139,416 results match your criteria antibacterial activity

Formulation, physicochemical characterization, and anti- E. coli activity of food-grade nanoemulsions incorporating clove, cinnamon, and lavender essential oils.

Food Chem 2021 Apr 27;359:129963. Epub 2021 Apr 27.

Laboratory of Aromatic and Medicinal Plants, Biotechnology Center of Borj-Cédria, BP 901, 2050 Hammam-lif, Tunisia.

This research studies the application of a specific nanoemulsion as anti-Escherichia coli agent. The specific mixture was generated by a simplex-centroid design. Physicochemical parameters such as droplet average diameter, pH, viscosity, density, turbidity, whitening index, refractive index, stability (thermal, physical, and osmotic stability), and antibacterial activity kinetic, have been assessed. Read More

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Complex formation of an estrone-salicylaldehyde semicarbazone hybrid with copper(II) and gallium(III): Solution equilibria and biological activity.

J Inorg Biochem 2021 Apr 24;220:111468. Epub 2021 Apr 24.

Department of Inorganic and Analytical Chemistry, Interdisciplinary Excellence Centre, University of Szeged, Dóm tér 7, H-6720 Szeged, Hungary; MTA-SZTE Lendület Functional Metal Complexes Research Group, University of Szeged, Dóm tér 7, H-6720 Szeged, Hungary.

The solution chemical properties such as proton dissociation, complex formation with copper(II) and gallium(III) ions in addition to antibacterial and antitumor activity of a novel tridentate salicyaldehyde semicarbazone-estrone hybrid (estrone-SC) and a related bicyclic compound (thn-SC) were investigated. The crystal structure of complex [Cu(thn-SCH)Cl] was studied by single crystal X-ray diffraction method. Estrone-SC and thn-SC form mono-ligand complexes with Cu(II) characterized by relatively high stability, however, they are much less stable than their thiosemicarbazone analogues. Read More

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Study of the ultrastructure of Enterococcus faecalis and Streptococcus mutans incubated with salivary antimicrobial peptides.

Clin Exp Dent Res 2021 May 5. Epub 2021 May 5.

Departamento de Microbiología y Parasitología, Facultad de Medicina, Col. Universidad Nacional Autónoma de México, Mexico City, Mexico.

Objectives: Enterococcus faecalis has been associated with root canal infections, while Streptococcus mutans has a central role in the etiology of dental caries. One of the main reasons of endodontic failure has been associated to the presence of E. faecalis and the formation of biofilms. Read More

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Characterization of a lytic EBP bacteriophage with large size genome against Enterobacter cloacae.

APMIS 2021 May 5. Epub 2021 May 5.

Department of Microbiology and Molecular Genetics, University of the Punjab, Lahore, Pakistan.

Enterobacter cloacae (E. cloacae) is an emerging nosocomial pathogen that had acquired antibiotic resistance against multiple classes of antibiotics. The current study was aimed to isolate and characterize lytic bacteriophage against E. Read More

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Physicochemical properties and biological effects of quaternary ammonium methacrylates in an experimental adhesive resin for bonding orthodontic brackets.

J Appl Oral Sci 2021 3;29:e20201031. Epub 2021 May 3.

Universidade Federal do Rio Grande, Pós-Graduação em Odontologia da do Sul, Porto Alegre, RS, Brasil.

Methodology: Fixed orthodontic appliances may lead to biofilm accumulation around them that may increase caries risk. This study aimed to evaluate the influence of quaternary ammonium methacrylates (QAMs) on the physicochemical properties, cytotoxicity, and antibacterial activity of adhesive resins for orthodontic purposes. A base resin was prepared with a comonomer blend and photoinitiator/co-initiator system. Read More

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Crystal structures of UDP-N-acetylmuramic acid L-alanine ligase (MurC) from Mycobacterium bovis with and without UDP-N-acetylglucosamine.

Acta Crystallogr D Struct Biol 2021 May 14;77(Pt 5):618-627. Epub 2021 Apr 14.

Department of Chemistry, Chonnam National University, Gwangju 61186, Republic of Korea.

