13,199 results match your criteria antibiotic-resistant


Current and Novel Diagnostics for Orthopedic Implant Biofilm Infections: A Review.

APMIS 2021 Dec 4. Epub 2021 Dec 4.

University of Maryland, Department of Civil and Environmental Engineering, USA.

Biofilm infections involving orthopedic implants are a global problem. They contribute to severe complications and mortality, as well as increased use of antibiotic treatments and development of antibiotic-resistant microorganisms. More than 1 million hip and knee arthroplasties are performed each year in the United States. Read More

View Article and Full-Text PDF
December 2021

Acetic acid dressings used to treat pseudomonas colonised burn wounds: A UK national survey.

Burns 2021 Jul 26. Epub 2021 Jul 26.

Department of Burns and Plastic Surgery, Southmead Hospital, North Bristol NHS Foundation Trust, BS10 5BN, United Kingdom.

Introduction: Wound infection following burn injury can be clinically challenging to manage. Its presence in a thermally compromised patient can detrimentally affect the ability of the wound to heal leading not only to wound progression but ultimately contribute to a large part of the economic health burden expenditure in the National Health Service. Despite meticulous wound care and infection control measures the colonisation of burn wounds by bacterial pathogens has and continues to be the case. Read More

View Article and Full-Text PDF

Cellulose-Based Nanofibril Composite Materials as a New Approach to Fight Bacterial Infections.

Front Bioeng Biotechnol 2021 11;9:732461. Epub 2021 Nov 11.

Research Center for Biochemistry and Nutrition in Metabolic Diseases, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, Iran.

Antibiotic resistant microorganisms have become an enormous global challenge, and are predicted to cause hundreds of millions of deaths. Therefore, the search for novel/alternative antimicrobial agents is a grand global challenge. Cellulose is an abundant biopolymer with the advantages of low cost, biodegradability, and biocompatibility. Read More

View Article and Full-Text PDF
November 2021

Genomic Analysis of Multidrug-Resistant Strains From Patients in Kazakhstan.

Front Genet 2021 9;12:683515. Epub 2021 Nov 9.

Laboratory of Bioinformatics and Systems Biology, Center for Life Sciences, National Laboratory Astana, Nazarbayev University, Nur-Sultan, Kazakhstan.

Tuberculosis (TB) is an infectious disease that remains an essential public health problem in many countries. Despite decreasing numbers of new cases worldwide, the incidence of antibiotic-resistant forms (multidrug resistant and extensively drug-resistant) of TB is increasing. Next-generation sequencing technologies provide a high-throughput approach to identify known and novel potential genetic variants that are associated with drug resistance in (). Read More

View Article and Full-Text PDF
November 2021

Antibiotic resistance modifying ability of phytoextracts in anthrax biological agent Bacillus anthracis and emerging superbugs: a review of synergistic mechanisms.

Ann Clin Microbiol Antimicrob 2021 Dec 2;20(1):79. Epub 2021 Dec 2.

Singapore Centre for 3D Printing, School of Mechanical and Aerospace Engineering, Nanyang Technological University, Singapore, Singapore.

Background And Objectives: The chemotherapeutic management of infections has become challenging due to the global emergence of antibiotic resistant pathogenic bacteria. The recent expansion of studies on plant-derived natural products has lead to the discovery of a plethora of phytochemicals with the potential to combat bacterial drug resistance via various mechanisms of action. This review paper summarizes the primary antibiotic resistance mechanisms of bacteria and also discusses the antibiotic-potentiating ability of phytoextracts and various classes of isolated phytochemicals in reversing antibiotic resistance in anthrax agent Bacillus anthracis and emerging superbug bacteria. Read More

View Article and Full-Text PDF
December 2021

Bad bugs: Antibiotic-resistant bacteriuria in pregnancy and risk of pyelonephritis.

Am J Obstet Gynecol MFM 2021 Nov 29:100540. Epub 2021 Nov 29.

Department of Obstetrics and Gynecology, Duke University Health System, Durham, NC.

