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Optimizing use of L-asparaginase-based treatment of adults with acute lymphoblastic leukemia.

Blood Rev 2021 Nov 12:100908. Epub 2021 Nov 12.

Hematology Adolescent and Young Adult Unit, Saint Louis Hospital, URP-3518, Université de Paris, Paris, France. Electronic address:

Acute lymphoblastic leukemia (ALL) is a malignancy of lymphoid progenitor cells occurring at an annual incidence rate of approximately 1.1 to 2.1 per 100,000 person-years globally. Read More

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November 2021

Antibodies to watch in 2022.

MAbs 2022 Jan-Dec;14(1):2014296

The Antibody Society, Inc, Framingham, MA, USA.

In this 13th annual installment of the annual 'Antibodies to Watch' article series, we discuss key events in commercial antibody therapeutics development that occurred in 2021 and forecast events that might occur in 2022. Regulatory review of antibody therapeutics that target the SARS-CoV-2 coronavirus proceeded at an unprecedented pace in 2021, resulting in both emergency use authorizations and full approvals for sotrovimab, regdanvimab, REGEN-COV2, as well as others, in numerous countries. As of November 1, a total of 11 antibody therapeutics had been granted first approvals in either the United States or European Union in 2021 (evinacumab, dostarlimab loncastuximab tesirine, amivantamab, aducanumab, tralokinumab, anifrolumab, bimekizumab, tisotumab vedotin, regdanvimab, REGEN-COV2). Read More

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January 2022

Effect of mindfulness-based stress reduction on stigma, coping styles, and quality of life in patients with permanent colorectal cancer stoma: A protocol for systematic review and meta-analysis.

Medicine (Baltimore) 2022 Jan;101(1):e28421

The National Hospital of Enshi Autonomous Prefecture, Enshi, Hubei Province, China.

Background: : Colorectal cancer patients with permanent colostomy may suffer stigma, negative coping style, and low quality of life at varying degrees, which may be improved by the mindfulness-based stress reduction (MBSR). In recent years, MBSR has been used in the comprehensive treatment of colorectal cancer with permanent colostomy, hoping to bring a positive outcome. However, the practical application effect of MBSR has not been elucidated so far. Read More

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January 2022

The effect of perennial and annual wheat forages, fed with or without lucerne, on the fatty acid profile and oxidative status of lamb meat.

Vet Anim Sci 2022 Mar 2;15:100230. Epub 2022 Jan 2.

Centre for Red Meat and Sheep Development, NSW Department of Primary Industries, Cowra NSW 2794, Australia.

The current study investigated the fatty acid profile and oxidative status of the meat from lambs that were fed a novel perennial wheat or a conventional annual wheat, either as a cereal monoculture or lucerne biculture. Twelve lambs were assigned to each of the four dietary treatments (48 lambs in total) and held within individual pens for the duration of the 28 day feeding study. Lambs were slaughtered and the (LL) and (SM) muscles analysed. Read More

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Dental manpower and treated dental diseases in department of dentistry, Taipei Hospital (the predecessor of National Taiwan University Hospital) in 1923.

J Dent Sci 2022 Jan 7;17(1):170-175. Epub 2021 Jul 7.

Department of Dentistry, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan.

Background/purpose: In 1906, there was a dental treatment room established in the department of surgery of Taipei Hospital to introduce modern dental services to Taiwan. It is undoubtedly the earliest hospital dentistry in Taiwan. This study tried to assess the dental manpower and treated dental diseases in Taipei Hospital, and hence to explore the appearance of Taiwan's early hospital dentistry. Read More

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January 2022

Higher-order aberrations and their association with axial elongation in highly myopic children and adolescents.

Br J Ophthalmol 2022 Jan 13. Epub 2022 Jan 13.

Shanghai Eye Disease Prevention and Treatment Center, Shanghai Eye Hospital, Shanghai, China.

Background: Vision-dependent mechanisms play a role in myopia progression in childhood. Thus, we investigated the distribution of ocular and corneal higher-order aberrations (HOAs) in highly myopic Chinese children and adolescents and the relationship between HOA components and 1-year axial eye growth.

Methods: Baseline cycloplegic ocular and corneal HOAs, axial length (AL), spherical equivalent (SE), astigmatism and interpupillary distance (IPD) were determined for the right eyes of 458 highly myopic (SE ≤-5. Read More

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January 2022

Risk-Adjusted, 30-Day Home Time After Transcatheter Aortic Valve Replacement as a Hospital-Level Performance Metric.