Peptidoglycan comprises repeating units of N-acetylmuramic acid, N-acetylglucosamine and short cross-linking peptides. After the conversion of UDP-N-acetylglucosamine (UNAG) to UDP-N-acetylmuramic acid (UNAM) by the MurA and MurB enzymes, an amino acid is added to UNAM by UDP-N-acetylmuramic acid L-alanine ligase (MurC). As peptidoglycan is an essential component of the bacterial cell wall, the enzymes involved in its biosynthesis represent promising targets for the development of novel antibacterial drugs. Read More

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Bactericidal urea crown ethers target phosphatidylethanolamine membrane lipids.

Org Biomol Chem 2021 May;19(17):3838-3843

Department of Chemistry, Tulane University, New Orleans, Louisiana 70118, USA.

An increasing number of people are infected with antibiotic-resistant bacteria each year, sometimes with fatal consequences. In this manuscript, we report a novel urea-functionalized crown ether that can bind to the bacterial lipid phosphatidylethanolamine (PE), facilitate PE flip-flop and displays antibacterial activity against the Gram-positive bacterium Bacillus cereus with a minimum inhibitory concentration comparable to that of the known PE-targeting lantibiotic duramycin. Read More

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Gelatinase-responsive release of an antibacterial photodynamic peptide against .

Biomater Sci 2021 May;9(9):3433-3444

Department of Chemistry, the Chinese University of Hong Kong, Shatin, Hong Kong SAR, China.

Staphylococcus aureus (S. aureus) related staphylococcal infection is one of the most common types of hospital-acquired infections, which requires selective and effective treatment in clinical practice. Considering gelatinase as a characteristic feature of S. Read More

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antimicrobial activity of selected essential oils against bacteria and yeasts isolated from the genital tract of mares.

Nat Prod Res 2021 May 5:1-6. Epub 2021 May 5.

Department of Veterinary Science, University of Pisa, Pisa, Italy.

The aim of the present study, the first to test clinical equine isolates, was to evaluate the antimicrobial activity of commercial essential oils (EOs) obtained from and against spp., spp., and spp. Read More

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Multifunctional graphene-based nanocomposites for simultaneous enhanced photocatalytic degradation and photothermal antibacterial activity by visible light.

Environ Sci Pollut Res Int 2021 May 4. Epub 2021 May 4.

College of International Education, Zhongyuan University of Technology, Zhengzhou, 450007, People's Republic of China.

A new strategy for the wastewater treatment was proposed by combining polyvinylpyrrolidone-functionalized silver nanoparticles with reduced graphene oxide (AgNPs-PVP@rGO) as a visible light-triggered photoactive nanocomposite. The nanocomposite with enhanced photocatalytic degradation and photothermal antibacterial activity can simultaneously decrease the content of organic pollutants and bacteria in the wastewater under visible light irradiation. The efficiency of photocatalytic degradation can be significantly improved by the conjugation of AgNPs onto the rGO surface. Read More

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Chemical approaches in the development of natural nontoxic peptide Polybia-MP1 as a potential dual antimicrobial and antitumor agent.

Amino Acids 2021 May 4. Epub 2021 May 4.

Faculty of Pharmacy, PHENIKAA University, Hanoi, 12116, Vietnam.

Polybia-MP1 is a well-known natural antimicrobial peptide that has been intensively studied recently due to its therapeutic potential. MP1 exhibited not only potent antibacterial activity but also antifungal and anticancer properties. More importantly, MP1 shows relatively low hemolytic activity compared to other antimicrobial peptides having a similar origin. Read More

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atpD gene sequencing, multidrug resistance traits, virulence-determinants, and antimicrobial resistance genes of emerging XDR and MDR-Proteus mirabilis.

Sci Rep 2021 May 4;11(1):9476. Epub 2021 May 4.

Department of Bacteriology, Immunology, and Mycology, Faculty of Veterinary Medicine, Suez Canal University, Ismailia, 41522, Egypt.

Proteus mirabilis is a common opportunistic pathogen causing severe illness in humans and animals. To determine the prevalence, antibiogram, biofilm-formation, screening of virulence, and antimicrobial resistance genes in P. mirabilis isolates from ducks; 240 samples were obtained from apparently healthy and diseased ducks from private farms in Port-Said Province, Egypt. Read More

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Antibacterial application of gentamicin-silk protein coating with smart release function on titanium, polyethylene, and AlO materials.

Mater Sci Eng C Mater Biol Appl 2021 May 26;124:112069. Epub 2021 Mar 26.

