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History of otorhinolaryngology in Germany before 1921.

HNO 2021 Apr 13. Epub 2021 Apr 13.

Klinik und Poliklinik für Hals-Nasen-Ohrenheilkunde, Kopf- und Halschirurgie "Otto Körner", Universitätsmedizin Rostock, Doberaner Str. 137-139, 18057, Rostock, Germany.

In 2021, the German Society of Otorhinolaryngology, Head and Neck Surgery is celebrating the 100th anniversary of its foundation. The aim of this article is to present the main inventions and progress made in Germany before 1921, the date the society was founded. Three chronological periods are discernible: the history of otorhinolaryngology (ORL) in Germany until the beginning of the 19th century, focusing mainly on the development of scattered knowledge; the birth of the sub-specialties otology, laryngology (pharyngo-laryngology and endoscopy), and rhinology in the 19th century, combining advances in knowledge and implementation of academic structures; and the creation of the ORL specialty at the turn of the 20th century, mainly concentrating on academic organization and expansion. Read More

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Functional interpretation of ATAD3A variants in neuro-mitochondrial phenotypes.

Genome Med 2021 Apr 12;13(1):55. Epub 2021 Apr 12.

Aging and Metabolism Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, 73104, USA.

Background: ATPase family AAA-domain containing protein 3A (ATAD3A) is a nuclear-encoded mitochondrial membrane-anchored protein involved in diverse processes including mitochondrial dynamics, mitochondrial DNA organization, and cholesterol metabolism. Biallelic deletions (null), recessive missense variants (hypomorph), and heterozygous missense variants or duplications (antimorph) in ATAD3A lead to neurological syndromes in humans.

Methods: To expand the mutational spectrum of ATAD3A variants and to provide functional interpretation of missense alleles in trans to deletion alleles, we performed exome sequencing for identification of single nucleotide variants (SNVs) and copy number variants (CNVs) in ATAD3A in individuals with neurological and mitochondrial phenotypes. Read More

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EGAH editorial- to mark the 50th anniversary of SEGH.

Environ Geochem Health 2021 Apr 12. Epub 2021 Apr 12.

School of Environmental Science and Engineering, Southern University of Science and Technology, Shenzhen, China.

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Emergency Medicine/Internal Medicine Combined Residency Graduates Have High Career Satisfaction and Commonly Practice in Both Specialties.

AEM Educ Train 2021 Apr 24;5(2):e10493. Epub 2020 Jul 24.

The Ohio State University College of Medicine Columbus OH USA.

Objectives: The first combined emergency medicine/internal medicine (EM/IM) residency was established in 1991. As the 30th anniversary of this unique dual-training opportunity approaches, multiple changes to the practice and educational landscape have occurred. Previous surveys examining this topic are now more than 10 years old and occurred prior to the establishment of the EM/IM/critical care medicine (EM/IM/CCM) pathway. Read More

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Nonprofit Advocacy at the American Heart Association: Creating a Visionary Way Forward at Our 40th Anniversary: An American Heart Association Policy Statement.

Circulation 2021 Apr 12:CIR0000000000000972. Epub 2021 Apr 12.

In 2021, the American Heart Association celebrates its 40th anniversary in advocacy. This policy statement details the arc of the organization's nonpartisan, evidence-based, equity-focused approach to advocating for public policy change, highlighting key milestones and describing the core components of the association's capacity and activity at all levels of government. This policy statement presents a vision and strategic imperative for future American Heart Association advocacy efforts to inform and influence policy changes that advance equitable, impactful societal solutions that transform and improve cardiovascular health for everyone. Read More

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Myocardial Angiotensin Metabolism in End-Stage Heart Failure.

J Am Coll Cardiol 2021 Apr;77(14):1731-1743

Clinical Division of Cardiology, Department of Internal Medicine II, Medical University of Vienna, Vienna, Austria.

Background: The myocardium exhibits an adaptive tissue-specific renin-angiotensin system (RAS), and local dysbalance may circumvent the desired effects of pharmacologic RAS inhibition, a mainstay of heart failure with reduced ejection fraction (HFrEF) therapy.

Objectives: This study sought to investigate human myocardial tissue RAS regulation of the failing heart in the light of current therapy.

