340,247 results match your criteria antimicrobial activity

Atomic-engineering Au-Ag nanoalloys for screening antimicrobial agents with low toxicity towards mammalian cells.

Colloids Surf B Biointerfaces 2021 May 11;204:111831. Epub 2021 May 11.

School of Biomedical Engineering, Sun Yat-sen University, Guangzhou, Guangdong, 510006, China. Electronic address:

Silver nanoparticles (AgNPs) have shown potent antibacterial activity against numerous bacteria strains. However, their toxicity against mammalian cells is still a big challenge, limiting their in vivo applications. Here, we found that alloying Ag and Au in an atomic level to form Au-Ag nanoalloys (NAs) could effectively reduce the cytotoxicity of AgNPs, and the antimicrobial activity of NAs could be well maintained by tuning the composition of Ag. Read More

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Polymyxin B-inspired non-hemolytic tyrocidine A analogues with significantly enhanced activity against gram-negative bacteria: How cationicity impacts cell specificity and antibacterial mechanism.

Eur J Med Chem 2021 May 1;221:113488. Epub 2021 May 1.

National Pharmaceutical Engineering Center for Solid Preparation in Chinese Herbal Medicine, Jiangxi University of Traditional Chinese Medicine, Nanchang, 330004, PR China; Laboratoire de Méthodologie, Synthèse et Molécules Thérapeutiques (ICMMO), UMR 8182, CNRS, Université Paris-Saclay, Bât 410, Facultédes Sciences D'Orsay, Orsay, 291405, France; State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Guangxi Normal University, 15 Yuchai Road, Guilin, 541004, PR China. Electronic address:

Naturally occurring cyclic antimicrobial peptides (AMPs) such as tyrocidine A (Tyrc A) and gramicidin S (GS) are appealing targets for the development of novel antibiotics. However, their therapeutic potentials are limited by undesired hemolytic activity and relatively poor activity against Gram-negative bacteria. Inspired by polycationic lipopeptide polymyxin B (PMB), the so called 'last-resort' antibiotic for the treatment of infections caused by multidrug-resistant Gram-negative bacteria, we synthesized and biologically evaluated a series of polycationic analogues derived from Tyrc A. Read More

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Brazilian Red Propolis shows antifungal and immunomodulatory activities against Paracoccidioides brasiliensis.

J Ethnopharmacol 2021 May 12:114181. Epub 2021 May 12.

Federal University of Alfenas - UNIFAL. Alfenas, MG, Brazil. Electronic address:

Ethnopharmacological Relevance: Paracoccidioidomycosis (PCM) is a systemic mycosis with high prevalence in South America and especially in Brazil with severe clinical consequences that need broadened therapeutic options. Propolis is a natural resin from bees used in folk medicine for centuries with the first report in the ancient history of Egypt by Eberly papyrus, in Middle-Ages used to wash the newborn's umbilical cord and World War II as antiseptic or antibiotics. Nowadays it is a natural product worldwide consumed as food and traditionally used for oral and systemic diseases as an anti-inflammatory, antimicrobial, antifungal, and other diseases. Read More

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Successful use of azithromycin for Escherichia coli-associated renal allograft malakoplakia: a report of two cases.

Eur J Clin Microbiol Infect Dis 2021 May 14. Epub 2021 May 14.

Department of Infectious Diseases, Austin Health, 145 Studley Road, Heidelberg, Victoria, 3084, Australia.

Malakoplakia is a chronic granulomatous disease associated with incomplete clearance of bacterial pathogens. A multimodal approach to therapy includes antimicrobials with intracellular activity, reduction in immunosuppression, and debulking of lesions. Azithromycin has an intracellular mechanism of action and enhanced Gram-negative activity compared to other macrolides. Read More

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Gliadin-mediated green preparation of hybrid zinc oxide nanospheres with antibacterial activity and low toxicity.

Sci Rep 2021 May 14;11(1):10373. Epub 2021 May 14.