Department of Orthopaedics, Shanghai Jiao Tong University, Affiliated Sixth People's Hospital, Shanghai, China. Electronic address:

Peri-implant infection after hip and knee arthroplasty is a common and serious complication. Titanium (Ti), polyethylene (PE), and AlO materials used as joint prosthesis materials have good biocompatibility and mechanical strength but no antibacterial effect. This study aimed to provide a theoretical basis for the design and manufacture of joint prosthesis materials with antibacterial effect. Read More

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Aloe Vera extract-based composite nanofibers for wound dressing applications.

Mater Sci Eng C Mater Biol Appl 2021 May 26;124:112061. Epub 2021 Mar 26.

Department of Mechanical Engineering, University of Texas Rio Grande Valley, Edinburg, TX 78539, USA. Electronic address:

Natural, biocompatible, and biodegradable composite nanofibers made of Aloe vera extract, pullulan, chitosan, and citric acid were successfully produced via Forcespinning® technology. The addition of Aloe vera extract at different weight percent loadings was investigated. The morphology, thermal properties, physical properties, and water absorption of the nanofibers were characterized using scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), and thermogravimetric analysis (TGA). Read More

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Cerium and gallium containing mesoporous bioactive glass nanoparticles for bone regeneration: Bioactivity, biocompatibility and antibacterial activity.

Mater Sci Eng C Mater Biol Appl 2021 May 24;124:112050. Epub 2021 Mar 24.

Institute of Biomaterials, Department of Material Science and Engineering, University of Erlangen-Nuremberg, 91058 Erlangen, Germany. Electronic address:

In recent years, mesoporous bioactive glass nanoparticles (MBGNPs) have generated great attention in biomedical applications. In this study, cerium and gallium doped MBGNPs were prepared by microemulsion assisted sol-gel method in the binary SiO-CaO system. MBGNPs with spheroidal and pineal shaped morphology were obtained. Read More

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Antibacterial and antibiofilm activity of essential oil of clove against and Enteritidis.

Food Sci Technol Int 2021 May 4:10820132211013273. Epub 2021 May 4.

Departamento de Ingeniería Agronómica, Instituto de Biotecnología Vegetal, Universidad Politécnica de Cartagena, Cartagena, Spain.

The antibacterial and antibiofilm activity of essential oil of clove against and Enteritidis were investigated. The chemical composition of the oil was characterized by gas chromatography-mass spectrometry. Stock solution of the essential oil of clove was prepared in 95% (v/v) ethanol (EOC). Read More

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Synthesis and Antibacterial Activity of New Azole, Diazole and Triazole Derivatives Based on -Aminobenzoic Acid.

Molecules 2021 Apr 29;26(9). Epub 2021 Apr 29.

Department of Organic Chemistry, Kaunas University of Technology, Radvilėnų Rd. 19, LT-50254 Kaunas, Lithuania.

The aminobenzoic acid was applied for the synthesis of substituted 1-phenyl-5-oxopyrrolidine derivatives containing benzimidazole, azole, oxadiazole, triazole, dihydrazone, and dithiosemicarbazide moieties in the structure. All the obtained compounds were evaluated for their in vitro antimicrobial activity against , , , , and by using MIC and MBC assays. This study showed a good bactericidal activity of -amino acid and benzimidazoles derivatives. Read More

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Recent Advances on Nanoparticle Based Strategies for Improving Carotenoid Stability and Biological Activity.

Antioxidants (Basel) 2021 Apr 30;10(5). Epub 2021 Apr 30.

Department of Food Science, Fu Jen Catholic University, New Taipei City 24205, Taiwan.

Carotenoids are natural pigments widely used in food industries due to their health-promoting properties. However, the presence of long-chain conjugated double bonds are responsible for chemical instability, poor water solubility, low bioavailability and high susceptibility to oxidation. The application of a nanoencapsulation technique has thus become a vital means to enhance stability of carotenoids under physiological conditions due to their small particle size, high aqueous solubility and improved bioavailability. Read More

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Photophysical and Antibacterial Properties of Porphyrins Encapsulated inside Acetylated Lignin Nanoparticles.

Antibiotics (Basel) 2021 Apr 30;10(5). Epub 2021 Apr 30.

PEIRENE Laboratory, Faculty of Sciences and Techniques, University of Limoges, 87060 Limoges, France.