J Am Coll Cardiol 2022 Jan;79(2):132-144

Division of Cardiology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA. Electronic address:

Background: Patient-centric measures of hospital performance for transcatheter aortic valve replacement (TAVR) are needed.

Objectives: This study evaluated 30-day, risk-adjusted home time as a hospital performance metric for patients who underwent TAVR.

Methods: This study identified 160,792 Medicare beneficiaries who underwent elective TAVR from 2015 to 2019. Read More

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January 2022

Annual report of the Committee on Gynecologic Oncology, the Japan Society of Obstetrics and Gynecology: Annual Patient Report for 2018 and Annual Treatment Report for 2013.

J Obstet Gynaecol Res 2022 Jan 13. Epub 2022 Jan 13.

Department of Gynecology and Obstetrics, Tohoku University Graduate School of Medicine, Sendai, Japan.

To provide information including the trend of gynecological malignancies in Japan, we hereby present the Annual Patient Report for 2018 and the Annual Treatment Report for 2013, on the outcomes of patients who started treatment in 2013. The Japan Society of Obstetrics and Gynecology maintains an annual tumor registry, where information on gynecological malignancies from various participating institutions is gathered. The data of patients whose treatment with gynecologic malignancies was initiated in 2018 were analyzed retrospectively. Read More

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January 2022

Comparison of nitrogen losses from different manure treatment and application management systems in China.

J Environ Manage 2022 Jan 11;306:114430. Epub 2022 Jan 11.

Institute of Environmental and Sustainable Development in Agriculture, Chinese Academy of Agriculture Sciences, Beijing, 100081, China. Electronic address:

There is a worldwide focus on reducing the environmental impacts of livestock manure management. In China, there are different manure treatment and application modes, including complete treatment to remove nitrogen (N) for direct discharge into watercourses. But we lack a systematic quantitative comparison of the environmental losses that occur from different management modes. Read More

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January 2022

Ovarian cancer and KiSS-1 gene expression: A consideration of the use of Kisspeptin plus Kisspeptin aptamers in diagnostics and therapy.

Eur J Pharmacol 2022 Jan 11;917:174752. Epub 2022 Jan 11.

Department of Pharmacy, School of Applied Sciences, University of Huddersfield, Huddersfield, HD1 3DH, United Kingdom. Electronic address:

Gynaecological cancers continue to present a significant health burden upon the health of the global female population. This deficit is most prominent with ovarian cancer which possesses the lowest survival rate compared to all other cancers occurring within this anatomical region, with an annual UK-mortality of 7,300. The poor tolerability and selectively of the treatment options that are currently available is likely to have contributed to this high mortality rate thus, demonstrating the need for the development of enhanced therapeutic approaches. Read More

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January 2022

Trends in all-cause mortality among people with diagnosed diabetes in high-income settings: a multicountry analysis of aggregate data.

Lancet Diabetes Endocrinol 2022 Jan 10. Epub 2022 Jan 10.

Laboratory of Cardiovascular Prevention, Mario Negri Institute for Pharmacological Research IRCCS, Milan, Italy.

Background: Population-level trends in mortality among people with diabetes are inadequately described. We aimed to examine the magnitude and trends in excess all-cause mortality in people with diabetes.

Methods: In this retrospective, multicountry analysis, we collected aggregate data from 19 data sources in 16 high-income countries or jurisdictions (in six data sources in Asia, eight in Europe, one from Australia, and four from North America) for the period from Jan 1, 1995, to Dec 31, 2016, (or a subset of this period) on all-cause mortality in people with diagnosed total or type 2 diabetes. Read More

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January 2022

Changes in type 2 diabetes incidence and mortality associated with introduction of HbA1c as diagnostic option: A Danish 24-year population-based study.

Lancet Reg Health Eur 2022 Mar 1;14:100291. Epub 2022 Jan 1.

Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark.

Background: In 2011, the World Health Organization began recommending glycated haemoglobin (HbA) as a measure for diagnosing type 2 diabetes (T2D). This initiative may have changed basic T2D epidemiology. Consequently, we examined time changes in T2D incidence and mortality during 1995-2018. Read More

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Global Trends in Incidence and Burden of Urolithiasis from 1990 to 2019: An Analysis of Global Burden of Disease Study Data.