Department of Dermatology, Huashan Hospital, Fudan University, Jing'an District, Shanghai, 200040, China.

The development of inorganic antibacterial agents that impart antibacterial properties to biomaterials has attracted wide attention. The paper introduced a kind of hybrid nanosphere antibacterial agent composed of wheat gliadin (WG) and zinc oxide (ZnO), with antibacterial efficacy and low toxicity. The ZnO/WG hybrid nanospheres were environment-friendly integrated by molecular self-assembly co-precipitating and freeze-drying transformation, and were characterized using X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), scanning electron microscope (SEM), atomic absorption spectroscopy (AAS), specific surface and pore size analysis, bacteriostasis test, reactive oxygen species (ROS) determination and safety evaluation. Read More

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Antimicrobial-resistance gene transfer of in mono- and dual-species biofilms.

Appl Environ Microbiol 2021 May 14. Epub 2021 May 14.

Food, Nutrition and Health Program, Faculty of Land and Food Systems, The University of British Columbia, Vancouver, BC, V6T 1Z4, Canada

Horizontal gene transfer (HGT) is a driving force for the dissemination of antimicrobial resistance (AMR) genes among , a leading cause of foodborne gastroenteritis worldwide Although HGT is well documented for planktonic cells, the role of biofilms in AMR spread that likely to occur in the environment is poorly understood. Here, we developed a co-cultivation model to investigate the HGT of chromosomally-encoded AMR genes between two F38011 AMR mutants in biofilms. Compared to planktonic cells, biofilms significantly promoted HGT ( < 0. Read More

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Antifungal Azoles as Tetracycline Resistance-Modifiers in .

Appl Environ Microbiol 2021 May 14. Epub 2021 May 14.

Clinical Microbiology & Antimicrobial Research Laboratory, CSIR-Institute of Microbial Technology, Sector 39-A, Chandigarh-160036, India

has developed resistance to antimicrobials since its first use. The major facilitator superfamily (MFS) efflux pump Tet(K) contributes to resistance to tetracyclines. The efflux pump diminishes antibiotic accumulation, and biofilm hampers the diffusion of antibiotics. Read More

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Antimicrobial peptides purified from hydrolysates of kanihua (Chenopodium pallidicaule Aellen) seed protein fractions.

Food Chem 2021 Apr 24;360:129951. Epub 2021 Apr 24.

Laboratory of Molecular Biology - Faculty of Pharmacy and Biochemistry - National University of San Marcos, Lima 1, Peru.

The kanihua (Chenopodium pallidicaule Aellen) Andean grain from the Peruvian Altiplano presents proteins of 15% to 19%. The objective was to obtain purified bioactive antimicrobial peptides (AMPs), hydrolyzed with Alcalase and Pepsin-pancreatin sequential system of protein fractions of kanihua varieties Ramis (KR) and Cupi-Sayhua (KS), and hydrolysates with different degrees of hydrolysis (DH) and percentage inhibition (IP) of the growth of E. coli, S. Read More

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Antimicrobial core-shell electrospun nanofibers containing Ajwain essential oil for accelerating infected wound healing.

Int J Pharm 2021 May 11:120698. Epub 2021 May 11.

Department of Medical Mycology and Parasitology, School of Medicine, Shiraz University of Medical Sciences, Shiraz 71348-45794, Iran; Department of Medical Mycology and Parasitology, Basic Sciences in Infectious Diseases Research Center, School of Medicine, Shiraz University of Medical Sciences, Shiraz 71348-45794, Iran. Electronic address:

Treatment of skin injuries is still facing major challenges, such as chronicity and infections, particularly those caused by multi-drug resistance pathogens. An effective treatment of such wounds should accelerate the wound healing process while preventing bacterial contamination. Here, a novel core-shell nanofiber mat was fabricated comprising gelatin/polyvinyl alcohol (as a core) and aloe vera/arabinose/polyvinyl pyrrolidone (as a shell) for accelerating the healing process of bacteria-infected wounds. Read More

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Quaternary ammonium silane-reinforced agar/polyacrylamide composites for packaging applications.

