38,120 results match your criteria anti-cancer


Draft genome sequence of the cyanobacterium Sphaerospermopsis aphanizomenoides BCCUSP55 from the Brazilian semiarid region reveals potential for anti-cancer applications.

Arch Microbiol 2021 Dec 4;204(1). Epub 2021 Dec 4.

Department of Biological Sciences, "Luiz de Queiroz" College of Agriculture, University of São Paulo (USP), Piracicaba, SP, Brazil.

Sphaerospermopsis aphanizomenoides is a filamentous nitrogen-fixing and bloom-forming cyanobacterium, which biomass can fertilize natural water with nutrients, especially through nitrogen fixation. The Sphaerospermopsis aphanizomenoides strain BCCUSP55 was previously isolated from a water supply reservoir in the Brazilian semiarid region, and its draft genome assembly coupled with the gene contents are reported here. The obtained BCCUSP55 draft genome comprised 254 scaffolds with a genome size estimated of 6,096,273 bp. Read More

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December 2021

Chronic Stress: Impacts on Tumor Microenvironment and Implications for Anti-Cancer Treatments.

Front Cell Dev Biol 2021 19;9:777018. Epub 2021 Nov 19.

Department of Oncology, The Second Xiangya Hospital, Central South University, Changsha, China.

Chronic stress is common among cancer patients due to the psychological, operative, or pharmaceutical stressors at the time of diagnosis or during the treatment of cancers. The continuous activations of the hypothalamic-pituitary-adrenal (HPA) axis and the sympathetic nervous system (SNS), as results of chronic stress, have been demonstrated to take part in several cancer-promoting processes, such as tumorigenesis, progression, metastasis, and multi-drug resistance, by altering the tumor microenvironment (TME). Stressed TME is generally characterized by the increased proportion of cancer-promoting cells and cytokines, the reduction and malfunction of immune-supportive cells and cytokines, augmented angiogenesis, enhanced epithelial-mesenchymal transition, and damaged extracellular matrix. Read More

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November 2021

Mechanistic Insights Delineating the Role of Cholesterol in Epithelial Mesenchymal Transition and Drug Resistance in Cancer.

Front Cell Dev Biol 2021 19;9:728325. Epub 2021 Nov 19.

School of Molecular and Cell Biology, University of the Witwatersrand, Johannesburg, South Africa.

Despite the significant advancements made in targeted anti-cancer therapy, drug resistance constitutes a multifaceted phenomenon leading to therapy failure and ultimately mortality. Emerging experimental evidence highlight a role of cholesterol metabolism in facilitating drug resistance in cancer. This review aims to describe the role of cholesterol in facilitating multi-drug resistance in cancer. Read More

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November 2021

Editorial: Stimuli-Responsive Nanoparticles for Anti-cancer Therapy.

Front Bioeng Biotechnol 2021 15;9:797619. Epub 2021 Nov 15.

International Center for Materials Nanoarchitectonic, National Institute for Materials Science, Tsukuba, Japan.

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November 2021

Cancer-Immunity Cycle and Therapeutic Interventions- Opportunities for Including Pet Dogs With Cancer.

Front Oncol 2021 19;11:773420. Epub 2021 Nov 19.

Department of Veterinary Clinical Medicine, University of Illinois at Urbana-Champaign, Champaign, IL, United States.

The tumor-immune interplay represents a dynamic series of events executed by cellular and soluble participants that either promote or inhibit successful tumor formation and growth. Throughout a tumor's development and progression, the host organism's immune system reacts by generating anti-cancer defenses through various incremental and combinatorial mechanisms, and this reactive orchestration is termed the cancer-immunity cycle. Success or failure of the cancer-immunity cycle dictates the fate of both host and tumor as winner or loser. Read More

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November 2021

Management and Outcomes of Patients With Radiotherapy Interruption During the COVID-19 Pandemic.

Front Oncol 2021 19;11:754838. Epub 2021 Nov 19.

Department of Radiation Oncology, Hubei Cancer Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Purpose: This retrospective observational study examined patients who experienced radiotherapy (RT) interruption during the Wuhan lockdown for the novel coronavirus disease 2019 (COVID-19) pandemic.

