217,605 results match your criteria antibiotic resistance

Diversity, abundance and expression of the antibiotic resistance genes in a Chinese landfill: Effect of deposit age.

J Hazard Mater 2021 May 5;417:126027. Epub 2021 May 5.

Jiangsu Key Laboratory of Chemical Pollution Control and Resources Reuse, School of Environmental and Biological Engineering, Nanjing University of Science and Technology, Nanjing 210094, China. Electronic address:

Landfills are the hotspots for the occurrence of antibiotic resistance genes (ARGs) in the environment. However, limited information is available on the profile of ARGs in response to the varying age of refuse in landfills. In this study, the diversity, abundance and expression of ARGs in a Chinese landfill were assessed by high-throughput quantitative PCR. Read More

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Research Note: Characterization of antibiotic resistant phenotypes and linked genes of Escherichia coli and Klebsiella pneumoniae from healthy broiler chickens, Karnataka, India.

Poult Sci 2021 Mar 22;100(6):101094. Epub 2021 Mar 22.

Animal Disease Diagnostic Laboratory, Government Veterinary Hospital, Jail Road, Karangalpady, Mangalore, 575002, Karnataka, India.

The study was carried out to estimate the burden and pattern of antibiotic resistance and to identify antibiotic resistance genes with focus on ESBL producers, plasmid mediated quinolone resistance, and tetracycline efflux genes, in faecal bacterial isolates collected from poultry farms of coastal Southern Karnataka, India. High resistance to fluoroquinolones was observed with 94% Escherichia coli and 80% Klebsiella pneumoniae being resistant to both ciprofloxacin and levofloxacin. All the Escherichia coli strains were resistant to tetracycline (100%). Read More

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Co-occurrence of crAssphage and antibiotic resistance genes in agricultural soils of the Yangtze River Delta, China.

Environ Int 2021 May 11;156:106620. Epub 2021 May 11.

College of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310058, China; Zhejiang Provincial Key Laboratory of Organic Pollution Process and Control, Hangzhou 310058, China. Electronic address:

Agricultural soil is highly susceptible to manure contamination and thus is a potential source for the spread of pathogens and antibiotic resistance genes (ARGs). Routine monitoring fecal contamination in agricultural soil can reduce the manure-derived ARG contaminations. This study investigated the distribution of crAssphage, a highly human-specific indicator of fecal pollution, in agricultural soils in the Yangtze River Delta (YRD) of China, and its potential in serving as an indicator of soil ARGs. Read More

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Resistance elicited by sub-lethal concentrations of ampicillin is partially mediated by quorum sensing in Pseudomonas aeruginosa.

Environ Int 2021 May 11;156:106619. Epub 2021 May 11.

School of Environmental Science and Engineering, Zhejiang Gongshang University, Hangzhou 310012, China; Zhejiang Provincial Key Laboratory of Solid Waste Treatment and Recycling, Hangzhou 310012, China. Electronic address:

The rapid increase of antibiotic resistance is a serious challenge around the world. Antibiotics are present in various environments at sub-lethal concentrations, but how resistance emerges under sub-lethal conditions is not fully clear. In this study, we evolved Pseudomonas aeruginosa PAO1 under sub-lethal conditions, in the presence of either 15-30 μg/mL or 150-300 μg/mL of ampicillin. Read More

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Embelin-loaded chitosan gold nanoparticles interact synergistically with ciprofloxacin by inhibiting efflux pumps in multidrug-resistant Pseudomonas aeruginosa and Escherichia coli.

Environ Res 2021 May 11:111321. Epub 2021 May 11.

Department of Biotechnology, Modern College of Arts, Science and Commerce (Savitribai Phule Pune University), Ganeshkhind, Pune, 411016, India; Department of Environmental Science, Savitribai Phule Pune University, Pune, 411007, India. Electronic address:

A global upsurge in emergence and spread of antibiotic resistance (ABR) in bacterial populations is a serious threat for human health. Unfortunately, ABR is no longer confined to nosocomial environments and is frequently reported from community microbes as well. The ABR is resulting in shrinking potent antibiotics pool and thus necessitating novel and alternative therapies and therapeutics. Read More

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Trends of community-based systemic antibiotic consumption: Comparative analyses of data from Ethiopia and Norway calls for public health policy actions.

