432 results match your criteria antimony caused

Successful treatment of diffuse cutaneous leishmaniasis caused by Leishmania amazonensis.

An Bras Dermatol 2021 Jul 14. Epub 2021 Jul 14.

Hospital Universitário de Brasília, Universidade de Brasília, Brasília, DF, Brazil.

Diffuse cutaneous leishmaniasis is a rare universal disease associated with an inadequate host cell immune response, caused by different species: infantum, aethiopica, major, mexicana, and others, which presents the challenge of a poor therapeutic response. In Brazil, it is caused by L. amazonensis. Read More

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Antimony resistance associated with persistence of Leishmania (Leishmania) infantum infection in macrophages.

Parasitol Res 2021 Jul 17. Epub 2021 Jul 17.

Health Sciences Graduate Program, Federal University of Sergipe, Aracaju, Brazil.

Visceral leishmaniasis is a severe disease caused by protozoan parasites that include Leishmania (L.) infantum. The disease is established when parasites subvert the immune response of the host. Read More

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Involvement of nitric oxide (NO) in plant responses to metalloids.

J Hazard Mater 2021 Jul 7;420:126606. Epub 2021 Jul 7.

Department of Plant Biology, University of Szeged, H6726 Szeged Közép fasor 52., Hungary.

Plants respond to the limited or excess supply of metalloids, boron (B), silicon (Si), selenium (Se), arsenic (As), and antimony (Sb) via complex signaling pathways that are mainly regulated by nitric oxide (NO). The absorption of metalloids from the soil is facilitated by pathways that involve aquaporins, aquaglyceroporins, phosphate, and sulfate transporters; however, their regulation by NO is poorly understood. Using in silico software, we predicted the S-nitrosation of known metalloid transporters, proposing NO-dependent regulation of metalloid transport systems at the posttranslational level. Read More

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Antimony exposure promotes bladder tumor cell growth by inhibiting PINK1-Parkin-mediated mitophagy.

Ecotoxicol Environ Saf 2021 Sep 21;221:112420. Epub 2021 Jun 21.

Department of Urology, Tianjin Institute of Urology, The Second Hospital of Tianjin Medical University, Tianjin 300211, China. Electronic address:

Antimony is one of the heavier pnictogens and is widely found in human food chains, water sources, and as an air pollutant. Recent years have seen steadily increasing concentrations of antimony in the ecological environment; critically, several studies have indicated that antimony might pose a tumorigenic risk factor in several cancers. Therefore, antimony toxicity has attracted increasing research attention, with the molecular mechanisms underlying suspected antimony-mediated tumor transformation of greatest interest. Read More

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September 2021

Association of multi-metals exposure with intelligence quotient score of children: A prospective cohort study.

Environ Int 2021 Oct 18;155:106692. Epub 2021 Jun 18.

Department of Occupational and Environmental Health, Xiangya School of Public Health, Central South University, Changsha, China; Hunan Province Key Laboratory of Typical Environmental Pollution and Health Hazards, School of Public Health, Hengyang Medical College, University of South China, Hengyang 421001, China. Electronic address:

Background: Associations between most single metals and children's intelligence quotient (IQ) scores have been evaluated in previous studies. However, associations between multi-metal exposures and children's IQ scores have not been analyzed.

Objectives: To assess the joint effects of lead (Pb), manganese (Mn), antimony (Sb), tin (Sn) and titanium (Ti) co-exposure on children's IQ scores. Read More

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October 2021

Comparison of the single and combined effects of arsenic and antimony on growth and physiology of giant reed (Arundo donax L.).

Environ Sci Pollut Res Int 2021 Jun 17. Epub 2021 Jun 17.

Department of Plant Physiology, Faculty of Natural Sciences, Comenius University in Bratislava, Mlynská dolina B2, Ilkovičova 6, SK-842 15, Bratislava, Slovakia.

Fast-growing plant, giant reed (Arundo donax L.) has been gaining a lot of popularity in the phytoremediation of metal-polluted soils. However, information regarding the physiological background of tolerance and accumulation capacity of A. Read More

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Arsenic (III) and/or Antimony (III) induced disruption of calcium homeostasis and endoplasmic reticulum stress resulting in apoptosis in mice heart.

Ecotoxicol Environ Saf 2021 Sep 4;220:112394. Epub 2021 Jun 4.

