143,899 results match your criteria antibody prevalence


Eczematous drug eruption in psoriasis patients under anti-IL-17A: does IL-22 play a key role?

Clin Exp Dermatol 2021 Dec 4. Epub 2021 Dec 4.

Department of Health Sciences, University Magna Graecia of Catanzaro, Catanzaro, Italy.

Background: Eczematous drug eruption (EDE) is a spongiotic skin reaction in response to systemic medications. Up to now, EDE has been described in patients treated with anti-IL17A monoclonal antibodies with a prevalence of 2.2-12. Read More

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December 2021

Current challenges of severe acute respiratory syndrome coronavirus 2 seroprevalence studies among blood donors: A scoping review.

Vox Sang 2021 Dec 3. Epub 2021 Dec 3.

Epidemiology and Surveillance, Canadian Blood Services, Ottawa, Ontario, Canada.

Background And Objectives: Blood donors are increasingly being recognized as an informative resource for surveillance. We aimed to review severe acute respiratory syndrome coronavirus 2 seroprevalence studies conducted among blood donors to investigate methodological biases and provide guidance for future research.

Materials And Methods: We conducted a scoping review of peer-reviewed and preprint publications between January 2020 and January 2021. Read More

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December 2021

Non-human primate adenoviruses of the Human Adenovirus B species are potent and broadly-acting oncolytic vector candidates.

Hum Gene Ther 2021 Dec 3. Epub 2021 Dec 3.

Leiden Universitair Medisch Centrum, 4501, Cell and Chemical Biology, Leiden, Zuid-Holland, Netherlands;

The use of human adenoviruses (hAds) as oncolytic agents has demonstrated considerable potential. However, their efficacy in clinical studies is generally moderate and often varies between patients. This may in part be attributable to variable preexisting neutralizing immunity in patients which can impact the anti-tumor efficacy and lead to response heterogeneity. Read More

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December 2021

Confirmed circulation of SARS-CoV-2 in Irish blood donors prior to first national notification of infection.

J Clin Virol 2021 Nov 25;146:105045. Epub 2021 Nov 25.

Irish Blood Transfusion Service, National Blood Centre, James's Street, Dublin, D08 NH5R, Ireland; National Virus Reference Laboratory, University College Dublin, Dublin 4, Ireland. Electronic address:

Introduction: Blood donor studies offer a unique opportunity to screen healthy populations for the presence of antibodies to emerging infections. We describe the use of blood donor specimens to track the 'first-wave' of the COVID-19 pandemic in Ireland.

Methodology: A random selection of donor samples received by the Irish Blood Transfusion Service (IBTS) between February and September 2020 (n = 8,509) were screened by multiple commercial SARs-CoV-2 antibody assays. Read More

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November 2021

Current distribution of selected canine vector-borne diseases in domestic dogs from Barranquilla and Puerto Colombia, Atlántico, Colombia.

Vet Med Sci 2021 Dec 3. Epub 2021 Dec 3.

Zoonotic diseases and One Health Group, Laboratory of Parasitology, Faculty of Pharmacy, University of Salamanca, Salamanca, Spain.

Background: Climate change, the increase of travel with infected animals from endemic areas, the introduction of new vectors in these areas and environmental changes caused by human activity, among other factors, have contributed to the establishment and increase of canine vector-borne diseases (CVBDs), several of which are zoonotic and pose a risk to the human population. In Colombia, there are very few studies that address the prevalence of these diseases. The objective of this study was to update the prevalence of cardiopulmonary dirofilariosis, anaplasmosis, ehrlichiosis and Lyme borreliosis in dogs in Barranquilla and Puerto Colombia, areas of northern Colombia. Read More

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December 2021

Hepatitis C virus-specific markers in pediatric patients with chronic hepatitis C.

Minerva Pediatr (Torino) 2021 Dec 3. Epub 2021 Dec 3.

Department of Molecular Biology of Microorganisms, Skryabin Institute of Bioengineering, Federal Research Centre Fundamentals of Biotechnology, Russian Academy of Sciences, Moscow, Russian Federation.

Background: The study aimed to investigate hepatitis C virus (HCV) specific markers in chronically infected children. The main objective was to explore the patterns of marker variability.

Methods: HCV RNA, core antigen, anti-HCV IgM, and antibodies to individual viral proteins were detected using commercially available assays or experimental ELISA. Read More

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December 2021

Impact of diabetes status on immunogenicity of trivalent inactivated influenza vaccine in older adults.

