780,467 results match your criteria antibacterial agents

Novel DyO/ZnO-Au ternary nanocomposites: Green synthesis using pomegranate fruit extract, characterization and their photocatalytic and antibacterial properties.

Bioorg Chem 2021 Jul 23;115:105204. Epub 2021 Jul 23.

Department of Chemistry, Mahabad Branch, Islamic Azad University, Mahabad, Iran. Electronic address:

In this study for the first time, high efficient, eco-friendly and novel DyO/ZnO-Au ternary nanocomposites (Dy/ZnO-AuNCs) were prepared in presence of pomegranate fruit (PF) extract as capping and reducing agents (Dy/[email protected]). The influence of various parameters such as basic agents, reducing agents, sonication power, and sonication time were performed to reach the optimum condition. The formation of the products was characterized by FT-IR, HRTEM, XRD, FE-SEM, TEM, EDX and DRS techniques. Read More

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Recombinant production of Trx-Ib-AMP4 and Trx-E50-52 antimicrobial peptides and antimicrobial synergistic assessment on the treatment of methicillin-resistant Staphylococcus aureus under in vitro and in vivo situations.

Protein Expr Purif 2021 Jul 26:105949. Epub 2021 Jul 26.

Molecular and Medicine Research Center, Arak University of Medical Sciences, Arak, Iran. Electronic address:

Purpose: The production of alternative novel antimicrobial agents is considered an efficient way to cope with multidrug resistance among pathogenic bacteria. E50-52 and Ib-AMP4 antimicrobial peptides (AMPs) have illustrated great proven antibacterial effects. The aim of this study was recombinant production of these AMPs and investigation of their synergistic effects on methicillin-resistant Staphylococcus aureus (MRSA). Read More

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Gingipain-Responsive Thermosensitive Hydrogel Loaded with SDF-1 Facilitates Periodontal Tissue Regeneration.

ACS Appl Mater Interfaces 2021 Jul 29. Epub 2021 Jul 29.

Department of Periodontology, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University & Shandong Key Laboratory of Oral Tissue Regeneration & Shandong Engineering Laboratory for Dental Materials and Oral Tissue Regeneration, Jinan, Shandong 250012, China.

Existing local drug delivery systems for periodontitis suffer from poor antibacterial effect and unsatisfied periodontal regeneration. In this study, a smart gingipain-responsive hydrogel ([email protected]) was synthesized as an environmentally sensitive carrier for on-demand drug delivery. The [email protected] hydrogel was synthesized from polyethylene glycol diacrylate (PEG-DA) based scaffolds, dithiothreitol (DTT), and a novel designed functional peptide module (FPM) via Michael-type addition reaction, and the hydrogel was further loaded with stromal cell derived factor-1 (SDF-1). Read More

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Silver nanoparticles biosynthesized from secondary metabolite producing marine actinobacteria and evaluation of their biomedical potential.

Antonie Van Leeuwenhoek 2021 Jul 29. Epub 2021 Jul 29.

UNESCO UNISA Africa Chair in Nanosciences and Nanotechnology, College of Graduate Studies, University of South Africa, Pretoria, South Africa.

Biosynthesis of silver nanoparticles (AgNPs) from marine actinobacteria offers a promising avenue for exploring bacterial extracts as reducing and stabilizing agents. We report extracellular extracts of Rhodococcus rhodochrous (MOSEL-ME29) and Streptomyces sp. (MOSEL-ME28), identified by 16S rRNA gene sequencing for synthesis of AgNPs. Read More

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An MSN-based synergistic nanoplatform for root canal biofilm eradication Fenton-enhanced sonodynamic therapy.

J Mater Chem B 2021 Jul 29. Epub 2021 Jul 29.

The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) & Key Laboratory for Oral Biomedical Ministry of Education, School & Hospital of Stomatology, Wuhan University, Wuhan, People's Republic of China.

The validity and biocompatibility of irrigating agents are imperative for the success of root canal therapy. The imperfections in the currently available irrigants highlight the fact that more advanced technologies and strategies are required for complete disinfection in endodontic treatments. In the present study, a Fenton reaction-enhanced antimicrobial sonodynamic therapy (SDT) platform was fabricated for root canal disinfection. Read More

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Antimicrobial Properties of Food Nanopackaging: A New Focus on Foodborne Pathogens.

