132 results match your criteria anti-rnp higher

Clinical features and risk factors of Raynaud's phenomenon in primary Sjögren's syndrome.

Clin Rheumatol 2021 Apr 29. Epub 2021 Apr 29.

Department of Rheumatology, Peking Union Medical College Hospital, Chinese Academy of Medical Science & Peking Union Medical College, National Clinical Research Center for Dermatologic and Immunologic Diseases, State Key Laboratory of Complex Severe and Rare Diseases, Beijing, 100730, China.

Objective: The aim at the current study was to investigate the clinical characteristics and risk factors of Raynaud's phenomenon (RP) in patients with primary Sjögren's syndrome (pSS).

Methods: Retrospective analysis of the medical records of 333 new-onset pSS patients was performed. Demographic, clinical, and serological data were compared between individuals with and without RP. Read More

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Nailfold capillary abnormalities in childhood-onset systemic lupus erythematosus: a cross-sectional study compared with healthy controls.

Lupus 2021 Apr 3;30(5):818-827. Epub 2021 Mar 3.

Department of Pediatric Immunology, Rheumatology and Infectious Diseases, Emma Children's Hospital, Amsterdam University Medical Centers (Amsterdam UMC), University of Amsterdam, Amsterdam, the Netherlands.

Objectives: For selection of high-risk systemic lupus erythematosus (SLE) patients it is necessary to obtain indicators of disease severity that predict disease damage. As in systemic sclerosis, nailfold capillary abnormalities could be such a biomarker in SLE. The primary objective of this cross-sectional study is to describe capillary abnormalities in childhood-onset SLE (cSLE) cohort (onset < 18 years) and compare them with matched healthy controls. Read More

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[Significance of anti-tubulin-α-1C autoantibody in systemic sclerosis].

Beijing Da Xue Xue Bao Yi Xue Ban 2020 Dec;52(6):1009-1013

Objective: To detect the serum level of a novel autoantibody, anti-tubulin-α-1C, in patients with systemic sclerosis (SSc) and to investigate its clinical significance.

Methods: Anti-tubulin-α-1C antibody levels were determined by enzyme-linked immunosorbent assay (ELISA) in 62 patients with SSc, 38 systemic lupus erythematosus (SLE), 24 primary Sjögren's syndrome (pSS) patients, and 30 healthy controls (HCs). Erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), immunoglobulin A(IgA), immunoglobulin M (IgM), immunoglobulin G (IgG), C3, C4, rheumatoid factor (RF), antinuclear antibody(ANA), anti-centromere antibodies(ACA), anticardiolipin (aCL), anti-dsDNA antibody, anti-Sm antibody, anti-RNP antibody, anti-Scl-70 antibody, anti-Ro52 antibody, anti-SSA antibody, anti-SSB antibody, centromere protein A(CENP-A), centromere protein B (CENP-B) were measured by standard laboratory techniques. Read More

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December 2020

Pregnancy outcome in systemic lupus erythematosus patients: a monocentric cohort analysis.

Rheumatology (Oxford) 2021 Apr;60(4):1747-1754

Lupus Clinic, Dipartimento di Scienze Cliniche Internistiche, Anestesiologiche e Cardiovascolari, Sapienza University of Rome, Rome, Italy.

Objective: SLE is an autoimmune disease, mainly affecting women of childbearing age, with possible impact on pregnancy. In this study, we evaluated pregnancy outcomes in all pregnant patients affected by SLE, followed in the context of a rheumatology/gynaecology multi-disciplinary team.

Methods: Since 2008, we evaluated 70 consecutive pregnancies occurring in 50 SLE patients referring to the Lupus Clinic of Sapienza University of Rome; as controls we evaluated 100 consecutive pregnancies in 100 women without autoimmune diseases. Read More

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Oxidative DNA Damage Accelerates Skin Inflammation in Pristane-Induced Lupus Model.

Front Immunol 2020 24;11:554725. Epub 2020 Sep 24.