Int J Biol Macromol 2021 May 11. Epub 2021 May 11.

Department of Fiber System Engineering, Yeungnam University, South Korea. Electronic address:

Agar/polyacrylamide/quaternary ammonium silane-based (A/P/QAS-based) composite films were developed for food and biomedical packaging applications. The structural, optical, and surface morphological properties of the A/P and A/P/QAS composites were characterized by various characterization techniques in terms of thermogravimetric analysis, differential scanning calorimetry analyses, mechanical and rheological properties. Results showed that the 5% gravimetric loss (57. Read More

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Preparation of chitosan from waste shrimp shells fermented with Paenibacillus jamilae BAT1.

Int J Biol Macromol 2021 May 11. Epub 2021 May 11.

Department of Molecular Biology and Genetics, Science Faculty, Ataturk University, Erzurum, Turkey. Electronic address:

In this study, chitin extraction from shrimp shell powder (SSP) using locally isolated Paenibacillus jamilae BAT1 (GenBank: MN176658), the preparation of chitosan from the extracted chitin, and the characterization and biological activity (antimicrobial and antioxidant) of the prepared chitosan (PC) were investigated. It was determined that P. jamilae BAT1 did not have chitinase activity but showed high protease activity and protein removal potential. Read More

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Phosphorus-nitrogen compounds: part 53-synthesis, characterization, cytotoxic and antimicrobial activity, DNA interaction and molecular docking studies of new mono- and dispirocyclotriphosphazenes with pendant arm(s).

Mol Divers 2021 May 14. Epub 2021 May 14.

Department of Physics, Hacettepe University, 06800, Ankara, Turkey.

Mono-/dispirocyclotriphosphazenes with pendant arm(s) are robust, but they are less investigated inorganic ring systems. In this study, a series of mono (3 and 4)- and dispirocyclotriphosphazenes with 4-chloro-benzyl pendant arm(s) (13-16) was obtained from the Cl exchange reactions of hexachlorocyclotriphosphazene with sodium (N-benzyl)aminopropanoxides (1 and 2). When compound (3) reacted with excess pyrrolidine, morpholine, tetra-1,4-dioxa-8-azaspiro[4,5]decane (DASD) and piperidine, the fully substituted monospirocyclotriphosphazenes (7, 9, 10 and 12) occurred. Read More

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Decoupling manufacturing from application in additive manufactured antimicrobial materials.

Biomater Sci 2021 May 14. Epub 2021 May 14.

Institute of Advanced Materials (INAM), Universitat Jaume I, 12071, Castellon, Spain.

3D printable materials based on polymeric ionic liquids (PILs) capable of controlling the synthesis and stabilisation of silver nanoparticles (AgNPs) and their synergistic antimicrobial activity are reported. The interaction of the ionic liquid moieties with the silver precursor enabled the controlled in situ formation and stabilisation of AgNPs via extended UV photoreduction after the printing process, thus demonstrating an effective decoupling of the device manufacturing from the on-demand generation of nanomaterials, which avoids the potential aging of the nanomaterials through oxidation. The printed devices showed a multi-functional and tuneable microbicidal activity against Gram positive (B. Read More

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Effects of Hydrophobicity on Antimicrobial Activity, Selectivity, and Functional Mechanism of Guanidinium-Functionalized Polymers.

Adv Healthc Mater 2021 May 14:e2100482. Epub 2021 May 14.

Institute of Bioengineering and Bioimaging, 31 Biopolis Way, Singapore, 138669, Singapore.