Materials And Methods: The data of all patients whose RT was interrupted during the Wuhan lockdown from January 23 to April 8, 2020 were collected. Patient-, cancer-, and treatment-related characteristics were analyzed, along with interruption time, disease progression type, and survival status. Read More

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November 2021

ATG4B Inhibitor UAMC-2526 Potentiates the Chemotherapeutic Effect of Gemcitabine in a Panc02 Mouse Model of Pancreatic Ductal Adenocarcinoma.

Front Oncol 2021 18;11:750259. Epub 2021 Nov 18.

Laboratory of Physiopharmacology, University of Antwerp, Antwerp, Belgium.

Resistance against anti-cancer therapy is one of the major challenges during treatment of multiple cancers. Gemcitabine is a standard first-line chemotherapeutic drug, yet autophagy is highly activated in the hypoxic microenvironment of solid tumors and enhances the survival of tumor cells against gemcitabine chemotherapy. Recently, we showed the add-on effect of autophagy inhibitor UAMC-2526 to prevent HT-29 colorectal tumor growth in CD1 Foxn1nu mice treated with oxaliplatin. Read More

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November 2021

Antitheilerial Activity of the Anticancer Histone Deacetylase Inhibitors.

Front Microbiol 2021 18;12:759817. Epub 2021 Nov 18.

National Institute of Animal Biotechnology (NIAB), Hyderabad, India.

The apicomplexan parasite, , is the most prevalent hemoprotozoan in livestock, causing significant economic losses worldwide. It is essential to develop new and improved therapeutics, as current control measures are compromised by the development of resistance against the only available antitheilerial drug, buparvaquone (BPQ). Histone deacetylase inhibitors (HDACi) were shown to treat cancer effectively and revealed antiparasitic activity against apicomplexan parasites such as and . Read More

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November 2021

Cell-Free Supernatant of Isolated From Human Feces Exhibits Anti-colorectal Cancer Activity.

Front Microbiol 2021 11;12:736343. Epub 2021 Nov 11.

Korean Collection for Type Cultures, Biological Resource Center, Korea Research Institute of Bioscience and Biotechnology, Jeongeup, South Korea.

The gut microbiota (GM) has been shown to be closely associated with the development of colorectal cancer (CRC). However, the involvement of GM is CRC has mainly been demonstrated by metagenomic profiling studies showing the compositional difference between the GM of healthy individuals and that of CRC patients and not by directly studying isolated gut microbes. Thus, to discover novel gut microbes involved in CRC, we isolated the GM from the feces of healthy individuals and evaluated its anti-CRC activity and . Read More

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November 2021

Receptor Tyrosine Kinases and Their Signaling Pathways as Therapeutic Targets of Curcumin in Cancer.

Front Pharmacol 2021 15;12:772510. Epub 2021 Nov 15.

Jeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia, Jalan Lagoon Selatan, Bandar Sunway, Malaysia.

Receptor tyrosine kinases (RTKs) are transmembrane cell-surface proteins that act as signal transducers. They regulate essential cellular processes like proliferation, apoptosis, differentiation and metabolism. RTK alteration occurs in a broad spectrum of cancers, emphasising its crucial role in cancer progression and as a suitable therapeutic target. Read More

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November 2021

Research Progress on the Ability of Astragaloside IV to Protect the Brain Against Ischemia-Reperfusion Injury.

Front Neurosci 2021 16;15:755902. Epub 2021 Nov 16.

Department of Anesthesiology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.

Stroke, a disease with a sudden onset and high morbidity and mortality rates, is difficult to treat in the clinic. Traditional Chinese medicine has become increasingly widely used in clinical practice. Modern pharmacological studies have found that Radix Astragali has a variety of medicinal properties, i. Read More

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November 2021

Profiling Activins and Follistatin in Colorectal Cancer According to Clinical Stage, Tumour Sidedness and Smad4 Status.

Pathol Oncol Res 2021 15;27:1610032. Epub 2021 Nov 15.

Medical Oncology Department, Oncology Centre, King Abdullah Medical City, Makkah, Saudi Arabia.

This study explored the roles of activins and follistatin in colorectal cancers. Paired malignant and normal colonic tissues were collected from archived paraffin-embedded ( = 90 patients) alongside fresh ( = 40 patients) specimen cohorts. Activin β-subunits, follistatin and Smad4 mRNAs and proteins were measured by real-time PCR and immunohistochemistry (IHC). Read More

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November 2021

Application of Cyanidin-3-Glucosides as a functional food ingredient in rice-based bakery products.

