26 results match your criteria anti-hyperlipidemic anti-hypertensive

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Traditional Applications, Phytochemistry, and Pharmacological Activities of DC.: A Comprehensive Review.

Front Pharmacol 2020 8;8:577124. Epub 2020 Dec 8.

Department of Pharmacology, College of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou, China.

DC. (EL) has a long history of traditional use in China to cure coughs, chronic bronchitis, lobar pneumonia, and hypertension. Because of this extensive use of EL in traditional medicine, this present review gives a systematic overview of the conventional applications, phytochemistry, and pharmacological effects of the herb. Read More

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December 2020

Effects of sesamin on fatty acid and cholesterol metabolism, macrophage cholesterol homeostasis and serum lipid profile: A comprehensive review.

Eur J Pharmacol 2020 Oct 1;885:173417. Epub 2020 Aug 1.

Department of Biology, Chemistry and Environmental Sciences, College of Arts and Sciences, American University of Sharjah, Sharjah, P.O. Box 26666, United Arab Emirates.

Sesamin is the major lignan constituent derived from Sesamum indicum seeds and sesame oil. Various studies have reported that sesamin possesses potent lipid-lowering properties. The lipid-lowering effects of sesamin have been mainly attributed to its ability in affecting key events in fatty acid and cholesterol metabolism and in lowering atherogenesis-triggering LDL, VLDL and TG levels, as well as in increasing atheroprotective HDL levels. Read More

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October 2020

The Protective Effects of Myricetin against Cardiovascular Disease.

J Nutr Sci Vitaminol (Tokyo) 2019 ;65(6):470-476

Department of Pharmacy, Jinan Central Hospital Affiliated to Shandong University.

Cardiovascular disease (CVD) is the leading cause of death globally, except Africa, and poses a severe health burden worldwide. Both in vitro and in vivo studies have demonstrated the protective effects of myricetin for preventing CVD. For this review, we have assessed the literature from 2009 to 2019 at home and abroad to uncover the protective roles of myricetin for preventing CVD. Read More

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Dietary Sparassis crispa Reduces Body Fat Mass and Hepatic Lipid Levels by Enhancing Energy Expenditure and Suppressing Lipogenesis in Rats.

J Oleo Sci 2018 Sep 14;67(9):1137-1147. Epub 2018 Aug 14.

Department of Nutrition, Faculty of Nursing and Nutrition, University of Nagasaki.

Accumulation of abdominal fat triggers metabolic syndrome, which is a cluster of metabolic abnormalities, such as dyslipidemia, glucose intolerance, insulin resistance or hyperinsulinemia, and hypertension, that leads to the development of diabetes and cardiovascular disease. Mushrooms have been used as a foodstuff and folk medicine worldwide. Among these mushrooms, Sparassis crispa (SC) is a relatively newly cultivated edible and medicinal mushroom, which has been reported to have anti-diabetic and anti-hypertensive properties. Read More

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September 2018

Improvement of Anti-Hyperlipidemic Activity and Oral Bioavailability of Fluvastatin Via Solid Self-Microemulsifying Systems and Comparative with Liquisolid Formulation.

Curr Drug Deliv 2018 ;15(9):1245-1260

Department of Nanotechnology, University College of Pharmaceutical Sciences, Kakatiya University, Warangal (U), Telangana State - 506009, India.

Background: FR&D scientists continuously try to increase the in vivo performance of low soluble and bioavailable drugs. Solid SMEDDS and liquisolid formulations are relatively simple to develop and fall within the novel drug delivery approaches. Here, a comparison is made to know relative superiority. Read More

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December 2018

Ferulic Acid Supplementation Improves Lipid Profiles, Oxidative Stress, and Inflammatory Status in Hyperlipidemic Subjects: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial.

Nutrients 2018 Jun 2;10(6). Epub 2018 Jun 2.

Department of Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok 10400, Thailand.

Ferulic acid is the most abundant phenolic compound found in vegetables and cereal grains. In vitro and animal studies have shown ferulic acid has anti-hyperlipidemic, anti-oxidative, and anti-inflammatory effects. The objective of this study is to investigate the effects of ferulic acid supplementation on lipid profiles, oxidative stress, and inflammatory status in hyperlipidemia. Read More

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Cowpea: an overview on its nutritional facts and health benefits.

J Sci Food Agric 2018 Oct 30;98(13):4793-4806. Epub 2018 Jun 30.

Division of Nutritional Biochemistry, National Institute of Fundamental Studies, Kandy, Sri Lanka.

