207 results match your criteria anth


YPIBP: A repository for phosphoinositide-binding proteins in yeast.

Comput Struct Biotechnol J 2021 24;19:3692-3707. Epub 2021 Jun 24.

Department of Electrical Engineering, College of Electrical Engineering and Computer Science, National Cheng Kung University, Tainan 701, Taiwan.

Phosphoinositides (PIs) are a family of eight lipids consisting of phosphatidylinositol (PtdIns) and its seven phosphorylated forms. PIs have important regulatory functions in the cell including lipid signaling, protein transport, and membrane trafficking. Yeast has been recognized as a eukaryotic model system to study lipid-protein interactions. Read More

View Article and Full-Text PDF

CALM supports clathrin-coated vesicle completion upon membrane tension increase.

Proc Natl Acad Sci U S A 2021 Jun;118(25)

College of Pharmacy, The Ohio State University, Columbus, OH 43210;

The most represented components of clathrin-coated vesicles (CCVs) are clathrin triskelia and the adaptors clathrin assembly lymphoid myeloid leukemia protein (CALM) and the heterotetrameric complex AP2. Investigation of the dynamics of AP180-amino-terminal-homology (ANTH) recruitment during CCV formation has been hampered by CALM toxicity upon overexpression. We used knock-in gene editing to express a C-terminal-attached fluorescent version of CALM, while preserving its endogenous expression levels, and cutting-edge live-cell microscopy approaches to study CALM recruitment at forming CCVs. Read More

View Article and Full-Text PDF

Structure of the endocytic adaptor complex reveals the basis for efficient membrane anchoring during clathrin-mediated endocytosis.

Nat Commun 2021 05 17;12(1):2889. Epub 2021 May 17.

European Molecular Biology Laboratory, Hamburg Outstation, Hamburg, Germany.

During clathrin-mediated endocytosis, a complex and dynamic network of protein-membrane interactions cooperate to achieve membrane invagination. Throughout this process in yeast, endocytic coat adaptors, Sla2 and Ent1, must remain attached to the plasma membrane to transmit force from the actin cytoskeleton required for successful membrane invagination. Here, we present a cryo-EM structure of a 16-mer complex of the ANTH and ENTH membrane-binding domains from Sla2 and Ent1 bound to PIP that constitutes the anchor to the plasma membrane. Read More

View Article and Full-Text PDF

Early Life Stress and the Fate of Kynurenine Pathway Metabolites.

Front Hum Neurosci 2021 29;15:636144. Epub 2021 Apr 29.

Contemporary Care, Danbury, CT, United States.

Early life stress (ELS) precedes alterations to neuro-immune activation, which may mediate an increased risk for stress-related psychiatric disorders, potentially through alterations of central kynurenine pathway (KP) metabolites, the latter being relatively unexplored. We hypothesized that ELS in a non-human primate model would lead to a reduction of neuroprotective and increases of neurotoxic KP metabolites. Twelve adult female bonnet macaques reared under conditions of maternal variable foraging demand (VFD) were compared to 27 age- and weight-matched non-VFD-exposed female controls. Read More

View Article and Full-Text PDF

Design and fabrication of green and sustainable vapochromic cellulose fibers embedded with natural anthocyanin for detection of toxic ammonia.

Talanta 2021 Aug 17;230:122292. Epub 2021 Mar 17.

Department of Chemistry, College of Science, King Saud University, Riyadh, 11451, Saudi Arabia.

Exposure to colorless ammonia gas may lead to damage in human organs or even death. Herein, we describe facile fabrication of an environmentally-friendly, portable, reversible, and sensitive solid-state colorimetric cellulose (Cell)/anthocyanin (Anth) vapochromic sensor that exhibits instant visual color change to both gaseous and aqueous phases of ammonia. The naturally occurring anthocyanin can be easily extracted from the red-cabbage plant and applied as a direct dyestuff onto viscose fibers in the presence of potassium aluminum sulfate as mordant to generate nanoparticles of mordant/anthocyanin coordinated complex. Read More

View Article and Full-Text PDF

Global Identification of Genes Involved in Rice Pollen Germination and Functional Characterization of a Key Member, OsANTH3.

Front Plant Sci 2021 13;12:609473. Epub 2021 Apr 13.

Department of Life Science and Environmental Biochemistry, Life and Industry Convergence Research Institute, Pusan National University, Miryang, South Korea.