Saudi J Biol Sci 2021 Dec 23;28(12):7472-7480. Epub 2021 Aug 23.

Department of Environmental Science, Bangabandhu Sheikh Mujibur Rahman Agricultural University, Gazipur 1706, Bangladesh.

Background: Black pericarp rice has recently become popular among rice consumers for its diverse health benefits specially anti-cancer effect. Cyanidin-3-Glucosides (C3G), an prominant bioactive component of anthocyanins which is abundantly present in black pericarp rice.

Objectives: We investigated, how effectively it can be used to fortify Cyanidin-3-Glucosides (C3G) content in red and white pericarp polished rice or rice based bakery products for more nutritional value. Read More

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December 2021

Cytotoxicity effect of honey, bee pollen, and propolis from seven stingless bees in some cancer cell lines.

Saudi J Biol Sci 2021 Dec 10;28(12):7182-7189. Epub 2021 Aug 10.

Department of Agro-Environmental Sciences, Faculty of Agriculture, Kyushu University, Fukuoka, Japan.

Our effort to find new material for anti cancer from natural resources leads us to focus on stingless bee products such as honey, bee pollen, and propolis. The products were from seven stingless bees named The stingless bee products were evaluated for their cytotoxicity effect on MCF-7, HeLa and Caco-2 cancer cell lines. This is the first time to be reported that the honey, ethanol extracts of bee pollen and propolis of displayed more potent cytotoxicity than other stingless bee products. Read More

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December 2021

Fustin ameliorates hyperglycemia in streptozotocin induced type-2 diabetes via modulating glutathione/Superoxide dismutase/Catalase expressions, suppress lipid peroxidation and regulates histopathological changes.

Saudi J Biol Sci 2021 Dec 2;28(12):6963-6971. Epub 2021 Aug 2.

Department of Biochemistry, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi Arabia.

Streptozotocin (STZ) 60 mg/kg, i.p.-induced diabetes in rat's results into hyperglycemia, impaired oxidative stress, lipid profile, insulin levels and changes in body weight. Read More

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December 2021

Hesperidin and its aglycone hesperetin in breast cancer therapy: A review of recent developments and future prospects.

Saudi J Biol Sci 2021 Dec 21;28(12):6730-6747. Epub 2021 Jul 21.

Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Health Sciences, Universiti Kuala Lumpur Royal College of Medicine Perak, Ipoh - 30450, Perak, Malaysia.

Breast cancer (BC) has high incidence and mortality rates, making it a major global health issue. BC treatment has been challenging due to the presence of drug resistance and the limited availability of therapeutic options for triple-negative and metastatic BC, thereby urging the exploration of more effective anti-cancer agents. Hesperidin and its aglycone hesperetin, two flavonoids from citrus species, have been extensively evaluated for their anti-cancer potentials. Read More

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December 2021

Toxicological Evaluation of a Probiotic-Based Delivery System for P8 Protein as an Anti-Colorectal Cancer Drug.

Drug Des Devel Ther 2021 27;15:4761-4793. Epub 2021 Nov 27.

R&D Center, Cell Biotech, Co., Ltd., Gimpo-si, Gyeonggi-do, Korea.

Purpose: This study aimed to toxicological evaluate a probiotics-based delivery system for p8 protein as an anti-colorectal cancer drug.

Introduction: Lactic acid bacteria (LAB) have been widely ingested for many years and are regarded as very safe. Recently, a SL4 (PP) strain that secretes the probiotic-derived anti-cancer protein P8 (PP-P8) has been developed as an anti-colorectal cancer (CRC) biologic by Cell Biotech. Read More

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November 2021

Excellent Anti-lung Cancer Activity of Populus nigra and Phylogenetic Analysis.

J Oleo Sci 2021 ;70(12):1783-1789

Department of Thoracic Surgery, Tangdu Hospital, Air Force Military University.

Lung cancer has the highest incidence rate among malignant tumors all over the world, and it is also the leading cause of death. In this present research, we aimed to evaluate the anti-cancer activity of the Populus nigra extract against the lung cancer and study the genome evolution of the Populus nigra. Firstly, the inhibitory activity of the Populus nigra extract on the NCI-H292 lung cancer cell viability was determined with Cell Counting Kit-8 (CCK-8) assay. Read More

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January 2021

Is there an optimal adjunct therapy to traditional cytotoxic induction?