Front Microbiol 2021 12;12:690706. Epub 2021 Jul 12.

Department of Food Hygiene, Science and Research Branch, Islamic Azad University, Tehran, Iran.

Food products contaminated by foodborne pathogens (bacteria, parasites, and viruses) cause foodborne diseases. Today, great efforts are being allocated to the development of novel and effective agents against food pathogenic microorganisms. These efforts even might have a possible future effect in coronavirus disease 2019 (COVID-19) pandemic. Read More

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Facile Synthesis of Metal Nanoparticle-Loaded Polymer Nanocomposite with Highly Efficient an Optically Enhanced Biocidal and Anticancer agents.

J Biomater Sci Polym Ed 2021 Jul 28:1-15. Epub 2021 Jul 28.

School of Chemical Engineering, Yeungnam University, Gyeongsan, Gyeongbuk-do 38541, Republic of Korea.

In this work, we prepared silver nanoparticles (AgNPs)-loaded poly(2,5-dimethoxyaniline;PDMA) nanocomposite via a simple chemical oxidative method to develop new effective biocidal and anticancer agents systems. In situ UV-vis and fluorescence spectroscopy has been used to monitor the formation of PDMA/Ag is strongly dependent on the concentration of PDMA in the present system. The FTIR and XRD studies exhibit that the rate of polymer formation and oxidation state of PDMA/Ag nanocomposite, which confirmed the AgNPs is strongly binding with the PDMA matrix. Read More

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Anti-biofilm potential of preparations against .

Appl Environ Microbiol 2021 Jul 28:AEM0109921. Epub 2021 Jul 28.

Biotechnical Faculty, Department of Food Science, University of Ljubljana, 1000 Ljubljana, Slovenia.

New approaches for the control of biofilms in the food industry are being studied intensively. Natural products are promising alternative antimicrobial substances to control biofilm production, with particular emphasis on plant extracts. Dried flowers of were used to produce LEO, LEF, and LEW. Read More

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Functionalized Masks: Powerful Materials against COVID-19 and Future Pandemics.

Small 2021 Jul 28:e2102453. Epub 2021 Jul 28.

Department of Chemical Engineering, University of New Brunswick, Fredericton, New Brunswick, E3B 5A3, Canada.

The outbreak of COVID-19 revealed the vulnerability of commercially available face masks. Without having antibacterial/antiviral activities, the current masks act only as filtering materials of the aerosols containing microorganisms. Meanwhile, in surgical masks, the viral and bacterial filtration highly depends on the electrostatic charges of masks. Read More

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Low-temperature flow-synthesis-assisted urethane-grafted zinc oxide-based dental composites: physical, mechanical, and antibacterial responses.

J Mater Sci Mater Med 2021 Jul 28;32(8):87. Epub 2021 Jul 28.

Department of Dental Materials, Army Medical College, National University of Medical Sciences, Rawalpindi, 46000, Pakistan.

A novel way was adopted to graft zinc oxide (ZnO) with urethane-modified dimethacrylate (UDMA) in order to utilize them as reinforcing agents in resin-based dental composites. Experimental novel composites were synthesized having UDMA-grafted and nongrafted ZnO, at a concentration of 0 wt.%, 5 wt. Read More

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Fatty acid modified-antimicrobial peptide analogues with potent antimicrobial activity and topical therapeutic efficacy against Staphylococcus hyicus.

Appl Microbiol Biotechnol 2021 Jul 28. Epub 2021 Jul 28.

Gene Engineering Laboratory, Feed Research Institute, Chinese Academy of Agricultural Sciences, 12 Zhongguancun Nandajie St., Haidian District, Beijing, 100081, People's Republic of China.

There is an urgent need to explore new antimicrobial agents due to the looming threat of bacteria resistance. Bovine lactoferricin (LfcinB), as a multifunctional peptide, has the potential to be a new active drug in the future. In this study, it aims to investigate the effect of fatty acid conjugation on antimicrobial peptide activity and topical therapeutic efficacy in a mouse model infected with Staphylococcus hyicus. Read More

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Synergistic antibacterial activity of an active compound derived from against methicillin-resistant and its clinical isolates.