Pollen in angiosperms plays a critical role in double fertilization by germinating and elongating pollen tubes rapidly in one direction to deliver sperm. In this process, the secretory vesicles deliver cell wall and plasma membrane materials, and excessive materials are sequestered via endocytosis. However, endocytosis in plants is poorly understood. Read More

View Article and Full-Text PDF

[Effects of potassium-solubilizing bacteria promoting the growth of seedlings under salt stress.]

Ying Yong Sheng Tai Xue Bao 2021 Apr;32(4):1289-1297

College of Biological Science and Engineering, North Minzu University, Yinchuan 750021, China.

We investigated the effects of potassium-releasing bacteria on physiological and bioche-mical characteristics of (Cultivar Ningqi 1) under salt stress, with an experiment with treatments following randomized block design. The treatments included control (CK), 100 mmol·L NaCl stress (NaCl), 100 mmol·LNaCl stress+KSBGY01 bacteria (NaCl-M1), 100 mmol·LNaCl stress+KSBGY02 bacteria (NaCl-M2), and 100 mmol·LNaCl stress+KSBGY01+KSBGY02 (NaCl-M3). We measued chlorophyll content, polyphenol content, superoxide anion (O) content, hydrogen peroxide (HO) content, soluble sugar content, antioxidant enzyme activity and sucrose metabolic enzyme activity of seedlings. Read More

View Article and Full-Text PDF

Effect of Cellulose Nanocrystal Addition on the Physicochemical Properties of Hydroxypropyl Guar-Based Intelligent Films.

Membranes (Basel) 2021 Mar 29;11(4). Epub 2021 Mar 29.

Key Laboratory of Biobased Material and Green Papermaking, Qilu University of Technology, Jinan 250353, China.

As an important functional material in food industry, intelligent packaging films can bring great convenience for consumers in the field of food preservation and freshness detection. Herein, we fabricated pH-sensing films employing hydroxypropyl guar (HPG), 1-butyl-3-methylimidazolium chloride (BmimCl), and anthocyanin (Anth). Besides, the effects of adding cellulose nanocrystals (CNC) into the composite films upon the films' structures and physicochemical properties are elucidated. Read More

View Article and Full-Text PDF

Association of spectroscopically determined leaf nutrition related traits and breeding selection in Sassafras tzumu.

Plant Methods 2021 Mar 31;17(1):33. Epub 2021 Mar 31.

Research Institute of Subtropical Forestry, Chinese Academy of Forestry, Fuyang, 311400, Zhejiang, China.

Background: Plant traits related to nutrition have an influential role in tree growth, tree production and nutrient cycling. Therefore, the breeding program should consider the genetics of the traits. However, the measurement methods could seriously affect the progress of breeding selection program. Read More

View Article and Full-Text PDF

Safety culture implications on safe work practices and work place exposure incidents in Operation Theater.

Pak J Med Sci 2021 Mar-Apr;37(2):379-383

Dr. Murtaza Ahmad, MBBS, Resident Surgery, Sir Ganga Ram Hospital, Lahore, Pakistan.

Background & Objectives: The study was undertaken to estimate the prevalence of body and blood fluid exposure incidents such as needle stick injuries, direct contact, splashes, and cuts among health care personnel (HCP) in operation theaters (OTs). The study objective was to investigate perception of safety culture and potential challenges faced by HCP in Pakistani context.

Methods: An analytical cross-sectional survey was conducted in four tertiary care hospitals of Rawalpindi and Islamabad that were Akbar Niazi Teaching Hospital (ANTH), Fauji Foundation Hospital (FFH), Benazir Bhutto Hospital (BBH) and Holy Family Hospital (HFH) during March, 2019 to June, 2019. Read More

View Article and Full-Text PDF

Tuning p-Si(111) Photovoltage via Molecule|Semiconductor Electronic Coupling.

J Am Chem Soc 2021 Feb 3;143(6):2567-2580. Epub 2021 Feb 3.

Department of Chemistry, The University of Texas at Austin, Austin, Texas 78712, United States.

Photoelectrochemical (PEC) device efficiency depends heavily on the energetics and band alignment of the semiconductor|overlayer junction. Exerting energetic control over these junctions via molecular functionalization is an extremely attractive strategy. Herein we report a study of the structure-function relationship between chemically functionalized pSi(111) and the resulting solar fuels performance. Read More

View Article and Full-Text PDF
February 2021

Improving characteristic band selection in leaf biochemical property estimation considering interrelations among biochemical parameters based on the PROSPECT-D model.