Division of Pediatric Infectious Diseases and Immunology, Cedars-Sinai Medical Center, Los Angeles, CA, United States.

Systemic Lupus Erythematosus (SLE) is a chronic inflammatory autoimmune disease in which type I interferons (IFN) play a key role. The IFN response can be triggered when oxidized DNA engages the cytosolic DNA sensing platform cGAS-STING, but the repair mechanisms that modulate this process and govern disease progression are unclear. To gain insight into this biology, we interrogated the role of oxyguanine glycosylase 1 (OGG1), which repairs oxidized guanine 8-Oxo-2'-deoxyguanosine (8-OH-dG), in the pristane-induced mouse model of SLE. Read More

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Cutaneous vasculitis in SLE.

Lupus Sci Med 2020 09;7(1)

Division of Rheumatology, Johns Hopkins Medicine, Baltimore, Maryland, USA.

Objectives: We determined the temporal association between clinical and serological disease manifestations and development of cutaneous small vessel vasculitis in a large prospective multiethnic cohort.

Methods: Patients with SLE diagnosed according to the Systemic Lupus International Collaborating Clinics (SLICC) classification criteria or the revised classification criteria as defined by the American College of Rheumatology (ACR) were enrolled in the Hopkins Lupus Cohort. Cutaneous small vessel vasculitis was determined as a component of the Systemic Lupus Erythematosus Disease Activity Index. Read More

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September 2020

Clinical and autoantibody profile in male and female patients with systemic lupus erythematosus: A retrospective study in 603 Brazilian patients.

Eur J Rheumatol 2020 Sep 3. Epub 2020 Sep 3.

Department of Medicine, Mackenzie Evangelical School of Medicine, Curitiba, Brazil.

Objective: Sex and ethnic background may influence the clinical and autoantibody profile in systemic lupus erythematosus (SLE). This retrospective study aimed to compare the clinical and autoantibody profiles of male and female patients with SLE in a sample of Brazilian patients.

Methods: This was a retrospective study of 603 patients (48 males and 555 females) from a single rheumatology center. Read More

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September 2020

Cachexia in Systemic Lupus Erythematosus: Risk Factors and Relation to Disease Activity and Damage.

Arthritis Care Res (Hoboken) 2020 Aug 2. Epub 2020 Aug 2.

Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, United States.

Objective: Cachexia is a disorder characterized by involuntary weight loss in addition to loss of homeostatic control of both energy and protein balance. Despite an abundance of data from other inflammatory diseases, cachexia in SLE remains a largely undescribed syndrome.

Methods: 2406 patients in a prospective SLE cohort had their weight assessed at each visit. Read More

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Premature ovarian failure in patients affected by systemic lupus erythematosus: a cross-sectional study.

Clin Exp Rheumatol 2020 May-Jun;38(3):450-454. Epub 2020 Feb 14.

Lupus Clinic, Reumatologia, Dipartimento Medicina Interna e Specialità Mediche, Sapienza Università di Roma, Italy.

Objectives: We evaluated age at natural menopause and the prevalence of premature ovarian failure (POF) in a monocentric Caucasian cohort of patients with systemic lupus erythematosus (SLE).

Methods: In this cross-sectional study, we enrolled women affected by SLE compared with healthy controls (HC) to investigate data about natural menopause (amenorrhoea for at least 12 months at ≥40 years) and POF (amenorrhoea for at least 12 months at <40 years).

Results: We enrolled 196 SLE (median age 47. Read More

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September 2020

Comparison of urinary parameters, biomarkers, and outcome of childhood systemic lupus erythematosus early onset-lupus nephritis.

Adv Rheumatol 2020 02 1;60(1):10. Epub 2020 Feb 1.

Pediatric Rheumatology Division, Faculdade de Medicina de Botucatu, Universidade Estadual Paulista (UNESP), Botucatu, Brazil.

Background: Urinary parameters, anti-dsDNA antibodies and complement tests were explored in patients with childhood-Systemic Lupus Erythematosus (cSLE) early-onset lupus nephritis (ELN) from a large multicenter cohort study.