Guangdong Provincial Key Laboratory of Food Quality and Safety, College of Food Science, South China Agricultural University, Guangzhou 510642, China. Electronic address:

Arsenic (As) and antimony (Sb) are known as an environmental contaminant with cardiotoxicity properties. The endoplasmic reticulum (ER) is the largest calcium reservoir in the cell, and its calcium homeostasis disorder plays a vital role in endoplasmic reticulum stress (ERS) and apoptosis. The objective of this study was to investigate whether As and Sb induced apoptosis via endoplasmic reticulum stress (ERS) linked to calcium homeostasis disturbance. Read More

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September 2021

Disintegrable, transparent and mechanically robust high-performance antimony tin oxide/nanocellulose/polyvinyl alcohol thermal insulation films.

Carbohydr Polym 2021 Aug 7;266:118175. Epub 2021 May 7.

State Key Lab of Pulp and Paper Engineering, South China University of Technology, Guangzhou 510640, China. Electronic address:

Polymer-based thermal insulation films are widely utilized to reduce the influence of solar radiation. However, current thermal insulation films face several challenges from poor thermal insulation performance and severe environmental pollution, which are caused by the non-disintegratability of polymer substrates. Here, cellulose nanofiber (CNF)/antimony tin oxide (ATO) hybrid films with and without polyvinyl alcohol (PVA) are presented and they can be used as window thermal barrier films and personal thermal management textiles. Read More

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Antimony induced structural and ultrastructural changes in Trapa natans.

Sci Rep 2021 May 21;11(1):10695. Epub 2021 May 21.

Department of Environmental Science, Tezpur University, Napaam, Tezpur, Assam, India.

Antimony (Sb) is considered as a priority toxic metalloid in the earth crust having no known biological function. The current study was carried out in a hydroponic experiment to study the accumulation of ecotoxic Sb in subcellular level, and to find out the ultrastructural damage caused by Sb in different vegetative parts of Trapa natans. Sb-induced structural and ultrastructural changes of T. Read More

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Effects of different antimony contamination levels on paddy soil bacterial diversity and community structure.

Ecotoxicol Environ Saf 2021 Sep 18;220:112339. Epub 2021 May 18.

Guizhou Provincial Key Laboratory for Information System of Mountainous Areas and Protection of Ecological Environment, Guizhou Normal University, Guiyang 550001, China.

To clarify the response mechanism of paddy soil microorganisms to contamination caused by antimony (Sb) alone, we added K(SbO)CHO.1/2 HO with different contents to uncontaminated paddy soil and carried out related studies. 16S rRNA was sequenced in V3-V4 regions of paddy soil bacteria with different Sb contamination levels. Read More

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September 2021

Developmental neurotoxicity of antimony (Sb) in the early life stages of zebrafish.

Ecotoxicol Environ Saf 2021 May 8;218:112308. Epub 2021 May 8.

Key Laboratory for Biorheological Science and Technology of Ministry of Education, State and Local Joint Engineering Laboratory for Vascular Implants, Bioengineering College of Chongqing University, Chongqing 400030, China. Electronic address:

Accumulating studies have revealed the toxicity of antimony (Sb) to soil-dwelling and aquatic organisms at the individual level. However, little is known about the neurotoxic effects of antimony and its underlying mechanisms. To assess this issue, we investigated the neurotoxicity of antimony (0, 200, 400, 600 and 800 mg/L) in zebrafish embryos. Read More

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Drug-Induced Lipid Remodeling in Parasites.

Microorganisms 2021 Apr 9;9(4). Epub 2021 Apr 9.

Department of Biological Sciences, Texas Tech University, Lubbock, TX 79409, USA.

parasites efficiently develop resistance against several types of drugs including antimonials, the primary antileishmanial drug historically implemented. The resistance to antimonials is considered to be a major risk factor for effective leishmaniasis treatment. To detect biomarkers/biopatterns for the differentiation of antimony-resistant strains, we employed untargeted global mass spectrometry to identify intracellular lipids present in antimony sensitive and resistant parasites before and after antimony exposure. Read More

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High Anti- IgG Antibody Levels Are Associated With Severity of Mucosal Leishmaniasis.

Front Cell Infect Microbiol 2021 9;11:652956. Epub 2021 Apr 9.

Serviço de Imunologia, Hospital Universitário Prof. Edgard Santos, Universidade Federal da Bahia, Salvador, Brazil.

