48,771 results match your criteria anti-inflammatory properties


Protective effect of melatonin entrapped PLGA nanoparticles on radiation-induced lung injury through the the miR-21/TGF-β1/Smad3 pathway.

Int J Pharm 2021 Apr 19:120584. Epub 2021 Apr 19.

State Key Laboratory of Trauma, Burns and Combined Injury, Institute of Combined Injury, Chongqing Engineering Research Center for Nanomedicine, College of Preventive Medicine, Third Military Medical University, No.30 Gaotanyan Street, Shapingba District, Chongqing, 400038, China. Electronic address:

Radiation-induced lung injury (RILI) is a complication commonly found in victims suffering from nuclear accidents and patients treated with chest tumor radiotherapy, and drugs are limited for effective prevention and treatment. Melatonin (MET) has an anti-radiation effect, but its metabolic period in the body is short. In order to prolong the metabolism period of MET, we prepared MET entrapped poly (lactic-co-glycolic acid) nanoparticles (MET/PLGANPS) for the treatment of RILI. Read More

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The in vitro and in vivo study of novel formulation of Andrographolide PLGA nanoparticle embedded into gelatin-based hydrogel to prolong delivery and extend residence time in joint.

Int J Pharm 2021 Apr 19:120618. Epub 2021 Apr 19.

Laboratory of Drug Delivery Systems, Faculty of Pharmaceutical Sciences, Kobe Gakuin University, 1-1-3 Minatojima, Chuo-ku, Kobe, Hyogo 650-8586, Japan. Electronic address:

Andrographolide (AG), a well-known traditional medicinal plant in Southeast Asia, is widely used for treatment of many chronic diseases. Interestingly, AG has been reported to have inhibitory effects on osteoclast function and anti-inflammatory properties. Because of these therapeutic properties, this study aimed to develop and optimize the formulation of AG using PLGA nanocarriers and gelatin-based hydrogel to prolong the retention time in the joint. Read More

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Selective anticancer effects of Serjania marginata Casar. extract in gastric cells are mediated by antioxidant response.

Environ Toxicol 2021 Apr 22. Epub 2021 Apr 22.

Department of General Biology, Center of Biological Sciences, State University of Londrina (UEL), Londrina, Brazil.

Gastric cancer is the fifth most common malignancy worldwide. Serjania marginata Casar. (SM) displays anti-inflammatory properties and has been used to treat gastrointestinal disorders. Read More

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Açaí (Euterpe oleracea Mart.) reduces the inflammatory response triggered in vitro by the antipsychotic drug olanzapine in RAW 264.7 macrophage cells.

Acta Sci Pol Technol Aliment 2021 Apr-Jun;20(2):149-163

Graduate Program in Gerontology, Universidade Federal de Santa Maria, Brazil.

Background: Açaí (Euterpe oleracea Mart), a Brazilian fruit, is considered a "superfruit" due its energetic properties and bioactive compounds. The açai's anti-inflammatory effects could attenuate the undesirable metabolic and pro-inflammatory side effects triggered by some antipsychotic drugs, such as Olanzapine (OLZ). It is possible to infer that açai supplement could potentially minimize the adverse effects of OLZ. Read More

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Gut microbiota regulation and anti-inflammatory effect of β-carotene in dextran sulfate sodium-stimulated ulcerative colitis in rats.

J Food Sci 2021 Apr 21. Epub 2021 Apr 21.

College of Animal Science and Technology, Jilin Agricultural University, Changchun, China.

β-Carotene displays antioxidant and anti-inflammatory activities and prevents the development of cancer. Ulcerative colitis (UC) is a kind of inflammatory bowel disease that is accompanied by a certain risk of colon cancer. However, the role of β-carotene in the modulation of gut microbiota and UC improvement is unclear. Read More

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Boric acid is as effective as hyaluronic acid-based agent in preventing intra-abdominal adhesions in a rat model.

Ulus Travma Acil Cerrahi Derg 2021 May;27(3):284-289

Department of General Surgery, University of Health Sciences, Gülhane Training and Research Hospital, Ankara-Turkey.

Background: In this experimental rat model, we aimed to investigate boric acid's possible protective effect against the formation of post-operative abdominal adhesions through its anti-inflammatory and antioxidant properties.

