18,652 results match your criteria anterior uveitis

Clinical benefits and potential risks of adalimumab in non-JIA chronic paediatric uveitis.

Acta Ophthalmol 2021 Sep 16. Epub 2021 Sep 16.

Department of Ophthalmology, University Medical Centre Utrecht, Utrecht, The Netherlands.

Purpose: To describe the treatment results with adalimumab in chronic paediatric uveitis, not associated with juvenile idiopathic arthritis (JIA).

Methods: Medical records of children with non-JIA-uveitis were reviewed retrospectively. Children without an underlying systemic disease were pre-screened with brain magnetic resonance imaging (MRI) to exclude white matter abnormalities/demyelination. Read More

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September 2021

Acute retinal necrosis caused by co-infection with multiple viruses in a natalizumab-treated patient: a case report and brief review of literature.

BMC Ophthalmol 2021 Sep 16;21(1):337. Epub 2021 Sep 16.

Imam Hossein Medical Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Background: Acute retinal necrosis is considered a rare infectious uveitis. This condition is usually caused by varicella-zoster virus or herpes simplex virus. Acute retinal necrosis caused by co-infection with multiple viruses is extremely rare. Read More

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September 2021

Reactive arthritis: a clinical review.

J R Coll Physicians Edinb 2021 Sep;51(3):288-297

Department of Rheumatology, University Hospitals of Leicester NHS Trust, Leicester; College of Life Sciences, University of Leicester, Leicester.

Reactive arthritis (ReA) is a form of inflammatory arthritis triggered by a remote antecedent infection, usually in the genitourinary or gastrointestinal tract. It is part of the spondyloarthropathy (SpA) spectrum, an umbrella term for a group of distinct conditions with shared clinical features. Typically, it presents with an asymmetric oligoarthritis of the lower limb joints, and patients may also have sacroiliitis, enthesitis and dactylitis. Read More

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September 2021

Diagnosis and treatment of uveitis associated with juvenile idiopathic arthritis.

Med Pharm Rep 2021 Aug 10;94(Suppl No 1):S28-S32. Epub 2021 Aug 10.

Department of Pediatrics Clinic I, Emergency Clinical Hospital for Children, Cluj-Napoca, Romania.

Juvenile idiopathic arthritis (JIA) is the most common rheumatic disease in pediatric population, with uveitis as the most common and severe extra-articular manifestation. Eye damage (bilateral in 70-80% of cases) is usually anterior, chronic and asymptomatic. Young age, female gender, oligoarticular form and ANA positivity are risk factors for chronic anterior uveitis (CAU). Read More

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Biological Therapy in Noninfectious Pediatric Uveitis: A Systematic Review.

Clin Ophthalmol 2021 7;15:3765-3776. Epub 2021 Sep 7.

Department of Surgical Specialties and Anesthesiology (Ophthalmology Division), Botucatu Medical School, São Paulo State University (UNESP), Botucatu, São Paulo, Brazil.

Purpose: Noninfectious pediatric uveitis is a potentially blinding disease often associated with systemic conditions. In cases of chronic anterior uveitis without adequate response to steroids and immunosuppressants, biological response modifiers would be viable therapeutic options. Still, evidence is lacking on the safety of the long-term use of these drugs in children. Read More

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September 2021

Using hierarchical similarity to examine the genetics of Behçet's disease.

BMC Res Notes 2021 Sep 10;14(1):353. Epub 2021 Sep 10.

Department of Computer Science, Baylor University, One Bear Place, Waco, TX, USA.

Objective: Behçet's disease (BD) is a multisystem inflammatory disease that affects patients along the historic silk road. Thus far, the pathogenesis of the disease has proved elusive due to the complex genetic interactions of the disease. In this paper, we seek to clarify the genetic factors of the disease while also uncovering other diseases of interest that present with a similar genotype as BD. Read More

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September 2021


Cesk Slov Oftalmol 2021 ;77(4):163-168

Immune mediated inflammatory diseases are categorized into autoimmune and autoinflammatory. Autoimmune etiology is represented by autoreactive lymphocytes or autoantibodies, e.g. Read More

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September 2021

Intravitreal lupeol: A new potential therapeutic strategy for noninfectious uveitis.

