: A rich source of hepatoprotective polyphenols.

Biomed Pharmacother 2021 May 6;139:111673. Epub 2021 May 6.

Department of Pharmacy, Noakhali Science and Technology University, Sonapur, Noakhali 3814, Bangladesh. Electronic address:

Zingiber roseum is native to Bangladesh and widely used in folk medicine. This present study was designed to assess the ameliorative potential of Zingiber roseum rhizome extract in carbon tetrachloride (CCl) induced hepatotoxicity in mice model. Seven phenolic compounds were identified and quantified by HPLC analysis in the plant extract, including quercetin, myricetin, catechin hydrate, trans-ferulic acid, trans-cinnamic acid, (-) epicatechin, and rosmarinic acid. Read More

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Syzygium samarangense leaf extract mitigates indomethacin-induced gastropathy via the NF-κB signaling pathway in rats.

Biomed Pharmacother 2021 May 6;139:111675. Epub 2021 May 6.

AgroBioSciences, Mohammed VI Polytechnic University, Lot 660, Hay Moulay Rachid, Ben-Guerir 43150, Morocco. Electronic address:

We previously profiled the chemical composition of wax apple, Syzygium samarangense, leaf extract using HR-LC-MS/MS and reported its antioxidant, hepatoprotective and antitrypanosomal activities. The plant is widely used in traditional medicine to cure several ailments like bronchitis, asthma, diabetes, fever, pathogenic infections, gut spasms, as well as renal diseases. However, neither the gastroprotective effects nor the underlying mechanisms were explored. Read More

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Astaxanthin and Nrf2 signaling pathway: a novel target for new therapeutic approaches.

Mini Rev Med Chem 2021 May 4. Epub 2021 May 4.

Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

Astaxanthin (AST) is a naturally occurring compound isolated from various sources such as fungi, plants, salmon, and crab. However, Haematococcus Pluvialis, a green alga, is the primary source of this beta carotenoid compound. AST has several favourable biological and pharmacological activities such as antioxidant, anti-inflammatory, anti-tumor, anti-diabetes, hepatoprotective and neuroprotective. Read More

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Nicotinamide improves NAD levels to protect against acetaminophen-induced acute liver injury in mice.

Hum Exp Toxicol 2021 May 5:9603271211014573. Epub 2021 May 5.

Department of Pathophysiology, Chongqing Medical University, Chongqing, China.

Acetaminophen (APAP) overdose causes acute liver injury (ALI). Nicotinamide adenine dinucleotide (NAD) is an essential coenzyme, and NAD is oxidized type which synthesized from nicotinamide (NAM). The present study aimed to investigate the role of NAD in ALI and protective property of NAM. Read More

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Phytochemical properties, biological activities and medicinal use of Centaurium erythraea Rafn.

J Ethnopharmacol 2021 Apr 30;276:114171. Epub 2021 Apr 30.

Laboratory of Human Pathologies Biology, Department of Biology, Faculty of Sciences, And Genomic Center of Human Pathologies, Faculty of Medicine and Pharmacy, Mohammed V University in Rabat, Morocco. Electronic address:

Ethnopharmacological Relevance: Centaurium erythraea is an important medicinal plant in many countries, e.g. Morocco, Algeria, Italy, Spain, Portugal, and countries of Balkan Peninsula. Read More

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Wheat embryo globulin protects against acute alcohol-induced liver injury in mice.

Food Chem Toxicol 2021 Apr 28;153:112240. Epub 2021 Apr 28.

School of Biological Engineering, Henan University of Technology, Zhengzhou, 450001, PR China; Henan Provincial Key Laboratory of Biological Processing and Nutritional Function of Wheat, Zhengzhou, 450001, PR China; Henan Cooperativity Medical Science and Technology Research Institute Co., LTD, Luoyang, 471000, PR China. Electronic address:

Wheat Embryo Globulin (WEG) is a high-quality plant-derived protein with anti-inflammatory, antioxidant, and immunity enhancement effects. WEG was prepared and characterized using free amino acid analysis, circular dichroism (CD), and scanning electron microscope (SEM). The liver protection effect of WEG on mice after acute alcohol stimulation was also investigated. Read More

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Ferulic acid-mediated modulation of apoptotic signaling pathways in cancer.

Adv Protein Chem Struct Biol 2021 9;125:215-257. Epub 2021 Feb 9.