Methods: Clinical and laboratory features of cSLE cases with kidney involvement at presentation, were reviewed. Disease activity parameters including SLEDAI-2 K scores and major organ involvement at onset and follow up, with accrued damage scored by SLICC-DI, during last follow up, were compared with those without kidney involvement. Read More

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February 2020

Differences in clinical manifestations and increased severity of systemic lupus erythematosus between two groups of Hispanics: European Caucasians versus Latin American mestizos (data from the RELESSER registry).

Lupus 2020 Jan 4;29(1):27-36. Epub 2019 Dec 4.

Rheumatology Department, Son Llatzer Hospital, Mallorca, Spain.

Background: Systemic lupus erythematosus (SLE) is regarded as a prototype autoimmune disease because it can serve as a means for studying differences between ethnic minorities and sex. Traditionally, all Hispanics have been bracketed within the same ethnic group, but there are differences between Hispanics from Spain and those from Latin America, not to mention other Spanish-speaking populations.

Objectives: This study aimed to determine the demographic and clinical characteristics, severity, activity, damage, mortality and co-morbidity of SLE in Hispanics belonging to the two ethnic groups resident in Spain, and to identify any differences. Read More

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January 2020

Predictors of predominant Lupus Low Disease Activity State (LLDAS-50).

Lupus 2019 Dec 6;28(14):1648-1655. Epub 2019 Nov 6.

Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

Aim: The Lupus Low Disease Activity State (LLDAS) is a potential treat to target goal in systemic lupus erythematosus (SLE). SLE patients in LLDAS for more than half of the observation time have about a 50% lower risk of new organ damage and have reduced mortality. We identified predictors of being in LLDAS ≥50% of the observation time. Read More

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December 2019

Anti-RNP positivity in primary Sjögren's syndrome is associated with a more active disease and a more frequent muscular and pulmonary involvement.

RMD Open 2019 1;5(2):e001033. Epub 2019 Oct 1.

Department of Rheumatology, AP-HP, Paris-Sud University Hospitals, Le Kremlin-Bicêtre Hospital, Le Kremlin-Bicêtre, France.

Objectives: To describe and compare the clinical and biological characteristics of subjects with primary Sjögren's syndrome (pSS) with and without anti-RNP antibodies.

Methods: Patients fulfilling the American College of Rheumatology (ACR)/EULAR 2016 criteria for pSS and having anti-RNP antibodies, without other connective tissue disease diagnosed and no anti-dsDNA antibodies were retrieved from the database from our French National Reference Center. These patients were compared with all other patients with pSS with negative anti-Sm, anti-RNP and anti-dsDNA antibodies. Read More

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Autoantibody status in systemic sclerosis patients defines both cancer risk and survival with ANA negativity in cases with concomitant cancer having a worse survival.

Oncoimmunology 2019;8(6):e1588084. Epub 2019 Mar 24.

Department of Medicine 'B', The Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Ramat Gan, Israel.

: A higher rate of cancer in systemic sclerosis (SSc) is recognized but the role of SSc-linked autoantibodies status (positive/negative and autoantibody specificities) in the survival of SSc-patients with cancer remains poorly understood. : We utilized the Clalit-Health-Services medical database in a case-control study to evaluate the autoantibody status and specificities of SSc-patients with age- and sex-matched controls with regard to the prevalence of different cancer-subtypes and their impact on mortality. SSc-linked autoantibodies (ANA, anti-centromere, anti-RNP, anti-RNA polymerase III (RNAPIII) and anti-Scl-70) status was assessed in terms of cancer risk and outcome. Read More

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The clinical significance of antinuclear antibodies and specific autoantibodies in juvenile and adult systemic lupus erythematosus patients.

Asian Pac J Allergy Immunol 2019 Apr 23. Epub 2019 Apr 23.

Center of Excellence in Immunology and Immune-mediated Diseases, Department of Microbiology.