Lignin has recently attracted the attention of the scientific community, as a suitable raw material for biomedical applications. In this work, acetylated lignin was used to encapsulate five different porphyrins, aiming to preserve their photophysical properties, and for further use as antibacterial treatment. The obtained nanoparticles were physically characterized, through dynamic light scattering size measurement, polydispersity index and zeta potential values. Read More

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Oxyresveratrol Ameliorates Dextran Sulfate Sodium-Induced Colitis in Rats by Suppressing Inflammation.

Molecules 2021 Apr 30;26(9). Epub 2021 Apr 30.

Department of Integrated Biomedical and Life Sciences, Graduate School, Korea University, Seoul 02841, Korea.

Colitis causes destruction of the intestinal mucus layer and increases intestinal inflammation. The use of antioxidants and anti-inflammatory agents derived from natural sources has been recently highlighted as a new approach for the treatment of colitis. Oxyresveratrol (OXY) is an antioxidant known to have various beneficial effects on human health, such as anti-inflammatory, antibacterial activity, and antiviral activity. Read More

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Fast and Sensitive Bacteria Detection by Boronic Acid Modified Fluorescent Dendrimer.

Sensors (Basel) 2021 Apr 30;21(9). Epub 2021 Apr 30.

Department of Materials and Life Sciences, Faculty of Science and Technology, Sophia University, 7-1 Kioi-cho, Chiyoda-ku, Tokyo 102-8554, Japan.

This study reports a novel, fast, easy, and sensitive detection method for bacteria which is urgently needed to diagnose infections in their early stages. Our work presents a complex of poly(amidoamine) dendrimer modified by phenylboronic acid and labeled by a fluorescent dansyl group (Dan-B8.5-PAMAM). Read More

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Size Control of Synthesized Silver Nanoparticles by Simultaneous Chemical Reduction and Laser Fragmentation in Extract: Antibacterial Application.

Materials (Basel) 2021 Apr 30;14(9). Epub 2021 Apr 30.

Physics Department, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi Arabia.

In this work, silver nanoparticles (Ag NPs) were synthesized using a chemical reduction approach and a pulsed laser fragmentation in liquid (PLFL) technique, simultaneously. A laser wavelength of 532 nm was focused on the as produced Ag NPs, suspended in an extract solution, with the aim of controlling their size. The effect of liquid medium concentration and irradiation time on the properties of the fabricated NPs was studied. Read More

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Barbel steed (Hemibarbus labeo) NK-lysin protects against Aeromonas hydrophila infection via immunomodulatory activity.

Dev Comp Immunol 2021 May 1:104114. Epub 2021 May 1.

College of Ecology, Lishui University, Lishui, 323000, China.

NK-lysins (NKLs) are a family of multifunctional antimicrobial peptides that have activity against various microorganisms. However, the immunomodulatory activity of NKL in fish remains unclear. In this study, the cDNA sequence of barbel steed (Hemibarbus labeo) NKL gene was cloned. Read More

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Novel Lignin-Capped Silver Nanoparticles against Multidrug-Resistant Bacteria.

ACS Appl Mater Interfaces 2021 May 4. Epub 2021 May 4.

Faculty of Medicine, Division of Infectious Diseases, University of British Columbia, Vancouver, British Columbia V6T 1Z4, Canada.

The emergence of bacteria resistant to antibiotics and the resulting infections are increasingly becoming a public health issue. Multidrug-resistant (MDR) bacteria are responsible for infections leading to increased morbidity and mortality in hospitals, prolonged time of hospitalization, and additional burden to financial costs. Therefore, there is an urgent need for novel antibacterial agents that will both treat MDR infections and outsmart the bacterial evolutionary mechanisms, preventing further resistance development. Read More

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Photostable 1-Trifluoromethyl Cinnamyl Alcohol Derivatives Designed as Potential Fungicides and Bactericides.

J Agric Food Chem 2021 May 4. Epub 2021 May 4.

Key Laboratory of Green Prevention and Control of Tropical Plant Diseases and Pests, Ministry of Education, College of Plant Protection, Hainan University, Haikou, Hainan 570228, People's Republic of China.

In the current work, a series of 1-trifluoromethyl cinnamyl alcohol derivatives were designed and synthesized and their antifungal activities were evaluated. The bioassay result showed that most compounds exhibited excellent antifungal activity at 10 μg mL. Next, photostable and easily synthesized compound with broad-spectrum antifungal activity was selected as a potential candidate to evaluate its antibacterial and antifungal activities. Read More

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Multifunctional Applications of Blow-Spinning Structured Fibrous Membranes in Water Purification.