Methods: Forty healthy male albino rats were randomly and evenly allocated to vehicle, hyaluronic acid-based (HA-b) material, boric acid 50 (BA50), boric acid 100 (BA100), and sham groups. Intra-abdominal adhesions were induced by mechanical cecal abrasion. Read More

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Chlorogenic acid abates oxido-inflammatory and apoptotic responses in the liver and kidney of Tamoxifen-treated rats.

Toxicol Res (Camb) 2021 Mar 13;10(2):345-353. Epub 2021 Feb 13.

School of Chemistry & Biochemistry, Parker H. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA 30332-0400, USA.

Plant-derived phenolics are utilized as chemopreventive agents to abate adverse toxic responses associated with drug-induced damages. Tamoxifen (TAM)-a chemotherapeutic agent-is used in managing all stages of hormone-dependent breast cancer. Notwithstanding TAM's clinical side effect-including hepatic toxicity-its use is commonplace. Read More

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Metabonomic approaches investigate diosbulbin B-induced pulmonary toxicity and elucidate its underling mechanism in male mice.

Toxicol Res (Camb) 2021 Mar 23;10(2):272-276. Epub 2021 Mar 23.

Beijing Institute of Pharmacology\remvoliss and Toxicology, No. 27 Taiping Road, Haidian District, 100850 Beijing, China.

Air Potato Yam is widely used in the treatment of many conditions such as cancer, inflammation, and goiter. Diosbulbin B (DIOB) is the primary active component of Air Potato Yam, and it exhibits anti-tumor and anti-inflammatory properties. The main purpose of this study was to determine the mechanism by which DIOB induces lung toxicity, using metabonomics and molecular biology techniques. Read More

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Potency of Bone Marrow-Derived Mesenchymal Stem Cells and Indomethacin in Complete Freund's Adjuvant-Induced Arthritic Rats: Roles of TNF-, IL-10, iNOS, MMP-9, and TGF-1.

Stem Cells Int 2021 5;2021:6665601. Epub 2021 Apr 5.

Physiology Division, Zoology Department, Faculty of Science, Beni-Suef University, P.O. Box 62521, Beni-Suef, Egypt.

Rheumatoid arthritis (RA) is an autoimmune syndrome affecting joint spaces, leading to the disabled state. Currently, there is no optimal therapy for RA except for systemic immunosuppressants that have variable undesirable effects after long-term use. Hence, the need for other treatment modalities has emerged in an attempt to develop a treating agent that is effective but without bad effects. Read More

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A Synthetic Curcuminoid Analogue, 2,6-Bis-4-(Hydroxyl-3-Methoxybenzylidine)-Cyclohexanone (BHMC) Ameliorates Acute Airway Inflammation of Allergic Asthma in Ovalbumin-Sensitized Mice.

Mediators Inflamm 2021 3;2021:9725903. Epub 2021 Apr 3.

Department of Biomedical Science, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang 43300, Malaysia.

2,6-Bis-(4-hydroxyl-3-methoxybenzylidine) cyclohexanone (BHMC), a synthetic curcuminoid analogue, has been shown to exhibit anti-inflammatory properties in cellular models of inflammation and improve the survival of mice from lethal sepsis. We further evaluated the therapeutic effect of BHMC on acute airway inflammation in a mouse model of allergic asthma. Mice were sensitized and challenged with ovalbumin (OVA), followed by intraperitoneal administration of 0. Read More

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Isovitexin Depresses Osteoarthritis Progression via the Nrf2/NF-κB Pathway: An in vitro Study.

J Inflamm Res 2021 13;14:1403-1414. Epub 2021 Apr 13.

The Third Affiliated Hospital of Zhejiang Chinese Medicine University, Hangzhou, 310005, People's Republic of China.

Purpose: Osteoarthritis (OA) is a multifactorial joint disease and inflammatory processes contribute to joint destruction. Isovitexin (IVX) is a flavone component found in passion flower, Cannabis and, and the palm that is known for its anti-inflammatory properties.

Materials And Methods: This study investigated in vitro the role and underlying mechanism used by IVX in its regulation of OA development. Read More

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Effects of imperatorin on apoptosis and synaptic plasticity in vascular dementia rats.