Lake Erie College of Osteopathic Medicine, Bradenton, FL, United States. Electronic address:

Ferulic acid (4-hydroxy-3-methoxycinnamic acid, FA), a hydroxycinnamic acid derived from various seeds, nuts, leaves, and fruits, exists in a free form as well as is covalently conjugated with polysaccharides, glycoproteins, polyamines, lignin, and hydroxy fatty acids of plant cell walls. It exhibits a variety of pharmacological effects, such as antioxidant, anti-inflammatory, vasodilatory, antithrombotic, antimicrobial, anti-allergic, antiviral, hepatoprotective, and anticancer activities. FA induces the expression of cell cycle-related proteins, such as p53 and p21, and reduces cyclin D1 and cyclin E levels. Read More

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February 2021

(Tarragon): A Review of Its Traditional Uses, Phytochemistry and Pharmacology.

Front Pharmacol 2021 13;12:653993. Epub 2021 Apr 13.

Chair and Department of Pharmaceutical Botany, Jagiellonian University, Medical College, Kraków, Poland.

L. (tarragon), Asteraceae, is a species that has long been used in traditional Asian medicine, mainly in Iran, Pakistan, Azerbaijan and India. It is known as a spice species in Asia, Europe and the Americas. Read More

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Review of the Traditional Uses, Phytochemistry, and Pharmacological Activities of Species (Vitaceae).

Molecules 2021 Apr 16;26(8). Epub 2021 Apr 16.

Department of Chemistry, Tshwane University of Technology, 175 Nelson Mandela Drive, Private Bag X680, Pretoria 0001, South Africa.

Species within the genus (Vitaceae) are commonly used in South African traditional medicine. The current review discusses the occurrence, distribution, traditional uses, phytochemistry, and pharmacological properties of species covering the period 1981-2020. The data reported were systematically collected, read, and analysed from scientific electronic databases including Scopus, Scifinder, Pubmed, and Google Scholar. Read More

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Phenolic Compounds from Are Characterized by Their Antioxidant, Anti-Inflammatory and Hepatoprotective Activities.

Antioxidants (Basel) 2021 Apr 23;10(5). Epub 2021 Apr 23.

CAS Key Laboratory of Plant Germplasm Enhancement and Specialty Agriculture, Wuhan Botanical Garden, Chinese Academy of Sciences, Wuhan 430074, China.

has been traditionally used for the treatment of various diseases due to its different pharmacological activities. However, the active compounds responsible for its potentially specific activities have rarely been explored. To this end, the ethyl acetate (EA) fraction was screened out and selected for further phytochemical isolation because of its promising activities in preliminary 2,2-diphenyl-1-picrylhydrazyl (DPPH), ferric reducing antioxidant power (FRAP) and COX-2 inhibition assays. Read More

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Custard Apple ( L.) Leaves: Nutritional Composition, Phytochemical Profile, and Health-Promoting Biological Activities.

Biomolecules 2021 Apr 21;11(5). Epub 2021 Apr 21.

Clinic for Conservative Dentistry and Periodontology, School of Dental Medicine, Christian-Albrecht's University, 24105 Kiel, Germany.

L. (custard apple) belongs to the family Annonaceae and is an important tropical fruit cultivated in the West Indies, South and Central America, Ecuador, Peru, Brazil, India, Mexico, the Bahamas, Bermuda, and Egypt. Leaves of custard apple plants have been studied for their health benefits, which are attributed to a considerable diversity of phytochemicals. Read More

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Anti-Neuroinflammatory Effects and Mechanism of Action of Extract in BV2 Microglia.

Plants (Basel) 2021 Apr 2;10(4). Epub 2021 Apr 2.

College of Korean Medicine, Dongguk University, Goyang 10326, Korea.

For centuries, (FLL; the fruit of Aiton or Thunb.) has been commonly used in traditional Chinese medicine for treating hepatitis and aging-related symptoms and in traditional Korean medicine to detoxify kidneys and the liver. Pharmacological research has shown FLL has antioxidant, anti-inflammatory, anticancer, anti-osteoporosis, and hepatoprotective activities. Read More

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UPLC-PDA-ESI/MS metabolic profiling of dill shoots bioactive fraction; evidence of its antioxidant and hepatoprotective effects in vitro and in vivo.

J Food Biochem 2021 Apr 26:e13741. Epub 2021 Apr 26.

Pharmacognosy Department, Faculty of Pharmacy, Cairo University, Cairo, Egypt.

Hydroxyl radical ( OH) scavenging capacity of aqueous dill (Anethum graveolens L.) shoot (ADSh) extract was assessed using electron paramagnetic resonance (EPR) spectroscopy. ADSh extract (at concentrations of 0. Read More

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Anti-oxidant and hepatoprotective effects of Lactuca serriola and its phytochemical screening by HPLC and FTIR analysis.

Pak J Pharm Sci 2020 Nov;33(6(Supplementary)):2823-2830

Department of Pharmacognosy, Faculty of Pharmacy, Ziauddin University Hospital Clifton, Karachi, Pakistan.