Biomed Pharmacother 2021 Sep 7;143:112145. Epub 2021 Sep 7.

Department of Pharmaceutical Products, Faculty of Pharmacy, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil. Electronic address:

Lupeol is a pentacyclic triterpene with known anti-inflammatory effects. However, its role in the treatment of noninfectious uveitis has not been explored. This work investigated anti-inflammatory activity of lupeol in ocular tissues with in vitro and in vivo models. Read More

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September 2021

Oral mucous membrane grafting for unilateral lid margin keratinization following radiotherapy.

Orbit 2021 Sep 6:1-4. Epub 2021 Sep 6.

Department of Vitreo-Retina & Uveitis, Eye Life, Mumbai, India.

We describe the outcomes of oral mucous membrane grafting as a surgical technique for unilateral lid margin keratinization following radiotherapy. A 47-year- old woman presented with an 8-month history of a white spot in her right eye. She had a history of adenoid cystic carcinoma of the right spheno-ethmoid sinus, for which she underwent radiotherapy. Read More

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September 2021

Increased serum level of interleukin-33 in Vogt-Koyanagi-Harada correlates with disease activity.

Clin Immunol 2021 Aug 31;231:108846. Epub 2021 Aug 31.

Department of Ophthalmology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China; Key Laboratory of Ocular Fundus Diseases, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China. Electronic address:

Objectives: To measure the serum level of IL-33 in patients with Vogt-Koyanagi-Harada disease (VKH) and Behçet's uveitis (BU) in the Chinese Han population and investigate its associations with disease activity and clinical parameters.

Methods: Serum was collected from 41 VKH patients (16 active and 25 inactive patients), 60 BU patients (24 active and 36 inactive patients), and 36 healthy controls. The serum level of IL-33 was measured using the enzyme-linked immunosorbent assay (ELISA) method. Read More

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Cytokine profile and cytoskeletal changes after herpes simplex virus type 1 infection in human trabecular meshwork cells.

J Cell Mol Med 2021 Sep 1. Epub 2021 Sep 1.

Department of Microbiology, College of Medicine, The Catholic University of Korea, Seoul, Korea.

Uveitis caused by herpes simplex virus (HSV)-1 is characterized by increased intraocular pressure (IOP) in the presence of anterior chamber inflammation. Despite their clinical significance, the pathogenic changes associated with HSV-1 infection in trabecular meshwork (TM) cells, the key cell type regulating IOP, have not been completely elucidated. In this study, cytokine array analyses showed a significant stepwise increase in monocyte chemoattractant protein (MCP)-1 expression upon HSV-1 infection in TM cells (p < 0. Read More

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September 2021

Ocular Syphilis Presenting As Non-arteritic Anterior Ischemic Optic Neuropathy.

Cureus 2021 Jul 28;13(7):e16694. Epub 2021 Jul 28.

Department of Medicine, Faculty of Medicine, Imam Mohammed Ibn Saud Islamic University, Riyadh, SAU.

Syphilis is a sexually transmitted disease caused by the spirochetal bacteria . It can cross the blood-brain barrier within days of the infection, causing neurosyphilis and ocular syphilis at any stage of the disease. Ocular syphilis can manifest in any part of the eye but usually as posterior uveitis and pan-uveitis or various types of inflammatory or immune-mediated optic neuritis. Read More

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Unilateral Retinal Arteritis and Macroaneurysm in Sarcoidosis.

Ocul Immunol Inflamm 2021 Aug 31:1-5. Epub 2021 Aug 31.

The Retina Service of Wills Eye Hospital, Mid Atlantic Retina, Philadelphia, Pennsylvania, USA.