Influenza Other Respir Viruses 2021 Dec 3. Epub 2021 Dec 3.

Influenza Division, US Centers for Disease Control and Prevention, Atlanta, Georgia, USA.

Individuals with type 2 diabetes mellitus experience high rates of influenza virus infection and complications. We compared the magnitude and duration of serologic response to trivalent influenza vaccine in adults aged 50-80 with and without type 2 diabetes mellitus. Serologic response to influenza vaccination was similar in both groups: greater fold-increases in antibody titer occurred among participants with lower pre-vaccination antibody titers. Read More

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December 2021

COVID-19 in Adults With Hypertrophic Cardiomyopathy.

Front Cardiovasc Med 2021 9;8:745790. Epub 2021 Nov 9.

Hypertrophic Cardiomyopathy Program, Leon H. Charney Division of Cardiology, New York University Grossman School of Medicine, New York, NY, United States.

Individuals with cardiovascular disease are considered high risk for severe COVID-19. However, the clinical impact of COVID-19 in patients with hypertrophic cardiomyopathy (HCM) is unknown. The purpose of this study was to describe the clinical course and outcomes of COVID-19 in patients with HCM. Read More

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November 2021

Altered Lipid Profiles and Vaccine Induced-Humoral Responses in Children Living With HIV on Antiretroviral Therapy in Tanzania.

Front Cell Infect Microbiol 2021 9;11:721747. Epub 2021 Nov 9.

National Institute for Medical Research (NIMR), Mbeya Medical Research Centre (MMRC), Mbeya, Tanzania.

People living with HIV, even under therapy, have a high burden of age-related co-morbidities including an increased risk of dyslipidemia (which often predisposes to cardiovascular diseases) and immune-aging. In this study, lipid profiles and antibody responses to measles and pertussis toxin vaccines were compared between ART experienced HIV+ children (n=64) aged 5-10 years, and their age- and sex-matched HIV- controls (n=47). Prevalence of high-density lipoprotein cholesterol (HDL-c) and triglyceride-driven dyslipidemia was higher among treated HIV+ children than in controls (51. Read More

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November 2021

Systemic Sclerosis in Zimbabwe: Autoantibody Biomarkers, Clinical, and Laboratory Correlates.

Front Immunol 2021 9;12:679531. Epub 2021 Nov 9.

Institute of Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, Edinburgh, United Kingdom.

Introduction: Systemic sclerosis (SScl) is an autoimmune disease whose prevalence is rarely reported in Africa. Autoantibodies are the biomarkers of the condition, precede overt disease and determine disease phenotypes. SSc specific autoantibodies also vary between racial groupings. Read More

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November 2021

Idiopathic inflammatory myopathies.

Nat Rev Dis Primers 2021 Dec 2;7(1):86. Epub 2021 Dec 2.

Clinical Research Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, USA.

Idiopathic inflammatory myopathies (IIM), also known as myositis, are a heterogeneous group of autoimmune disorders with varying clinical manifestations, treatment responses and prognoses. Muscle weakness is usually the classical clinical manifestation but other organs can be affected, including the skin, joints, lungs, heart and gastrointestinal tract, and they can even result in the predominant manifestations, supporting that IIM are systemic inflammatory disorders. Different myositis-specific auto-antibodies have been identified and, on the basis of clinical, histopathological and serological features, IIM can be classified into several subgroups - dermatomyositis (including amyopathic dermatomyositis), antisynthetase syndrome, immune-mediated necrotizing myopathy, inclusion body myositis, polymyositis and overlap myositis. Read More

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December 2021

Rationale and design of a double-blind randomized non-inferiority clinical trial to evaluate one or two doses of vaccine against human papillomavirus including an epidemiologic survey to estimate vaccine efficacy: The Costa Rica ESCUDDO trial.

Vaccine 2021 Nov 29. Epub 2021 Nov 29.

Agencia Costarricense de Investigaciones Biomédicas (ACIB)-Fundación INCIENSA, San José, Costa Rica.

HPV vaccination of adolescent girls is the most effective measure to prevent cervical cancer. The World Health Organization recommends that adolescent girls receive two doses of vaccine but only a small proportion of girls from regions with the highest disease burden are vaccinated because of cost and logistical considerations. Our Costa Rica HPV Vaccine trial suggested that one dose of the bivalent HPV vaccine provides robust and lasting protection against persistent HPV infections for over a decade. Read More

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November 2021

Label-free differentiation and quantification of ricin, abrin from their agglutinin biotoxins by surface plasmon resonance.