Background: The introduction of antibiotics has significantly reduced morbidity and mortality from microbial infections, but the rise of antibiotic-resistant and multi-drug-resistant microbes is of increasing clinical concern. Few studies have examined the prevalence of and impact from antibiotic resistance in common antenatal infections.

Objective: Determine whether pregnant women with a urine culture positive for antibiotic-resistant (AR) or multidrug-resistant (MDR) gram-negative bacteria are at increased risk for developing pyelonephritis compared to pregnant women infected with antibiotic-susceptible (AS) organisms. Read More

View Article and Full-Text PDF
November 2021

The highly diverse Antarctic Peninsula soil microbiota as a source of novel resistance genes.

Sci Total Environ 2021 Nov 29:152003. Epub 2021 Nov 29.

Grupo de Microbiología Integrativa, Laboratorio de Biología Estructural y Molecular BEM, Departamento de Biología, Facultad de Ciencias, Universidad de Chile, Santiago, Chile.

The rise of multiresistant bacterial pathogens is currently one of the most critical threats to global health, encouraging a better understanding of the evolution and spread of antimicrobial resistance. In this regard, the role of the environment as a source of resistance mechanisms remains poorly understood. Moreover, we still know a minimal part of the microbial diversity and resistome present in remote and extreme environments, hosting microbes that evolved to resist harsh conditions and thus a potentially rich source of novel resistance genes. Read More

View Article and Full-Text PDF
November 2021

Characterization of bacteria and antibiotic resistance in commercially-produced cheeses sold in China.

J Food Prot 2021 Dec 2. Epub 2021 Dec 2.

Shanghai Jiaotong University: Shanghai Jiao Tong University School of Agriculture and Biology 800 Dongchuan Road Minhang District Minhang CHINA Shanghai 200240.

The consumption of cheese in China is increasing rapidly. Little is known about the microbiota, the presence of antibiotic-resistant bacteria, or the distribution of antibiotic resistance genes (ARGs) in commercially-produced cheeses sold in China. These are important criteria for evaluating quality and safety. Read More

View Article and Full-Text PDF
December 2021

Prevalence of resistance genes to biocides in antibiotic-resistant Pseudomonas aeruginosa clinical isolates.

Mol Biol Rep 2021 Dec 1. Epub 2021 Dec 1.

Department of Microbiology, School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran.

Background: Biocides are frequently used as preservative, disinfectant and sterilizer against many microorganisms in hospitals, industry and home. However, the reduced susceptibility rate of Pseudomonas aeruginosa (P. aeruginosa) strains to biocides is increasing. Read More

View Article and Full-Text PDF
December 2021

Predictors of Short-Term Mortality Following First Episode of Spontaneous Bacterial Peritonitis in Hospitalized Cirrhotic Patients.

Cureus 2021 Oct 23;13(10):e18999. Epub 2021 Oct 23.

Internal Medicine, Hamad Medical Corporation, Doha, QAT.

Background and aims Spontaneous bacterial peritonitis (SBP) is an important cause of morbidity and mortality in patients with cirrhosis. This study aimed to identify the factors impacting morbidity and short-term mortality in a cohort of patients with cirrhosis following an index episode of SBP. Methods In a retrospective study of hospitalized cirrhotic cohort, 333 patient records were reviewed. Read More

View Article and Full-Text PDF
October 2021

Bacteriocins: Properties and potential use as antimicrobials.

J Clin Lab Anal 2021 Dec 1:e24093. Epub 2021 Dec 1.

Food and Drug Laboratory Research Center, Food and Drug Administration, MOH&ME, Tehran, Iran.

A variety of bacteriocins originate from lactic acid bacteria, which have recently been modified by scientists. Many strains of lactic acid bacteria related to food groups could produce bacteriocins or antibacterial proteins highly effective against foodborne pathogens such as Staphylococcus aureus, Pseudomonas fluorescens, P. aeruginosa, Salmonella typhi, Shigella flexneri, Listeria monocytogenes, Escherichia coli O157:H7, and Clostridium botulinum. Read More

View Article and Full-Text PDF
December 2021

Clones and Clusters of Antimicrobial-Resistant Klebsiella From Southwestern Nigeria.