Background: Mucosal leishmaniasis (ML), the most inflammatory form of tegumentary leishmaniasis, is predominantly caused by . The disease is characterized by the development of lesions, mainly in the nasal mucosa. An exacerbated inflammatory response has been associated with the presence of destructive and disfiguring lesions, with stages of severity ranging from small nodulations to the complete destruction of the nasal pyramid architecture. Read More

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The impact of artisanal gold mining, ore processing and mineralization on water quality in Marmato, Colombia.

Environ Geochem Health 2021 Apr 11. Epub 2021 Apr 11.

Gran Colombia Gold Corp., Medellín, Colombia.

Marmato, Colombia, has been an important centre of gold mining since before the first Spanish colonizers arrived in 1536. The Marmato deposit is hosted in a dacite and andesite porphyry stock as sheeted sulphide-rich veinlet systems. The district is currently experiencing a surge in both major mining projects and artisanal mining, driven by sustained high gold prices. Read More

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Inductively coupled plasma mass spectrometry method for plasma and intracellular antimony quantification applied to pharmacokinetics of meglumine antimoniate.

Bioanalysis 2021 Apr 8;13(8):655-667. Epub 2021 Apr 8.

Centro Internacional de Entrenamiento e Investigaciones Médicas, CIDEIM, Cali, Valle del Cauca, Colombia.

A high-throughput method using inductively coupled plasma mass spectrometry (ICP-MS) was developed and validated for the quantitative analysis of antimony in human plasma and peripheral blood mononuclear cells from patients with cutaneous leishmaniasis undergoing treatment with meglumine antimoniate. Antimony was digested in clinical samples with 1% tetramethylammonium hydroxide/1% EDTA and indium was used as internal standard. Accuracy, precision and stability were evaluated. Read More

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[Changes in Concentrations and Pollution Levels of Trace Elements of Floodplain Sediments of Poyang Lake Basin in Recent Twenty Years].

Huan Jing Ke Xue 2021 Apr;42(4):1724-1738

Institute of Geophysical & Geochemical Exploration, Chinese Academy of Geological Sciences, Langfang 065000, China.

Investigating the pollution conditions of trace elements in the Poyang Lake basin, identifying the pollution sources, evaluating the ecological risks play an important part in formulating the effective strategies for protecting the basin ecosystem. To understand the concentration characteristics, pollution levels, and ecological risks of twelve trace elements (Cd, Hg, Pb, As, Cu, Zn, Cr, Ni, Mn, Sb, W, and Sn) in the floodplain sediments of the five main tributaries in Poyang Lake basin in the past twenty years, we used the enrichment factor (EF) and modified pollution index (MPI) to quantify the pollution levels of the trace elements, and analyzed and discussed the pollution sources in the areas with significant pollution level changes. The results indicated that the concentrations of cadmium, zinc, manganese, tungsten and lead in the floodplain sediments of the Poyang Lake basin during the past twenty years have increased by 134%, 26%, 41%, 25%, and 8%, respectively, and mercury, arsenic, chromium, nickel, antimony, and tin have decreased by 35%, 15%, 22%, 10%, 14%, and 13%, respectively, while copper has not changed significantly. Read More

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Toxicity assessment of industrial engineered and airborne process-generated nanoparticles in a 3D human airway epithelial model.

Nanotoxicology 2021 May 18;15(4):542-557. Epub 2021 Mar 18.

Departamento de Saúde Ambiental, Instituto Nacional de Saúde Doutor Ricardo Jorge, Porto, Portugal.

The advanced ceramic technology has been pointed out as a potentially relevant case of occupational exposure to nanoparticles (NP). Not only when nanoscale powders are being used for production, but also in the high-temperature processing of ceramic materials there is also a high potential for NP release into the workplace environment. toxicity of engineered NP (ENP) [antimony tin oxide (SbO•SnO; ATO); zirconium oxide (ZrO)], as well as process-generated NP (PGNP), and fine particles (PGFP), was assessed in MucilAir™ cultures at air-liquid interface (ALI). Read More

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Influence of Obesity on Clinical Manifestations and Response to Therapy in Cutaneous Leishmaniasis caused by Leishmania braziliensis.

Clin Infect Dis 2021 Mar 16. Epub 2021 Mar 16.

Immunology Service, Professor Edgard Santos University Hospital Complex, Federal University of Bahia, Salvador, Bahia, Brazil.

