143,267 results match your criteria anti-inflammatory enzyme

Pinoresinol diglucoside alleviates ischemia/reperfusion-induced brain injury by modulating neuroinflammation and oxidative stress.

Chem Biol Drug Des 2021 Sep 21. Epub 2021 Sep 21.

Department of Neurology, Chenzhou No, People's Hospital, 423000, Hunan, China.

Brain ischemia/reperfusion (I/R) injury is a common pathological process after ischemic stroke. Pinoresinol diglucoside (PDG) has antioxidation and anti-inflammation activities. However, whether PDG ameliorates brain I/R injury is still unclear. Read More

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September 2021

A clinical perspective of soluble epoxide hydrolase inhibitors in metabolic and related cardiovascular diseases.

Curr Mol Pharmacol 2021 Sep 19. Epub 2021 Sep 19.

Department of Pharmacy, Banasthali Vidyapith. Banasthali-304022, Rajasthan. India.

Epoxide hydrolase (EH) is a crucial enzyme responsible for catabolism, detoxification, and regulation of signaling molecules in various organisms including human beings. In mammals, EHs are classified according to their DNA sequence, sub-cellular location, and activity into eight major classes: soluble EH (sEH), microsomal EH (mEH), leukotriene A4 hydrolase (LTA4H), cholesterol EH (ChEH), hepoxilin EH, paternally expressed gene 1 (peg1/MEST), EH3 and EH4. The sEH, an α/β-hydrolase fold family enzyme is an emerging pharmacological target in multiple diseases namely, cardiovascular disease, neurodegenerative disease, chronic pain, fibrosis, diabetes, pulmonary diseases, and immunological disease. Read More

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September 2021

Therapeutic Targets for Phenolic Compounds from Agro-industrial Byproducts against Obesity.

Curr Med Chem 2021 Sep 19. Epub 2021 Sep 19.

Department of Analytical Chemistry, Faculty of Science, University of Granada, Granada. Spain.

Background: Obesity is considered as a global epidemic worldwide. This disorder is associated to several health effects such as metabolic disturbances that need both prevention and treatment actions. In this sense, bioactive secondary metabolites can be obtained from cheap sources such as agro-industrial waste providing a sustainable alternative against obesity. Read More

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September 2021

Chemical, biological and protein-receptor binding profiling of Bauhinia scandens L. stems provide new insights into the management of pain, inflammation, pyrexia and thrombosis.

Biomed Pharmacother 2021 Sep 17;143:112185. Epub 2021 Sep 17.

Department of Clinical Pharmacy and Pharmacology, Faculty of Pharmacy, University of Dhaka, Dhaka 1000, Bangladesh. Electronic address:

Bauhinia scandens L. (Family, Fabaceae) is a medicinal plant used for conventional and societal medication in Ayurveda. The present study has been conducted to screen the chemical, pharmacological and biochemical potentiality of the methanol extracts of B. Read More

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September 2021

Leonurine protects against influenza A virus infection-induced pneumonia in mice.

Pathog Dis 2021 Sep 20. Epub 2021 Sep 20.

Department of pediatrics, Daqing Oilfield General Hospital, 9 Zhongkang Street, Daqing, 163001, China.

Background: Influenza A virus (H1N1), a swine-origin influenza A virus, causes seasonal epidemics that result in severe illnesses and deaths. Leonurine has been reported to function as an anti-inflammatory agent with protective effects on nervous, urinary and cardiovascular system. However, the therapeutic effects of leonurine on the pneumonia caused by H1N1 infection remains unclear. Read More

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September 2021

Dysregulated androgen synthesis and anti-androgen resistance in advanced prostate cancer.

Am J Clin Exp Urol 2021 25;9(4):292-300. Epub 2021 Aug 25.

Department of Urology, University of California, Davis Sacramento, CA 95817, USA.

