925,708 results match your criteria antibiotics

Beta-lactam induced morphological changes in serum of extended-spectrum beta-lactamase-producing Klebsiella pneumoniae blood isolates.

Microbes Infect 2022 Aug 6:105036. Epub 2022 Aug 6.

Department of Health Science and Technology, Medical Microbiology and Immunology, Aalborg University, Fredrik Bajers Vej 3b, 9220, Aalborg, Denmark. Electronic address:

Klebsiella pneumoniae is an opportunistic pathogen, which frequently causes bacteremia. Ceftazidime and meropenem, two important beta-lactam antibiotics for treatment of K. pneumoniae infections, induce morphological changes in bacteria when examined in vitro. Read More

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NDM-1 Zn1-binding residue His116 plays critical roles in antibiotic hydrolysis.

Biochim Biophys Acta Proteins Proteom 2022 Aug 6:140833. Epub 2022 Aug 6.

The State Key Laboratory of Chemical Biology and Drug Discovery, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, China. Electronic address:

Bacteria carrying NDM-1 have been labeled as superbugs because it confers upon them resistance to a broad range of β-lactam antibiotics. The enzyme has a di‑zinc active centre, with the Zn2 site extensively studied. The roles of active-site Zn1 ligand residues are, however, still not fully understood. Read More

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Biochemical and Molecular Mechanisms of Antibiotic Resistance in Salmonella spp.

Res Microbiol 2022 Aug 6:103985. Epub 2022 Aug 6.

Department of Biosciences and Biomedical Engineering, Indian Institute of Technology, Indore, Simrol, Khandwa Road, Indore - 453552, India. Electronic address:

Salmonella is a diverse Gram-negative bacterium that represents the major disease burden worldwide. According to WHO, Salmonella is one of the fourth global causes of diarrhoeal disease. Antibiotic resistance is a worldwide health concern, and Salmonella spp. Read More

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The production and influence of anti-Vibrio parahaemolytics IgY against experimental infection of V. parahaemolyticus in cultured Fenneropenaeus indicus.

Fish Shellfish Immunol 2022 Aug 6. Epub 2022 Aug 6.

Aquatic Animal Health Lab, Centre for Marine Science and Technology, Manonmaniam Sundaranar University, Rajakkamangalam, Kanyakumari Dist., Tamilnadu, 629502, India. Electronic address:

The increasing number of antibiotic-resistant bacteria emphasizes the need to find alternatives to complement antibiotics. Immunotherapy may also be used as a complementary treatment against pathogens that are difficult to treat with traditional antibiotics. Eggs are normal dietary components and there is practically no risk of toxic side effects of IgY given orally. Read More

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Alnustone inhibits Streptococcus pneumoniae virulence by targeting pneumolysin and sortase A.

Fitoterapia 2022 Aug 6:105261. Epub 2022 Aug 6.

State Key Laboratory for Zoonotic Diseases, Key Laboratory for Zoonosis Research, Ministry of Education, College of Veterinary Medicine, Jilin University, Changchun, China; College of Food Science and Engineering, Jilin University, Changchun, China. Electronic address:

Streptococcus pneumoniae (S. pneumoniae) is a major Gram-positive opportunistic pathogen that causes pneumonia, bacteremia, and other fatal infections. This bacterium is responsible for more deaths than any other single pathogen in the world. Read More

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Amoxicillin versus other antibiotic agents for the treatment of acute otitis media in children.

J Pediatr 2022 Aug 6. Epub 2022 Aug 6.

Division of Healthcare Quality Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.

Objectives: To compare the antibiotic treatment failure and recurrence rates between antibiotic agents (amoxicillin, amoxicillin-clavulanate, cefdinir, and azithromycin) for children with uncomplicated acute otitis media (AOM) STUDY DESIGN: We completed a retrospective cohort study of children 6 months-12 years of age with uncomplicated AOM identified in a nationwide claims database. The primary exposure was antibiotic agent, and the primary outcomes were treatment failure and recurrence. Logistic regression was used to estimate odds ratios and analyses were stratified by primary exposure, patient age and antibiotic duration. Read More

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Microbial community metabolic alterations and resistance to metals and antibiotics driven by chronic exposition to multiple pollutants in a highly impacted tropical coastal bay.

Chemosphere 2022 Aug 6:135928. Epub 2022 Aug 6.