Opt Express 2021 Jan;29(1):400-414

At present, many studies have mainly focused on analyzing the sensitivity and correlation to select characteristic bands. However, the interrelations between biochemical parameters were ignored, which may significantly influence the accuracy of biochemical concentration retrieval. The study aims to propose a new band selection method and to focus on the improving magnitude of characteristic band combination in leaf trait estimation when taking interrelations among different traits into consideration. Read More

View Article and Full-Text PDF
January 2021

Archaeological Central American maize genomes suggest ancient gene flow from South America.

Proc Natl Acad Sci U S A 2020 12 14;117(52):33124-33129. Epub 2020 Dec 14.

Department of Anthropology, University of California, Santa Barbara, CA 93106;

Maize ( ssp. ) domestication began in southwestern Mexico ∼9,000 calendar years before present (cal. BP) and humans dispersed this important grain to South America by at least 7,000 cal. Read More

View Article and Full-Text PDF
December 2020

9,10-Anthraquinones Disubstituted with Linear Alkoxy Groups: Spectroscopy, Electrochemistry, and Peculiarities of Their 2D and 3D Supramolecular Organizations.

Langmuir 2020 Dec 3;36(49):15048-15063. Epub 2020 Dec 3.

Institute of Physical Chemistry, Polish Academy of Sciences, Kasprzaka 44/52, 01-224 Warszawa, Poland.

Spectroscopic, electrochemical, and structural properties of 2,6-dialkoxy-9,10-anthraquinones (Anth-OC, = 4, 6, 8, 10, and 12) of increasing alkoxy substituents length were investigated. UV-vis spectroscopy showed a substitution-induced bathochromic shift of the least energetic band from 325 nm in the case of unsubstituted anthraquinone to ca. 350 nm for the studied derivatives. Read More

View Article and Full-Text PDF
December 2020

Further insights from structural mass spectrometry into endocytosis adaptor protein assemblies.

Int J Mass Spectrom 2020 Jan 18;447:116240. Epub 2019 Oct 18.

Heinrich Pette Institute, Leibniz Institute for Experimental Virology, Martinistrasse 52, 20251, Hamburg, Germany.

As a fundament in many biologically relevant processes, endocytosis in its different guises has been arousing interest for decades and still does so. This is true for the actual transport and its initiation alike. In clathrin-mediated endocytosis, a comparatively well understood endocytic pathway, a set of adaptor proteins bind specific lipids in the plasma membrane, subsequently assemble and thus form a crucial bridge from clathrin to actin for the ongoing process. Read More

View Article and Full-Text PDF
January 2020

Rapidly declining body temperature in a tropical human population.

Sci Adv 2020 Oct 28;6(44). Epub 2020 Oct 28.

School of Human Evolution and Social Change, Center for Evolution and Medicine, Arizona State University, Tempe, AZ, USA.

Normal human body temperature (BT) has long been considered to be 37.0°C. Yet, BTs have declined over the past two centuries in the United States, coinciding with reductions in infection and increasing life expectancy. Read More

View Article and Full-Text PDF
October 2020

Longin R-SNARE is retrieved from the plasma membrane by ANTH domain-containing proteins in .

Proc Natl Acad Sci U S A 2020 10 23;117(40):25150-25158. Epub 2020 Sep 23.

Division of Cellular Dynamics, National Institute for Basic Biology, 444-8585 Okazaki, Japan;

The plasma membrane (PM) acts as the interface between intra- and extracellular environments and exhibits a tightly regulated molecular composition. The composition and amount of PM proteins are regulated by balancing endocytic and exocytic trafficking in a cargo-specific manner, according to the demands of specific cellular states and developmental processes. In plant cells, retrieval of membrane proteins from the PM depends largely on clathrin-mediated endocytosis (CME). Read More

View Article and Full-Text PDF
October 2020

Whole Blueberry and Isolated Polyphenol-Rich Fractions Modulate Specific Gut Microbes in an In Vitro Colon Model and in a Pilot Study in Human Consumers.

Nutrients 2020 Sep 12;12(9). Epub 2020 Sep 12.

School of Microbiology, University College Cork, T12 K8AF Cork, Ireland.

Blueberry (BB) consumption is linked to improved health. The bioconversion of the polyphenolic content of BB by fermentative bacteria in the large intestine may be a necessary step for the health benefits attributed to BB consumption. The identification of specific gut microbiota taxa that respond to BB consumption and that mediate the bioconversion of consumed polyphenolic compounds into bioactive forms is required to improve our understanding of how polyphenols impact human health. Read More

View Article and Full-Text PDF
September 2020

Assessment of hyperspectral indicators related to the content of phenolic compounds and multispectral fluorescence records in chicory leaves exposed to various light environments.