Current therapies for treating castration resistant prostate cancer (CRPC) include abiraterone and enzalutamide which function by inhibiting androgen signaling by targeting androgen synthesis and antagonizing the androgen receptor (AR) respectively. While these therapies are initially beneficial, resistance inevitably develops. A number of pathways have been identified to contribute to CRPC progression and drug resistance. Read More

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Developing Cytokine Storm-Sensitive Therapeutic Strategy in COVID-19 Using 8P9R Chimeric Peptide and Soluble ACE2.

Front Cell Dev Biol 2021 3;9:717587. Epub 2021 Sep 3.

Department of Pharmacology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Currently, the COVID-19 pandemic is an international challenge, largely due to lack of effective therapies. Pharmacotherapy has not yet been able to find a definitive treatment for COVID-19. Since SARS-CoV-2 affects several organs, treatment strategies that target the virus in a wider range are expected to be ultimately more successful. Read More

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September 2021

Presence of anti-acetylated peptide antibodies (AAPA) in inflammatory arthritis and other rheumatic diseases suggests discriminative diagnostic capacity towards early rheumatoid arthritis.

Ther Adv Musculoskelet Dis 2021 23;13:1759720X211022533. Epub 2021 Jul 23.

Division of Rheumatology, Department of Internal Medicine 3, Medical University of Vienna, Vienna, Austria & Ludwig Boltzmann Institute for Arthritis and Rehabilitation, Vienna, Austria.

Aims: To determine the diagnostic value of anti-acetylated peptide antibodies (AAPA) in patients with rheumatoid arthritis (RA).

Methods: Three acetylated peptides (ac-lysine, ac-lysine.inv and ac-ornithine) derived from vimentin were employed to measure AAPA by enzyme-linked immunosorbent assay (ELISA) in sera of 120 patients with early RA (eRA), 195 patients with established RA (est RA), 99 healthy controls (HC), and 216 patients with other inflammatory rheumatic diseases. Read More

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Traditional Chinese Medicine Aconiti Radix Cocta Improves Rheumatoid Arthritis via Suppressing COX-1 and COX-2.

Evid Based Complement Alternat Med 2021 7;2021:5523870. Epub 2021 Sep 7.

School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.

According to Traditional Chinese Medicine (TCM), Aconiti Radix Cocta (AC) is clinically employed to expel wind, remove dampness, and relieve pain. We evaluated the antirheumatoid arthritis (RA) activities and underlying mechanisms of AC. The chemical constituents of AC were analyzed by high-performance liquid chromatography (HPLC) using three reference compounds (benzoylaconitine, benzoylmesaconine, and benzoylhypacoitine). Read More

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September 2021

Hordenine Protects Against Lipopolysaccharide-Induced Acute Lung Injury by Inhibiting Inflammation.

Front Pharmacol 2021 1;12:712232. Epub 2021 Sep 1.

Department of Respiratory and Critical Care Medicine, The Second Hospital of Jilin University, Changchun, China.

Acute lung injury (ALI) is a respiratory disease that leads to death in severe cases. Hordenine (Hor), a barley-derived natural product, has various biological activities, including anti-inflammatory, and anti-oxidation activities. We investigated the effect of Hor on lipopolysaccharide-induced ALI and its potential mechanism. Read More

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September 2021

A review on environmental occurrence, toxicity and microbial degradation of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs).

J Environ Manage 2021 Sep 16;300:113694. Epub 2021 Sep 16.

Department of Civil Engineering, Indian Institute of Technology, Kharagpur, 721302, India.

In recent years, Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) have surfaced as a novel class of pollutants due to their incomplete degradation in wastewater treatment plants and their inherent ability to promote physiological predicaments in humans even at low doses. The occurrence of the most common NSAIDs (diclofenac, ibuprofen, naproxen, and ketoprofen) in river water, groundwater, finished water samples, WWTPs, and hospital wastewater effluents along with their toxicity effects were reviewed. The typical concentrations of NSAIDs in natural waters were mostly below 1 μg/L, the rivers receiving untreated wastewater discharge have often showed higher concentrations, highlighting the importance of effective wastewater treatment. Read More

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September 2021

6-Gingerol protects against cerebral ischemia/reperfusion injury by inhibiting NLRP3 inflammasome and apoptosis via TRPV1 / FAF1 complex dissociation-mediated autophagy.