Sarcoidosis, an idiopathic systemic disorder characterized by noncaseating granulomas, is often associated with granulomatous uveitis. Anterior segment involvement can present with mutton-fat keratic precipitates, anterior chamber cell, and iris nodules. Sarcoid associated posterior uveitis may present with vitritis, retinal vasculitis, and choroidal lesions. Read More

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Epidemiology and treatment of Behçet's disease in the USA: insights from the Rheumatology Informatics System for Effectiveness (RISE) Registry with a comparison with other published cohorts from endemic regions.

Arthritis Res Ther 2021 08 30;23(1):224. Epub 2021 Aug 30.

Division of Rheumatology, Department of Medicine, University of California San Francisco, San Francisco, CA, USA.

Background: Behçet's disease (BD), a chronic systemic vasculitis, has distinct geographical and ethnic variation. Data regarding the epidemiology of patients with BD in the U.S. Read More

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[Development of classification criteria for uveitis by the standardization of uveitis nomenclature (SUN) working group].

Ophthalmologe 2021 Sep 30;118(9):913-918. Epub 2021 Aug 30.

Berliner Institut für Gesundheitsforschung in der Charité (BIH), Campus Virchow Klinikum, Augenklinik, Charité - Universitätsmedizin Berlin, Gliedkörperschaft der Freien Universität Berlin und der Humboldt-Universität zu Berlin, Augustenburger Platz 1, 13353, Berlin, Deutschland.

Background: The standardization of uveitis nomenclature (SUN) working group is an international expert committee, which follows the aim to develop a standardized and internationally recognized terminology for the field of uveitis. This appears to be important in view of the demand for evidence-based medicine, especially for relatively rare diseases such as uveitis.

Methods: A databank of > 4000 uveitis patients was compiled using formal consensus techniques, for whom a majority consensus was previously achieved in the diagnosis. Read More

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September 2021

Role of Adalimumab Biosimilar in the Treatment of Non-Anterior Uveitis Associated with Behçet's Syndrome.

Ophthalmol Ther 2021 Aug 30. Epub 2021 Aug 30.

Ophthalmology Unit, Department of Medicine, Surgery and Neuroscience, University of Siena, Siena, Italy.

Introduction: To evaluate the efficacy of SB5, an adalimumab biosimilar, in the management of Behçet's syndrome (BS)-related uveitis.

Methods: Data from eight BS patients (16 eyes) with active non-anterior uveitis and/or systemic uncontrolled disease or performing non-medical switch to SB5 were retrospectively collected and analyzed.

Results: Complete control of uveitis was observed in all 16 eyes without relapses during follow-up. Read More

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Fluorescein angiographic findings and Behcet's disease ocular attack score 24 (BOS24) as prognostic factors for visual outcome in patients with ocular Behcet's disease.

Int J Retina Vitreous 2021 Aug 28;7(1):48. Epub 2021 Aug 28.

Oculoplastic and Reconstructive Surgery Division, Department of Ophthalmology, Phramongkutklao Hospital, 315 Rajawithi Rd, Thung Phayathai, Ratchathewi, Bangkok, 10400, Thailand.

Purpose: To determine the application of fluorescein angiographic (FA) findings and Behcet's disease ocular attack score 24 (BOS24) scoring system in predicting poor visual outcome in patients with ocular Behcet's disease.

Study Design: Retrospective cohort study.

Methods: We included 73 eyes of 38 patients with ocular Behcet's disease who underwent FA and reviewed FA images, anterior chamber cells, vitreous opacity, retinal and optic disc lesions, which are parameters in BOS24. Read More

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Tick-borne encephalitis related uveitis: a case report.

BMC Ophthalmol 2021 Aug 28;21(1):315. Epub 2021 Aug 28.

Department of Ophthalmology, University of Lausanne, Jules-Gonin Eye Hospital, Fondation Asile des Aveugles, avenue de France 15, 1002, Lausanne, Switzerland.

Background: Tick-borne encephalitis (TBE) is an infectious disease of the central nervous system caused by the TBE virus (TBEV), which is usually transmitted by a tick-bite, with increasing incidence in northeastern Europe and eastern Asia during the past decade. Ocular involvement has not been described in the literature to date.

