51,964 results match your criteria antifungal activity

Identification and assessment of a biocontrol agent, I-5, for management of alfalfa root rot caused by .

Phytopathology 2021 Apr 14. Epub 2021 Apr 14.

Northeast Agricultural University, 12430, Harbin, Heilongjiang, China;

Alfalfa root rot caused by is one of the most important soil-borne diseases resulting in significant losses to alfalfa agriculture worldwide. Fungicides used in management of disease affect the environment and human health. In this study, a strain of (I-5), isolated from alfalfa rhizosphere soil, exhibited strong antifungal activity against a number of causative pathogens of alfalfa root rot, and showed the strongest antagonistic activity against (the longest radius/shortest radius ratio of 3. Read More

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Chemotype of damask rose with oleic acid (9 octadecenoic acid) and its antimicrobial effectiveness.

Sci Rep 2021 Apr 13;11(1):8027. Epub 2021 Apr 13.

Department Life and Environmental Sciences, University of Cagliari, Cagliari, Italy.

Essential oils are natural products that have great antimicrobial potential value against many fungi and bacteria. Rosa damascena Mill. is one of the most important aromatic species of the Rosaceae family from which essential oil and economically valuable products can be obtained. Read More

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Antifungal potential against Sclerotinia sclerotiorum (Lib.) de Bary and plant growth promoting abilities of Bacillus isolates from canola (Brassica napus L.) roots.

Microbiol Res 2021 Apr 2;248:126754. Epub 2021 Apr 2.

Departamento de Genética, Instituto de Biociências, Universidade Federal do Rio Grande do Sul (UFRGS), Av. Bento Gonçalves, 9500, Caixa Postal 15.053, 91501-970, Porto Alegre, RS, Brazil. Electronic address:

Endophytic bacteria show important abilities in promoting plant growth and suppressing phytopathogens, being largely explored in agriculture as biofertilizers or biocontrol agents. Bacteria from canola roots were isolated and screened for different plant growth promotion (PGP) traits and biocontrol of Sclerotinia sclerotiorum. Thirty isolates belonging to Bacillus, Paenibacillus, Lysinibacillus, and Microbacterium genera were obtained. Read More

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Deep eutectic solvent-homogenate based microwave-assisted hydrodistillation of essential oil from Litsea cubeba (Lour.) Pers. fruits and its chemical composition and biological activity.

J Chromatogr A 2021 Mar 22;1646:462089. Epub 2021 Mar 22.

School of Life Science, Institute of Life Science and Green Development, Hebei University, Baoding 071002, China. Electronic address:

As an important natural product, the sufficient separation of plant essential oil (EO) is helpful to improve its utilization value. In this work, deep eutectic solvent-homogenate based microwave-assisted hydrodistillation (DES-HMAHD) was developed and applied to isolate EO from the fruits of Litsea cubeba (Lour.) Pers. Read More

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Characterization of an L-α,β-diaminopropionic acid polymer with comb-like structure isolated from a poly(ε-L-lysine)-producing Streptomyces sp.

Appl Microbiol Biotechnol 2021 Apr 12. Epub 2021 Apr 12.

Department of Life Science and Biotechnology, Graduate School of Science and Engineering, Kansai University, 3-3-35 Yamate-cho, Suita, Osaka, 564-8680, Japan.

Polymers of basic amino acids function as polycationic compounds under physiological conditions and exhibit intriguing biological properties, such as antimicrobial and antiviral activities, immunopotentiating ability, and DNA-binding activity. Poly(ε-L-lysine) (ε-PL) produced by some strains of Streptomyces spp. is a cationic homopolymer of L-lysine linking between ε-amino and α-carboxylic acid functional groups and has been used as a food preservative based on its biocompatibility and biodegradability. Read More

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Tick defensin γ-core reduces Fusarium graminearum growth and abrogates mycotoxins production with high efficiency.

Sci Rep 2021 Apr 12;11(1):7962. Epub 2021 Apr 12.

INRAE, Mycology and Food Safety (MycSA), 33882, Villenave d'Ornon, France.

Fusarium graminearum is a major fungal pathogen affecting crops of worldwide importance. F. graminearum produces type B trichothecene mycotoxins (TCTB), which are not fully eliminated during food and feed processing. Read More

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Design, synthesis and docking studies of novel thiazole derivatives incorporating pyridine moiety and assessment as antimicrobial agents.

Sci Rep 2021 Apr 12;11(1):7846. Epub 2021 Apr 12.