In this study, a series of guanidinium-functionalized polycarbonate random co-polymers is prepared from organocatalytic ring-opening polymerization to investigate the effect of the hydrophobic side chain (ethyl, propyl, isopropyl, benzyl, and hexyl) on their antimicrobial activity and selectivity. Although the polymers exhibit similar minimum inhibitory concentrations, the more hydrophobic polymers exhibit a faster rate of bacteria elimination. At higher percentage content (20 mol%), polymers with more hydrophobic side chains suffer from poor selectivity due to their high hemolytic activity. Read More

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N-terminal acetylation of antimicrobial peptide L163 improves its stability against protease degradation.

J Pept Sci 2021 May 13:e3337. Epub 2021 May 13.

College of Information Science and Engineering, Henan University of Technology, Zhengzhou, China.

Antimicrobial peptide L163 was computationally designed by our laboratory; L163 is active against multidrug-resistant (MDR) bacteria but is easily degraded in the plasma and by trypsin. Amino acid substitution, cyclization, and amino-terminal (N-terminal) acetylation were performed to obtain L163 analogs with high stability in the plasma and in trypsin solutions. The stability, antimicrobial activity, and biosafety of L163 and its analogs were investigated. Read More

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Characterization of Iturin V, a Novel Antimicrobial Lipopeptide from a Potential Probiotic Strain Lactobacillus sp. M31.

Probiotics Antimicrob Proteins 2021 May 13. Epub 2021 May 13.

CSIR-Institute of Microbial Technology, Chandigarh, India.

Members of lactic acid bacteria group are known to produce various antimicrobial substances. Cyclic lipopeptides are one such potent class of amphipathic natural biosurfactants that exhibit bactericidal and immunomodulatory properties. In this study, we aimed to investigate antimicrobial and immunomodulatory activities of a lipopeptide secreted by a LAB isolate strain M31 identified as a member of the genus Lactobacillus. Read More

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Development of effective heparin extraction method from pig by-products and analysis of their bioavailability.

J Anim Sci Technol 2020 Nov 30;62(6):933-947. Epub 2020 Nov 30.

Department of Animal Science and Technology, Chung-Ang University, Anseong 17546, Korea.

This study was conducted to develop an effective heparin extraction method by using low-cost and highly effective enzymes from six pig by-products (liver, lung, heart, stomach, small intestine, and large intestine), and analyze their bioavailability. Low-cost and highly effective enzymes (alkaline-AK and papain) and a common enzyme (trypsin) were used for the heparin extraction. The angiotensin I - converting enzyme (ACE) inhibitory activity and the antimicrobial activity of extracted heparin were analyzed to verify their bioavailability. Read More

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November 2020

Biosynthesis of silver nano-drug using and its synergistic antibacterial activity against multidrug-resistant bacteria for wound dressing applications.

3 Biotech 2021 Jun 8;11(6):255. Epub 2021 May 8.

Department of Biotechnology, College of Science, Taif University, P.O. Box 11099, Taif, 21944 Saudi Arabia.

We report here the synthesis of silver nanoparticles (AgNPs) from an aqueous extract of and their use as an antimicrobial agent on their own or in combination with antibiotics in inhibiting multidrug-resistant bacteria (MDR). One strategy of bacterial infection control in wound healing is AgNP biosynthesis. We collected bacterial strains of patient skin infections from Al-Adwani Hospital. Read More

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Antiproliferative and antibacterial potential of tetrahexylammonium bromide-based ionic liquids.

Exp Ther Med 2021 Jul 23;22(1):672. Epub 2021 Apr 23.

ANAPATMOL Research Center, 'Victor Babes' University of Medicine and Pharmacy of Timisoara, 300041 Timisoara, Romania.

Ionic liquids (ILs) exhibit cytotoxic effects on prokaryotic and eukaryotic cells. In this study, the antibacterial and antiproliferative activities of tetrahexylammonium bromide-based ILs were investigated. In order to evaluate the therapeutic potential of these ionic liquids, firstly microbiological assay using both Gram-positive and Gram-negative bacteria were conducted by employing Disk-Diffusion and 2,3,5-triphenyltetrazolium chlorine (TTC) methods to assess the antimicrobial effects. Read More

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Minoxidil-Coated Lysozyme-Shelled Microbubbes Combined With Ultrasound for the Enhancement of Hair Follicle Growth: Efficacy and .