Case Presentation: A 58-year-old patient presented to the emergency department with occipital headaches and poor balance for 5 days. Read More

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[Four Times Aortic Valve Replacement for Recurrent Aortic Annulus Destruction Due to Behçet's Disease:Report of a Case].

Kyobu Geka 2021 Sep;74(9):681-685

Department of Cardiovascular Surgery, Nagoya Tokushukai General Hospital, Kasugai, Japan.

Surgical results of aortic regurgitation with Behcet's aortitis is associated with high morbidity and mortality due to risk of annular dehiscence. Here we describe a case of severe aortic regurgitation with Behcet's disease in 51-year-old man who underwent aortic valve replacement and subannular patch reconstruction for suspected infectious endocarditis with severe aortic regurgitation and subannular abcess. Then we performed three times aortic valve replacement for recurrent prosthetic valve dehiscence. Read More

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September 2021

A Novel Indomethacin-Tripeptide Hydrogel for Inhibiting Ocular Inflammation.

J Biomed Nanotechnol 2021 Jul;17(7):1417-1425

Institute of Biomedical Engineering, School of Ophthalmology & Optometry and Eye Hospital, Wenzhou Medical University, Wenzhou, 325027, P. R. China.

A highly efficient method for constructing indomethacin-peptide conjugates was developed using the natural amino acid tyrosine (Y) as the anchor for indomethacin (Idm). With pH = 6, Idm-YEE conjugate self-assembled in a low critical micelle concentration (CMC, 0.037 mg/mL) and formed a transparent hydrogel (0. Read More

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Traumatic Intralenticular Neovascularization in a HLA B27+ Pediatric Patient.

Diagnostics (Basel) 2021 Aug 18;11(8). Epub 2021 Aug 18.

Clinical Department of Ophthalmology, Carol Davila University of Medicine and Pharmacy, 020021 Bucharest, Romania.

(1) Background: Intralenticular tumors are an entity akin to Schrodinger's cat since, although the human crystalline cells themselves are not known to malignly proliferate, various entities can take the appearance and clinical presentation of a tumor originating in the lens. We present the peculiar case of an 11-year-old male patient of African descent, HLA B27+, with a previous history of minor ocular trauma and unilateral anterior uveitis a year before which was admitted to our department with total opacification of the crystalline lens in the right eye and lens neovascularization. During surgery, a vascular, white fibrotic mass measuring 0. Read More

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Vitreoretinal Lymphoma.

Cancers (Basel) 2021 Aug 4;13(16). Epub 2021 Aug 4.

Center of Ophthalmology, University of Tuebingen, 72076 Tuebingen, Germany.

Vitreoretinal lymphoma (VRL) is a rare variant of primary central nervous system lymphoma (PCNSL), mostly of diffuse large B cell lymphoma, which affects the retina and/or the vitreous with or without optic nerve involvement. The disease course is aggressive. Up to 90% of the patients develop central nervous system lymphoma within one year. Read More

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SARS-CoV-2 among the Potential Viral Triggers for Vogt-Konayagi-Harada Disease: First Case Report and Literature Review.

Ocul Immunol Inflamm 2021 Aug 26:1-7. Epub 2021 Aug 26.

Department of Ophthalmology, Ministerio de Saludi8, Panama.

Objective: To describe a case of Vogt-Koyanagi-Harada (VKH) disease associated with the novel coronavirus disease 2019 (COVID-19).

Materials And Methods: A retrospective review of patient records was carried out to obtain data for a case report. A literature review was conducted of cases of uveitis associated with COVID-19 reported to date. Read More

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[A case of neuro-Behçet's disease triggered by herpes zoster-associated uveitis].

Rinsho Shinkeigaku 2021 Aug 26. Epub 2021 Aug 26.

Department of Neurology, Shiga University of Medical Science.

A 69-year-old man was admitted for persistent fever, arthralgia, and visual impairment. Physical examination demonstrated bilateral uveitis and recurrent aphthous stomatitis. The PCR analysis of the aqueous humor of the anterior chamber was positive for the Varicella-zoster virus (VZV). Read More

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Evaluation of systemic immune-inflammation index level as a novel marker for severity of noninfectious uveitis.