Chemistry Department, Faculty of Science, Jazan University, Jazan, Saudi Arabia.

A novel series of substituted 4,6-dimethyl-2-oxo-1-(thiazol-2-ylamino)-1,2-dihydropyridine-3-carbonitrile derivatives 6, 9, 13, 15, and 17 was synthesized in a good to excellent yield from the reaction of 1-(3-cyano-4,6-dimethyl-2-oxopyridin-1(2H)-yl)thiourea with 2-oxo-N'-arylpropanehydrazonoyl chloride, chloroacetone, α-bromoketones, ethyl chloroacetate, and 2,3-dichloroquinoxaline, respectively. The potential DNA gyrase inhibitory activity was examined using in silico molecular docking simulation. The novel thiazoles exhibit dock score values between - 6. Read More

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Novel Prosopis juliflora leaf ethanolic extract as natural antimicrobial agent against food spoiling microorganisms.

Sci Rep 2021 Apr 12;11(1):7871. Epub 2021 Apr 12.

Department of Biological and Environmental Sciences, College of Art and Science, Qatar University, P.O. Box 2713, Doha, Qatar.

Fresh produces spoilage is a worldwide concern that accompany the global increase in food demand. Adverse human health and environmental effects of commercial spoilage control agents are major public concern. In this study, Prosopis juliflora leaves and fruit extracts had their antimicrobial activities evaluated against the growth of selected bacteria and yeast, and against mycelial growth and conidial germination of selected mycotoxins-producing fungi. Read More

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and Antifungal Activity of AmBisome Compared to Conventional Amphotericin B and Fluconazole against .

Antimicrob Agents Chemother 2021 Apr 12. Epub 2021 Apr 12.

Center for Medical Mycology, University Hospitals Cleveland Medical Center and Case

Antifungal activity of AmBisome against was determined and in AmBisome showed MIC and MIC values of 1 and 2 μg/mL, respectively. Unlike conventional amphotericin B, significant efficacy was observed in the AmBisome 7.5 mg/kg -treated group in survival and reduction of kidney tissue fungal burden compared to the untreated group. Read More

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Proteomic response of Escherichia coli to a membrane lytic and iron chelating truncated Amaranthus tricolor defensin.

BMC Microbiol 2021 Apr 12;21(1):110. Epub 2021 Apr 12.

Department of Chemistry, University of North Carolina at Chapel Hill, 125 South Rd. CB#3290, Chapel Hill, NC, 27599, USA.

Background: Plant defensins are a broadly distributed family of antimicrobial peptides which have been primarily studied for agriculturally relevant antifungal activity. Recent studies have probed defensins against Gram-negative bacteria revealing evidence for multiple mechanisms of action including membrane lysis and ribosomal inhibition. Herein, a truncated synthetic analog containing the γ-core motif of Amaranthus tricolor DEF2 (Atr-DEF2) reveals Gram-negative antibacterial activity and its mechanism of action is probed via proteomics, outer membrane permeability studies, and iron reduction/chelation assays. Read More

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Antifungal activity and potential mechanism of Asiatic acid alone and in combination with fluconazole against Candida albicans.

Biomed Pharmacother 2021 Apr 10;139:111568. Epub 2021 Apr 10.

Department of Clinical Pharmacy, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Shandong Engineering and Technology Research Center for Pediatric Drug Development, Shandong Medicine and Health Key Laboratory of Clinical Pharmacy, Jinan, Shandong Province 250014, People's Republic of China. Electronic address:

Candida albicans (C. albicans) infection remains a challenge to clinicians due to the limited available antifungals. With the widespread use of antifungals in the clinic, the drug resistance has been emerging continuously, especially fluconazole. Read More

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In silico and in vitro studies of isolated constituents from Callistemon citrinus leaves: Anti-microbial potential and inhibition of iNOS activity.

Phytochemistry 2021 Apr 9;186:112745. Epub 2021 Apr 9.

National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, University, MS, 38677, USA; Division of Pharmacognosy, Department of BioMolecular Sciences, School of Pharmacy, University of Mississippi, University, MS, 38677, USA. Electronic address:

Phytochemical investigation of Callistemon citrinus (Curtis) Skeels (syn. Callistemon lanceolatus (Sm.) Sweet and Melaleuca citrina (Curtis) Dum. Read More

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A comparison of the production of antimicrobial peptides and proteins by Galleria mellonella larvae in response to infection with two Pseudomonas aeruginosa strains differing in the profile of secreted proteases.