Background: Cutaneous leishmaniasis (CL) caused by L. braziliensis is characterized by a single ulcer or multiple cutaneous lesions with raised borders. Cure rates below 60% are observed in response to meglumine antimoniate therapy. Read More

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Heavy metal pollution and ecological risk assessment of tailings in the Qinglong Dachang antimony mine, China.

Environ Sci Pollut Res Int 2021 Feb 27. Epub 2021 Feb 27.

Resource and Environmental Engineering College, Guizhou University, 550025, Guiyang, People's Republic of China.

The pollution of heavy metals and their harm to human health and the ecological environment have caused widespread concern. In this research, we collected Qinglong antimony mine tailings (8-meter deep) and then analyzed the content changes, geochemical behavior, and ecological risk assessment of 7 heavy metals (Sb, As, Cr, Cd, Cu, Zn, Pb) in the tailing profile, providing a theoretical basis for strengthening the source control and risk control of heavy metals. In addition, the chemical forms of Sb and As were analyzed, and the relationship between their forms and their physical and chemical properties was analyzed by redundancy analysis (RDA). Read More

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February 2021

Difference in the binding mechanism of distinct antimony forms in bovine serum albumin.

Biometals 2021 Jun 15;34(3):493-510. Epub 2021 Feb 15.

Department of Chemistry, College of Sciences, Northeastern University, Shenyang, 110819, People's Republic of China.

The toxicity of antimony (Sb) is closely related to its chemical forms. To further realize the toxicity risk of different forms of Sb, the separate and simultaneous binding mechanisms of antimony potassium tartrate/potassium pyroantimonate with bovine serum albumin (BSA) were investigated with muti-spectroscopic methods. Fluorescence quenching result and UV-vis absorption spectra showed that a 1:1 complex was formed between antimony potassium tartrate/potassium pyroantimonate and BSA through a modest binding force. Read More

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Dynamic flow and pollution of antimony from polyethylene terephthalate (PET) fibers in China.

Sci Total Environ 2021 Jun 18;771:144643. Epub 2021 Jan 18.

State Key Laboratory of Water Environment Simulation, School of Environment, Beijing Normal University, Beijing 100875, China.

Antimony (Sb), a regulated contaminant, is added as a catalyst in the process of polyethylene terephthalate (PET) synthesis. Previously, Sb release from PET bottles and films was studied. However, Sb release from PET fibers (the most common form of PET) is limited. Read More

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Effectiveness of miltefosine in cutaneous leishmaniasis caused by Leishmania tropica in Pakistan after antimonial treatment failure or contraindications to first line therapy-A retrospective analysis.

PLoS Negl Trop Dis 2021 01 28;15(1):e0008988. Epub 2021 Jan 28.

Médecins Sans Frontières, Amsterdam, the Netherlands.

Background: Cutaneous leishmaniasis (CL) is a neglected tropical skin disease, caused by Leishmania protozoa. In Pakistan, where CL caused by L. tropica is highly endemic, therapy with pentavalent antimonials is the standard of care, but has significant toxicity when used in systemic therapy, while are no evidence-based safer alternative treatment options for L. Read More

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January 2021

Study on molecular level toxicity of Sb(V) to soil springtails: using a combination of transcriptomics and metabolomics.

Sci Total Environ 2021 Mar 16;761:144097. Epub 2020 Dec 16.

State Key Laboratory of Environmental Criteria and Risk Assessment, Chinese Research Academy of Environmental Sciences, Beijing 100000, China. Electronic address:

To date, numerous studies have focused on the toxicity of antimony (Sb) to soil-dwelling organisms at the individual level. However, little is known about Sb-caused molecular level toxicity. Here, an integrated transcriptomics and metabolomics approach was used to better reveal toxicity of Sb(V) to springtails Folsomia candida considering environmentally relevant speciation of Sb. Read More

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Diabetes Modifies the Clinic Presentation of Cutaneous Leishmaniasis.

Open Forum Infect Dis 2020 Dec 19;7(12):ofaa491. Epub 2020 Oct 19.

Immunology Service, Professor Edgard Santos University Hospital Complex, Federal University of Bahia, Salvador, Bahia, Brazil.

Background: Cutaneous leishmaniasis (CL) caused by is characterized by 1 or multiple well-limited ulcerated lesions. Diabetes mellitus (DM) impairs neutrophil and monocyte function, and there is a report of vegetative lesions in a patient with both diseases in Morocco. Here we evaluate the influence of DM on clinical manifestations, immune response, and in the treatment of CL. Read More

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December 2020

Microplastics generated under simulated fire scenarios: Characteristics, antimony leaching, and toxicity.