Plant Physiol Biochem 2020 Sep 4;154:429-438. Epub 2020 Jul 4.

Department of Plant Physiology, Slovak University of Agriculture, Nitra, A. Hlinku 2, 94976, Nitra, Slovak Republic.

Hyperspectral analysis represents a powerful technique for diagnostics of morphological and chemical information from aboveground parts of the plants, but the real potential of the method in pre-screening of phenolics in leaves is still insufficiently explored. In this study, assessment of the sensitivity and reliability of non-invasive methods of various phenolic compounds, also analyzed by HPLC in chicory plants (Cichorium intybus L.) exposed to various color light pretreatments was done. Read More

View Article and Full-Text PDF
September 2020

Anthracene-Tagged UiO-67-MOF as Highly Selective Aqueous Sensor for Nanoscale Detection of Arginine Amino Acid.

Inorg Chem 2020 Sep 1;59(18):13091-13097. Epub 2020 Sep 1.

Department of Inorganic Chemistry and Catalysis, Shahid Beheshti University, General Campus, Evin, Tehran 1983963113, Iran.

In the present paper, new functionalized UiO-67 metal-organic frameworks (MOF) which contain aromatic tagged groups such as phenyl, naphthyl, and anthracene have been synthesized, characterized, and used for sensing water-soluble amino acids. The results show that anthracene-tagged UiO-67-MOF is shown to act as a highly efficient and selective aqueous sensor for arginine over other water-soluble amino acids in nanoscale. Upon adding an increasing amount of arginine, PL bands of the anth-UiO-67 MOF quenched completely, while there is no perturbation in the PL bands for other amino acid observed. Read More

View Article and Full-Text PDF
September 2020

Huntingtin-interacting protein family members have a conserved pro-viral function from to humans.

Proc Natl Acad Sci U S A 2020 09 24;117(36):22462-22472. Epub 2020 Aug 24.

Department of Molecular Microbiology, School of Medicine, Washington University in St. Louis, St. Louis, MO 63110;

Huntingtin-interacting protein family members are evolutionarily conserved from yeast to humans, and they are known to be key factors in clathrin-mediated endocytosis. Here we identified the protein huntingtin-interacting protein-related 1 (HIPR-1) as a host factor essential for Orsay virus infection of Ablation of HIPR-1 resulted in a greater than 10,000-fold reduction in viral RNA, which could be rescued by ectopic expression of HIPR-1. Viral RNA replication from an endogenous transgene replicon system was not affected by lack of HIPR-1, suggesting that HIPR-1 plays a role during an early, prereplication virus life-cycle stage. Read More

View Article and Full-Text PDF
September 2020

HaploGrouper: a generalized approach to haplogroup classification.

Bioinformatics 2021 05;37(4):570-572

deCODE Genetics/Amgen, Reykjavik 101, Iceland.

Motivation: We introduce HaploGrouper, a versatile software to classify haplotypes into haplogroups on the basis of a known phylogenetic tree. A typical use case for this software is the assignment of haplogroups to human mitochondrial DNA (mtDNA) or Y-chromosome haplotypes. Existing state-of-the-art haplogroup-calling software is typically hard-wired to work only with either mtDNA or Y-chromosome haplotypes from humans. Read More

View Article and Full-Text PDF

Placental levels of polycyclic aromatic hydrocarbons (PAHs) and their association with birth weight of infants.

Drug Chem Toxicol 2020 Jun 29:1-10. Epub 2020 Jun 29.

Department of Chemistry, Dr. B. R. Ambedkar University, Agra, India.

As an alarming group of pollutants, polycyclic aromatic hydrocarbons (PAHs) gather much public health concern not only because of their carcinogenic or co-carcinogenic risk but also by interfering with hormone systems or by causing oxidative damage, henceforth liable to toxic actions on reproduction. Accordingly, the present study was aimed to explore the association between exposure to PAHs by evaluating their placental levels and infant birth weight among 110 healthy and nonsmoking pregnant women. Placental tissue samples were collected instantly after delivery and were analyzed for the presence of sixteen Environmental Protection Agency (EPA) listed PAHs with the help of Gas chromatography equipped with flame ionization detector (GC-FID). Read More

View Article and Full-Text PDF

Voluntary collective isolation as a best response to COVID-19 for indigenous populations? A case study and protocol from the Bolivian Amazon.

Lancet 2020 05 15;395(10238):1727-1734. Epub 2020 May 15.