Talanta 2022 Feb 9;238(Pt 1):122860. Epub 2021 Sep 9.

State Key Laboratory of Toxicology and Medical Countermeasures, and Laboratory of Toxicant Analysis, Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Beijing, 100850, China.

Here we describe an affinity molecule-directed surface plasmon resonance (SPR) immunosensor for a label-free, differentiation and quantification of ricin and abrin from their structural highly like agglutinin biotoxins. By an introduction of protein G as the affinity capturing molecule, we fulfilled a complete strategy contains (i) screening monoclonal antibodies to be paired in a sandwiched format, (ii) differentiate quantification from the agglutinin, (iii) ascertain of active from inactive biotoxin, and (iv) structural identification of captured biotoxins on a single chip. By the aid of an enrichment step from immunomagnetic beads, we could accurately measure ricin or abrin with a concentration lowered to 0. Read More

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February 2022

The efficacy of probiotics on virus titres and antibody production in virus diseases: A systematic review on recent evidence for COVID-19 treatment.

Clin Nutr ESPEN 2021 Dec 23;46:1-8. Epub 2021 Oct 23.

Department of Food Science and Technology, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran. Electronic address:

Background & Aims: There are some studies indicating the effects of probiotic-containing foods or supplements on viral diseases. We aimed to conduct a rapid review of probiotics with specific emphasis on their potential for early administration in patients at greater risk of SARS-CoV-2 infection.

Methods: We searched on PubMed, EMBASE, Google Scholar, Science Direct, Scopus and Web of Science up to February 2021 to identify interventional and observational studies documenting the effects of probiotics strains on interleukins, virus titers, and antibody production with a focus on probiotic-containing foods (PROSPERO Registration ID. Read More

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December 2021

Under-diagnosis of SARS-CoV-2 infections among children aged 0-15 years, a nationwide seroprevalence study, Israel, January 2020 to March 2021.

Euro Surveill 2021 Dec;26(48)

Department of Epidemiology and Preventive Medicine, School of Public Health, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Until recently, children and adolescents were not eligible for COVID-19 vaccination. They may have been a considerable source of SARS-CoV-2 spread. We evaluated SARS-CoV-2 IgG antibody seroprevalence in Israeli children aged 0-15 years from January 2020 to March 2021. Read More

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December 2021

Immunoglobulin (Ig)A seropositivity against SARS-CoV-2 in healthcare workers in Israel, 4 April to 13 July 2020: an observational study.

Euro Surveill 2021 Dec;26(48)

Sackler Faculty of Medicine, Tel-Aviv University, Israel.

IntroductionThe COVID-19 pandemic has put healthcare workers (HCW) at significant risk. Presence of antibodies can confirm prior severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.AimThis study investigates the prevalence of IgA and IgG antibodies against SARS-CoV-2 in HCW. Read More

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December 2021

Epidemiology and demographics of juvenile idiopathic arthritis in Africa and Middle East.

Pediatr Rheumatol Online J 2021 Dec 2;19(1):166. Epub 2021 Dec 2.

Pfizer Biopharmaceutical Group, Emerging Markets, Cairo, Egypt.

Juvenile Idiopathic Arthritis (JIA) is a group of chronic heterogenous disorders that manifests as joint inflammation in patients aged <16 years. Globally, approximately 3 million children and young adults are suffering from JIA with prevalence rates consistently higher in girls. The region of Africa and Middle East constitute a diverse group of ethnicities, socioeconomic conditions, and climates which influence the prevalence of JIA. Read More

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December 2021

Immune response to hepatitis B vaccine following complete immunization of children attending two regional hospitals in the Southwest region of Cameroon: a cross sectional study.

BMC Infect Dis 2021 Dec 2;21(1):1205. Epub 2021 Dec 2.

Faculty of Health Sciences, University of Buea, Buea, Cameroon.

Background: Hepatitis B virus (HBV) infection despite being a vaccine preventable disease remains a global public health problem. In Cameroon, the hepatitis B vaccine was introduced in the expanded program on immunisation in 2005, but there has been limited evaluation of the HBV surface antibody response post vaccination.