J Microbiol Biotechnol 2021 Jul 21;31(9):1-8. Epub 2021 Jul 21.

Department of Food Science and Technology, Pukyong National University, Busan 48513, Republic of Korea.

There are a growing number of reports of hospital-acquired infections caused by pathogenic bacteria, especially methicillin-resistant (MRSA). Many plant products have recently been used as a natural means of exploring antimicrobial agents against different types of human pathogenic bacteria. The aim of this research was to isolate and identify an active molecule from that has possible antibacterial activity against various clinical isolates of MRSA. Read More

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Design, Synthesis, Antibacterial Activity, and Mechanisms of Novel 1,3,4-Thiadiazole Derivatives Containing an Amide Moiety.

J Agric Food Chem 2021 Jul 28. Epub 2021 Jul 28.

State Key Laboratory Breeding Base of Green Pesticide and Agricultural Bioengineering, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Guizhou University, Guiyang 550025, P.R. China.

To discover novel antibacterial agents, a series of novel 1,3,4-thiadiazole derivatives containing an amide moiety were designed and synthesized, and their antibacterial activities were tested. Compound was designed and synthesized according to the CoMFA model. Compound exhibited higher antibacterial activities against pv. Read More

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An Overview of Recent Advances in Biomedical Applications of Click Chemistry.

Bioconjug Chem 2021 Jul 28. Epub 2021 Jul 28.

Amity Institute of Virology and Immunology, Amity University, Noida 201313, Uttar Pradesh, India.

Cu(I)-catalyzed azide-alkyne cycloaddition (CuAAC) is a modular and bio-orthogonal approach that is being adopted for the efficient synthesis of organic and bioorganic compounds. It leads to the selective formation of 1,4-disubstituted 1,2,3-triazole units connecting readily accessible building blocks via a stable and biocompatible linkage. The vast array of the bioconjugation applications of click chemistry has been attributed to its fast reaction kinetics, quantitative yields, minimal byproducts, and high chemospecificity and regioselectivity. Read More

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[Efficacy analysis of antibiotic bone cement in treating infectious wound of lower extremity].

Zhongguo Gu Shang 2021 Jul;34(7):670-3

Xiasha Campus, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310018, Zhejiang, China.

Objective: To discuss the clinical effect of antibiotic bone cement in the treatment of infectious wound of lower extremity.

Methods: From January 2016 to January 2019, 28 patients who had infection wounds of lower extremity were treated by antibiotic bone cement, including 21 males and 7 females with age of 34 to 76 (53.8±16. Read More

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Sensitivity of cultures of different biological origin to commercial bacteriophages and phages of var.

Vet World 2021 Jun 19;14(6):1588-1593. Epub 2021 Jun 19.

Research Station of the Institute of Veterinary Medicine of NAAS, Ternopil, Ukraine.

Background And Aim: Mastitis, an inflammation of the mammary gland, is an ongoing problem in dairy herds. In this study, we determined the sensitivity of cultures of different biological origins to commercial bacteriophages and phages of var which were isolated on dairy farms, to create a drug for the treatment of mastitis in cows.

Materials And Methods: We used cultures of isolated from different habitats, and other types of staphylococci isolated on dairy farms. Read More

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Synergistic broad-spectrum antibacterial activity of Hypoxis hemerocallidea-derived silver nanoparticles and streptomycin against respiratory pathobionts.

Sci Rep 2021 Jul 27;11(1):15222. Epub 2021 Jul 27.

Department of Chemistry and Biochemistry, University of Windsor, 401 Sunset Avenue, Windsor, ON, N9B 3P4, Canada.

Respiratory tract infections arise due to the introduction of microbes into the airway, disrupting the normal, healthy, complex interdependent microbiome. The selective disruption of this community can be either beneficial or dangerous. Nanoparticles are a potential tool for modifying this population. Read More

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Discovery and development of macrolides as anticancer agents.

Curr Top Med Chem 2021 Jul 27. Epub 2021 Jul 27.

Department of Emergency, Zhuji People's Hospital of Zhejiang Province, Zhuji, China.