PLoS One 2021 14;16(5):e0251400. Epub 2021 May 14.

Department of Pharmaceutical Analysis and Regulatory Affairs, Jimma University, Jimma, Oromia, Ethiopia.

Studies on antibiotic utilization trends are invaluable because they offer data for evaluation of impacts of antimicrobial stewardship policies. Such studies help determine correlations between the use of specific antibiotic classes and trends in emergence of resistance (resistance-epidemiology). This study aims to quantify the consumption systemic antibiotics (J01)-in defined daily doses (DDD) per 1000 inhabitants per day (DID)-in Ethiopia's public healthcare sector (2016-2020). Read More

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Regulation of gene expression by non-phosphorylated response regulators.

Int Microbiol 2021 May 13. Epub 2021 May 13.

Laboratory of Microbial Pathogenesis, Navarrabiomed-Universidad Pública de Navarra (UPNA)-Complejo Hospitalario de Navarra (CHN), IdiSNA, Irunlarrea 3, 31008, Pamplona, Navarra, Spain.

Two-component systems (TCSs) are a prominent sensory system in bacteria. A prototypical TCS comprises a membrane-bound sensor histidine kinase (HK) responsible for sensing the signal and a cytoplasmic response regulator (RR) that controls target gene expression. Signal binding activates a phosphotransfer cascade from the HK to the RR. Read More

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High Prevalence of in Smoked Duck: Antibiotic and Heat Resistance, Virulence, and Genetics of the Isolates.

Food Sci Anim Resour 2021 Mar 1;41(2):324-334. Epub 2021 Mar 1.

Department of Food and Nutrition, Sookmyung Women's University, Seoul 04310, Korea.

This study aimed at determining the genetic and virulence characteristics of the from smoked ducks. was isolated by plating, and the isolated colonies were identified by PCR. All the obtained seven isolates possessed the virulence genes (A, B, B, and A) and a 385 bp A amplicon. Read More

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Biosynthesis of silver nano-drug using and its synergistic antibacterial activity against multidrug-resistant bacteria for wound dressing applications.

3 Biotech 2021 Jun 8;11(6):255. Epub 2021 May 8.

Department of Biotechnology, College of Science, Taif University, P.O. Box 11099, Taif, 21944 Saudi Arabia.

We report here the synthesis of silver nanoparticles (AgNPs) from an aqueous extract of and their use as an antimicrobial agent on their own or in combination with antibiotics in inhibiting multidrug-resistant bacteria (MDR). One strategy of bacterial infection control in wound healing is AgNP biosynthesis. We collected bacterial strains of patient skin infections from Al-Adwani Hospital. Read More

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Vancomycin-Resistant Staphylococcus Aureus Infection Post-Liposuction in South Korea.

Cureus 2021 Apr 7;13(4):e14357. Epub 2021 Apr 7.

Department of Surgery, Metropolitan Medical Centre Hospital, Jakarta, IDN.

As antibiotic resistance becomes a serious health issue, medical tourism is an accelerating factor. Several studies report antibiotic-resistant cases in Southeast Asia are increasing every year. We report the first case of a vancomycin-resistant (VRSA) infection in an Indonesian post-liposuction in South Korea. Read More

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Corrigendum: Genome-Wide Association Studies for the Detection of Genetic Variants Associated With Daptomycin and Ceftaroline Resistance in .

Front Microbiol 2021 27;12:686197. Epub 2021 Apr 27.

Department of Infectious Diseases, Robert Koch-Institute, Wernigerode, Germany.

[This corrects the article DOI: 10.3389/fmicb.2021. Read More

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Metagenomic analysis reveals oropharyngeal microbiota alterations in patients with COVID-19.

Signal Transduct Target Ther 2021 May 13;6(1):191. Epub 2021 May 13.

School of Life Science and Technology, Harbin Institute of Technology, Harbin, China.