Int Ophthalmol 2021 Aug 25. Epub 2021 Aug 25.

Department of Rheumatology, Mustafa Kemal University Tayfur Ata Sökmen Faculty of Medicine, Antakya, Hatay, Turkey.

Purpose: To evaluate the association of systemic immune-inflammation index (SII) levels, neutrophil/lymphocyte ratio (NLR), and platelet/lymphocyte ratio (PLR) with severity of noninfectious uveitis.

Methods: This retrospective study included 46 patients with noninfectious uveitis (uveitis group) and 46 age- and sex-matched healthy subjects (control group). The demographic and ocular findings, localization, and activity of uveitis were recorded at the time of onset evaluation. Read More

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Axial spondyloarthritis: emerging drug targets.

Expert Opin Ther Targets 2021 Aug 30:1-12. Epub 2021 Aug 30.

Infection & Inflammation, Umr 1173, Inserm, UVSQ/Université Paris Saclay - 2, Avenue De La Source De La Bièvre, Montigny-le-Bretonneux, France.

Introduction: Axial spondyloarthritis (AxSpA) is an inflammatory disorder that affects the joints, entheses, and bone tissues and is sometimes associated with psoriasis, anterior uveitis, and gut inflammation. Its pathogenesis is not wholly understood and treatment strategies require optimization. Data concerning AxSpA pathogenesis support a critical role of abnormal CD4 T cell differentiation and exacerbated type 3 immune response. Read More

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Response to: "Zoledronate-induced acute anterior uveitis: a three-case report and brief review of literature".

Osteoporos Int 2021 Aug 22. Epub 2021 Aug 22.

Ophthalmology Department, Auckland District Health Board, Greenlane Clinical Centre, 214 Greenlane West, Epsom, Auckland, 1051, New Zealand.

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Past, present, and prospects in microsporidial keratoconjunctivitis- A review.

Ocul Surf 2021 Aug 19. Epub 2021 Aug 19.

Department of Cornea and Refractive Surgery, Medical Research Foundation, Sankara Nethralaya, Chennai, India.

Ocular microsporidiosis comprises two entirely different spectra of disease as keratoconjunctivitis and stromal keratitis. Microsporidial keratoconjunctivitis (MKC) has been increasingly reported in the past two decades, probably due to raised awareness, simpler diagnostic procedures, and a better understanding of the clinical presentation. It is characterized by the presence of raised, coarse, punctate, multifocal, round to oval, greyish-white corneal epithelial lesions which usually evolve into nummular scars before resolution. Read More

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Comparison of two different scleral fixation techniques of posterior chamber Carlevale lens.

Medicine (Baltimore) 2021 Aug;100(32):e26728

Department of Biomedical and Surgical Sciences, Section of Ophthalmology, University of Perugia, S. Maria della Misericordia Hospital, Perugia, Italy.

Abstract: To investigate the surgical outcomes of 2 different scleral fixation techniques of the new single-piece foldable acrylic Carlevale lens (Soleko) and to compare our results with previous reports of the literature.A retrospective, non-randomized comparative study involving 2 series of patients who underwent 2 different scleral fixation techniques of Carlevale lens was performed. Minimum follow-up of 3 months was requested for inclusion in the study. Read More

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COVID-19 Recombinant mRNA Vaccines and Serious Ocular Inflammatory Side Effects: Real or Coincidence?

J Ophthalmic Vis Res 2021 Jul-Sep;16(3):490-501. Epub 2021 Jul 29.

The Ocular Immunology and Uveitis Foundation, Waltham, MA, United States.

Purpose: To report two cases; bilateral arteritic anterior ischemic optic neuropathy (AAION) and bilateral acute zonal occult outer retinopathy (AZOOR) after COVID-19 mRNA vaccination.

Case Report: The first patient was a 79-year-old female was presented to us 35 days after a sudden bilateral loss of vision, which occurred two days after receiving the second recombinant mRNA vaccine (Pfizer) injection. Temporal artery biopsy was compatible with AAION. Read More

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