J Insect Physiol 2021 Apr 9:104239. Epub 2021 Apr 9.

Department of Immunobiology, Institute of Biological Sciences, Faculty of Biology and Biotechnology, Maria Curie-Skłodowska University, Akademicka 19 St., 20-033 Lublin, Poland.

The work presents identification of antimicrobial peptides and proteins (AMPs) in the hemolymph of Galleria mellonella larvae infected with two Pseudomonas aeruginosa strains (ATCC 27853 and PA18), differing in the profile of secreted proteases. The insects were immunized with bacteria cultivated in rich (LB) and minimal (M9) media, which resulted in appearance of a similar broad set of AMPs in the hemolymph. Among them, 13 peptides and proteins were identified, i. Read More

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Design, Synthesis, and Antifungal Activity of Novel Longifolene-Derived Diacylhydrazine Compounds.

ACS Omega 2021 Apr 24;6(13):9104-9111. Epub 2021 Mar 24.

Guangxi Key Laboratory of Chemistry and Engineering of Forest Products, Guangxi Collaborative Innovation Center for Chemistry and Engineering of Forest Products, Guangxi University for Nationalities, No. 188, Daxue Dong Road, Nanning, Guangxi 530006, China.

Succinate dehydrogenase (SDH) present in the inner mitochondrial membrane is an important target enzyme for the design of SDH inhibitor-type fungicides. Using SDH as the target enzyme, 22 novel longifolene-derived diacylhydrazine compounds were designed and synthesized using the renewable natural product longifolene as the starting material. Their structures were confirmed by IR, H NMR, C NMR, electrospray mass spectrometry, and elemental analysis. Read More

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Piperidine based 1,2,3-triazolylacetamide derivatives induce cell cycle arrest and apoptotic cell death in .

J Adv Res 2021 Mar 10;29:121-135. Epub 2020 Nov 10.

Clinical Microbiology and Infectious Diseases, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg 2193, South Africa.

The fungal pathogen , is a serious threat to public health and is associated with bloodstream infections causing high mortality particularly in patients with serious medical problems. As this pathogen is generally resistant to all the available classes of antifungals, there is a constant demand for novel antifungal drugs with new mechanisms of antifungal action. Therefore, in this study we synthesised six novel piperidine based 1,2,3-triazolylacetamide derivatives (pta1-pta6) and tested their antifungal activity and mechanism of action against clinical isolates. Read More

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Mitochondrial Reactive Oxygen Species Regulate Immune Responses of Macrophages to .

Front Immunol 2021 25;12:641495. Epub 2021 Mar 25.

Medical Research Council Centre for Medical Mycology at the University of Exeter, Geoffrey Pope Building, University of Exeter, Exeter, United Kingdom.

Reactive Oxygen Species (ROS) are highly reactive molecules that can induce oxidative stress. For instance, the oxidative burst of immune cells is well known for its ability to inhibit the growth of invading pathogens. However, ROS also mediate redox signalling, which is important for the regulation of antimicrobial immunity. Read More

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Isolation and Identification of Antibacterial Bioactive Compounds From L2.

Front Microbiol 2021 24;12:645484. Epub 2021 Mar 24.

Key Laboratory of Plant Resource Conservation and Germplasm Innovation in Mountainous Region (Ministry of Education), Collaborative Innovation Center for Mountain Ecology & Agro-Bioengineering, College of Life Sciences/Institute of Agro-bioengineering, Guizhou University, Guiyang, China.

Bacterial metabolites exhibit a variety of biologically active compounds including antibacterial and antifungal activities. It is well known that is considered to be a promising source of bioactive secondary metabolites. Most plant pathogens have an incredible ability to mutate and acquire resistance, causing major economic losses in the agricultural field. Read More

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Bioadhesive-Thermosensitive Vaginal Gel of the Gel Flake-Solid Dispersion of Itraconazole for Enhanced Antifungal Activity in the Treatment of Vaginal Candidiasis.

ACS Appl Mater Interfaces 2021 Apr 11. Epub 2021 Apr 11.

School of Pharmacy, Queen's University Belfast, Belfast BT9 7BL, United Kingdom.