Clin Infect Dis 2021 Dec;73(Supplement_4):S308-S315

Global Health Research  Unit on Genomic Surveillance of Antimicrobial Resistance, Department of Pharmaceutical Microbiology, Faculty of Pharmacy, University of Ibadan, Ibadan, Nigeria.

Background: Klebsiella pneumoniae is a World Health Organization high-priority antibiotic-resistant pathogen. However, little is known about Klebsiella lineages circulating in Nigeria.

Methods: We performed whole-genome sequencing (WGS) of 141 Klebsiella isolated between 2016 and 2018 from clinical specimens at 3 antimicrobial-resistance (AMR) sentinel surveillance tertiary hospitals in southwestern Nigeria. Read More

View Article and Full-Text PDF
December 2021

The role of new carbapenem combinations in the treatment of multidrug-resistant Gram-negative infections.

Authors:
Emilio Bouza

J Antimicrob Chemother 2021 Nov;76(Supplement_4):iv38-iv45

Department of Clinical Microbiology and Infectious Diseases, Hospital Gregorio Marañon, Department of Medicine Universidad Complutense, CIBERES, Ciber de Enfermedades Respiratorias, Madrid, Spain.

Multi-drug resistant (MDR) Gram-negative bacteria represent a growing threat, with an increasing prevalence of carbapenem-resistant Enterobacterales (CRE) infections, for which treatment options are limited. New treatment combinations composed of a β-lactam antibiotic plus a potent β-lactamase inhibitor (BLI) with anti-carbapenemase activity have been developed, including two carbapenem/BLI combinations that are commercially available-meropenem/vaborbactam (Vabomere® in the US, Vaborem® in Europe; Melinta Therapeutics) and imipenem/cilastatin/relebactam (Recarbrio®; Merck Sharp & Dohme), plus one other (meropenem/nacubactam) in early clinical development. This review provides a summary of the preclinical evidence supporting the use of carbapenem/BLI combinations and presents the clinical evidence across a range of MDR Gram-negative infections, with a focus on the use of meropenem/vaborbactam. Read More

View Article and Full-Text PDF
November 2021

Phylogenetic relationships and codon usage bias amongst cluster K mycobacteriophages.

G3 (Bethesda) 2021 Oct;11(11)

School of Life Sciences, Arizona State University, Tempe, AZ 85281, USA.

Bacteriophages infecting pathogenic hosts play an important role in medical research, not only as potential treatments for antibiotic-resistant infections but also offering novel insights into pathogen genetics and evolution. A prominent example is cluster K mycobacteriophages infecting Mycobacterium tuberculosis, a causative agent of tuberculosis in humans. However, as handling M. Read More

View Article and Full-Text PDF
October 2021

An assessment of resistome and mobilome in wastewater treatment plants through temporal and spatial metagenomic analysis.

Water Res 2021 Nov 22;209:117885. Epub 2021 Nov 22.

Environmental Microbiome Engineering and Biotechnology Laboratory, Center for Environmental Engineering Research, Department of Civil Engineering, The University of Hong Kong, Hong Kong, China. Electronic address:

Wastewater treatment plants (WWTPs) are regarded as critical points in disseminating antibiotic resistance genes (ARGs). In particular, the discharging effluents from WWTPs generally bring downstream catchment areas exogenous ARGs and resistant bacteria. However, there lacks a sufficient assessment of the resistome and mobilome in effluents. Read More

View Article and Full-Text PDF
November 2021

Campylobacter Express Resistance Array for detecting the presence of fluoroquinolone- and macrolide-resistant Campylobacter jejuni and Campylobacter coli in broiler farms.

J Appl Microbiol 2021 Nov 30. Epub 2021 Nov 30.

Division of Bioresources, Hokkaido University International Institute for Zoonosis Control, Sapporo, Hokkaido, Japan.

Aims: The aim of the study was to develop a microarray-based method for the detection of antibiotic-resistant Campylobacter in broiler farms to decrease the risk of contamination of chicken meat.