Universite de Pau et des Pays de l'Adour, E2S UPPA, CNRS, IPREM, Pau, France. Electronic address:

Microbial communities from Sepetiba Bay (SB, Rio de Janeiro, Brazil), characterized by 16S rRNA gene (V4-V5 region) sequencing analysis, were found to be correlated with the metallic contamination factor and the Quality Ratio (QR) index. Consistently, the predicted function of microbial communities, obtained with Tax4Fun2, showed that the functional patterns in SB internal sector under the highest anthropogenic pressure were different from that observed in the external sector with the lowest contamination level. Signal transduction, cellular community, membrane transport, and energy metabolism were among the KEGG pathways favored by metallic contamination in the SB internal sector, while lipid metabolism, transcription, and translation were among the pathways favored in the SB external sector. Read More

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Visible-light-driven photocatalytic degradation of ofloxacin by BiOBr nanocomposite modified with oxygen vacancies and N-doped CQDs: Enhanced photodegradation performance and mechanism.

Chemosphere 2022 Aug 6:135976. Epub 2022 Aug 6.

Beijing Key Laboratory for Source Control Technology of Water Pollution, Engineering Research Center for Water Pollution Source Control and Eco-remediation, Beijing Forestry University, Beijing, 100083, China.

The rapid recombination of photogenerated carriers and weak light absorption capacity are two major challenges for bismuth-based photocatalysts. Here, N-CQDs/BiOBr micro-flower photocatalysts with the visible-light activity were fabricated through the ethylene glycol solvothermal method for the first time, and oxygen vacancies (OVs) and N-doped carbon quantum dots (N-CQDs) were simultaneously introduced on the surface of BiOBr. OVs were introduced to form defective BiOBr (BiOBr). Read More

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Surface-bound hydroxyl radical-dominated degradation of sulfamethoxazole in the amorphous FeOOH/ peroxymonosulfate system: The key role of amorphous structure enhancing electron transfer.

Environ Res 2022 Aug 6:113964. Epub 2022 Aug 6.

School of Civil Engineering, Beijing International Scientific and Technological Cooperation Base of Water Pollution Control Techniques for Antibiotics and Resistance Genes, Beijing Jiaotong University, 3 Shangyuancun, Beijing, 100044, PR China. Electronic address:

In this study, activation of peroxymonosulfate (PMS) by amorphous FeOOH to degrade sulfamethoxazole (SMX) was investigated. The amorphous FeOOH showed a better performance in the decomposition of PMS and the degradation of SMX than the crystallized α-FeOOH and β-FeOOH. The quenching experiments and EPR measurements suggested that the mechanism of PMS activation by amorphous FeOOH was mainly the surface-bound radicals (OH and SO). Read More

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Heterogeneity in disease resistance and the impact of antibiotics in the US.

Econ Hum Biol 2022 Jul 27;47:101155. Epub 2022 Jul 27.

University of Wisconsin-Madison, United States. Electronic address:

We hypothesize that the impact of antibiotics is moderated by a population's inherent (genetic) resistance to infectious disease. Using the introduction of sulfa drugs in 1937, we show that US states that are more genetically susceptible to infectious disease saw larger declines in their bacterial mortality rates following the introduction of sulfa drugs in 1937. This suggests area-level genetic endowments of disease resistance and the discovery of medical technologies have acted as substitutes in determining levels of health across the US. Read More

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Enhanced medium-chain fatty acids production from Cephalosporin C antibiotic fermentation residues by ionizing radiation pretreatment.

J Hazard Mater 2022 Aug 4;440:129714. Epub 2022 Aug 4.

Laboratory of Environmental Technology, INET, Tsinghua University, Beijing 100084, PR China; Beijing Key Laboratory of Radioactive Waste Treatment, INET, Tsinghua University, Beijing 100084, PR China. Electronic address:

Antibiotic fermentation residues (AFRs) have been classified as hazardous waste in China. Anaerobic fermentation may be a good approach for AFRs treatment, through which value-added chemicals could be obtained simultaneously. This study firstly explored medium-chain fatty acids (MCFAs) production from AFRs through two-stage anaerobic fermentation, and gamma radiation was adopted for AFRs pretreatment. Read More

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Emergence of plasmid-mediated tigecycline, β-lactam and florfenicol resistance genes tet(X), bla and floR in Riemerella anatipestifer isolated in China.

Poult Sci 2022 Jul 14;101(10):102057. Epub 2022 Jul 14.

Research Center of Avian Diseases, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan, China; Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan, China; Key Laboratory of Animal Disease and Human Health of Sichuan Province, Chengdu, Sichuan, China. Electronic address:

Bacterial antimicrobial resistance (AMR) continues to develop, with the horizontal transfer of antibiotic resistance genes (ARGs) through plasmids playing a major role. Recently, the antimicrobial resistance of R. anatipestifer has become increasingly severe, jeopardizing the development of the poultry industry. Read More

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Antimicrobial peptides for tackling cystic fibrosis related bacterial infections: A review.