The poor solubility of itraconazole (ITZ) has limited its efficacy in the treatment of vaginal candidiasis. Accordingly, the improvement of ITZ solubility using a solid dispersion technique was important to enhance its antifungal activity. Besides, as the purpose of this research was to develop local-targeting formulations, bioadhesive-thermosensitive vaginal gel combined with the gel-flake system was found to be the most suitable choice. Read More

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Fabrication of different SnO nanorods for enhanced photocatalytic degradation and antibacterial activity.

Environ Sci Pollut Res Int 2021 Apr 10. Epub 2021 Apr 10.

King Abdullah Institute for Nanotechnology, King Saud University, P.O. Box 2455, Riyadh, 11451, Saudi Arabia.

The acid-mediated (oxalic acid [OXA], cinnamic acid [CA], and itaconic acid [IA]) SnO nanorods were synthesized by the hydrothermal method. The synthesized SnO nanorods, in turn, were analyzed with various physico-chemical techniques such as the X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FT-IR), scanning electron microscope (SEM), and Raman spectroscopy. Furthermore, the photocatalytic activity of the different SnO nanorods was investigated with the malachite green (MG) dye under visible light illumination. Read More

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ReviewArticle: The in vivo Anti-Candida albicans Activity of Flavonoids.

J Oral Biosci 2021 Apr 8. Epub 2021 Apr 8.

Western University of Health Sciences, Pomona, CA, 91766-1854. Electronic address:

Background: Emerging drug-resistant strains of Candida albicans have led to the recurrence of fungal disease, rendering conventional drug therapies ineffective. Although in vitro studies on flavonoids as novel antifungal products have shown promising results, there is currently limited information regarding their in vivo effects. The aim of this review is to evaluate in vivo studies on the antifungal activity of flavonoids against C. Read More

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Efficacy of short-synthetic antifungal peptides on pathogenic Aspergillus flavus.

Pestic Biochem Physiol 2021 May 27;174:104810. Epub 2021 Feb 27.

Department of Biochemistry, University College of Science, Osmania University, Hyderabad 500007, Telangana State, India. Electronic address:

The efficacies of three short synthetic antifungal peptides were tested for their inhibitory action on pathogenic fungi, Aspergillus flavus. The sequences of the short synthetic peptides are PPD1- FRLHF, 66-10-FRLKFH, 77-3- FRLKFHF, respectively. These test peptides inhibited fungal growth and showed a membranolytic activity. Read More

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Characterization of Prototheca CYP51/ERG11 as a possible target for therapeutic drugs.

Med Mycol 2021 Apr 10. Epub 2021 Apr 10.

Department of Microbiology, Dokkyo Medical University School of Medicine, Tochigi 321-0293, Japan.

Prototheca spp. are achlorophyllous algae, ubiquitous in nature. An increasing number of human and animal cases of Prototheca infection (protothecosis) are reported, and antifungal azoles, which inhibit sterol 14α-demethylase (CYP51/ERG11) involved in ergosterol biosynthesis, have empirically been used for the treatment of protothecosis. Read More

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Antibacterial and Antifungal Activities and Toxicity of the Essential Oil from Callistemon viminalis Complexed with β-Cyclodextrin.

Curr Microbiol 2021 Apr 10. Epub 2021 Apr 10.

Departamento de Química, Universidade Federal de Lavras, C.P. 3037, Lavras, MG, CEP 37.200-900, Brazil.

The essential oil from Callistemon viminalis (EOC) is rich in monoterpenes, with a variety of biological properties: antibacterial, antifungal, insecticide, and antioxidant. Inclusion complexes (ICs) with cyclodextrins (CDs) is an alternative to prevent toxicity, improve the activity, and reduce the concentration to be used. Thus, the objective of this work was to prepare an IC (EOC/β-CD) and evaluate the antibacterial, antifungal and phospholipase activities, as well as the toxicity. Read More

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Inhibitors of DNA topoisomerases I and II applied to Candida dubliniensis reduce growth, viability, the generation of petite mutants and toxicity, while acting synergistically with fluconazole.

FEMS Yeast Res 2021 Apr 10. Epub 2021 Apr 10.

Laboratorio de Biología Molecular de Bacterias y Levaduras, Departamento de Microbiología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Prol. de Carpio y Plan de Ayala. Col. Sto. Tomás, 11340 México City, México.

The increasing resistance of Candida species to azoles emphasizes the urgent need for new antifungal agents with novel mechanisms of action. The aim of this study was to examine the effect of three DNA topoisomerase inhibitors of plant origin (camptothecin, etoposide and curcumin) on the growth of Candida dubliniensis. The phylogenetic analysis showed a close relationship between the topoisomerase enzymes of C. Read More

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Synthesis and Biological Activity of Novel Pyrazolo[3,4-d]pyrimidin-4-one Derivatives as Potent Antifungal Agent.