Int Immunopharmacol 2021 Sep 17;100:108146. Epub 2021 Sep 17.

Department of Pathology, Chongqing Medical University, Chongqing 400016, China; Institute of Neuroscience, Chongqing Medical University, Chongqing 400016, China. Electronic address:

Background: Our previous studies demonstrated that autophagy alleviates cerebral I/R injury by inhibiting NLRP3 inflammasome-mediated inflammation. 6-Gingerol, a phenolic compound extracted from ginger, was reported to possess potent antiapoptotic and anti-inflammatory activities and is associated with autophagy. However, the effects of 6-Gingerol in cerebral I/R injury have not been elucidated, and whether they involve autophagy-induced NLRP3 inflammasome inhibition remains unclear. Read More

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September 2021

An IL-1β homologue induced inflammation and antibacterial immune defense in Siberian sturgeon (Acipenser baeri).

Fish Shellfish Immunol 2021 Sep 16. Epub 2021 Sep 16.

Beijing Fisheries Research Institute & Beijing Key Laboratory of Fishery Biotechnology, Beijing, 100068, People's Republic of China; National Freshwater Fisheries Engineering Technology Research Center, Beijing, 100068, People's Republic of China. Electronic address:

Interleukin-1β is a key pro-inflammatory cytokine functioning in initiation of inflammatory responses against bacterial- and viral-infections. In the present study, a putative IL-1β counterpart was identified from Siberian sturgeon (Acipenser baeri) and designated as AbIL-1β. The Abil-1β cDNA sequence consists of 1130 bp with an open reading frame (ORF) of 585 bp, which encodes a 194 amino acid (aa) protein. Read More

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September 2021

Effect of diclofenac and naproxen and their mixture on spring barley seedlings and Heterocypris incongruens.

Environ Toxicol Pharmacol 2021 Sep 15;88:103746. Epub 2021 Sep 15.

Jan Długosz University in Czestochowa, The Faculty of Science and Technology, 13/15 Armii Krajowej Av., 42-200, Czestochowa, Poland.

Nonsteroidal anti-inflammatory drugs (NSAIDs) are a popular group of drugs used worldwide. These drugs are also available over the counter, which implies that their consumption is not strictly regulated. They are released through wastewater and feces and can have adverse effects on the environment. Read More

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September 2021

Gossypol ameliorates the IL-1β-induced apoptosis and inflammation in chondrocytes by suppressing the activation of TLR4/MyD88/NF-κB pathway via downregulating CX43.

Tissue Cell 2021 Aug 10;73:101621. Epub 2021 Aug 10.

Department of Joint Orthopedics, The Second Affiliated Hospital of Nanjing University of Chinese Medicine, Jianye District, Nanjing City, Jiangsu Province, 210017, China. Electronic address:

The effects of anti-inflammatory drug gossypol on osteoarthritis (OA) treatment were discussed in this paper. After identified using toluidine blue and immunofluorescence staining of type II collagen, chondrocytes from OA patients were treated with interleukin-1β (IL-1β), gossypol, and overexpressed connexin43 (CX43). In treated chondrocytes, according to MTT assay and flow cytometry, gossypol increased viability and reduced apoptosis of IL-1β induced chondrocytes. Read More

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Phytomelatonin: a potential phytotherapeutic intervention on COVID-19-exposed individuals.

Microbes Infect 2021 Sep 14:104886. Epub 2021 Sep 14.