Cowpea (Vigna unguiculata) is a legume consumed as a high-quality plant protein source in many parts of the world. High protein and carbohydrate contents with a relatively low fat content and a complementary amino acid pattern to that of cereal grains make cowpea an important nutritional food in the human diet. Cowpea has gained more attention recently from consumers and researchers worldwide as a result of its exerted health beneficial properties, including anti-diabetic, anti-cancer, anti-hyperlipidemic, anti-inflammatory and anti-hypertensive properties. Read More

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October 2018

Novel RAS inhibitor 25-O-methylalisol F attenuates epithelial-to-mesenchymal transition and tubulo-interstitial fibrosis by selectively inhibiting TGF-β-mediated Smad3 phosphorylation.

Phytomedicine 2018 Mar 19;42:207-218. Epub 2018 Mar 19.

Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, School of Life Science, Northwest University, No. 229 Taibai North Road, Xi'an, Shaanxi 710069, China. Electronic address:

Background: Tubulo-interstitial fibrosis (TIF) is the common pathway in the chronic kidney disease (CKD). Epithelial-to-mesenchymal transition (EMT) is a major contributor to the TIF by the increased myofibroblasts. Renin-angiotensin system (RAS) is critical mediator on EMT in progressive CKD. Read More

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A mini review: garlic extract and vascular diseases.

Neurol Res 2018 Jun 20;40(6):421-425. Epub 2018 Mar 20.

a China-America Institute of Neuroscience, Beijing Luhe Hospital , Capital Medical University , Beijing , China.

Vascular diseases refer to medical conditions that narrow blood vessels. Narrowed cardiac or cerebral arteries can lead to myocardial infarction or ischemic stroke. Risk factors including atherosclerosis, hypertension, and diabetes may induce either cardiovascular or cerebral complications. Read More

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Phytochemistry, pharmacology, and therapeutic uses of black seed (Nigella sativa).

Chin J Nat Med 2016 Oct 31;14(10):732-745. Epub 2016 Oct 31.

Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Black seed (Nigella sativa) is an annual flowering plant from Ranunculaceae family, native to southwest Asia. This plant has many food and medicinal uses. The use of its seeds and oil is common for treatment of many diseases, including rheumatoid arthritis, asthma, inflammatory diseases, diabetes and digestive diseases. Read More

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October 2016

Overview of the preclinical pharmacological properties of Nigella sativa (black seeds): a complementary drug with historical and clinical significance.

J Physiol Pharmacol 2016 Dec;67(6):801-817

Western Michigan University Homer Stryker M.D. School of Medicine, Kalamazoo, Michigan, USA.

Nigella sativa (N. sativa, black seeds; or sometimes known by many other names such as the blessed seed by the Arabs, black cumin in the Holy Bible, black caraway and Kalonji in South Asia) has been traditionally used for many years not only as a food but also as complementary drug. It is the objective of this communication to review the evidence-based pre-clinical pharmacological actions of N. Read More

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December 2016

Regionalization of Habitat Suitability of Masson's Pine based on geographic information system and Fuzzy Matter-Element Model.

Sci Rep 2016 10 3;6:34716. Epub 2016 Oct 3.

Guangdong TCM Key Laboratory for Metabolic Diseases, Guangzhou 510006, People's Republic of China.

Pine needles have been widely used in the development of anti-hypertensive and anti-hyperlipidemic agents and health food. However, the widespread distribution of this tree poses great obstacles to the quality control and efficacy evaluation. To facilitate the effective and rational exploitation of Masson's pine (Pinus massoniana Lamb), as well as ensure effective development of Masson's pine needles as a medicinal agent, we investigated the spatial distribution of habitat suitability and evaluated the optimal ranges of ecological factors of P. Read More

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October 2016

The Health Benefits of Selected Culinary Herbs and Spices Found in the Traditional Mediterranean Diet.

Crit Rev Food Sci Nutr 2016 Dec;56(16):2728-46

a Division of Nutritional Sciences, Department of Food Science and Human Nutrition , University of Illinois Urbana-Champaign , Urbana , Illinois USA.

The Mediterranean diet is considered one of the healthiest diets in the world. This is often attributed to low saturated fat consumption, moderate wine consumption, and high vegetable consumption. However, herbs and spices associated with these diets may also play an important role in the quality of this diet. Read More

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December 2016

Anti-hyperglycemic and anti-hyperlipidemic potential of a polyherbal preparation "Diabegon" in metabolic syndrome subject with type 2 diabetes.