Background: Juvenile systemic lupus erythematosus (JSLE) and adult SLE (ASLE) patients present with different clinical manifestations, but it is unknown if there are differences in their antinuclear autoantibody (ANA) profiles or if staining patterns are associated with specific autoantibodies and clinical manifestations.

Objective: To determine whether distinct types and numbers of ANA-staining patterns are associated with specific autoantibodies and clinical manifestations in JSLE and ASLE patients.

Methods: A retrospective study was performed in Thai children (n = 146) and adults (n = 180) diagnosed with SLE using the Systemic Lupus International Collaborating Clinics classification criteria. Read More

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Gastrointestinal manifestations on impaired quality of life in systemic sclerosis.

J Dig Dis 2019 May 2;20(5):256-261. Epub 2019 Apr 2.

Department of Gastroenterology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China.

Objective: To analyze the impact of gastrointestinal manifestations on quality of life in patients with systemic sclerosis (SSc) and to provide clinical evidence for their early treatment and health-related management.

Methods: Altogether 65 patients admitted to the Peking Union Medical College Hospital selected from a disease cohort and 127 matched controls were enrolled. A self-assessment questionnaire was completed by all participants. Read More

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Anti-RNA binding protein positivity in idiopathic interstitial pneumonia.

Respir Med 2019 01 22;146:23-27. Epub 2018 Nov 22.

Section of Pulmonary & Critical Care, Department of Medicine, The University of Chicago, Chicago, IL, USA.

Introduction: Idiopathic interstitial pneumonias (IIP) are diffuse lung diseases whose cause is unknown and often present with features of autoimmunity despite not meeting criteria for a connective tissue disease (CTD). Recent studies suggest that anti-RNA binding protein (anti-RBP) antibodies, which include anti-SSA, anti-SSB, anti-Sm, and anti-RNP, play a role in the loss of immune tolerance and severity of pulmonary hypertension (PH) in CTDs. We hypothesized that anti-RBP positive (RBP+) subjects would have worse measures of lung function, radiographic findings, PH, and survival than anti-RBP negative (RBP-) subjects. Read More

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January 2019

Primary respiratory disease in patients with systemic lupus erythematosus: data from the Spanish rheumatology society lupus registry (RELESSER) cohort.

Arthritis Res Ther 2018 12 19;20(1):280. Epub 2018 Dec 19.

Complexo Hospitalario Universitario de Vigo, Vigo, Spain.

Background: The purpose of this study was to assess the prevalence, associated factors, and impact on mortality of primary respiratory disease in a large systemic lupus erythematosus (SLE) retrospective cohort.

Methods: All adult patients in the RELESSER-TRANS (Registry of Systemic Lupus Erythematosus Patients of the Spanish Society of Rheumatology [SER], cross-sectional phase) registry were retrospectively investigated for the presence of primary pleuropulmonary manifestations.

Results: In total 3215 patients were included. Read More

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December 2018

Are serum autoantibodies associated with brain changes in systemic lupus erythematosus? MRI data from the Leiden NP-SLE cohort.

Lupus 2019 Jan 8;28(1):94-103. Epub 2018 Dec 8.

1 Department of Rheumatology, Leiden University Medical Center, Leiden, the Netherlands.

Objective: The effect of serum autoantibodies on the brain of systemic lupus erythematosus (SLE) patients remains unclear. We investigated whether serum autoantibodies, individually and assessed in groups, are associated with specific brain-MRI abnormalities or whether these structural changes are associated with other SLE-related or traditional cardiovascular disease risk factors.

Methods: All patients underwent brain 3Tesla-MRI. Read More

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January 2019

Association of anti-RNP with HLADR4 and its prevalence in rheumatoid arthritis patients.

J Immunoassay Immunochem 2018 17;39(6):595-608. Epub 2018 Oct 17.

e Department of Biochemistry, Faculty of Science , Damietta University , Damietta , Egypt.

Background: Autoantibodies are useful diagnostic tools for a variety of rheumatic autoimmune disorders.