Sci Rep 2021 Apr 21;11(1):8590. Epub 2021 Apr 21.

School of Basic Medicine, Gannan Medical University, Ganzhou, 341000, Jiangxi, China.

In view of the complicated pathophysiological process of vascular dementia (VD), drugs for the clinical treatment of VD mainly target related risk factors, while drugs with excellent efficacy in cognitive function are still relatively lacking. Imperatorin (IMP), an active constituent extracted from angelica dahuricae and notopterygium Notopterygii, which has anti-inflammatory, vasodilator, anticoagulant, block calcium channel, anticonvulsant, and anti oxygen free radical injury properties. Therefore,the present study examined its effects on VD rats and the underlying molecular mechanisms, in order to provide promising therapeutic methods. Read More

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Agathisflavone Modifies Microglial Activation State and Myelination in Organotypic Cerebellar Slices Culture.

J Neuroimmune Pharmacol 2021 Apr 21. Epub 2021 Apr 21.

Department of Biochemistry and Biophysics, Institute of Health Sciences, Federal University of Bahia, Bahia, Brazil.

Oligodendrocytes produce the myelin that is critical for rapid neuronal transmission in the central nervous system (CNS). Disruption of myelin has devastating effects on CNS function, as in the demyelinating disease multiple sclerosis (MS). Microglia are the endogenous immune cells of the CNS and play a central role in demyelination and repair. Read More

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The impact of Sambucus nigra L. extract on inflammation, oxidative stress and tissue remodeling in a rat model of lipopolysaccharide-induced subacute rhinosinusitis.

Inflammopharmacology 2021 Apr 21. Epub 2021 Apr 21.

Department of Physiology, "Iuliu Hatieganu" University of Medicine and Pharmacy, Clinicilor Street, No. 1-3, 400006, Cluj-Napoca, Romania.

Rhinosinusitis is a common disorder related to inflammation of paranasal sinuses and nasal cavity mucosa. Herbal medicines could be an option in the treatment of rhinosinusitis due to their anti-inflammatory and anti-oxidative properties. The study aims to investigate the effect of intranasal Sambucus nigra L. Read More

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Arrabidaea chica Verlot fractions reduce MIA-induced osteoarthritis progression in rat knees.

Inflammopharmacology 2021 Apr 21. Epub 2021 Apr 21.

Biological and Health Sciences Center, Federal University of Maranhão, Av. dos Portugueses 1966, São Luís, MA, 65085-580, Brazil.

This study aims to investigate the activity of n-hexane, ethyl acetate and butanol fractions obtained from Arrabidaea chica Verlot against MIA-induced osteoarthritis (OA). The antinociceptive potentials of each fraction were evaluated through a cyclooxygenase (COX) 1 and 2 inhibition test and an in vivo OA-model. In addition, toxicity assessments in the liver, spleen and kidney, as well as radiographic and histopathological knee analyses, were performed. Read More

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Polyvinyl alcohol/chitosan composite hydrogels with sustained release of traditional Tibetan medicine for promoting chronic diabetic wound healing.

Biomater Sci 2021 Apr 21. Epub 2021 Apr 21.

College of Medicine, Southwest Jiaotong University, Chengdu, 610031, China. and Key Laboratory of Advanced Technologies of Materials (Ministry of Education), School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu, 610031, China.

The Tibetan eighteen flavor dangshen pills (TEP) are composed of 18 traditional Tibetan medicines, which are commonly used in the treatment of skin diseases in the Tibetan medical system. They have anti-inflammatory and analgesic effects, and healing properties. However, TEP contain large doses and have strong side effects and low bioavailability. Read More

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Anti-Inflammatory and Antimicrobial Activities of Compounds Isolated from .

Biomed Res Int 2021 6;2021:6624347. Epub 2021 Apr 6.

Faculty of Pharmacy, Ton Duc Thang University, Ho Chi Minh City, Vietnam.

is a native black ginger that grows in Vietnam. In point of fact, there is limitation of available information in the literature making mention of the chemical constituents and bioactive properties of this plant. This study is aimed at isolating -coumaric acid (), -cinnamic acid (), and borneol () from the rhizomes of Q. Read More

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The Effect of Thermal-Treating on Drug Release from Sustained Release Alginate-Eudragit RS Matrices.