Front Pharmacol 2021 27;12:668754. Epub 2021 Apr 27.

Department of Dermatology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.

Lysozyme (Lyz) is an antimicrobial peptide, a safe adjunct, and it has been indicated that Lyz can promote vibrissae follicle growth by enhancing the hair-inductive capacity of dermal papilla cells in mice. The present study produced a new type of minoxidil (Mx)-coated antifungal Lyz-shelled microbubble (LyzMB) for inhibiting bacteria and allergies on the oily scalp. The potential of Mx-coated LyzMBs (Mx-LyzMBs) combined with ultrasound (US) and the role of LyzMB fragments in enhancing hair follicle growth were investigated. Read More

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PARP Inhibitors: An Innovative Approach to the Treatment of Inflammation and Metabolic Disorders in Sepsis.

J Inflamm Res 2021 6;14:1827-1844. Epub 2021 May 6.

Chair of Internal Medicine and Department of Internal Medicine in Nursing, Faculty of Health Sciences, Medical University of Lublin, Lublin, Poland.

Sepsis is not only a threat to the health of individual patients but also presents a serious epidemiological problem. Despite intensive research, modern sepsis therapy remains based primarily on antimicrobial treatment and supporting the functions of failing organs. Finding a cure for sepsis represents a great and as yet unfulfilled need in modern medicine. Read More

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MC-100093, a novel β-lactam GLT-1 enhancer devoid of antimicrobial properties attenuates cocaine relapse in rats.

J Pharmacol Exp Ther 2021 May 13. Epub 2021 May 13.

School of Pharmacy, Temple University, United States.

Cocaine use disorder (CUD) currently lacks FDA-approved treatments. In rodents, the glutamate transporter-1 (GLT-1) is downregulated in the nucleus accumbens following cocaine self-administration and increasing the expression and function of GLT-1 reduces the reinstatement of cocaine-seeking. The beta-lactam antibiotic ceftriaxone upregulates GLT-1 and attenuates cue- and cocaine-induced cocaine seeking without affecting motivation for natural rewards. Read More

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Dual Functions of a Stable Peptide against Citrus Huanglongbing Disease.

Trends Plant Sci 2021 May 10. Epub 2021 May 10.

Department of Biological Sciences, University of South Carolina, Columbia, SC 29208, USA. Electronic address:

The most prominent problem in the current citrus industry worldwide is the epidemic of citrus Huanglongbing (HLB), also known as greening disease. Huang et al. identified a stable peptide, which has antimicrobial activities and induces systemic immune response against HLB, from Australian finger lime. Read More

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Maternal supplementation with cobalt sources, folic acid, and rumen-protected methionine and its effects on molecular and functional correlates of the immune system in neonatal Holstein calves.

J Dairy Sci 2021 May 10. Epub 2021 May 10.

Department of Animal Sciences and Division of Nutritional Sciences, University of Illinois, Urbana 61801. Electronic address:

Calves born to multiparous Holstein cows fed during the last 30 d of pregnancy 2 different cobalt sources [cobalt glucoheptonate (CoPro) or cobalt pectin (CoPectin)], folic acid (FOA), and rumen-protected methionine (RPM) were used to study neonatal immune responses after ex vivo lipopolysaccharide (LPS) challenge. Groups were (n = 12 calves/group) CoPro, FOA+CoPro, FOA+CoPectin, and FOA+CoPectin+RPM. Calves were weighed at birth and blood collected at birth (before colostrum), 21 d of age, and 42 d of age (at weaning). Read More

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Real-life experience with ceftolozane/tazobactam in Canada; results from the CLEAR (Canadian LEadership on Antimicrobial Real-life usage) registry.

J Glob Antimicrob Resist 2021 May 10. Epub 2021 May 10.