Methods And Results: A combination of DNA microarray and primer extension for rapid and simultaneous detection of fluoroquinolone- and macrolide-resistant Campylobacter jejuni/Campylobacter coli, termed Campylobacter Express Resistance Array (CAMERA), was used to analyze chicken caecal droppings. CAMERA assays could detect at least 10 colony forming units of C. Read More

View Article and Full-Text PDF
November 2021

In vitro study examining the effectiveness of antiseptic prophylaxis for antibiotic-resistant bacterial endophthalmitis.

J Cataract Refract Surg 2021 Dec;47(12):1581-1586

From the Department of Ophthalmology, Royal Victoria Eye and Ear Hospital, Dublin, Ireland (O'Rourke, Barry, Khan); Department of Microbiology, The National Maternity Hospital, Dublin, Ireland (Knowles, Curry, Kealy); European Society of Cataract and Refractive Surgeons, Dublin, Ireland (Barry, Khan).

Purpose: To assess the effectiveness of current antiseptic agents on multidrug-resistant (MDR) isolates in an in vitro setting.

Setting: Department of Microbiology, The National Maternity Hospital, Dublin, Ireland.

Design: Organisms were selected based on current review of endophthalmitis literature: methicillin-resistant Staphylococcus aureus (MRSA), methicillin-resistant Staphylococcus epidermidis (MRSE), Pseudomonas aeruginosa, carbapenem-resistant and extended-spectrum β-lactamase Klebsiella pneumoniae, and vancomycin-resistant (VRE) Enterococcus faecalis. Read More

View Article and Full-Text PDF
December 2021

Nasogastric enteral feeding tubes modulate preterm colonization in early life.

Pediatr Res 2021 Nov 29. Epub 2021 Nov 29.

Department of Neonatology, La Paz University Hospital of Madrid, Madrid, Spain.

Background: Preterm infants are generally fed through nasogastric enteral feeding tubes (NEFTs). The aim of this work was to evaluate the role of NEFTs in the initial colonization of the preterm gut and its evolution within the first 2 weeks after birth.

Methods: For this purpose, fecal and NEFT-derived samples from 30 preterm infants hospitalized in a neonatal intensive care unit (NICU) were collected from birth to the second week of life. Read More

View Article and Full-Text PDF
November 2021

Silver nanoparticles as a bioadjuvant of antibiotics against biofilm-mediated infections with methicillin-resistant Staphylococcus aureus and Pseudomonas aeruginosa in chronic rhinosinusitis patients.

Pathology 2021 Nov 26. Epub 2021 Nov 26.

Department of Surgery-Otolaryngology Head and Neck Surgery, Basil Hetzel Institute for Translational Health Research, Central Adelaide Local Health Network, Woodville South, SA, Australia; The University of Adelaide, Adelaide, SA, Australia. Electronic address:

Infectious diseases caused by antibiotic-resistant bacteria in planktonic and biofilm form are difficult to treat with conventional antibiotics. Silver nanoparticles (Ag NPs) can be used as alternatives to antibiotics and can alter the susceptibility of bacteria to antibiotics. Here, the antibacterial properties of 16 different antibiotics and Ag NPs, alone and in combination, were tested against clinical isolates of Pseudomonas aeruginosa (n=3), Staphylococcus aureus (n=3) and methicillin-resistant Staphylococcus aureus (MRSA) (n=2) isolated from chronic rhinosinusitis (CRS) patients. Read More

View Article and Full-Text PDF
November 2021

Eco-risk management of tylosin fermentation residues using vermicomposting.

J Environ Manage 2021 Nov 26;303:114126. Epub 2021 Nov 26.

School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai, 200240, China. Electronic address:

Tylosin fermentation residues (TFR) pose an ecotoxicological risk through antibiotic resistant bacteria (ARBs) and their corresponding genes (ARGs). This study evaluated the ecotoxicity of TFR to soil biological activity, and further explored the mechanisms of vermicomposting to reduce the toxicological risk. The results showed that tylosin (TYL) was moderately degradable with a half-life (t) of 37. Read More

View Article and Full-Text PDF
November 2021

Repurposing phytochemicals as anti-virulent agents to attenuate quorum sensing-regulated virulence factors and biofilm formation in Pseudomonas aeruginosa.