COVID-19 remains a serious emerging global health problem, and little is known about the role of oropharynx commensal microbes in infection susceptibility and severity. Here, we present the oropharyngeal microbiota characteristics identified by shotgun metagenomic sequencing analyses of oropharynx swab specimens from 31 COVID-19 patients, 29 influenza B patients, and 28 healthy controls. Our results revealed a distinct oropharyngeal microbiota composition in the COVID-19 patients, characterized by enrichment of opportunistic pathogens such as Veillonella and Megasphaera and depletion of Pseudopropionibacterium, Rothia, and Streptococcus. Read More

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Transcriptome RNA Sequencing Data Set of Differential Gene Expression in Escherichia coli BW25113 Wild-Type and Mutant Strains.

Microbiol Resour Announc 2021 May 13;10(19). Epub 2021 May 13.

Department of Biological Sciences, Louisiana State University, Baton Rouge, Louisiana, USA.

laboratory strains remain instrumental for the development of tools and techniques in molecular microbiology. The transcriptional regulator SlyA, associated with host-derived oxidative stress, antibiotic resistance, and virulence, is prominent in Here, we announce a transcriptome data set detailing the global gene expression in BW25113 and its mutant. Read More

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Complete Genome Assembly of Multidrug-Resistant Yersinia enterocolitica Y72, Isolated in Sweden.

Microbiol Resour Announc 2021 May 13;10(19). Epub 2021 May 13.

Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden

Here, we report the complete genome sequence of a Swedish clinical strain of , Y72. With emerging outbreaks circulating in Nordic countries, the Y72 genome will provide more insights on the genetic relatedness and antibiotic resistance dissemination in future studies. Read More

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MC-100093, a novel β-lactam GLT-1 enhancer devoid of antimicrobial properties attenuates cocaine relapse in rats.

J Pharmacol Exp Ther 2021 May 13. Epub 2021 May 13.

School of Pharmacy, Temple University, United States.

Cocaine use disorder (CUD) currently lacks FDA-approved treatments. In rodents, the glutamate transporter-1 (GLT-1) is downregulated in the nucleus accumbens following cocaine self-administration and increasing the expression and function of GLT-1 reduces the reinstatement of cocaine-seeking. The beta-lactam antibiotic ceftriaxone upregulates GLT-1 and attenuates cue- and cocaine-induced cocaine seeking without affecting motivation for natural rewards. Read More

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Removal of antibiotic-resistant genes during drinking water treatment: A review.

J Environ Sci (China) 2021 Jun 30;104:415-429. Epub 2020 Dec 30.

Zhejiang Key Laboratory of Drinking Water Safety and Distribution Technology, Zhejiang University, Hangzhou 310058, China; Ocean College, Zhejiang University, Hangzhou 310058, China. Electronic address:

Once contaminate the drinking water source, antibiotic resistance genes (ARGs) will propagate in drinking water systems and pose a serious risk to human health. Therefore, the drinking water treatment processes (DWTPs) are critical to manage the risks posed by ARGs. This study summarizes the prevalence of ARGs in raw water sources and treated drinking water worldwide. Read More

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Antibiotics florfenicol and flumequine in the water column and sediments of Puyuhuapi Fjord, Chilean Patagonia.

Chemosphere 2021 Jul 24;275:130029. Epub 2021 Feb 24.

Departamento de Oceanografía and Centro de Investigación Oceanográfica COPAS Sur-Austral (PIA ANID), Universidad de Concepción, Concepción, Chile. Electronic address:

Chile is a major global producer of farmed salmon in the fjords of Patagonia, and therefore a major consumer of antibiotics. We tested whether the antibiotics florfenicol and flumequine persisted in the large Puyuhuapi Fjord after the six months following mandatory concerted treatment by all salmon farms present in the fjord. Antibiotics were detected in 26% of analyzed samples, but only within the particulate phase, with concentrations of florfenicol of up to 23. Read More

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Mechanistic insight of simultaneous removal of tetracycline and its related antibiotic resistance bacteria and genes by ferrate(VI).

Sci Total Environ 2021 May 3;786:147492. Epub 2021 May 3.