Lactucaserriola (L. serriola), commonly known asprickly lettuce, is an annual and biennial herb. The plant is traditionally used as sedative, hypnotic, cough suppressant, expectorant, purgative, diuretic, vasorelaxant, demulcent, antiseptic and antispasmodic. Read More

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November 2020

Hepato-protective role of itraconazole mediated cytochrome p450 pathway inhibition in liver fibrosis.

Pak J Pharm Sci 2020 Nov;33(6(Supplementary)):2751-2758

Institute of Molecular Biology and Biotechnology (IMBB), The University of Lahore, Lahore, Pakistan.

Liver is a vital organ and is routinely exposed to toxins. Carbon tetrachloride is one such noxious agent which cause toxicity in liver when CYP450 enzyme bio-activates it. Many hepatoprotective agents are available in market with severe side effects. Read More

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November 2020

Antihyperlipidemic effect of selected pyrimidine derivatives mediated through multiple pathways.

Fundam Clin Pharmacol 2021 Apr 19. Epub 2021 Apr 19.

State Key Laboratory of Oncogenomics, School of Chemical Biology and Biotechnology, Shenzhen Graduate School, Peking University, Shenzhen, China.

Hyperlipidemia is worth-mentioning risk factor in quickly expanding atherosclerosis, myocardial infarction, and stroke. This study attempted to determine effectiveness of selected pyrimidine derivatives: 5-(3-Hydroxybenzylidene)-2, 4, 6(1H, 3H, 5H)-pyrimidinetrione (SR-5), 5-(4-Hydroxybenzylidene)-2, 4, 6(1H, 3H, 5H)-pyrimidinetrione (SR-8), 5-(3-Chlorobenzylidene)-2, 4, 6(1H, 3H, 5H)-pyrimidinetrione (SR-9), and 5-(4-Chlorobenzylidene)-2, 4, 6(1H, 3H, 5H)-pyrimidinetrione (SR-10) against hyperlipidemia. In silico results revealed that SR-5, SR-8, SR-9, and SR-10 exhibited high affinity with 3-hydroxy-3-methylglutaryl coenzyme A (HMGCoA) possessing binding energy values of -8. Read More

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Chemical profiling and bioactivities on the leaf extracts of Vitex neugundo.

Pak J Pharm Sci 2020 Nov;33(6):2535-2541

Department of Chemistry COMSATS, Institute of Information Technology, Abbottabad, Pakistan.

The Vitex negeundo is a widely used medicinal plant which has not been fully investigated in the past. We assessed the in vivo hepatoprotective and in vitro antioxidant, antibacterial, cytotoxicity and anti proliferative study of leaf extracts of V. neugundo. Read More

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November 2020

Alpinetin exerts anti-inflammatory, anti-oxidative and anti-angiogenic effects through activating the Nrf2 pathway and inhibiting NLRP3 pathway in carbon tetrachloride-induced liver fibrosis.

Int Immunopharmacol 2021 Apr 14;96:107660. Epub 2021 Apr 14.

Department of General Surgery, Affiliated Maternity and Child Health Care Hospital of Nantong University, Nantong 226018, China. Electronic address:

Alpinetin is the major active ingredient of Alpiniakatsumadai Hayata. As a kind of novel plant-derived flavonoid, alpinetin has shown potent hepatoprotective effect against many liver diseases such as non-alcoholic fatty liver and lipopolysaccharide/d-Galactosamine-induced liver injury. However, its roles in liver fibrosis remain to be determined. Read More

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Ethnomedicinal Uses, Phytochemistry and Pharmacology of Different Cichorium Species (Asteraceae): A Review.

Adv Exp Med Biol 2021 ;1308:501-546

Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

Cichorium species have been used widely in traditional medicine universally. It is reported as a treatment for various respiratory and gastrointestinal disorders, as well as diabetes and rheumatism. A range of constituents including phenolic and poly phenolic compounds, fatty and organic acids and essential oils comprise the chemical composition of Cichorium species. Read More

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Beneficial Effects of Plant-Derived Natural Products on Non-alcoholic Fatty Liver Disease.

Adv Exp Med Biol 2021 ;1308:257-272

Unidad de Investigación Biomédica, Delegación Durango, Instituto Mexicano del Seguro Social, Durango, México.

Non-alcoholic fatty liver disease is becoming in one of the most prevalent liver diseases that leads to liver transplantation. This health problem is a multisystem disease with a complex pathogenesis that involves liver, adipose tissue, gut, and muscle. Although several pharmacological agents have been investigated to prevent or treat non-alcoholic fatty liver disease, currently there is no effective treatment for the management of this chronic liver disease. Read More

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Heliconia rostrata rhizomes mitigate chemical-induced liver injury by debilitating oxidative stress in HepG2 cells and rats.