Microb Biotechnol 2021 Nov 29. Epub 2021 Nov 29.

Department of Microbiology, Panjab University, Chandigarh, India.

Unregulated consumption and overexploitation of antibiotics have paved the way for emergence of antibiotic-resistant strains and 'superbugs'. Pseudomonas aeruginosa is among the opportunistic nosocomial pathogens causing devastating infections in clinical set-ups globally. Its artillery equipped with diversified virulence elements, extensive antibiotic resistance and biofilms has made it a 'hard-to-treat' pathogen. Read More

View Article and Full-Text PDF
November 2021

Effective Treatment Strategies for the Removal of Antibiotic-Resistant Bacteria, Antibiotic-Resistance Genes, and Antibiotic Residues in the Effluent From Wastewater Treatment Plants Receiving Municipal, Hospital, and Domestic Wastewater: Protocol for a Systematic Review.

JMIR Res Protoc 2021 Nov 26;10(11):e33365. Epub 2021 Nov 26.

Environmental Interventions Unit, Infectious Disease Division, icddr,b (International Centre for Diarrhoeal Disease Research, Bangladesh), Dhaka, Bangladesh.

Background: The widespread and unrestricted use of antibiotics has led to the emergence and spread of antibiotic-resistant bacteria (ARB), antibiotic-resistance genes (ARGs), and antibiotic residues in the environment. Conventional wastewater treatment plants (WWTPs) are not designed for effective and adequate removal of ARB, ARGs, and antibiotic residues, and therefore, they play an important role in the dissemination of antimicrobial resistance (AMR) in the natural environment.

Objective: We will conduct a systematic review to determine the most effective treatment strategies for the removal of ARB, ARGs, and antibiotic residues from the treated effluent disposed into the environment from WWTPs that receive municipal, hospital, and domestic discharge. Read More

View Article and Full-Text PDF
November 2021

Environmental antibiotics and resistance genes as emerging contaminants: Methods of detection and bioremediation.

Curr Res Microb Sci 2021 Dec 14;2:100027. Epub 2021 Mar 14.

Department of Botany, Nanda Nath Saikia College, Titabar, Assam 785630, India.

In developing countries, the use of antibiotics has helped to reduce the mortality rate by minimizing the deaths caused by pathogenic infections, but the costs of antibiotic contamination remain a major concern. Antibiotics are released into the environment, creating a complicated environmental problem. Antibiotics are used in human, livestock and agriculture, contributing to its escalation in the environment. Read More

View Article and Full-Text PDF
December 2021

Bioprospecting of cowdung microflora for sustainable agricultural, biotechnological and environmental applications.

Curr Res Microb Sci 2021 Dec 16;2:100018. Epub 2020 Dec 16.

Centre for Food Biology and Environment Studies, Bhubaneswar 751019, India.

The review aims at highlighting the manifold applications of cow dung (CD) and CD microflora covering agricultural, biotechnological and environmental applications. The update research on CD microflora and CD in agricultural domain such as biocontrol, growth promotion, organic fertilizer, sulfur oxidation, phosphorus solubilization, zinc mobilization and underlying mechanisms involved in these processes are discussed. The significance of CD applications in tropical agriculture in context to climate change is briefly emphasized. Read More

View Article and Full-Text PDF
December 2021

Molecular characterization of isolated from milk samples with regard to virulence factors and antibiotic resistance.

Vet World 2021 Sep 17;14(9):2410-2418. Epub 2021 Sep 17.

Department of Microbiology, Faculty of Veterinary Medicine, South Valley University, Qena, 83523, Egypt.

Background And Aim: Raw milk is considered an essential source of nutrition during all stages of human life because it offers a valuable supply of protein and minerals. Importantly, milk is considered a good media for the growth and contamination of many pathogenic bacteria, especially food-borne pathogens such as . Thus, the objective of this study was to characterize and detect its virulence factors and antibiotic resistance from raw milk samples. Read More

View Article and Full-Text PDF
September 2021

Gene sharing among plasmids and chromosomes reveals barriers for antibiotic resistance gene transfer.