School of Environment and Safety Engineering, Jiangsu University, 212013 P.R. China; Department of Zoology and Environmental Biology, University of Nigeria, Nsukka, 410001, Enugu State, Nigeria; Biofuels Institute, Jiangsu University, Zhenjiang, 212013 P.R. China; Organization of African Academic Doctors (OAAD), Off Kamiti Road, 25305000100, Nairobi, Kenya. Electronic address:

Phytomelatonin is a pleiotropic molecule that originated in higher plants with many diverse actions and is primarily an antioxidant. The recent identification and advancement of phytomelatonin unraveled the potential of this modulatory molecule being considered a new plant hormone, suggesting its relevance in treating respiratory infections, including COVID-19. Besides, this molecule is also involved in multiple hormonal, physiological, and biological processes at different levels of cell organization and has been marked for its ability to cross the blood-brain barrier and prominent antioxidant effects, reducing mitochondrial electron leakage, up-regulating antioxidant enzymes, acting as a free radical scavenger, and interfering with pro-inflammatory signaling pathways as seen in mood swings, body temperature, sleep, cancer, cardiac rhythms, and immunological regulation modulators. Read More

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September 2021

Methods in sulfide and persulfide research.

Nitric Oxide 2021 Sep 14;116:47-64. Epub 2021 Sep 14.

Department of Environmental Medicine and Molecular Toxicology, Tohoku University Graduate School of Medicine, Sendai, 980-8575, Japan. Electronic address:

Sulfides and persulfides/polysulfides (R-S-R', n > 2; R-S-H, n > 1) are endogenously produced metabolites that are abundant in mammalian and human cells and tissues. The most typical persulfides that are widely distributed among different organisms include various reactive persulfides-low-molecular-weight thiol compounds such as cysteine hydropersulfide, glutathione hydropersulfide, and glutathione trisulfide as well as protein-bound thiols. These species are generally more redox-active than are other simple thiols and disulfides. Read More

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September 2021

Molecular hydrogen suppresses Porphyromonas gingivalis lipopolysaccharide-induced increases in interleukin-1 alpha and interleukin-6 secretion in human gingival cells.

Mol Cell Biochem 2021 Sep 17. Epub 2021 Sep 17.

Hiroshima Kasei, Ltd., 2-2-11 Matsuhama-cho, Fukuyama city, Hiroshima, 720-0802, Japan.

Periodontitis is defined as a multifactorial polymicrobial infection accompanied by inflammatory reactions. Porphyromonas gingivalis (Pg) is known as a major pathogen in the initiation and progression of periodontitis, and a major virulence factor is Pg lipopolysaccharide (LPS). Molecular hydrogen (H) has been reported to act as a gaseous antioxidant, which suppresses periodontitis progression by decreasing gingival oxidative stress. Read More

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September 2021

Natural inhibitors against potential targets of cyclooxygenase, lipoxygenase and leukotrienes.

Comb Chem High Throughput Screen 2021 Sep 16. Epub 2021 Sep 16.

Global Institute of Pharmaceutical Education and Research (Affiliated to Uttarakhand Technical University), Kashipur-244713, India.

Background: The cyclooxygenase (COX) and lipoxygenase (LOX) enzymes catalyze the production of pain mediators like prostaglandins (PGs) and leukotrienes (LTs) respectively from arachidonic acid.

Introduction: The COX and LOX enzyme modulators are responsible for the major PGs and LTs mediated complications like asthma, osteoarthritis, rheumatoid arthritis, cancer, Alzheimer's disease, neuropathy and cardiovascular syndromes (CVS). Many synthetic nonsteroidal anti-inflammatory drugs (NSAIDs) used in the treatment have serious side effects like nausea, vomiting, hyperacidity, gastrointestinal ulcers, CVS, etc. Read More

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September 2021

Omarigliptin protects against nonalcoholic fatty liver disease by ameliorating oxidative stress and inflammation.

J Biochem Mol Toxicol 2021 Sep 17:e22914. Epub 2021 Sep 17.