College of the Environment and Ecology, Xiamen University, Xiamen 361102, China. Electronic address:

The emergence of antibiotics and their corresponding antibiotic resistant bacteria (ARB) and antibiotic resistance genes (ARGs) have posed great challenges to the public health. The paper demonstrates the removal of co-existing tetracycline (TC), its resistant Escherichia coli (E. coli), and ARGs (tetA and tetR) in a mixed system by applying ferrate(VI) (FeO, Fe(VI)) at pH 7. Read More

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Prescription pattern of antimicrobial use in small animal veterinary practice in Cameroon.

Top Companion Anim Med 2021 May 10:100540. Epub 2021 May 10.

College of Technology, University of Bamenda, Bambili, Cameroon. Electronic address:

Retrospective data on antimicrobial use (AMU) within the period ranging from January 2012 to December 2015 was collected to assess the antimicrobial prescription patterns in pets (cats and dogs) treated by 16 veterinary private practitioners in the two main urban cities of Cameroon (Douala and Yaounde). The vet practitioners were interviewed in order to analyze prescribing behavior and factors influencing antimicrobial prescription. Out of a total of 3928 antimicrobial prescriptions, 3673(93. Read More

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In vivo fitness of carbapenem-resistant Acinetobacter baumannii (CRAB) strains in murine infection is associated with treatment failure in human infections.

Clin Microbiol Infect 2021 May 10. Epub 2021 May 10.

Division of Epidemiology and Preventive Medicine, Tel Aviv Sourasky Medical Center, National Institute for Antibiotic Resistance and Infection Control, Israel Ministry of Health, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Objectives: Mortality among patients with carbapenem-resistant Acinetobacter baumannii (CRAB) infections varies between studies. We examined whether in vivo fitness of CRAB strains is associated with clinical outcomes in patients with CRAB infections.

Methods: Isolates were collected from patients enrolled in the AIDA trial with hospital-acquired pneumonia, bloodstream infections, and/or urinary tract infections caused by CRAB. Read More

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Assessment of antibacterial and antifungal potential of Curcuma longa and synthesized nanoparticles: A comparative study.

J Basic Microbiol 2021 May 13. Epub 2021 May 13.

Department of Bioinformatics and Biotechnology, International Islamic University, Islamabad, Pakistan.

Curcumin nanoparticles were most recently considered in medical research because of their antibacterial properties. The main objective of the study was to develop the green synthesis and antibacterial activity of curcumin nanoparticles using Curcuma longa. The processing of curcumin nanoparticles was carried out after the collection, identification, and extraction of curcumin. Read More

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Melittin as a promising anti-protozoan peptide: current knowledge and future prospects.

AMB Express 2021 May 13;11(1):69. Epub 2021 May 13.

Skin Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Protozoan diseases such as malaria, leishmaniasis, Chagas disease, and sleeping sickness still levy a heavy toll on human lives. Deplorably, only few classes of anti-protozoan drugs have thus far been developed. The problem is further compounded by their intrinsic toxicity, emergence of drug resistance, and the lack of licensed vaccines. Read More

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CORR Insights®: Tolerant Small-colony Variants Form Prior to Resistance Within a Staphylococcus aureus Biofilm Based on Antibiotic Selective Pressure.

Clin Orthop Relat Res 2021 May 10. Epub 2021 May 10.

D. Schlatterer, Vice Chair, Department of Orthopedic Surgery, Atlanta Medical Center, Atlanta, GA, USA.

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Can growth be modulated by natural compounds?

J Biol Regul Homeost Agents 2021 Jan-Feb;35(1 Suppl. 2):21-25

UOC di Otorinolaringoiatria, Dipartimento Scienze dell'Invecchiamento,Neurologiche, Ortopediche e della testa collo. Fondazione Policlinico Universitario A. Gemelli IRCCS, Roma, Italy.

is an opportunistic human pathogen that frequently induces antibiotic resistance, as it mainly tends to form biofilms. Iron chelation may be an intriguing strategy to contrast bacterial growth. Lactoferrin is a natural compound able to chelate iron. Read More

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Antibiotic resistance gene dissipation in soil microcosms amended with antibiotics and swine manure.