Microbiol Res 2022 Jul 30;263:127152. Epub 2022 Jul 30.

Institute of Chemical Sciences and Technologies "G. Natta" (SCITEC) - UoS Rome, National Research Council (CNR), Rome, Italy.

Antibiotic resistance is a serious health and social problem that will have a substantial impact in the coming years on the world health and economy. Thus, the increasing demand for innovative antibiotics, has prompted many researchers in the medical, microbiological, and biochemical fields to exploit the properties of antimicrobial peptides (AMPs). When properly used, designed, and conveyed, AMPs can really represent a valid alternative to conventional drugs especially in situations that are particularly difficult to treat such as chronic infections found in Cystic Fibrosis (CF) patients. Read More

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Impact of sulfamethoxazole and organic supplementation on mixotrophic denitrification process: Nitrate removal efficiency and the response of functional microbiota.

J Environ Manage 2022 Aug 6;320:115818. Epub 2022 Aug 6.

Shandong Provincial Key Laboratory of Marine Environment and Geological Engineering (MEGE), College of Environmental Science and Engineering, Ocean University of China, Qingdao, 266100, China; Key Lab of Marine Environmental Science and Ecology (Ocean University of China), Ministry of Education, Qingdao, 266100, China. Electronic address:

Recirculating aquaculture systems (RAS) effluent is characterized by low COD to total inorganic nitrogen ratio (C/N), excessive nitrate, and the presence of traces of antibiotics. Hence, it urgently needs to be treated before recycling or discharging. In this study, four denitrification bioreactors at increasing C/N ratios (0, 0. Read More

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Critical review of technologies for the on-site treatment of hospital wastewater: From conventional to combined advanced processes.

J Environ Manage 2022 Aug 6;320:115769. Epub 2022 Aug 6.

Department of Chemical and Environmental Technology, ESCET, Rey Juan Carlos University, C/Tulipán s/n, 28933, Móstoles, Madrid, Spain.

This review aims to assess different technologies for the on-site treatment of hospital wastewater (HWW) to remove pharmaceutical compounds (PhCs) as sustances of emerging concern at a bench, pilot, and full scales from 2014 to 2020. Moreover, a rough characterisation of hospital effluents is presented. The main detected PhCs are antibiotics and psychiatric drugs, with concentrations up to 1. Read More

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Fate characteristics, exposure risk, and control strategy of typical antibiotics in Chinese sewerage system: A review.

Environ Int 2022 Jul 7;167:107396. Epub 2022 Jul 7.

State Key Joint Laboratory of Environment Simulation and Pollution Control, School of Environment, Tsinghua University, Beijing 100084, China. Electronic address:

In China, the sewerage system plays an essential role in antibiotic removal; however, the fate profiles of antibiotics in sewers are not well understood, and risk identification throughout the sewerage system is inadequate. Based on the extensive detection results for typical groups of antibiotics in the discharge sources, influent and effluent from wastewater treatment plants (WWTPs), and excess sludge, a comprehensive evaluation was conducted to reveal the elimination profiles of the antibiotics, identify the fate characteristics in both sewers and WWTPs, assess the exposure risk levels, and propose a control strategy. The total concentration (based on the median concentrations of the target antibiotics) in aqueous waters was estimated to decrease from 7383. Read More

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Effects of litter from antimicrobial-fed broiler chickens on soil bacterial community structure and diversity.

Can J Microbiol 2022 Aug 9. Epub 2022 Aug 9.

McGill University, Deptartment of Animal Science, Montreal, Quebec, Canada;

This study examined changes in soil bacterial community composition and diversity in response to fertilization with litter from chickens fed diet with no antibiotics, bambermycin, penicillin, bacitracin, salinomycin, and mix of salinomycin and bacitracin. Litter was applied to 24 agricultural-plots. Non-fertilized plots were used as a negative control. Read More

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Colistin resistance screening by 3 μg/ml colistin agar in Carbapenemase-producing Enterobacterales.

J Clin Lab Anal 2022 Aug 9:e24639. Epub 2022 Aug 9.

Department of Microbiology, School of Medicine and PhD Program in Clinical Medicine and Public Health, University of Granada & ibs, Granada, Spain.