Cancer is a life-threatening destructive disease. In the past several decades, the incidence of cancer has been dramatically increased mostly due to lifestyle changes. Chemotherapy plays an important role in the treatment of cancer, but the development of resistance against chemotherapeutic agents, the side effects, and non-specific toxicity threatens the efficiency of anticancer agents. Read More

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Design, synthesis, molecular docking and in silico ADMET profile of pyrano[2,3-d]pyrimidine derivatives as antimicrobial and anticancer agents.

Bioorg Chem 2021 Jul 22;115:105186. Epub 2021 Jul 22.

Department of Biochemistry, Faculty of Science, Ain Shams University, Abbassia, Cairo, Egypt.

Pyrano[2,3-d]pyrimidine derivatives were synthesized by treating cyclic compounds containing active methylene group with aldehyde and malononitrile in butanol. The behavior of pyrano[2,3-d]pyrimidine towards some electrophlies namely triethylorthoformate followed by nitrogen nucleophiles as isobutylamine, urea, phenylthiourea, p-toluidine, o-phenylenediamine, o-aminophenol, 2-amino-4-methyl-pyridine and acetic acid with the aim of obtaining some interesting non-mixed heterocyclic compounds. All synthesized compounds to some extent have shown good antimicrobial activity against different microbial strains that had been extracted by inhibiting cell wall synthesis. Read More

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Application of Dimethyl Sulfoxide as a Therapeutic Agent and Drug Vehicle for Eye Diseases.

J Ocul Pharmacol Ther 2021 Jul 26. Epub 2021 Jul 26.

Department of Oncology, National Children Hospital, Hanoi, Vietnam.

Dimethyl sulfoxide (DMSO) is an amphipathic molecule widely used as a solvent for water-insoluble substances, cryopreserving, and cell-biological therapies. It has known properties as an inducer of cellular differentiation, a free radical scavenger, and a radioprotectant. In addition, DMSO is used for its various therapeutic and pharmaceutical properties, such as anti-inflammatory, local and systemic analgesic, antibacterial, antifungal, antiviral, and membrane penetration enhancement agents. Read More

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Epidemiology and Risk Factors for Healthcare-Associated Viral Infections in Children.

J Pediatric Infect Dis Soc 2021 Jul 27. Epub 2021 Jul 27.

Pediatric Infectious Diseases Epidemiology and Antimicrobial Stewardship (IDEAS) Research Program, Division of Infectious Diseases, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.

Background: Healthcare-associated viral infections (HA-VIs) are common in hospitalized children and are increasingly recognized as a cause of preventable harm; however, the epidemiology and modifiable risk factors for pediatric HA-VIs are poorly understood.

Methods: We performed a retrospective case-control study to identify risk factors and outcomes associated with pediatric HA-VIs at a quaternary care children's hospital. HA-VI surveillance was performed hospital-wide using Centers for Disease Control and Prevention (CDC) definitions. Read More

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Bevacizumab-associated implant presence-triggered osteonecrosis: A case report and literature review.

J Oral Implantol 2021 Jul 26. Epub 2021 Jul 26.

Department of Oral and Maxillofacial Surgery, Nara Medical University, 840 Shijo-cho, Kashihara, Nara 634-8522, Japan.

The effect of bevacizumab-related osteonecrosis of the jaw on previously osseointegrated dental implants has not been adequately studied. Here, we report a case of osteonecrosis of the jaw detected around dental implants placed prior to bevacizumab therapy. A 66-year-old woman undergoing bevacizumab therapy for metastatic triple-negative breast cancer, developed malocclusion following buccal gingival swelling and pain in the #18, #19, and #20 tooth region. Read More

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Recent developments of metal-based compounds against fungal pathogens.

Chem Soc Rev 2021 Jul 27. Epub 2021 Jul 27.

Chimie ParisTech, PSL University, CNRS, Institute of Chemistry for Life and Health Sciences, Laboratory for Inorganic Chemical Biology, 75005 Paris, France.