Department of Medical Microbiology and Infectious Diseases, Max Rady College of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada. Electronic address:

Objectives: Ceftolozane/tazobactam is a cephalosporin/β-lactamase inhibitor combination with activity against Gram-negative bacilli. We report the use of ceftolozane/tazobactam in Canada using a national registry.

Methods: The CLEAR registry uses REDCap (Research Electronic Data Capture) (online survey, https://is. Read More

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Poly(glycidyl methacrylate) macromolecular assemblies as biocompatible nanocarrier for the antimicrobial lysozyme.

Int J Pharm 2021 May 10:120695. Epub 2021 May 10.

Department of Chemical Engineering, Universidad de Alcalá, 28805 Alcalá de Henares, Madrid, Spain.

The antimicrobial lysozyme (Lys) was electrostatically incorporated to negatively charged crosslinked poly(glycidyl methacrylate) (c-PGMA) macromolecular assemblies. The resulting material was characterized by AFM, infrared spectra, water contact angle measurements and the staining with the primary amino specific dye fluorescamine. c-PGMA nanoparticles were successfully loaded with Lys reaching ratios of 27. Read More

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Fabrication of dual layered biocompatible herbal biopatch from biological waste for skin - tissue regenerative applications.

Int J Biol Macromol 2021 May 10;183:1106-1118. Epub 2021 May 10.

Department of Biomedical Engineering, K.P.R. Institute of Engineering and Technology, Coimbatore 641407, India.

A dual layered herbal biopolymeric patch (biopatch) with enhanced wound healing efficiency and skin mimicking functions was fabricated for skin-tissue regenerative applications. In this study, hoof keratin (KE) extracted from biological waste and gelatin (GE) was employed for KE-GE biosheet fabrication using a simple casting method. Further, the top layer of the fabricated KE-GE biosheet was coated with bioactive Matricaria recutita (Chamomile flower) extract (CH) with gelatin through an electrospraying method. Read More

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Phytochemical composition, antisnake venom and antibacterial activities of ethanolic extract of Aegiphila integrifolia (Jacq) Moldenke leaves.

Toxicon 2021 May 10. Epub 2021 May 10.

Chemical Engineering Section, Military Institute of Engineering, Rio de Janeiro, RJ, Brazil. Electronic address:

Snakebites are considered a major neglected tropical disease, resulting in around 100,000 deaths per year. The recommended treatment by the WHO is serotherapy, which has limited effectiveness against the toxins involved in local tissue damage. In some countries, patients use plants from folk medicines as antivenoms. Read More

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Oral peroxidases: From antimicrobial agents to ecological actors (Review).

Mol Med Rep 2021 Jul 13;24(1). Epub 2021 May 13.

Faculty of Medicine, Université Libre de Bruxelles, B‑1070 Brussels, Belgium.

Sialoperoxidase and myeloperoxidase are the two main peroxidase enzymes found in the oral cavity. Sialoperoxidase is present in salivary secretions and in the biofilms that line the oral surfaces, while myeloperoxidase is abundant in the dento‑gingival sulcus area. In the presence of hydrogen peroxide (HO), oral peroxidases catalyze the oxidation of the pseudohalide anion thiocyanate (SCN) to hypothiocyanite (OSCN), a strong oxidant that serves an antimicrobial role. Read More

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Can growth be modulated by natural compounds?

J Biol Regul Homeost Agents 2021 Jan-Feb;35(1 Suppl. 2):21-25

UOC di Otorinolaringoiatria, Dipartimento Scienze dell'Invecchiamento,Neurologiche, Ortopediche e della testa collo. Fondazione Policlinico Universitario A. Gemelli IRCCS, Roma, Italy.

is an opportunistic human pathogen that frequently induces antibiotic resistance, as it mainly tends to form biofilms. Iron chelation may be an intriguing strategy to contrast bacterial growth. Lactoferrin is a natural compound able to chelate iron. Read More

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