Philos Trans R Soc Lond B Biol Sci 2022 Jan 29;377(1842):20200467. Epub 2021 Nov 29.

Institute of General Microbiology, Kiel University, Kiel, Germany.

The emergence of antibiotic resistant bacteria is a major threat to modern medicine. Rapid adaptation to antibiotics is often mediated by the acquisition of plasmids carrying antibiotic resistance (ABR) genes. Nonetheless, the determinants of plasmid-mediated ABR gene transfer remain debated. Read More

View Article and Full-Text PDF
January 2022

MSI-1 combats drug-resistant S. aureus by affecting bacterial viability and inhibiting carotenoid pigment production.

Microbiol Res 2021 Oct 27;255:126909. Epub 2021 Oct 27.

School of Life Science and Technology, China Pharmaceutical University, 639 Longmian Road, Nanjing, Jiangsu, 211198, China. Electronic address:

Development of novel therapeutic strategies and antibacterial agents against antibiotic-resistant Staphylococcus aureus (S. aureus) is urgent. In this study, antibacterial activities and possible mechanisms of peptide MSI-1 against multiple drug-resistant S. Read More

View Article and Full-Text PDF
October 2021

Simultaneous Ultrasound-Assisted Hybrid Polyzwitterion/Antimicrobial Peptide Nanoparticles Synthesis and Deposition on Silicone Urinary Catheters for Prevention of Biofilm-Associated Infections.

Nanomaterials (Basel) 2021 Nov 21;11(11). Epub 2021 Nov 21.

Grup de Biotecnologia Molecular i Industrial, Department of Chemical Engineering, Universitat Politècnica de Catalunya, Rambla Sant Nebridi 22, 08222 Terrassa, Spain.

Nosocomial infections caused by antibiotic-resistant bacteria are constantly growing healthcare threats, as they are the reason for the increased mortality, morbidity, and considerable financial burden due to the poor infection outcomes. Indwelling medical devices, such as urinary catheters, are frequently colonized by bacteria in the form of biofilms that cause dysfunction of the device and severe chronic infections. The current treatment strategies of such device-associated infections are impaired by the resistant pathogens but also by a risk of prompting the appearance of new antibiotic-resistant bacterial mechanisms. Read More

View Article and Full-Text PDF
November 2021

Functionalized MoS Nanoflowers with Excellent Near-Infrared Photothermal Activities for Scavenging of Antibiotic Resistant Bacteria.

Nanomaterials (Basel) 2021 Oct 25;11(11). Epub 2021 Oct 25.

College of Life Science & Technology, Xinjiang University, Urumqi 830046, China.

Presently, antibiotic resistant bacteria (ARB) have been commonly found in environment, such as air, soil and lakes. Therefore, it is urgent and necessary to prepare antimicrobial agents with excellent anti-antibiotic resistant bacteria. In our research, poly-ethylene glycol functionalized molybdenum disulfide nanoflowers (PEG-MoS NFs) were synthesized via a one-step hydrothermal method. Read More

View Article and Full-Text PDF
October 2021

Relationship between the Biofilm-Forming Capacity and Antimicrobial Resistance in Clinical Isolates: Results from a Laboratory-Based In Vitro Study.

Microorganisms 2021 Nov 18;9(11). Epub 2021 Nov 18.

Department of Oral Biology and Experimental Dental Research, Faculty of Dentistry, University of Szeged, Tisza Lajos körút 63, 6720 Szeged, Hungary.

The relationship between the multidrug-resistant (MDR) phenotype and biofilm-forming capacity has been a topic of extensive interest among biomedical scientists, as these two factors may have significant influence on the outcomes of infections. The aim of the present study was to establish a possible relationship between biofilm-forming capacity and the antibiotic-resistant phenotype in clinical () isolates. A total of n = 309 isolates were included in this study. Read More

View Article and Full-Text PDF
November 2021