This review provides insight into the rapidly expanding field of metal-based antifungal agents. In recent decades, the antibacterial resistance crisis has caused reflection on many aspects of public health where weaknesses in our medicinal arsenal may potentially be present - including in the treatment of fungal infections, particularly in the immunocompromised and those with underlying health conditions where mortality rates can exceed 50%. Combination of organic moieties with known antifungal properties and metal ions can lead to increased bioavailability, uptake and efficacy. Read More

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Degradation of micropollutant cephalexin by ultraviolet (UV) and assessment of residual antimicrobial activity of transformation products.

Water Sci Technol 2021 Jul;84(2):374-383

Programa de Pós-Graduação em Biotecnologia - Univates, Avenida Avelino Talini, 171, Lajeado, Rio Grande do Sul, ZIP CODE: 95914-014, Brazil.

Cephalexin (CEX) is an antibiotic commonly used to treat bacterial infections in humans and animals. However, it is also a micropollutant. Thus, this study evaluated the degradation of CEX using ultraviolet irradiation (UV-C) and analyzed the by-products as well as their residual antimicrobial activity. Read More

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Sieve-like preretinal exudates in endogenous endophthalmitis.

BMJ Case Rep 2021 Jul 26;14(7). Epub 2021 Jul 26.

Vitreo-retina, LV Prasad Eye Institute Bhubaneswar Campus, Bhubaneswar, India

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Rapid onset vancomycin-induced thrombocytopenia confirmed by vancomycin antibody test.

BMJ Case Rep 2021 Jul 26;14(7). Epub 2021 Jul 26.

College of Pharmacy, University of Florida, Gainesville, Florida, USA

We report a case of vancomycin-induced thrombocytopenia (VIT) with rapid onset after re-exposure to vancomycin. A 58-year-old man with cellulitis was initiated on vancomycin. Approximately 1 hour into the vancomycin infusion, the patient developed an infusion-related reaction. Read More

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Asymptomatic But Altered? When Urinalysis Holds the Key.

Sr Care Pharm 2021 Aug;36(8):381-386

Altered mental status (AMS) is a common symptom in geriatric patients, especially in the long-term care setting. Traditionally, AMS has been associated with urinary tract infections (UTIs) in older people. However, data correlating UTIs with AMS are lacking. Read More

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Biofilm associated genotypes of multiple antibiotic resistant Pseudomonas aeruginosa.

BMC Genomics 2021 Jul 26;22(1):572. Epub 2021 Jul 26.

Faculty of Science and Engineering, Manchester Metropolitan University, Chester Street, Manchester, United Kingdom.

Background: Pseudomonas aeruginosa is a ubiquitous environmental microorganism and also a common cause of infection. Its ability to survive in many different environments and persistently colonize humans is linked to its presence in biofilms formed on indwelling device surfaces. Biofilm promotes adhesion to, and survival on surfaces, protects from desiccation and the actions of antibiotics and disinfectants. Read More

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Determination of nasal carriage and skin colonization, antimicrobial susceptibility and genetic relatedness of Staphylococcus aureus isolated from patients with atopic dermatitis in Szczecin, Poland.

BMC Infect Dis 2021 Jul 23;21(1):701. Epub 2021 Jul 23.

Independent Laboratory of Medical Microbiology, Pomeranian Medical University, al. Powstańców Wielkopolskich 72, 70-111, Szczecin, Poland.

Background: Atopic dermatitis (AD) is one of the most frequent chronic and inflammatory skin condition. AD is characterized by damaged epidermal barrier, xerosis and pruritus of eczematous skin lesions which tend to flare. The duration and frequency of exacerbation of AD symptoms markedly affects the quality of patient life. Read More

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Vanillic acid combats Vibrio alginolyticus by cell membrane damage and biofilm reduction.

J Fish Dis 2021 Jul 26. Epub 2021 Jul 26.

School of Food and Biological Engineering, Shaanxi University of Science & Technology, Xi'an, China.

Antibiotics are the most powerful weapon against bacterial infectious diseases in aquaculture. However, the indiscriminate usage of antibiotics often culminates in the emerging development of antibiotic-resistant bacteria, making it imperative to search for novel types of antimicrobial agents. This study investigated the antibacterial and antivirulence effects of vanillic acid (VA) against the fish pathogen, Vibrio alginolyticus. Read More

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