Adv Pharm Bull 2021 Feb 19;11(2):318-326. Epub 2020 Apr 19.

Department of Pharmaceutics, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.

The main objective of the present study was to develop the colonic delivery system for 5-aminosalicylic acid (5-ASA) as an anti-inflammatory drug. Matrix pellets containing various proportions of alginate, calcium and Eudragit RS were prepared by extrusion-spheronization technique. Thermal treatment was used to investigate the effect of the curing process on the surface morphology, mechanical and physicochemical properties and drug release profile of pellets. Read More

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February 2021

Hydrogen (H) Alleviates Osteoarthritis by Inhibiting Apoptosis and Inflammation via the JNK Signaling Pathway.

J Inflamm Res 2021 13;14:1387-1402. Epub 2021 Apr 13.

Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325000, People's Republic of China.

Background: Osteoarthritis (OA) is a very common condition and leads to joint pain, disability, and price tag all over the world. Pathogenesis of OA is closely related to numerous inflammatory and apoptosis cytokines. Hydrogen (H) reportedly exhibits a diversity of effects such as anti-apoptotic, anti-inflammatory, and anti-oxidative properties via the JNK pathway. Read More

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Dihydroartemisinin as a Sensitizing Agent in Cancer Therapies.

Onco Targets Ther 2021 13;14:2563-2573. Epub 2021 Apr 13.

Department of Clinical Laboratory, Affiliated Hospital of North Sichuan Medical College, Nanchong, 637000, People's Republic of China.

Cancer is one of the major threats to human health. Although humans have struggled with cancer for decades, the efficacy of treatments for most tumors is still very limited. Dihydroartemisinin (DHA) is a derivative of artemisinin, a first-line antimalarial drug originally developed in China. Read More

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Improved Bioactivity of 3-O-β-D-Glucopyranosyl Platycosides in Biotransformed Root Extract by Pectinase from .

J Microbiol Biotechnol 2021 Apr 14;31(5). Epub 2021 Apr 14.

Department of Bioscience and Biotechnology, Konkuk University, Seoul 05029, Republic of Korea.

(balloon flower) root (Platycodi radix) is used as health supplement owing to its beneficial bioactive properties. In the present study, the anti-inflammatory, antioxidant, and whitening effects of deglycosylated saponins biotransformed by pectinase from were investigated. The bioactivities of platycosides improved when the number of sugar moieties attached to the aglycone platycosides was decreased. Read More

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Rationales and uncertainties for aspirin use in COVID-19: a narrative review.

Fam Med Community Health 2021 Apr;9(2)

Department of Family Medicine, Suez Canal University Faculty of Medicine, Ismailia, Egypt.

Objectives: To review the pathophysiology of COVID-19 disease, potential aspirin targets on this pathogenesis and the potential role of aspirin in patients with COVID-19.

Design: Narrative review.

Setting: The online databases PubMed, OVID Medline and Cochrane Library were searched using relevant headlines from 1 January 2016 to 1 January 2021. Read More

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Salvia miltiorrhiza hydroalcoholic extract inhibits postoperative peritoneal adhesions in rats.

BMC Complement Med Ther 2021 Apr 20;21(1):126. Epub 2021 Apr 20.

Department of Clinical Sciences, Faculty of Veterinary Medicine, Lorestan University, Khorramabad, Iran.

Background: One of the most prevalent postoperative complications is believed to be intra-abdominal peritoneal adhesions, which is followed by several complications. Several adhesion prevention products have been examined, yet none of them were found to be completely effective. The current research is conducted to evaluate the beneficial effects of Salvia miltiorrhiza hydroalcoholic extract in inhibiting postoperative peritoneal adhesions in rats. Read More

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Prospects of Saffron and its Derivatives in Alzheimer's Disease.

Arch Iran Med 2021 Mar 1;24(3):233-252. Epub 2021 Mar 1.

Psychiatric Research Center, Roozbeh Hospital, Tehran University of Medical Sciences, Tehran, Iran.