Eur Urol Open Sci 2022 Jan 3;35:37-46. Epub 2022 Jan 3.

University of Toledo College of Medicine and Life Sciences, Toledo, OH, USA.

Background: Urolithiasis is among the most common urologic diagnoses globally, with substantial burden and cost on healthcare systems worldwide. Increasing evidence links urolithiasis with an array of risk factors, including diet and lifestyle trends, noncommunicable diseases such as diabetes and obesity, and global warming.

Objective: To examine geographic, temporal, and sociodemographic patterns to better understand global disease burden of urolithiasis. Read More

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January 2022

Annual surgeon and hospital volume of gastrectomy and gastric adenocarcinoma survival in a population-based cohort study.

Acta Oncol 2022 Jan 13:1-8. Epub 2022 Jan 13.

Upper Gastrointestinal Surgery, Department of Molecular Medicine and Surgery, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden.

Background: It is uncertain whether centralization of gastrectomy to fewer surgeons and larger centers improves survival in gastric adenocarcinoma in Western populations. The aim of this study was to examine if higher annual surgeon or hospital volumes of gastrectomy increase gastric adenocarcinoma survival in a population-based Swedish cohort.

Methods: This study included almost all patients who underwent curatively intended gastrectomy for gastric adenocarcinoma in Sweden between 2006 and 2015 with follow-up throughout 2020. Read More

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January 2022

Lifelong Effect of Therapy in Young Patients with the COL4A5 Alport Missense Variant p.(Gly624Asp): a Prospective Cohort Study.

Nephrol Dial Transplant 2022 Jan 12. Epub 2022 Jan 12.

Clinic for Nephrology and Rheumatology, University Medical Center Göttingen, Göttingen, Germany.

Background: Angiotensin-converting enzyme inhibitors (ACEis) have evolved as a first-line therapy for delaying end-stage renal failure (ESRF) in Alport syndrome. The present study tested the hypothesis of a superior nephroprotective potential of an early ACEi intervention, examining a cohort with the COL4A5 missense variant p.(Gly624Asp). Read More

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January 2022

Cost-Effectiveness and Value-Based Pricing of Aducanumab for Patients With Early Alzheimer Disease.

Neurology 2022 Jan 12. Epub 2022 Jan 12.

Institute For Clinical and Economic Review, Boston, MA.

Introduction: Aducanumab was granted accelerated approval with a conflicting evidence base, near-unanimous FDA Advisory Committee vote to reject approval, and a widely criticized launch price of $56,000 per year. The objective of this analysis was to estimate its cost-effectiveness.

Methods: We developed a Markov model to compare aducanumab in addition to supportive care to supportive care alone over a lifetime horizon. Read More

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January 2022

Iron in airway macrophages and infective exacerbations of chronic obstructive pulmonary disease.

Respir Res 2022 Jan 12;23(1). Epub 2022 Jan 12.

Department of Medicine, McMaster University, Hamilton, Canada.

Background: Excess pulmonary iron has been implicated in the pathogenesis of lung disease, including asthma and COPD. An association between higher iron content in sputum macrophages and infective exacerbations of COPD has previously been demonstrated.

Objectives: To assess the mechanisms of pulmonary macrophage iron sequestration, test the effect of macrophage iron-loading on cellular immune function, and prospectively determine if sputum hemosiderin index can predict infectious exacerbations of COPD. Read More

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January 2022

Alcohol-related Opioid Overdose Deaths in Minnesota Between 2011 and 2020: Trends by Sex.

J Addict Med 2022 Jan 11. Epub 2022 Jan 11.

Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN (JKF); Division of Environmental Health Sciences, School of Public Health, University of Minnesota, Minneapolis, MN (NW); Injury and Violence Prevention Section, Minnesota Department of Health, Saint Paul, MN (NW, KMG).

Objectives: To characterize the overall trend and differences by sex in opioid overdose death (OOD) and alcohol-related opioid overdose deaths (AOOD) in Minnesota between 2011 and 2020 in relation to drug overdose deaths.