Afr J Tradit Complement Altern Med 2014 28;11(2):249-56. Epub 2014 Jan 28.

SOS in Biochemistry Jiwaji University, Gwalior (M.P), India.

Background: In the present study, "Diabegon" a poly-herbal preparation, with hypoglycemic activity, was evaluated for its preventive effect in metabolic syndrome subjects with type 2 diabetes and also to reveal its side effects, on liver and kidney.

Materials And Methods: Type 2 diabetic subjects with metabolic syndrome (N=58) were categorized on the basis of age and fasting blood glucose. The grouping was as follows: Group I (35-50 yrs), Group II (51-65 yrs), Group III >65 yrs, Group IV FBS<145. Read More

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Dohaekseunggi-tang extract inhibits obesity, hyperlipidemia, and hypertension in high-fat diet-induced obese mice.

BMC Complement Altern Med 2014 Oct 4;14:372. Epub 2014 Oct 4.

Herbal Medicine Resources Group, Herbal Medicine Research Division, Korea Institute of Oriental Medicine, 1672 Yuseong-daero, Yuseong-gu, Daejeon 305-811, Republic of Korea.

Background: Dohaekseunggi-tang (DHSGT) is a traditional plant-based medicine prescribed to promote blood circulation and to treat obesity and hypertension. The present study aimed to identify potential anti-obesity activities of DHSGT extract.

Methods: Anti-obesity, anti-hyperlipidemic, and anti-hypertensive effects of orally-administered DHSGT extract were evaluated in high-fat diet- (HFD)-induced obese mice. Read More

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October 2014

Impact of time to treatment intensification on glycemic goal attainment among patients with type 2 diabetes failing metformin monotherapy.

J Diabetes Complications 2014 Nov-Dec;28(6):831-5. Epub 2014 Jun 19.

Merck & Co., Inc. Whitehouse Station, NJ.

Background: Patients with type 2 diabetes on metformin monotherapy frequently require treatment intensification with another anti-hyperglycemic medication over time. Previous studies have indicated that a high proportion of patients with diabetes have a significant delay in the initiation of oral add-on therapy after metformin alone fails to achieve targeted glycemic control. In this study, we evaluated the impact of the timing of treatment intensification with oral add-on drug on glycemic goal attainment among diabetic patients failing metformin monotherapy. Read More

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Mitochondria-targeted antioxidants as a therapeutic strategy for protecting endothelium in cardiovascular diseases.

Curr Med Chem 2014 ;21(25):2989-3006

FISABIO-University Hospital Doctor Peset, Avda Gaspar Aguilar 90, 46017, Valencia, Spain.

Endothelial dysfunction involving dysfunctional mitochondria precedes the development of cardiovascular diseases. This impairment results from an increase in reactive oxygen species, which leads to oxidative stress and a reduced bioavailability of nitric oxide. It has been demonstrated that oxidative stress and alterations in glucose and lipid homeostasis (e. Read More

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September 2015

Lexical concept distribution reflects clinical practice.

AMIA Annu Symp Proc 2012 3;2012:61-6. Epub 2012 Nov 3.

Quality Performance Management, Partners HealthCare, Boston, MA, USA.

It is not known whether narrative medical text directly reflects clinical reality. We have tested the hypothesis that the pattern of distribution of lexical concept of medication intensification in narrative provider notes correlates with clinical practice as reflected in electronic medication records. Over 29,000 medication intensifications identified in narrative provider notes and 444,000 electronic medication records for 82 anti-hypertensive, anti-hyperlipidemic and anti-hyperglycemic medications were analyzed. Read More

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Review of biological and pharmacological activities of the endemic Taiwanese bitter medicinal mushroom, Antrodia camphorata (M. Zang et C. H. Su) Sh. H. Wu et al. (higher Basidiomycetes).

Int J Med Mushrooms 2012 ;14(3):241-56

Department of Biology, Hong Kong Baptist University, Kowloon, Hong Kong SAR.

Antrodia camphorata is an extremely rare fungus native to the forested regions of Taiwan. It is also a traditional Chinese medicine, and Taiwanese aborigines applied it for treating liver diseases and protecting from food and drug intoxication. Scientific studies have demonstrated that A. Read More

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December 2012

Serum paraoxonase 1 activity predicts arterial stiffness in renal transplant recipients.

J Atheroscler Thromb 2011 6;18(10):901-5. Epub 2011 Jul 6.

Ege University School of Medicine, Division of Nephrology, Izmir, Turkey.