J Environ Qual 2021 May 13. Epub 2021 May 13.

Department of Agricultural and Biosystems Engineering, Iowa State University, Elings Hall, 605 Bissell Road, Ames, IA, 50011, USA.

The use of antibiotics in animal agriculture has exacerbated the presence of both antibiotic resistance genes (ARGs) and residual antibiotics excreted in animal manure. Field application of this manure is a common practice as its nutrient rich material can benefit crop growth. However, this practice can also introduce antibiotics and ARGs into non-agricultural settings. Read More

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antimicrobial activity of De Wild and Banks ex C. F. Gaertn on selected foodborne pathogens associated to gastroenteritis.

Heliyon 2021 Apr 19;7(4):e06830. Epub 2021 Apr 19.

Centre for Food and Nutrition Research, Institute of Medical Research and Medicinal Plants Studies, POBOX 13033, Yaoundé Cameroon.

This study aimed at evaluating the antimicrobial potential of aqueous, ethanolic and methanolic extracts of two Cameroonian plants against selected foodborne pathogens. Bioactive compounds were extracted from De Wild seeds and Banks ex. C. Read More

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System Economic Costs of Antibiotic Use Elimination in the US Beef Supply Chain.

Front Vet Sci 2021 26;8:606810. Epub 2021 Apr 26.

Department of Population Medicine and Diagnostic Sciences, Cornell College of Veterinary Medicine, Ithaca, NY, United States.

There is consumer pressure on the US beef cattle industry to minimize antibiotic use (ABU) in order to aid in the global antimicrobial resistance mitigation efforts. Our objective was to estimate the economic costs of ABU constraints in a conceptual US integrated beef supply chain (IBSC) to aid the beef industry in mitigating the ever-increasing risk of antimicrobial resistance, by reducing their ABU. An IBSC network model was developed and differentiated into 37 different nodes of production. Read More

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var. Enteritidis osteomyelitis with pulmonary involvement in an immunocompetent young woman.

IDCases 2021 18;24:e01127. Epub 2021 Apr 18.

Department of Infectious Diseases, Japanese Red Cross Ise Hospital, Ise, 516-8512, Japan.

Primary bacteremia due to non-typhoid often occurs in immunocompromised individuals, but may also occur in immunocompetent individuals. Contrastingly, vertebral osteomyelitis with respiratory involvement caused by non-typhoid in immunocompetent individuals is extremely rare. A 21-year-old healthy woman with histories of eating ready-to-eat roasted beef and a recent vertebral compression fracture developed high-grade fever and was diagnosed with bacteremia, complicated by vertebral osteomyelitis with pulmonary involvement characterized as an extra-intestinal infection. Read More

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The antimicrobial activity of silver acetate against in a infection model.

PeerJ 2021 22;9:e11196. Epub 2021 Apr 22.

School of Science and Technology, Nottingham Trent University, Nottingham, UK.

Background: The increasing prevalence of bacterial infections that are resistant to antibiotic treatment has caused the scientific and medical communities to look for alternate remedies aimed at prevention and treatment. In addition to researching novel antimicrobials, there has also been much interest in revisiting some of the earliest therapies used by man. One such antimicrobial is silver; its use stretches back to the ancient Greeks but interest in its medicinal properties has increased in recent years due to the rise in antibiotic resistance. Read More

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Patient perception about the need for antibiotics after tooth extractions: A cross-sectional study.

J Clin Exp Dent 2021 May 1;13(5):e499-e504. Epub 2021 May 1.

DDS, MS, PhD, EBOS. Professor of Oral Surgery and Director of the Master degree program in Oral Surgery and Implantology, School of Medicine and Health Sciences, University of Barcelona. Researcher at the IDIBELL Institute. Barcelona, Spain.

Background: Although the current scientific literature does not support the routine use of antibiotics after dental extractions, patients believe that these drugs offer clear benefit during the postoperative period. The main objective of this study was to describe patient perception of the need for antibiotics after routine tooth extraction and to assess knowledge about the benefits and adverse effects of antibiotic therapy.

Material And Methods: A cross-sectional study was carried out. Read More

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