Environ Pollut 2021 Jan 20;269:115905. Epub 2020 Oct 20.

Key Laboratory of Microbial Technology for Industrial Pollution Control of Zhejiang Province, College of Environment, Zhejiang University of Technology, Hangzhou, 310014, China. Electronic address:

Intentional or incidental thermal changes inevitably occur during the lifecycle of plastics. High temperatures accelerate the aging of plastics and promote their fragmentation to microplastics (MPs). However, there is little information available on the release of MPs after fires. Read More

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January 2021

Multiple effects of nitrate amendment on the transport, transformation and bioavailability of antimony in a paddy soil-rice plant system.

J Environ Sci (China) 2021 Feb 24;100:90-98. Epub 2020 Jul 24.

Guangdong Key Laboratory of Integrated Agro-environmental Pollution Control and Management, Guangdong Institute of Eco-environmental Science & Technology, Guangzhou 510650, China.

Nitrate (NO) is known to be actively involved in the processes of mineralization and heavy metal transformation; however, it is unclear whether and how it affects the bioavailability of antimony (Sb) in paddy soils and subsequent Sb accumulation in rice. Here, the effects of NO on Sb transformation in soil-rice system were investigated with pot experiments over the entire growth period. Results demonstrated that NO reduced Sb accumulation in brown rice by 15. Read More

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February 2021

Synthesis of raspberry-like antimony-platinum (SbPt) nanoparticles as highly active electrocatalysts for hydrogen evolution reaction.

J Colloid Interface Sci 2021 Feb 6;584:729-737. Epub 2020 Oct 6.

Department of Chemical Engineering, National Tsing Hua University, 101, Section 2, Kuang-Fu Road, Hsinchu 30013, Taiwan. Electronic address:

Binary transition metals can facilitate the hydrogen evolution reaction (HER) through the synergistic integration of different electrochemical properties. To determine binary transition metals that are highly active, Greely et al. conducted a simulation of 256 different binary transition metals. Read More

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February 2021

Study on antimony mobility in a contaminated shallow lake sediment using the diffusive gradients in thin films technique.

Chemosphere 2021 Mar 19;267:128913. Epub 2020 Nov 19.

National Engineering Laboratory for Lake Pollution Control and Ecological Restoration, State Environmental Protection Key Laboratory for Lake Pollution Control, Chinese Research Academy of Environmental Sciences, Anwai, Beiyuan, Beijing, 100012, China.

Antimony is a priority environmental contaminant. Increasing attention is being paid to the behaviors and mobilities of the various Sb species in the environment. Sb speciation in the environment and the mobilities of Sb species at mining sites have been studied well, but Sb speciation and mobility in shallow lakes requires further study. Read More

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CXCL10 immunomodulatory effect against infection caused by an antimony refractory isolate of Leishmania braziliensis in mice.

Parasite Immunol 2021 03 19;43(3):e12805. Epub 2020 Nov 19.

Department of Pathology and Legal Medicine, Federal University of Ceará, Fortaleza, Brazil.

Leishmania braziliensis is the main causative agent of American tegumentary leishmaniasis in Brazil. Current treatment includes different drugs that have important side effects and identification of cases of parasite resistance to treatment support the search for new therapeutic strategies. Recent findings have indicated that CXCL10, a chemokine that recruits and activates Th1 cells, NK cells, macrophages, dendritic cells and B lymphocytes, is a potential alternative to treat Leishmania infection. Read More

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Rational Design of [email protected]@TiO Triple-Shell Nanoboxes for High-Performance Sodium-Ion Batteries.

Small 2020 Oct 28;16(43):e2001976. Epub 2020 Sep 28.

Sichuan Research Center of New Materials, Institute of Chemical Materials, China Academy of Engineering Physics, Chengdu, 610200, China.

Antimony is an attractive anode material for sodium-ion batteries (SIBs) owing to its high theoretical capacity and appropriate sodiation potential. However, its practical application is severely impeded by its poor cycling stability caused by dramatic volumetric variations during sodium uptake and release processes. Here, to circumvent this obstacle, [email protected]@TiO triple-shell nanoboxes (TSNBs) are synthesized through a template-engaged galvanic replacement approach. Read More

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October 2020