Objective: The aim of the present study was to investigate autoantibodies against the 70-kD polypeptide of U1 ribonucleoprotein antibodies (RNP) in patients with rheumatoid arthritis (RA) and to investigate the relationship between anti-RNP and HLARD4 in RA patients.

Patients And Methods: In this prospective study, we studied 80 RA patients. Read More

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November 2018

The burden of depression in systemic sclerosis patients: a nationwide population-based study.

J Affect Disord 2019 01 21;243:427-431. Epub 2018 Sep 21.

Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel; Ness-Ziona, Mental Health Center, Beer-Yaakov, Israel.

Background: Systemic sclerosis (SSc) can clinically present with psychological symptoms, including pain, depression, and distress about disfigurement, physical and social functioning. The existing small studies have reported a prevalence of depression ranging from 36% to 65% among SSc patients, likely reflecting the disease impact on the patient's self-image and function.

Aim Of The Study: To investigate the association between SSc and depression using big data analysis methods. Read More

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January 2019

Association of extrapituitary prolactin promoter polymorphism with disease susceptibility and anti-RNP antibodies in Mexican patients with systemic lupus erythematosus.

Arch Med Sci 2018 08 2;14(5):1025-1032. Epub 2016 Sep 2.

Instituto de Investigación en Ciencias Biomédicas, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Jalisco, México.

Introduction: Prolactin (PRL) is a 23-kDa protein that can be synthesized and secreted by pituitary and extrapituitary tissues such as immune cells due to its expression being regulated by two independent promoter regions. The promoter which is responsible for extrapituitary expression contains the single nucleotide polymorphism (SNP) -1149 G/T previously associated with autoimmune diseases in various populations. This study evaluates the relationship of PRL -1149 G/T polymorphism with PRL serum levels and clinical characteristics in systemic lupus erythematosus (SLE) patients from western Mexico. Read More

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Autoantibody profile and clinical patterns in 619 Italian patients with cutaneous lupus erythematosus.

J Eur Acad Dermatol Venereol 2019 Apr 12;33(4):742-752. Epub 2018 Jul 12.

Department of Surgery and Translational Medicine, Section of Dermatology, University of Florence, Florence, Italy.

Background: Anti-nuclear antibodies (ANA), anti-extractable nuclear antigens (ENA) and anti-dsDNA antibodies are often associated with cutaneous lupus erythematosus (CLE), with variable frequency depending on skin subtype. However, specific data based on large case-series on the pathogenetic, diagnostic and prognostic meaning of such autoantibodies are still lacking.

Objective: To characterize the correlations between CLE subtypes as well as LE-non-specific skin lesions and their autoantibody pattern. Read More

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Predicting eventual development of lupus nephritis at the time of diagnosis of systemic lupus erythematosus.

Semin Arthritis Rheum 2018 12 23;48(3):462-466. Epub 2018 Feb 23.

Division of Rheumatology, Department of Medicine, University of Ulsan, College of Medicine, Asan Medical Center, 88 Olympic-ro 43-gil, Songpa-gu, Seoul 05505, Republic of Korea. Electronic address:

Objectives: To investigate factors predictive of future lupus nephritis development when systemic lupus erythematosus (SLE) is diagnosed.

Methods: Patients with newly diagnosed SLE without renal manifestations were followed for development of lupus nephritis, comparing findings at baseline between those who did or did not develop nephritis. Albumin-to-globulin ratio (AGR) was calculated as albumin/(total protein-albumin). Read More

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December 2018

The lupus patient with positive rheumatoid factor.

Lupus 2018 Jul 20;27(8):1368-1373. Epub 2018 Feb 20.

1 Rheumatology Service, Evangelical University Hospital of Curitiba, Curitiba, Brazil.

Background Patients with systemic lupus erythematosus (SLE) may form clusters with clinical manifestations and autoantibodies. Objective The objective of this report is to study whether SLE patients with positive rheumatoid factor (RF) have a special clinical and/or serological profile. Methods A retrospective study of 467 SLE patients seen at a single rheumatology unit was conducted. Read More

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Chinese lupus treatment and research group (CSTAR) registry: X. family history in relation to lupus clinical and immunological manifestations.