Objective: We investigated the immune response to hepatitis B vaccine in infants who received the DPT-Hep B-Hib vaccine, and we assessed HBsAg carriage in non-responders. Read More

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December 2021

Investigating the risk factors for seroprevalence and the correlation between CD4+ T-cell count and humoral antibody responses to Toxoplasma gondii infection amongst HIV patients in the Bamenda Health District, Cameroon.

PLoS One 2021 2;16(12):e0256947. Epub 2021 Dec 2.

Department of Microbiology and Parasitology, University of Buea, Buea, Cameroon.

Background: Toxoplasmosis is caused by an obligate intracellular tissue protozoan parasite, Toxoplasma gondii that infect humans and other warm-blooded animals. Transmission to humans is by eating raw or inadequately cooked infected meat or through ingestion of oocysts that cats have passed in faeces. Studies have shown life-threatening and substantial neurologic damage in immunocompromised patients; however, 80% of humans remain asymptomatic. Read More

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December 2021

Liver Disease: Evaluation of Patients With Abnormal Liver Test Results.

FP Essent 2021 Dec;511:11-22

Department of Family Medicine - Tufts University School of Medicine, 136 Harrison Ave, Boston, MA 02111.

The prevalence of abnormal liver test results in the general population is estimated to be between 10% and 20%. The terms or are recommended to describe more accurately the tests used to assess liver health, instead of the term . Defining normal ranges for liver transaminase levels can be challenging. Read More

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December 2021

Safety Practices and Covid-19 Antibody Positivity among Health Care Workers in a Tertiary Hospital in Southern Nigeria.

West Afr J Med 2021 Oct;Vol. 38(10):930-935

Department of Internal Medicine, University of Uyo Teaching Hospital, Uyo, Akwa Ibom, Nigeria.

Introduction: The COVID-19 pandemic has surpassed 211 million cases and 4.4 million deaths globally. Seroprevalence among Health care workers (HCWs) ranges from 10. Read More

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October 2021

Impairment of early neuronal maturation in anti-NMDA-receptor encephalitis.

Psychopharmacology (Berl) 2021 Dec 2. Epub 2021 Dec 2.

Department of Neuropsychiatry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, Okayama, 700-8558, Japan.

Rationale: Adequate immunotherapies for anti-NMDAR encephalitis during pregnancy produce a relatively good clinical outcome for pregnant mothers and their infants, but there are no reports about the future growth of their babies. The damage of anti-NMDAR antibodies to early neuronal development is still unknown.

Objectives: Serum or cerebrospinal fluid from one patient with anti-NMDAR encephalitis (the index patient) and one patient with schizophrenia (the control patient) was administered to primary cultures of dissociated rat cortical neurons, and dendritic outgrowth, centrosome elimination, and branching of dendrites were investigated. Read More

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December 2021

Significance of anti-HBc serological status in primary immune thrombocytopenia.

Br J Haematol 2021 Dec 1. Epub 2021 Dec 1.

Department of Hematology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.

The association of previous hepatitis B virus (HBV) exposure [hepatitis B surface antigen (HBsAg) negative, hepatitis B core antibody (anti-HBc/HBcAb) positive] with disease severity and decision on treatment option in primary immune thrombocytopenia (ITP) patients remains unclear. Data from 725 patients diagnosed with ITP were analyzed to elucidate the association between anti-HBc serological status and disease severity. Data from a published prospective study [high-dose dexamethasone (HD-DXM), HD-DXM plus recombinant human thrombopoietin, NCT01734044] and two retrospective studies (standard-dose and low-dose rituximab) were rearranged to evaluate the impact of anti-HBc serological status on the response and outcome to ITP-specific treatments and the risk of HBV reactivation related to these treatments. Read More

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December 2021

Global epidemiology of vasculitis.

Nat Rev Rheumatol 2021 Dec 1. Epub 2021 Dec 1.

Department of Clinical Sciences, Division of Rheumatology, Lund University and Department of Rheumatology, Skåne University Hospital, Lund, Sweden.

The many forms of vasculitis are characterized by inflammation of blood vessels, leading to potentially long-term sequelae including vision loss, aneurysm formation and kidney failure. Accurate estimation of the incidence and prevalence has been hampered by the absence of reliable diagnostic criteria and the rarity of these conditions; however, much progress has been made over the past two decades, although data are still lacking from many parts of the world including the Indian subcontinent, China, Africa and South America. Giant cell arteritis occurs in those aged 50 years and over and seems to mainly affect persons of northern European ancestry, whereas Takayasu arteritis occurs mainly in those aged under 40 years. Read More

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December 2021

Persistent pulmonary pathology after COVID-19 is associated with high viral load, weak antibody response, and high levels of matrix metalloproteinase-9.