Aim: Paraoxanase 1 (PON 1) has been shown to protect against atherosclerosis by modifying lipoproteins. Its activity decreases in dialysis patients but is restored after transplantation. Whether it affects arterial stiffness is unclear. Read More

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February 2012

cis9, trans11-Conjugated Linoleic Acid Differentiates Mouse 3T3-L1 Preadipocytes into Mature Small Adipocytes through Induction of Peroxisome Proliferator-activated Receptor γ.

J Clin Biochem Nutr 2010 Sep 20;47(2):167-73. Epub 2010 Aug 20.

Laboratory of Physiological Chemistry, Osaka University of Pharmaceutical Sciences, 4-20-1 Nasahara, Takatsuki, Osaka 569-1094, Japan.

Dietary conjugated linoleic acid (CLA) has been reported to exhibit a number of therapeutic effects in animal models and patients, such as anti-hypertensive, anti-hyperlipidemic, anti-arteriosclerotic, anti-carcinogenic, and anti-diabetic effects. However, the underlying mechanism is not well-characterized. In the present study, the effects of cis(c)9, trans(t)11-CLA on the differentiation of mouse 3T3-L1 preadipocytes into mature adipocytes were examined. Read More

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September 2010

A preliminary study on the inhibitory effect of Chunghyul-dan on stroke recurrence in patients with small vessel disease.

Neurol Res 2008 Jul 21;30(6):655-8. Epub 2008 May 21.

Department of Cardiovascular and Neurologic Diseases (Stroke Center), College of Oriental Medicine, Kyung-Hee University, Seoul, Korea.

Objective: Chunghyul-dan is a combinatorial herbal medicine, and previous works reported that it had therapeutic effects for microangiopathy, which is a major part in the progression of small vessel disease, as having anti-hypertensive, anti-hyperlipidemic, anti-apoptotic, anti-oxidative and anti-inflammatory activities. Therefore, we examined the inhibitory effect of Chunghyul-dan on stroke recurrence in patients with small vessel disease.

Methods: We prescribed Chunghyul-dan 600 mg a day to the patients with small vessel disease, and monitored stroke recurrence, drug compliances and adverse effect for 2 years. Read More

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Protective role of pravastatin in the pathogenesis of the metabolic syndrome.

Med Hypotheses 2006 19;66(3):609-11. Epub 2005 Sep 19.

Department of Medicine, Kurume University School of Medicine, 67 Asahi-machi, Kurume 830-0011, Japan.

The metabolic syndrome is strongly associated with insulin resistance and consists of a constellation of factors such as hypertension and hyperlipidemia that raise the risk for cardiovascular diseases and diabetes mellitus. There is a growing body of evidence to show that 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors, statins, reduce cardiovascular-related morbidity and mortality in patients with or without coronary artery disease. Recent clinical observations argue for a simple strategy of considering routine statin therapy for patients with type 2 diabetes. Read More

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Professional accountability for diabetes care in Taiwan.

Diabetes Res Clin Pract 2006 Feb 8;71(2):192-201. Epub 2005 Aug 8.

Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, No. 7, Chung-Shan South Road, 100 Taipei, Taiwan.

This study examined the performance of diabetes care measures in Taiwan and evaluated the influencing factors for professional accountability. We analyzed the year 2001 claims data from National Health Insurance (NHI) program in Taipei Branch. Professional accountability for diabetes care was measured by the adherence for laboratory monitor, either from patient- or hospital-viewpoint. Read More

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February 2006

A comparison of tacrolimus and cyclosporine in liver transplantation: effects on renal function and cardiovascular risk status.

Am J Transplant 2005 May;5(5):1111-9

University of Wisconsin Medical School, Madison, WI, USA.

A retrospective chart review of 1065 consecutive liver allograft recipients in 11 centers from January 1997 to September 1998 was performed. Patients were followed for 3 years or until graft loss. Patients received either tacrolimus (n = 594), cyclosporine (n = 450) or no calcineurin inhibitor (n = 21). Read More

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Cyclic nucleotides and platelet aggregation in hypertensive rats with ectopic pituitary tumor.

Artery 1980 ;6(4):290-306

The transplantable pituitary tumor MtT-F4 secretes several pituitary hormones in Fisher rats, resulting in severe cardiovascular disease with a mineralocorticoid type of hypertension and hyperlipidemia. The mineralocorticoid-dependent hypertension possesses particular characteristics in humans and animals. It was of interest to study cyclic nucleotides and platelet aggregation in the Fisher rat with an MtT-F4 tumor in order to evaluate the type of abnormalities in this form of hypertension. Read More

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September 1980
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