ACS Appl Mater Interfaces 2021 May 4. Epub 2021 May 4.

Joint Laboratory of Advanced Biomedical Materials (NFU-UGent), Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, Nanjing Forestry University, Nanjing 210037, P. R. China.

With increasing water pollution and human health problems caused by oily wastewater, the fabrication of oil-water separation materials has become an urgent task. However, most of the reported materials have a single function and poor performance. In this paper, a multifunctional zinc oxide/polyaniline/polyacrylonitrile (ZnO/PANI/PAN) nanofibrous membrane with needle-like ZnO nanorods was prepared by synthesis of PANI and a hydrothermal reaction on a highly stable self-standing PAN blow-spinning fibrous membrane. Read More

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Multifunctional liquid marbles to stabilize and transport reactive fluids.

Soft Matter 2021 May 4. Epub 2021 May 4.

Centre for Nanotechnology, Indian Institute of Technology Guwahati, Assam - 781039, India and Department of Chemical Engineering, Indian Institute of Technology Guwahati, Assam - 781039, India.

The self-organized transport and delivery of reactive liquids without spillage or loss of activity have been among the most daunting challenges for a long time. In this direction, we employ the concept of forming "liquid marbles" (LMs) to encapsulate and transport reactive hydrogen peroxide (H2O2) coated with functional microparticles. For example, peroxide marbles coated with a toner ink display remote-controlled magnetotactic movement inside a fluidic medium, thus overcoming the weaknesses associated with use of the bare droplets. Read More

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Titanium dioxide nanotubes as drug carriers for infection control and osteogenesis of bone implants.

Drug Deliv Transl Res 2021 May 3. Epub 2021 May 3.

Frontiers Science Center for Flexible Electronics, Xi'an Institute of Flexible Electronics (IFE), and Xi'an Institute of Biomedical Materials & Engineering (IBME), Northwestern Polytechnical University, 127 West Youyi Road, Xi'an, 710072, China.

Titanium implants have been widely used as one of the most effective treatments of bone defects. However, the lack of osteogenesis and bacteria-resistant activities result in high infection and loosening rates of titanium implants. Anodic oxidation could easily construct titanium dioxide nanotubes (TNTs) array on the surface of titanium, and the rough surface of TNTs is beneficial to the growth of osteoblast-related cells on the surface. Read More

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Evaluation of antibacterial activity and reversal of the NorA and MepA efflux pump of estragole against Staphylococcus aureus bacteria.

Arch Microbiol 2021 May 3. Epub 2021 May 3.

Departamento de Química Biológica, Laboratório de Farmacologia E Química Molecular - LFQM, Universidade Regional Do Cariri-URCA, Rua Cel. Antônio Luís 1161, Pimenta, Crato, CE, 63105-000, Brazil.

The antibacterial activity of the monoterpene estragole was evaluated against two strains of bacteria with an efflux pump mechanism, which are Staphylococcus aureus 1199B and S. aureus K2068, which have a NorA and MepA pump, respectively. For that, the methodology proposed by CLSI with modifications was followed, and to evaluate the reversal of the efflux pump, subinhibitory concentrations (MIC/8) of estragole and standard pump inhibitors, CCCP and Chlorpromazine were used and it was verified whether they managed to modulate the action of Norfloxacin, Ciprofloxacin and Ethidium Bromide, an indicator of an efflux pump. Read More

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Development and Preclinical Evaluation of New Inhaled Lipoglycopeptides for the Treatment of Persistent Pulmonary MRSA Infections.

Antimicrob Agents Chemother 2021 May 3. Epub 2021 May 3.

Insmed Incorporated, Bridgewater, New Jersey, USA

Chronic pulmonary MRSA disease in cystic fibrosis (CF) has a high probably of recurrence following treatment with standard-of-care antibiotics and represents an area of unmet need associated with reduced life expectancy. We developed a lipoglycopeptide therapy customized for pulmonary delivery that not only demonstrates potent activity against planktonic MRSA but also against protected colonies of MRSA both in biofilms and within cells, the latter of which have been linked to clinical antibiotic failure. A library of next-generation potent lipoglycopeptides were synthesized with an emphasis on attaining superior pharmacokinetics (PK) and pharmacodynamics to similar compounds of their class. Read More

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