Methods: Using Minnesota death certificate data from 2011 to 2020, we identified OOD and AOOD among Minnesota residents aged 15 and older who died of a drug overdose death. We calculated significant differences in the annual proportion of OOD and AOOD and sex differences using Pearson x2 tests. Read More

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January 2022

Quantifying the economic effects of ravulizumab versus eculizumab treatment in patients with atypical hemolytic uremic syndrome.

J Med Econ 2022 Jan 12:1-16. Epub 2022 Jan 12.

Alexion, AstraZeneca Rare Disease, Boston, MA, USA.

Aims: This study compared the aggregate duration of treatment administration of approved eculizumab and ravulizumab treatment regimens and resultant productivity implications for patients with atypical hemolytic uremic syndrome (aHUS) and their caregivers.

Methods: The aggregate duration of treatment administration (which includes waiting time for medication preparation and time for infusion, recovery, and travel to and from the clinic) was determined for a hypothetical population of patients with aHUS treated with eculizumab (10 mg/mL) or ravulizumab (10 or 100 mg/mL), in clinic or at home, for one year, in Germany, Italy, UK, and USA. The data for US patients treated in clinic was used to extend a previously published cost-minimization model (CMM) to estimate the annual lost productivity associated with treatment administration and to compare the overall annual treatment costs for hypothetical adult and pediatric patients in the USA. Read More

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January 2022

Cancer statistics, 2022.

CA Cancer J Clin 2022 Jan 12;72(1):7-33. Epub 2022 Jan 12.

Surveillance and Health Equity Science, American Cancer Society, Atlanta, Georgia.

Each year, the American Cancer Society estimates the numbers of new cancer cases and deaths in the United States and compiles the most recent data on population-based cancer occurrence and outcomes. Incidence data (through 2018) were collected by the Surveillance, Epidemiology, and End Results program; the National Program of Cancer Registries; and the North American Association of Central Cancer Registries. Mortality data (through 2019) were collected by the National Center for Health Statistics. Read More

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January 2022

Influence of Long-term Non-Aspirin NSAID use on Risk of Frailty in Men ≥60 years: The Physicians' Health Study.

J Gerontol A Biol Sci Med Sci 2022 Jan 9. Epub 2022 Jan 9.

New England GRECC (Geriatric Research, Education, and Clinical Center), VA Boston Healthcare System, Boston, MA.

Background: Inflammation is a central pathway leading to frailty but whether commonly used non-aspirin non-steroidal anti-inflammatory drugs (NSAIDs) can prevent frailty is unknown.

Methods: Prospective cohort study of male physicians ≥60 who participated in the Physicians' Health Study. Annual questionnaires collected data on NSAID use, lifestyle and morbidity. Read More

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January 2022

Assessment of diabetes self-management amongst Nigerians using the diabetes self-management questionnaire: a cross-sectional study.

Pan Afr Med J 2021 24;40:178. Epub 2021 Nov 24.

Department of Internal Medicine, University of Benin Teaching Hospital, Benin City, Nigeria.

Introduction: self-management is probably the most important factor contributing to achieving euglycaemia. The Diabetes Self-Management Questionnaire (DSMQ) is an instrument that shows favourable prospects compared to older measures. This study aimed to investigate the association between self-management and glycaemic control using the DSMQ, and determine factors that affect glycaemic control in patients living with diabetes mellitus. Read More

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January 2022

Knowledge, Attitude and Practice about radiation safety among the undergraduates in Eastern province dental college.

J Pharm Bioallied Sci 2021 Nov 10;13(Suppl 2):S1442-S1447. Epub 2021 Nov 10.

Department of Interns, College of Dentistry, King Faisal University, Al Ahsa, KSA.

Background: Despite the fact that X-rays have a direct or indirect effect on tissues, imaging techniques have become an important part of modern dentistry, and dentists rely on them for diagnosis, treatment, and follow-up. This necessitates that dentists have adequate expertise and attitude in order to defend themselves and their patients.

Aim: The present study was conducted to assess the knowledge, attitude, and practice of clinical side dental students and General Dental Practitioners (GDPs) regarding dental radiation protection safety protocol. Read More

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November 2021

A systematic review and meta-analysis of the catastrophic costs incurred by tuberculosis patients.

Sci Rep 2022 Jan 11;12(1):558. Epub 2022 Jan 11.

Epidemiology Department, High Institute of Public Health, Alexandria University, Alexandria, Egypt.