Sci Rep 2021 12 1;11(1):23205. Epub 2021 Dec 1.

Department of Pulmonary Medicine, Oslo University Hospital Ullevål, Nydalen, Postboks 4950, 0424, Oslo, Norway.

The association between pulmonary sequelae and markers of disease severity, as well as pro-fibrotic mediators, were studied in 108 patients 3 months after hospital admission for COVID-19. The COPD assessment test (CAT-score), spirometry, diffusion capacity of the lungs (DL), and chest-CT were performed at 23 Norwegian hospitals included in the NOR-SOLIDARITY trial, an open-labelled, randomised clinical trial, investigating the efficacy of remdesivir and hydroxychloroquine (HCQ). Thirty-eight percent had a CAT-score ≥ 10. Read More

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December 2021

Epidemiological study in a small rural area of Veneto (Italian region) during Sars-Cov-2 Pandemia.

Sci Rep 2021 12 1;11(1):23247. Epub 2021 Dec 1.

Head of Medicine Unit and Medical Department, Monastier di Treviso Hospital, Veneto, Italy.

The emergence of severe acute respiratory syndrome type 2 coronavirus (SARS-CoV-2) and its complications have demonstrated the devastating impact of a new infectious pathogen. The organisational change promulgated by the isolation of affected communities is of extreme importance to achieve effective containment of the contagion and good patient care. The epidemiological study of the population of a small rural community in the North East of Italy revealed how much the virus had circulated during Spring, 2020, and how contagion has evolved after a prolonged lockdown. Read More

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December 2021

Evolution of SARS-CoV-2 Seroprevalence Among Employees of a United States Academic Children's Hospital During the COVID-19 Pandemic.

Infect Control Hosp Epidemiol 2021 Dec 2:1-24. Epub 2021 Dec 2.

Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Objectives: Describe cumulative seroprevalence of SARS-CoV-2 antibodies during the COVID-19 pandemic among employees of a large pediatric healthcare system.

Design, Setting, And Participants: Prospective observational cohort study open to adult employees at Children's Hospital of Philadelphia, conducted April 20 - December 17, 2020.

Methods: Employees were recruited starting with high-risk exposure groups, utilizing emails, flyers, and announcements at virtual town halls. Read More

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December 2021

Diagnostic accuracy of dried blood spots for serology of vaccine-preventable diseases: a systematic review.

Expert Rev Vaccines 2021 Dec 1. Epub 2021 Dec 1.

Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.

Introduction: Venous serum and plasma are optimal specimens for serological testing but may be logistically infeasible. Dried blood spots (DBS) are a feasible alternative, provided results are adequately sensitive and specific. We aimed to assess the diagnostic accuracy of DBS to measure IgG and IgM antibodies for vaccine-preventable diseases and compare test validity of DBS with venous blood. Read More

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December 2021

Case Report: First Confirmed Case of Coinfection of SARS-CoV-2 With .

Front Trop Dis 2021 10;2:769330. Epub 2021 Nov 10.

Department of Research in Emerging and Zoonotic Infectious Diseases, Gorgas Memorial Institute for Health Studies, Panama City, Panama.

The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a major international public health concern. The World Health Organization (WHO) declared the pandemic of coronavirus disease 2019 (COVID-19) on March 11, 2020. In Panama, the first SARS-CoV-2 infection was confirmed on March 9, 2020, and the first fatal case associated to COVID-19 was reported on March 10. Read More

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November 2021

High prevalence of thyroid hormone autoantibody and low rate of thyroid hormone detection interference.

J Clin Lab Anal 2021 Dec 1:e24124. Epub 2021 Dec 1.

Department of Endocrinology, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China.

Objective: Thyroid hormone autoantibody (THAb) is a common antibody in autoimmune disease and can interfere with the detection of thyroid hormone (TH). There was no research reporting the prevalence of THAb in Chinese and the rate of THAb interfering with TH detection.

Methods: We collected 114 patients with autoimmune thyroid disease (AITD) (Hashimoto's thyroiditis, 57 cases; Graves' disease, 57 cases), 106 patients with nonthyroid autoimmune diseases (NTAID), and 120 healthy subjects. Read More

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December 2021