Arch Microbiol 2021 May 3. Epub 2021 May 3.
Departamento de Química Biológica, Laboratório de Farmacologia E Química Molecular - LFQM, Universidade Regional Do Cariri-URCA, Rua Cel. Antônio Luís 1161, Pimenta, Crato, CE, 63105-000, Brazil.
The antibacterial activity of the monoterpene estragole was evaluated against two strains of bacteria with an efflux pump mechanism, which are Staphylococcus aureus 1199B and S. aureus K2068, which have a NorA and MepA pump, respectively. For that, the methodology proposed by CLSI with modifications was followed, and to evaluate the reversal of the efflux pump, subinhibitory concentrations (MIC/8) of estragole and standard pump inhibitors, CCCP and Chlorpromazine were used and it was verified whether they managed to modulate the action of Norfloxacin, Ciprofloxacin and Ethidium Bromide, an indicator of an efflux pump. Read More