Background: In low- and middle-income countries, the use of colistin in therapeutic regimens is common, to treat infections produced for Carbapenemase-producing Enterobacterales (CPE) due to limited access to the recently discovered-approved antibiotics. Furthermore, the technical limitations to perform colistin susceptibility tests make it difficult to assess the suitability of this treatment for each patient, as well as to monitor the rates of resistance. In the present study, we describe the use of agar dilution using a unique colistin concentration of 3 μg/ml to discriminate isolates with colistin resistance in CPE obtained from clinical samples. Read More

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A data compendium associating the genomes of 12,289 Mycobacterium tuberculosis isolates with quantitative resistance phenotypes to 13 antibiotics.

PLoS Biol 2022 Aug 9;20(8):e3001721. Epub 2022 Aug 9.

University of Oxford, Oxford, United Kingdom.

The Comprehensive Resistance Prediction for Tuberculosis: an International Consortium (CRyPTIC) presents here a data compendium of 12,289 Mycobacterium tuberculosis global clinical isolates, all of which have undergone whole-genome sequencing and have had their minimum inhibitory concentrations to 13 antitubercular drugs measured in a single assay. It is the largest matched phenotypic and genotypic dataset for M. tuberculosis to date. Read More

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Preparation of Graphite-UiO-66(Zr)/Ti electrode for efficient electrochemical oxidation of tetracycline in water.

PLoS One 2022 9;17(8):e0271075. Epub 2022 Aug 9.

State Key Laboratory of Pollution Control and Resources Reuse, School of the Environment, Nanjing University, Nanjing, PR China.

Tetracycline (TC) is widely-used antibiotic pollutant with high toxicity, refractory, persistence and bacteriostasis, and its removal from water needs to be enhanced. In this work, a novel Graphite-UiO-66(Zr)/Ti electrode was successfully prepared and evaluated for electrochemical oxidation degradation of TC. The electrochemical performance tests indicate the Graphite-UiO-66(Zr)/Ti electrode had higher electrochemical oxidation activity, which achieved higher TC removal efficiency (98. Read More

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Streptococcus canis sequence type 43 may be associated with treatment failure in dogs with corneal ulceration.

J Am Vet Med Assoc 2022 Jul 15:1-7. Epub 2022 Jul 15.

2Large Animal Clinical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, Canada.

Objective: To profile Streptococcus canis isolates obtained from corneal ulcers in dogs.

Animals: 10 dogs.

Procedures: Medical records were searched to identify dogs diagnosed with ulcerative keratitis by a veterinary ophthalmologist and having a positive corneal culture for S canis during the year 2020. Read More

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Septic Shock Induced by Acute Pyelonephritis Resulting from Kidney Stones Treated by Double-J Ureteral Stents in a Pregnant Woman: A Case Report and Literature Review.

Am J Case Rep 2022 Aug 9;23:e936967. Epub 2022 Aug 9.

Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China (mainland).

BACKGROUND Bacteriuria occurs in many pregnant women which may result in symptomatic urinary tract infection (UTI), including acute pyelonephritis (APN), which can lead to septic shock. However, there was no standard protocol of managing pregnant women with APN about the regimen, timing, length of antibiotic appliance as well as the indication of implanting double-J ureteral stents in those with kidney stones. CASE REPORT A 26-year-old pregnant woman (G1P0, 27 weeks plus 3 days) presented to our hospital on account of fever and pain in the flanks and was admitted on account of suspected UTI due to bacteriuria and elevated inflammatory markers. Read More

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Risk factors for developing Inflammatory Bowel Disease Within and Across Families with Family History of IBD.

J Crohns Colitis 2022 Aug 9. Epub 2022 Aug 9.

Gastrounit, Medical Division, Hvidovre Hospital, University of Copenhagen, Hvidovre, Denmark.

Introduction: A family history of IBD is the strongest risk factor for disease. However, some first-degree relatives (FDRs) will develop disease, while others will not.

Methods: Using the nationwide Danish National Patient Register, we examined risk factors in families with ≥2 affected FDRs. Read More

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The biogenesis of β-lactamase enzymes.

Microbiology (Reading) 2022 Aug;168(8)

Department of Molecular Biosciences, The University of Texas at Austin, Austin, Texas, USA.

The discovery of penicillin by Alexander Fleming marked a new era for modern medicine, allowing not only the treatment of infectious diseases, but also the safe performance of life-saving interventions, like surgery and chemotherapy. Unfortunately, resistance against penicillin, as well as more complex β-lactam antibiotics, has rapidly emerged since the introduction of these drugs in the clinic, and is largely driven by a single type of extra-cytoplasmic proteins, hydrolytic enzymes called β-lactamases. While the structures, biochemistry and epidemiology of these resistance determinants have been extensively characterized, their biogenesis, a complex process including multiple steps and involving several fundamental biochemical pathways, is rarely discussed. Read More

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Patterns of use and outcomes of peripherally inserted central catheters in hospitalized patients with solid tumors: A multicenter study.