Alzheimer's disease (AD) is a progressive neurodegenerative disorder and the most common form of dementia in the old age population, making it a worldwide concern. Unfortunately, few drugs have been presented for treatment of mild and moderate AD. To meet this need, more effective anti-AD agents are emerging. Read More

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Polyphenols: Natural compounds with promising potential in treating polycystic ovary syndrome.

Reprod Biol 2021 Apr 17;21(2):100500. Epub 2021 Apr 17.

Department of Clinical Biochemistry, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran. Electronic address:

Polyphenols are natural compounds used by plants as a defense system against various stresses. In recent years, the importance of these polyhydroxyphenols has extensively increased due to their potent cardioprotection, anti-carcinogenic, anti-oxidant, anti-apoptotic, and anti-inflammatory properties. Therefore, various studies have reported promising results from the studies investigating their efficacy as a therapeutic strategy in various disorders such as human malignancies, cardiovascular diseases, nervous system impairments, diabetes, metabolic syndrome, aging, and inflammation-associated disorders, as well as a polycystic ovarian syndrome (PCOS). Read More

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Phytochemical add-on therapy to DMARDs therapy in rheumatoid arthritis: In vitro and in vivo bases, clinical evidence and future trends.

Pharmacol Res 2021 Apr 17:105618. Epub 2021 Apr 17.

Inflammation Pharmacology Division, CSIR- Indian Institute of Integrative Medicine, Canal Road, Jammu, J&K, India-180001; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad-201002, India. Electronic address:

The use of biologically active compounds derived from plants i.e. phytochemicals, have been known for ages for their pharmacological activities in the treatment of autoimmune disorders like rheumatoid arthritis (RA). Read More

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The effects of flavonoids, green tea polyphenols and coffee on DMBA induced LINE-1 DNA hypomethylation.

PLoS One 2021 20;16(4):e0250157. Epub 2021 Apr 20.

Department of Public Health Medicine, Medical School, University of Pécs, Pécs, Hungary.

The intake of carcinogenic and chemopreventive compounds are important nutritional factors related to the development of malignant tumorous diseases. Repetitive long interspersed element-1 (LINE-1) DNA methylation pattern plays a key role in both carcinogenesis and chemoprevention. In our present in vivo animal model, we examined LINE-1 DNA methylation pattern as potential biomarker in the liver, spleen and kidney of mice consuming green tea (Camellia sinensis) extract (catechins 80%), a chinese bayberry (Morella rubra) extract (myricetin 80%), a flavonoid extract (with added resveratrol) and coffee (Coffee arabica) extract. Read More

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2-Undecanone Protects against Fine Particle-Induced Kidney Inflammation via Inducing Mitophagy.

J Agric Food Chem 2021 Apr 20. Epub 2021 Apr 20.

Department of Food Nutrition and Safety, Dalian Medical University, No. 9W. Lushun South Road, Dalian 116044, China.

Exposure to particulate matter has been associated with diseases of the respiratory and cardiovascular systems. Owing to the dense vasculature of the kidney, it has also been identified as a PM target organ. A potential contributor to PM-mediated damage may be the promotion of inflammation. Read More

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Silver nanoparticles green synthesis via cyanobacterium Phormidium sp.: characterization, wound healing, antioxidant, antibacterial, and anti-inflammatory activities.

Eur Rev Med Pharmacol Sci 2021 Apr;25(7):3083-3096

Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa, Saudi Arabia.

Objective: Green synthesis of silver nanoparticles (AgNPs) using cyanobacterial platforms is becoming more popular nowadays. In this study, the filamentous non-heterocystous cyanobacterium Phormidium sp. was used for AgNPs production. Read More

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Modulation of proteasome activity by curcumin and didemethylcurcumin.

J Biomol Struct Dyn 2021 Apr 20:1-8. Epub 2021 Apr 20.

Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, Houston, TX, USA.

Modulation of proteasome function by pharmacological interventions and molecular biology tools is an active area of research in cancer biology and neurodegenerative diseases. Curcumin (diferuloylmethane) is a naturally occurring polyphenol that affects multiple signaling pathways. Curcumin shows anti-inflammatory, antioxidant, anti-angiogenic, or anti-apoptotic properties. Read More

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