Department of Gastroenterology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.

Nonalcoholic fatty liver disease (NAFLD) is a prevalent liver disease with high morbidity. Omarigliptin is a novel antidiabetic drug that inhibits dipeptidyl peptidase-4 and alleviates inflammation and insulin resistance. In the present study, the anti-inflammatory and antioxidative stress property of omarigliptin will be investigated to explore the potential therapeutic effects of omarigliptin on NAFLD in mice models. Read More

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September 2021

Isorhamnetin inhibits amplification of influenza A H1N1 virus inflammation mediated by interferon via the RIG-I/JNK pathway.

Ann Transl Med 2021 Aug;9(16):1327

State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.

Background: Interferon (IFN) amplifies the influenza virus-mediated inflammatory response by forming a paracrine signal feedback loop, which is considered an important cause of excessive inflammatory damage. Isorhamnetin has a wide spectrum of beneficial pharmacological properties, including anti-inflammatory and antiviral effects. The regulatory effect and mechanism of isorhamnetin on influenza virus-mediated inflammation have not yet been reported. Read More

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Adiponectin alleviated renal cell apoptosis and inflammation via inactivation of JAK2/STAT3 signal pathway in an acute pyelonephritis mouse model.

Guoyu Dai Yao He

Ann Transl Med 2021 Aug;9(16):1311

Department of Urology, Xiangya Hospital, Central South University, Changsha, China.

Background: Acute pyelonephritis (APN), an acute and severe kidney infection, is usually treated with antibiotics. However, APN treatment has become increasingly challenging because of bacterial resistance. Adiponectin, an adipokine, has recently been reported to exhibit profound anti-inflammatory and anti-apoptotic effects. Read More

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Glucose Metabolism Reprogramming of Regulatory T Cells in Concanavalin A-Induced Hepatitis.

Front Pharmacol 2021 31;12:726128. Epub 2021 Aug 31.

Department of Gastroenterology and Hepatology, Sichuan University-University of Oxford Huaxi Joint Centre for Gastrointestinal Cancer, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu, China.

Autoimmune hepatitis (AIH) is an inflammatory liver disease caused by a dysregulated immune response. Although the pathogenesis of AIH remains unclear, impaired regulatory T cells (Tregs) have been considered a driver of AIH development. Unlike autoreactive T cells, Tregs mainly utilize oxidative phosphorylation (OXPHOS) as their energy supply. Read More

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Kakkonto Inhibits Cytokine Production Induced by Rhinovirus Infection in Primary Cultures of Human Nasal Epithelial Cells.

Front Pharmacol 2021 31;12:687818. Epub 2021 Aug 31.

Department of Education and Support for Regional Medicine, Tohoku University Hospital, Sendai, Japan.

Rhinovirus (RV) is a primary etiologic agent of common cold that can subsequently acutely exacerbate bronchial asthma or chronic obstructive pulmonary disease. Kakkonto (Ge-gen-tang in Chinese), one of the most frequently prescribed traditional Japanese (Kampo) medicines, is used for treating common cold, shoulder stiffness, or inflammatory diseases of the upper body. Previous experimental studies have indicated that kakkonto exerts antiviral and anti-inflammatory effects on the influenza virus and the human respiratory syncytial virus. Read More

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Protective effects of sunscreen (50+) and octatrienoic acid 0.1% in actinic keratosis and UV damages.

J Investig Med 2021 Sep 16. Epub 2021 Sep 16.

Human Microbiome Advanced Project, Milan, Italy.

Actinic keratosis is a form of dysplastic epidermal lesion resulting from chronic and excessive UV exposure with a certain risk of becoming cancerous. Current guidelines advocated the use of sunscreens to prevent photodamage. An efficient photoprotection must involve both primary protective factors such as UV filters and secondary factors (eg, antioxidants) able to disrupt the photochemical and genetic cascade triggered by UVs. Read More

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September 2021

Predictors for early readmission in patients hospitalized with new onset pediatric lupus nephritis.