Best Pract Res Clin Haematol 2021 Dec 23;34(4):101326. Epub 2021 Oct 23.

Medical College of Wisconsin, Froedtert Hospital, WI, 53266, USA. Electronic address:

The traditional cytotoxic induction regimen for acute myeloid leukemia (AML) is seven days of standard-dose cytarabine and three days of an anthracycline antibiotic (such as daunorubicin or idarubicin), commonly known as "7 + 3." Many studies have been conducted to find an additional agent that might improve efficacy. Data from select studies has shown, in certain populations, benefit to adding cladribine, clofarabine and lomustine to a traditional backbone. Read More

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December 2021

Phytochemical analysis and anticancer activity of Falcaria vulgaris Bernh growing in Moghan plain, northwest of Iran.

BMC Complement Med Ther 2021 Dec 5;21(1):294. Epub 2021 Dec 5.

Molecular Medicine Research Center, Biomedicine Institute, Tabriz University of Medical Sciences, Tabriz, Iran.

Background: Falcaria vulgaris Bernh among the most important member of Apiaceae family has been used for medical investigation in Iran and some regions in the world. This plant possesses a range of coumarin and flavonoids compounds that have many therapeutic properties such as gastrointestinal and liver diseases, skin ulcers, gastric ulcers, and intestinal inflammation. It has also been found that these compounds lead to cytotoxic effects. Read More

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December 2021

[Chinese expert consensus on diagnosis and treatment of uveal melanoma (2021)].

Authors:

Zhonghua Yan Ke Za Zhi 2021 Dec;57(12):886-897

Uveal melanoma (UM) is the most common primary intraocular malignant tumor in adults that seriously endangers the life and visual function of patients. After repeated discussions by domestic experts from the Ophthalmological Society of China Medicine Education Association, the Oculoplastic and Orbital Disease Group of Chinese Ophthalmological Society of Chinese Medical Association, and the Ocular Oncology Committee of China Anti-Cancer Association, we put forward consensus opinions on the standardization of UM diagnosis and treatment, hoping to provide references for ophthalmologists and relevant professional clinicians in their work practice, so as to improve the level of clinical diagnosis and treatment of UM. . Read More

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December 2021

Biocompatible Vibration-Actuated Omni-Droplets Rectifier with Large Volume Range Fabricated by Femtosecond Laser.

Adv Mater 2021 Dec 5:e2108567. Epub 2021 Dec 5.

Department of Mechanical Engineering, City University of Hong Kong, Hong Kong, China.

High-performance droplet transport is crucial for diverse applications such as biomedical detection, chemical micro-reaction, and droplet microfluidics. Despite extensive progresses, traditional passive strategies and active strategies are restricted to limited liquid types, small droplet volume ranges, and poor biocompatibilities. Moreover, more challenges occur for the biological fluids due to the large viscosity and low surface tension. Read More

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December 2021

Cisplatin fastens chromatin irreversibly even at a high chloride concentration.

Nucleic Acids Res 2021 Dec;49(21):12035-12047

Center for Molecular Spectroscopy and Dynamics, Institute for Basic Science, Seoul 02841, Korea.

Cisplatin is one of the most potent anti-cancer drugs developed so far. Recent studies highlighted several intriguing roles of histones in cisplatin's anti-cancer effect. Thus, the effect of nucleosome formation should be considered to give a better account of the anti-cancer effect of cisplatin. Read More

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December 2021

Complementation of fission yeast kinesin-5/Cut7 with human Eg5 provides a versatile platform for screening of anti-cancer compounds.

Biosci Biotechnol Biochem 2021 Dec 4. Epub 2021 Dec 4.

Laboratory of Molecular and Chemical Cell Biology, Graduate School of Integrated Sciences for Life, Hiroshima University, Higashi-Hiroshima 739-8530, Japan.

Kinesin-5 family proteins are essential for bipolar spindle assembly to ensure mitotic fidelity. Here we demonstrate evolutionary functional conservation of kinesin-5 between human and fission yeast. Human Eg5 expressed in the nucleus replaces fission yeast counterpart Cut7. Read More

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December 2021

Anti-cancer effects of 3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one derivatives on hepatocellular carcinoma harboring FGFR4 activation.