Clin Exp Rheumatol 2018 Jan-Feb;36(1):81-87. Epub 2017 Jul 7.

Department of Rheumatology, Peking Union Medical College Hospital, and Peking Union Medical College & Chinese Academy of Medical Sciences, Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing, China.

Objectives: This study aimed to examine the associations between family history and clinical manifestations and immunologic characteristics of lupus in China.

Methods: Based on their family history, lupus patients from the Chinese lupus treatment and research group (CSTAR) registry were categorised: familial lupus (FL), family history of other rheumatic disorders (RD), and sporadic lupus (SL). Demographic data, clinical manifestations, and laboratory data were compared among these three groups. Read More

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Anti-ENA antibody profiles in patients with hepatitis C virus infection.

J Clin Lab Anal 2018 Mar 12;32(3). Epub 2017 Jun 12.

Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, SC, USA.

Background: The presence of antinuclear antibodies (ANA) has been described following hepatitis C virus (HCV). Very few studies have investigated the presence of anti-extractable nuclear antigens (ENA) in HCV infection.

Methods: The aim of this study was to assess the prevalence of ENA antibodies in 100 patients with HCV infection compared to the prevalence of ENA antibodies in 100 healthy control patients. Read More

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Anti-ribosomal P antibody: a multicenter study in childhood-onset systemic lupus erythematosus patients.

Lupus 2017 Apr;26(5):484-489

1 Pediatric Rheumatology Unit, Children's Institute, Faculdade de Medicina da Universidade de São Paulo (FMUSP), Brazil.

Objectives Anti-ribosomal P protein (anti-P) autoantibodies are highly specific for systemic lupus erythematosus (SLE). However, the evaluation of this autoantibody in childhood-onset SLE (cSLE) populations has been limited to a few small series, hampering the interpretation of the clinical and laboratorial associations. Therefore, the objective of this multicenter cohort study was to evaluate demographic, clinical/laboratorial features, and disease damage score in cSLE patients with and without the presence of anti-P antibody. Read More

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Anti-RO/SSA and anti-La/SSB antibodies: Association with mild lupus manifestations in 645 childhood-onset systemic lupus erythematosus.

Autoimmun Rev 2017 Feb 14;16(2):132-135. Epub 2016 Dec 14.

Pediatric Rheumatology Unit, Children's Institute, Faculdade de Medicina da Universidade de São Paulo, Brazil; Division of Rheumatology, Faculdade de Medicina da Universidade de São Paulo, Brazil. Electronic address:

Background: To our knowledge there are no studies assessing anti-Ro/SSA and anti-La/SSB autoantibodies in a large population of childhood-systemic lupus erythematosus (cSLE) patients.

Methods: This was a retrospective multicenter cohort study performed in 10 Pediatric Rheumatology services, São Paulo state, Brazil. Anti-Ro/SSA and anti-La/SSB antibodies were measured by enzyme linked immunosorbent assay (ELISA) in 645 cSLE patients. Read More

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February 2017

Estrogen receptor alpha gene ( ESR1) polymorphism can contribute to clinical findings in systemic lupus erythematosus patients.

Lupus 2017 Mar 29;26(3):294-298. Epub 2016 Sep 29.

1 Federal University of Santa Catarina, Department of Cell Biology, Embryology and Genetics, Florianopolis, Brazil.

Background Estrogens have a modulatory effect on several immune responses, many of which are correlated to autoimmune diseases. Estrogens act through binding to their receptors, and an overexpression of these receptors has been identified in patients with different autoimmune diseases. Here we analyzed the association of a putative functional genetic variant in the main estrogen receptor (ERα) gene ( ESR1), and the susceptibility to clinical findings and severity of SLE. Read More

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