Lupus 2021 Sep 16:9612033211044648. Epub 2021 Sep 16.

Department of Pediatrics, Division of Pediatric Rheumatology, 12239Emory University School of Medicine and Children's Healthcare of Atlanta, Atlanta, GA, USA.

Objective: The objective is to determine the 30-day hospital readmission rate following a hospitalization due to pediatric lupus nephritis of recent onset and characterize the risk factors associated with these early readmissions.

Methods: The study included 76 children hospitalized from 01/01/2008 to 4/30/2017 due to a new diagnosis of lupus nephritis. We calculated the 30-day hospital readmission rate and compared the characteristics of the patients that were readmitted to patients that were not readmitted using univariable and multivariable analysis. Read More

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September 2021

Activation of angiotensin-converting enzyme 2/angiotensin (1-7)/mas receptor axis triggers autophagy and suppresses microglia proinflammatory polarization via forkhead box class O1 signaling.

Aging Cell 2021 Sep 16:e13480. Epub 2021 Sep 16.

Institute of Clinical Pharmacy and Pharmacology, Jining First People's Hospital, Jining Medical University, Jining, China.

Brain renin-angiotensin (Ang) system (RAS) is implicated in neuroinflammation, a major characteristic of aging process. Angiotensin (Ang) II, produced by angiotensin-converting enzyme (ACE), activates immune system via angiotensin type 1 receptor (AT1), whereas Ang(1-7), generated by ACE2, binds with Mas receptor (MasR) to restrain excessive inflammatory response. Therefore, the present study aims to explore the relationship between RAS and neuroinflammation. Read More

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September 2021

A comprehensive analysis of TDO2 expression in immune cells and characterization of immune cell phenotype in TDO2 knockout mice.

Transgenic Res 2021 Sep 16. Epub 2021 Sep 16.

Institute of Clinical Pharmacology, Key Laboratory of Anti-Inflammatory and Immune Medicine, Ministry of Education, Anhui Collaborative Innovation Center of Anti-Inflammatory and Immune Medicine, Anhui Medical University, 81 Meishan Road, Hefei, 230032, China.

Tryptophan 2,3-dioxygenase (TDO2) was an initial rate-limiting enzyme of the kynurenine (Kyn) pathway in tryptophan (Trp) metabolism. We undertook this study to determine a comprehensive analysis of TDO2 expression in immune cells and assess the characterization of immune cell phenotype in TDO2 knockout mice. The expression of TDO2 in various tissues of DBA/1 mice was detected by quantitative real-time PCR (qPCR) and immunohistochemistry. Read More

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September 2021

[Pathogenesis of acute pancreatitis].

Internist (Berl) 2021 Sep 16. Epub 2021 Sep 16.

Comprehensive Cancer Center München TUM am Klinikum rechts der Isar, Technische Universität München, Ismaninger Straße 22, 81675, München, Deutschland.

Acute pancreatitis is characterized by the autodigestion of the pancreas by its own digestive enzymes. The pathophysiological onset of the disease occurs in the acinar cells. The normally inactive precursors of secreted proteases are prematurely activated and as a result digest the cells from within. Read More

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September 2021

The Programmed Cell Death Ligand-1/Programmed Cell Death-1 Pathway Mediates Pregnancy-Induced Analgesia via Regulating Spinal Inflammatory Cytokines.

Anesth Analg 2021 Sep 14. Epub 2021 Sep 14.

Department of Obstetrics, Xiangya Hospital, Central South University, Changsha, China.

Background: The maternal pain threshold gradually increases during pregnancy, especially in late pregnancy. A series of mechanisms underlying pregnancy-induced analgesia have been reported. However, these mechanisms are still not completely clear, and the underlying molecular mechanisms need further investigation. Read More

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September 2021