One of the strategies of the World Health Organization End Tuberculosis (TB) was to reduce the catastrophic costs incurred by TB-affected families to 0% by 2020.Catastrophic cost is defined by the total cost related to TB management exceeding 20% of the annual pre-TB household income. This study aimed to estimate the pooled proportion of TB affected households who incurred catastrophic costs. Read More

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January 2022

Disease risk analysis for schizophrenia patients by an automatic AHP framework.

BMC Med Inform Decis Mak 2022 Jan 11;21(Suppl 9):375. Epub 2022 Jan 11.

Guangdong Mental Health Center, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, People's Republic of China.

Background: Based on more than 15 million follow-up records of 404,426 patients from Guangdong Mental Health Center over the past 10 years, this study aims to propose a disease risk analysis and prediction model to support chronic disease management and clinical research for schizophrenia patients.

Methods: Based on a mental health information and intelligent data processing platform, we design an automatic AHP framework called AutoAHP to analyze and predict the disease risks of schizophrenia patients. Through automatic extraction, transformation and integration of follow-up data in the real world such as demography, treatment, and the disease course, a chronic database of patient status is established. Read More

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January 2022

Diphtheria resurgence in Sada'a-Yemen, 2017-2020.

BMC Infect Dis 2022 Jan 11;22(1):46. Epub 2022 Jan 11.

Yemen Field Epidemiology Training Program, Sana'a, Yemen.

Background: Diphtheria is a contagious vaccine-preventable disease that contributes to the high morbidity and mortality among under 5 children, especially in Yemen. As a consequence of war and collapse of the health system, a fatal epidemic occurred at the end of 2017. This study aims to describe the epidemiology of diphtheria by time, place, and person and vaccination status of affected children. Read More

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January 2022

Cardiorenal disease in the United States: future health care burden and potential impact of novel therapies.

J Manag Care Spec Pharm 2022 Jan 12:1-10. Epub 2022 Jan 12.

BioPharmaceuticals R & D, AstraZeneca, Gothenburg, Sweden.

Currently, concerted efforts to identify, prevent, and treat type 2 diabetes mellitus (T2DM), heart failure (HF), and chronic kidney disease (CKD) comorbidities are lacking at the institutional level, with emphasis placed on individual specialties. An integrated approach to tackle T2DM, HF, and CKD within the context of cardiorenal disease has the potential to improve outcomes and reduce costs at the system level. To synthesize published evidence describing the burden of those diagnosed with T2DM, HF, and CKD in the United States as individual discrete chronic conditions, in order to evaluate the potential economic impact of novel therapies in this population. Read More

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January 2022

Familial amyotrophic lateral sclerosis induced by gene mutation of SOD1G142A: a case report.

Ann Palliat Med 2021 Dec;10(12):12900-12905

Department of Neurology, Nanfang Hospital, Southern Medical University, Guangzhou, China.

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease involving both upper and lower motor neurons. The total prevalence of ALS is [2-9]/100,000, with an annual incidence rate of 3/100,000. The disease progresses rapidly and clinically is considered to be progressive degeneration of the upper and lower motor neurons. Read More

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December 2021

Society for palliative radiation oncology: report from the Eighth Annual Meeting (2021).

Ann Palliat Med 2021 Dec;10(12):13030-13034

New York Proton Center, New York, NY, USA.

The Society for Palliative Radiation Oncology (SPRO) is an international group of clinicians whose primary aim is to advance the field of palliative radiation oncology by promoting evidence-based palliative radiation therapy and excellence in primary palliative care through research, education, collaboration, and patient advocacy. SPRO held its 8th Annual Meeting on November 4th, 2021 in association with the American Society for Radiation Oncology (ASTRO) 63rd Annual Meeting. Accomplishments and goals from the prior year, including SPRO gaining official non-profit status, were discussed. Read More

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December 2021

Arthroscopic treatment of osteoarthritis: a bibliometric study.

Ann Palliat Med 2021 Dec;10(12):12575-12588

Department of Orthopedics, Huludao Central Hospital, Huludao, China.

Background: Osteoarthritis is a common disease among middle-aged and older adults. The arthroscopic approach is among the less traumatic of the treatments and provides quicker recovery. The purpose of this study was to use bibliometrics analysis to clarify the current status and existing problems in the research of the arthroscopic treatment of osteoarthritis. Read More

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December 2021