J Ethnopharmacol 2021 Apr 20;275:114113. Epub 2021 Apr 20.

Department of Pharmaceutical Analysis, School of Pharmaceutical Sciences, Siksha O Anusnadhan Deemed to Be University, Kalinga Nagar, Bhubaneswar, Odisha, 751003, India. Electronic address:

Ethnopharmacological Relevance: Heliconia rostrata Ruiz and Pav. belongs to the family Heliconiaceae. Plant was traditionally used to cure jaundice, intestinal pain, diabetes and hypertension. Read More

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Grape seed extract ameliorated Ehrlich solid tumor-induced hepatic tissue and DNA damage with reduction of PCNA and P53 protein expression in mice.

Environ Sci Pollut Res Int 2021 Apr 13. Epub 2021 Apr 13.

Chemistry Department, Faculty of Science, Menoufia University, Sheben Elkom, Egypt.

This study evaluated the ameliorative potential of grape seed extract (GSE) against Ehrlich solid tumor (EST)-induced hepatic tissue alterations in mice. The control group was infused with physiological saline. The second group received GSE (50 mg/kg day by day orally) for 2 weeks. Read More

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Modulation of multiple cellular signalling pathways as targets for anti-inflammatory and anti-tumorigenesis action of Scopoletin.

J Pharm Pharmacol 2021 Apr 13. Epub 2021 Apr 13.

Department of Biochemistry, PSG College of Arts & Science, Coimbatore, Tamil Nadu, India.

Objectives: Scopoletin (6-methoxy-7-hydroxycoumarin) is a naturally occurring coumarin belonging to the category of secondary metabolites. Coumarins are commonly found in several herbs and play a prominent role in the defense mechanism of plants. Beneficial effects of scopoletin including antioxidant, anti-diabetic, hepatoprotective, neuroprotective and anti-microbial activity induced via numerous intracellular signalling mechanisms have been widely studied. Read More

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Exploration of the hepatoprotective effect and mechanism of magnesium isoglycyrrhizinate in mice with arsenic trioxide‑induced acute liver injury.

Mol Med Rep 2021 Jun 13;23(6). Epub 2021 Apr 13.

Department of Pharmacology, School of Pharmacy, Hebei University of Chinese Medicine, Shijiazhuang, Hebei 050200, P.R. China.

Arsenic trioxide (ATO)‑induced hepatotoxicity limits the therapeutic effect of acute myelogenous leukemia treatment. Magnesium isoglycyrrhizinate (MgIG) is a natural compound extracted from licorice and a hepatoprotective drug used in liver injury. It exhibits anti‑oxidant, anti‑inflammatory and anti‑apoptotic properties. Read More

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Protective Effects of Mill. Fruit on Carbon Tetrachloride-induced Hepatotoxicity Mediated through Mitochondria and Restoration of Cellular Energy Content.

Iran J Pharm Res 2020 ;19(4):354-364

Department of Medicinal Chemistry, School of Pharmacy, Zanjan University of Medical Sciences, Zanjan, Iran.

Quince ( Mill.) is one of the medicinal plant with a broad range of pharmacological activities such as hepatoprotective effect. The present study was conducted to evaluate the effect of aqueous extract of Mill. Read More

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January 2020

Influence of silymarin components on keratinocytes and 3D reconstructed epidermis.

Toxicol In Vitro 2021 Aug 8;74:105162. Epub 2021 Apr 8.

Palacky University Olomouc, Faculty of Medicine and Dentistry, Department of Medical Chemistry and Biochemistry, Hněvotínská 3, 775 15 Olomouc, Czech Republic.

Silymarin is a flavonoid complex isolated from the plant Silybum marianum which is well known for its antioxidant, hepatoprotective and immunomodulatory effects. Since little is known about its anti-inflammatory properties and healing effects, our study focused on whether or not silymarin components reduce inflammation and support epidermis regeneration. Lipopolysaccharides (LPS) and sodium dodecyl sulfate (SDS) were used to induce inflammation in normal human epidermal keratinocytes (NHEKs) and reconstructed epidermis (RHE), respectively. Read More

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Hepatoprotective effect of Ziziphus oxyphylla Edgew in paracetamol-induced hepatotoxic rat model.

Pak J Pharm Sci 2020 Sep;33(5(Special)):2449-2454

Faculty of Pharmacy, Department of Pharmacology, The University of Lahore, Lahore, Pakistan.

Ziziphus oxyphylla Edgew (Z. oxyphylla) is a small shrub to a medium sized tree. The aim of the present study was to evaluate the hepatoprotective activity of Z. Read More

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September 2020