Cancer 2022 Aug 9. Epub 2022 Aug 9.

Department of Medicine, University of Colorado, Denver, Aurora, Colorado, USA.

Background: The risk of peripherally inserted central catheter (PICC)-related complications in patients hospitalized with solid tumors remains unclear. Existing studies are limited by single-center, outpatient designs and include heterogenous patients.

Methods: A retrospective cohort study was designed and included adult patients with solid organ cancers who were admitted to a general medicine ward or intensive care unit and received a PICC. Read More

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Characterization of Extended-Spectrum β-Lactamase-Producing Isolates That Cause Diarrhea in Sheep in Northwest China.

Microbiol Spectr 2022 Aug 9:e0159522. Epub 2022 Aug 9.

College of Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi, China.

Development of extended-spectrum-β-lactamase (ESBL)-producing Escherichia coli is one the greatest threats faced by mankind. Among animals, chickens, pigs, and cattle are reservoirs of these pathogens worldwide. Nevertheless, there is a knowledge gap on ESBL-producing E. Read More

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Proton Motive Force Inhibitors Are Detrimental to Methicillin-Resistant Staphylococcus aureus Strains.

Microbiol Spectr 2022 Aug 9:e0202422. Epub 2022 Aug 9.

Department of Chemical and Biomolecular Engineering, University of Houstongrid.266436.3, Houston, Texas, USA.

Methicillin-resistant Staphylococcus aureus (MRSA) strains are tolerant of conventional antibiotics, making them extremely dangerous. Previous studies have shown the effectiveness of proton motive force (PMF) inhibitors at killing bacterial cells; however, whether these agents can launch a new treatment strategy to eliminate antibiotic-tolerant cells mandates further investigation. Here, using known PMF inhibitors and two different MRSA isolates, we showed that the bactericidal potency of PMF inhibitors seemed to correlate with their ability to disrupt PMF and permeabilize cell membranes. Read More

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In vitro killing of multidrug/extensively drug-resistant by fosfomycin alone or in combination with antipseudomonal antibiotics.

J Chemother 2022 Aug 9:1-12. Epub 2022 Aug 9.

Faculty of Pharmacy and Biochemistry, University of Zagreb, Croatia.

is a leading cause of nosocomial infections. Given the constant rise in resistance, adequate therapy is increasingly demanding. Fosfomycin recently became an appealing treatment option of bacterial infections due to multidrug-resistant bacteria (MDR). Read More

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Healthcare-associated central nervous system infections.

Curr Opin Anaesthesiol 2022 Aug 10. Epub 2022 Aug 10.

Department of Surgical, Oncological and Oral Science (Di.Chir.On.S.), University of Palermo.

Purpose Of Review: The aim of this review is to provide a practical and updated summary on healthcare-associated central nervous system infections and their management.

Recent Findings: The term 'healthcare-associated ventriculitis and meningitis' has recently been coined and clinical practical guidelines have been published on the management of these nosocomial infections. Many aspects have still to be further investigated (e. Read More

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Seasonal variation of the composition of essential oils from Vell and Kunth, ADMET study, DFT calculations, molecular docking and dynamics studies of major components as potent inhibitors of the heterodimer methyltransferase complex NSP16-NSP10 SARS COV-2 protein.

J Biomol Struct Dyn 2022 Aug 9:1-19. Epub 2022 Aug 9.

Department of Chemistry, Group of Theoretical Chemistry and Electrochemistry, FAFIDAM Campus, State University of Ceará, Limoeiro do Norte, Ceará, Brazil.

Coronavirus disease (COVID-19) has the virus that causes the SARS-CoV-2 severe acute respiratory syndrome, which has reached a pandemic proportion, with thousands of deaths worldwide already registered. It has no standardized effective clinical treatment, arousing the urgent need for the discovery of bioactive compounds for the treatment of symptoms of COVID-19. In this context, the present study aimed to evaluate the influence of seasonality on the yield and chemical composition of the essential oils of and as well as to evaluate the anti-SARS-CoV-2 potential of the major components of each oil by molecular docking and quantum chemical calculation (Density Functional Theory method), being possible indicate that the winter and autumn periods, the seasons of the year where it is possible to obtain the highest percentage of and oils, respectively. Read More

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