Neoplasia 2021 Dec 2;24(1):34-49. Epub 2021 Dec 2.

KU-KIST Graduate School of Converging Science and Technology, Korea University, 145 Anam-ro, Seongbuk-gu, Seoul, 02841, Republic of Korea; Severance Biomedical Science Institute, Graduate School of Medical Science, Brain Korea 21 Project, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Republic of Korea. Electronic address:

Hepatocellular carcinoma (HCC) is disease with a high mortality rate and limited treatment options. Alterations of fibroblast growth factor receptor 4 (FGFR4) has been regarded as an oncogenic driver for HCC and a promising target for HCC therapeutics. Herein, we report that GNF-7, a multi-targeted kinase inhibitor, and its derivatives including SIJ1263 (IC < 1 nM against FGFR4) are highly potent FGFR4 inhibitors and are capable of strongly suppressing proliferation of HCC cells and Ba/F3 cells transformed with wtFGFR4 or mtFGFR4. Read More

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December 2021

Noncovalent CDK12/13 dual inhibitors-based PROTACs degrade CDK12-Cyclin K complex and induce synthetic lethality with PARP inhibitor.

Eur J Med Chem 2021 Nov 25;228:114012. Epub 2021 Nov 25.

Institute of Pharmacology & Toxicology, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, PR China; Center for Drug Safety Evaluation and Research of ZJU, Hangzhou, 310058, PR China; Innovation Institute for Artificial Intelligence in Medicine, Zhejiang University, Hangzhou, 310016, PR China. Electronic address:

Cyclin-dependent kinase 12 (CDK12) plays a crucial role in DNA-damage response gene transcription and has recently been validated as a promising target in cancer therapy. However, existing CDK12 inhibitors potently inhibit its closest isoform CDK13, which could cause potential toxicity. Therefore, the development of CDK12 inhibitors with isoform-selectivity against CDK13 continues to be a challenge. Read More

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November 2021

Preventive effects of cristacarpin on experimentally induced uveitis by targeting NF-κB.

Biomed Pharmacother 2021 Dec 1;145:112474. Epub 2021 Dec 1.

School of Pharmacy, Sungkyunkwan University, 2066 Seobu-ro, Jangan-gu, Suwon, Gyeonggi-do 16419, South Korea. Electronic address:

Cristacarpin is a novel prenylated pterocarpan that reportedly exhibits broad anti-cancer activity by enhancing endoplasmic reticulum stress. However, whether and how cristacarpin affects in-flammatory processes remain largely unknown. In the present study, the anti-inflammatory effect of cristacarpin on lipopolysaccharide (LPS)-induced inflammation was investigated using zebrafish embryos, RAW 264. Read More

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December 2021

Oxidative stress-responsive apoptosis inducing protein (ORAIP) plays a critical role in doxorubicin-induced apoptosis in rat cardiac myocytes.

Int J Cardiol 2021 Dec 2. Epub 2021 Dec 2.

Department of Biofunctional Microbiota, Graduate School of Medicine, Juntendo University, Tokyo 113-8421, Japan. Electronic address:

Background: Oxidative stress is implicated in the pathogenesis of doxorubicin-induced apoptosis in cardiac myocytes. However, the precise mechanism remains uncertain. We identified an apoptosis-inducing humoral factor, in a conditioned medium from cardiac myocytes subjected to hypoxia/reoxygenation, to be 69th tyrosine-sulfated eukaryotic translation initiation factor 5A (eIF5A). Read More

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December 2021

Drugs repurposed: An advanced step towards the treatment of breast cancer and associated challenges.

Biomed Pharmacother 2021 Dec 1:112375. Epub 2021 Dec 1.

Pharmacology and Toxicology Department, College of Pharmacy, University of Hail, Hail, Saudi Arabia. Electronic address:

Breast cancer (BC) is mostly observed in women and is responsible for huge mortality in women subjects globally. Due to the continued development of drug resistance and other contributing factors, the scientific community needs to look for new alternatives, and drug repurposing is one of the best opportunities. Here we light upon the drug repurposing with a major focus on breast cancer. Read More

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December 2021