Tsimane Health and Life History Project, San Borja, Bolivia; Department of Anthropology, University of California, Santa Barbara CA, USA. Electronic address:

Indigenous communities worldwide share common features that make them especially vulnerable to the complications of and mortality from COVID-19. They also possess resilient attributes that can be leveraged to promote prevention efforts. How can indigenous communities best mitigate potential devastating effects of COVID-19? In Bolivia, where nearly half of all citizens claim indigenous origins, no specific guidelines have been outlined for indigenous communities inhabiting native communal territories. Read More

View Article and Full-Text PDF

Lipid-protein interactions for ECA1 an N-ANTH domain protein involved in stress signaling in plants.

Chem Phys Lipids 2020 09 13;231:104919. Epub 2020 May 13.

Biological Sciences, Kent State University, PO Box 5109, 44242 Kent, OH, USA. Electronic address:

Epsin-like Clathrin Adaptor 1 (ECA1/ PICALM1A) is an A/ENTH domain protein that acts as an adaptor protein in clathrin-mediated endocytosis. ECA1 is recruited to the membrane during salt stress signaling in plants in a phosphatidic acid (PA)-dependent manner. PA is a lipid second messenger that rapidly and transiently increases in concentration under stress stimuli. Read More

View Article and Full-Text PDF
September 2020

Reduced Arene Complexes of Scandium.

Chemistry 2020 Aug 13;26(45):10290-10296. Epub 2020 Jul 13.

Institute of Inorganic Chemistry, RWTH Aachen University, Landoltweg 1, 52056, Aachen, Germany.

Alkali metal naphthalenide or anthracenide reacted with scandium(III) anilides [Sc(X){N(tBu)Xy} (thf)] (X=N(tBu)Xy (1); X=Cl (2); Xy=C H -3,5-Me ) to give scandium complexes [M(thf) ][Sc{N(tBu)Xy} (RA)] (M=Li-K; n=1-6; RA=C H (3-Naph-K) and C H (3-Anth-M)) containing a reduced arene ligand. Single-crystal X-ray diffraction revealed the scandium(III) center bonded to the naphthalene dianion in a σ :π-coordination mode, whereas the anthracene dianion is symmetrically attached to the scandium(III) center in a σ -fashion. All compounds have been characterized by multinuclear, including Sc NMR spectroscopy. Read More

View Article and Full-Text PDF

Synthetic routes to nanoconjugates of anthracyclines.

Bioorg Chem 2020 03 25;96:103617. Epub 2020 Jan 25.

Centre of Molecular and Macromolecular Studies, Polish Academy of Sciences, Sienkiewicza 112, 90-363 Lodz, Poland. Electronic address:

Anthracyclines (Anth) are widely used in the treatment of various types of cancer. Unfortunately, they exhibit serious adverse effects, such as hematopoietic depression and cardiotoxicity, leading to heart failure. In this review, we focus on recently developed conjugates of anthracyclines with a range of nanocarriers, such as polymers, peptides, DNA or inorganic systems. Read More

View Article and Full-Text PDF

Chemical characterization of fine aerosols in respect to water-soluble ions at the eastern Middle Adriatic coast.

Environ Sci Pollut Res Int 2020 Apr 13;27(10):10249-10264. Epub 2020 Jan 13.

Division for Marine and Environmental Research, Ruđer Bošković Institute, Zagreb, Croatia.

Fine particulate matter (PM) concentrations at the Middle Adriatic coastal site of Croatia were affected by different air-mass inflows and/or local sources and meteorological conditions, and peaked in summer. More polluted continental air-mass inflows mostly affected the area in the winter period, while southern marine pathways had higher impact in spring and summer. Chemical characterization of the water-soluble inorganic and organic ionic constituents is discussed with respect to seasonal trends, possible sources, and air-mass inputs. Read More

View Article and Full-Text PDF

Protein Amphipathic Helix Insertion: A Mechanism to Induce Membrane Fission.

Front Cell Dev Biol 2019 10;7:291. Epub 2019 Dec 10.

Institute of Biochemistry and Cell Biology, National Research Council, Naples, Italy.

One of the fundamental features of biomembranes is the ability to fuse or to separate. These processes called respectively membrane fusion and fission are central in the homeostasis of events such as those related to intracellular membrane traffic. Proteins that contain amphipathic helices (AHs) were suggested to mediate membrane fission via shallow insertion of these helices into the lipid bilayer. Read More

View Article and Full-Text PDF
December 2019