Pest Manag Sci 2021 Apr 9. Epub 2021 Apr 9.

School of Science, Anhui Agricultural University, Hefei, China.

Background: To promote the discovery and development of new fungicide with novel scaffolds or modes of action, a series of novel 5-(2-chloroethyl)-1-phenyl-6-(pyridin-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one derivatives were synthesized, and evaluated for their antifungal activities.

Results: The bioassay data showed that compound 8IIId (EC = 1.93 mg/L) is superior to boscalid (EC = 6. Read More

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Bioactivity-guided separation of antifungal compounds by preparative high-performance liquid chromatography.

J Sep Sci 2021 Apr 9. Epub 2021 Apr 9.

Engineering Research Center of Pharmaceutical Process Chemistry, Ministry of Education, School of Pharmacy, East China University of Science and Technology, Shanghai, 200237, PR China.

Bioactivity-guided chromatographic methods are of great significance for the isolation of the active compounds in complex samples. In this study, four anti-fungal compounds were located by activity screening and successfully isolated from a microbial fermentation sample by preparative high-performance liquid chromatography. Separation performance of columns including C18, positively charged C18, negatively charged C18 and C8 were firstly investigated. Read More

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Biochar as a biocompatible mild anti-inflammatory supplement for animal feed and agricultural fields.

Chem Biodivers 2021 Apr 9. Epub 2021 Apr 9.

Mersin Universitesi, Biotechnology, Çiftlikköy Kampüsü Fen Edeb. Fakültesi Biyoteknoloji Bölümü, 33310, Mersin, TURKEY.

Biochar is an organic material and high in carbon content, besides its use for energy purposes, it is also a material that serves the purpose of improving soil fertility, organic matter content of soils and removing heavy metals from water and soil. This study aims to investigate the antimicrobial effects of biochar whose beneficial effects on agricultural productivity has been proven by different studies. Scientific literature concerning the antibacterial, antifungal and antiviral effects of the apricot seed and olive seed biochar is limited. Read More

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Reassessing the Use of Undecanoic Acid as a Therapeutic Strategy for Treating Fungal Infections.

Mycopathologia 2021 Apr 9. Epub 2021 Apr 9.

Department of Genetics, Ribeirão Preto Medical School, University of São Paulo, USP, Ribeirão Preto, SP, 14049-900, Brazil.

Treating fungal infections is challenging and frequently requires long-term courses of antifungal drugs. Considering the limited number of existing antifungal drugs, it is crucial to evaluate the possibility of repositioning drugs with antifungal properties and to revisit older antifungals for applications in combined therapy, which could widen the range of therapeutic possibilities. Undecanoic acid is a saturated medium-chain fatty acid with known antifungal effects; however, its antifungal properties have not been extensively explored. Read More

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In vitro activities of and extracts combined with amphotericin B against in production of hydrolytic enzymes.

Curr Med Mycol 2020 Sep;6(3):27-32

University Center of Naâma, Naâma, Algeria.

Background And Purpose: is an important microorganism in the normal flora of a healthy subject; however, it has an expedient pathogenic character that induces hydrolytic virulence. Regarding this, the present study aimed to find an in vitro alternative that could reduce the virulence of this yeast.

Materials And Methods: For the purpose of the study, the effect of amphotericin B (AmB) combined with the extract of (E1) or (E2) was evaluated against the hydrolytic activities of esterase, protease, and phospholipase. Read More

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September 2020

Comparison of antifungal efficacy of ethanolic extracts of leaf and peel in uncontrolled diabetic patients wearing removable dentures: A randomized controlled clinical trial.

Curr Med Mycol 2020 Sep;6(3):15-20

Department of Oral Medicine and Radiology, Mamata Dental College, Khammam, Telangana, India.

Background And Purpose: The search for the development of a suitable novel antimicrobial agent for fungal diseases continues to be a key problem in the current clinical field. The present investigation was aimed to determine the antifungal effect of the ethanolic crude extracts of leaf (Wfl) and Punica granatum peel (Pgp) in uncontrolled diabetic patients wearing removable dentures.

Materials And Methods: The ethanolic extracts of both plants were prepared using the soxhlet extraction method, and the obtained metabolites were confirmed by thin- layer chromatography. Read More

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September 2020