Methods: Fifty-two end-stage HFrEF patients undergoing heart transplantation (no RAS inhibitor: n = 9; angiotensin-converting enzyme [ACE] inhibitor: n = 28; angiotensin receptor blocker [ARB]: n = 8; angiotensin receptor neprilysin-inhibitor [ARNi]: n = 7) were enrolled. Read More

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Insulin action in adipocytes, adipose remodeling, and systemic effects.

Cell Metab 2021 Apr;33(4):748-757

Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA. Electronic address:

On this 100 anniversary of the discovery of insulin, we recognize the critical role that adipocytes, which are exquisitely responsive to insulin, have played in determining the mechanisms for insulin action at the cellular level. Our understanding of adipose tissue biology has evolved greatly, and it is now clear that adipocytes are far more complicated than simple storage depots for fat. A growing body of evidence documents how adipocytes, in response to insulin, contribute to the control of whole-body nutrient homeostasis. Read More

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Mazzini at 150: the Italian death of a London exile.

Intern Emerg Med 2021 Apr 7. Epub 2021 Apr 7.

Warwick Medical School, Biomedical Sciences, The University of Warwick, Coventry, CV4 7AL, UK.

The year 2022 will mark the 150th anniversary of the death of Giuseppe Mazzini, the spiritual father of the Italian Republic and one of the best political minds of the nineteenth century. In this review, we revisit the events surrounding Mazzini's death, based on a report published in 1872 by Dr. Giovanni Rossini, the Italian physician who cared for him during his last days in Pisa. Read More

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[Academician A.A. Bogomolets. Life dedicated to science. On the occasion of the 140th anniversary of his birth].

Arkh Patol 2021 ;83(3):65-68

Russian Medical Academy of Continuous Professional Education, Moscow, Russia.

The paper presents the life and career of Aleksander Aleksandrovich Bogomolets, outstanding pathophysiologist of the country; famous statesman and public figure; founder of a large scientific school; Academician and Vice-President of the USSR Academy of Sciences; Academician of the UkrSSR Academy of Sciences; Academician of the BelSSR Academy of Sciences; Academician of the USSR Academy of Medical Sciences; Honored Scientist of the RSFSR and UkrSSR; USSR State Prize Winner, and Hero of Socialist Labor. Read More

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[The Corypheus in Russian pathological anatomy. On the occasion of the 120th anniversary of the birth of Anatoly Ivanovich Strukov].

Authors:
V S Paukov

Arkh Patol 2021 ;83(3):62-64

I.M. Sechenov First Moscow State Medical University (Sechenov University) of the Ministry of Health of Russia, Moscow, Russia.

The article dedicated to the 120 anniversary of the birth of Academician A.I. Strukov shows his role in the development of Russian and European pathological anatomy and describes his life and merits in the modernization of teaching pathological anatomy at medical universities. Read More

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IBFAN News Brief: IBFAN Celebrates the 40th Anniversary of the 1981-2021.

J Hum Lact 2021 Apr 5:890334421994766. Epub 2021 Apr 5.

390256 IBFAN, Toronto, Canada.

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Remembering William Hunter (1718-1783) the Pioneer in Obstetrics: A Prelude to Sestercentennial Anniversary of .

J Obstet Gynaecol India 2021 Feb 16;71(1):97-100. Epub 2019 Oct 16.

Department of Anatomy, 3rd Floor, Academic Building, All India Institute of Medical Sciences, Phulwarisharif, Patna, Bihar 801507 India.

William Hunter (1718-1783) was a Scottish anatomist and physician. He started his career as a man midwife and went on to become the leading obstetrician in London. He prepared anatomically dissected specimens depicting anatomy of gravid uterus and undelivered fetus with placenta in different stages of gestation. Read More

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February 2021

25 Years of the International Bipolar Collaborative Network (BCN).

Int J Bipolar Disord 2021 Apr 2;9(1):13. Epub 2021 Apr 2.

Department of Psychiatry, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

Background: The Stanley Foundation Bipolar Treatment Outcome Network (SFBN) recruited more than 900 outpatients from 1995 to 2002 from 4 sites in the United States (US) and 3 in the Netherlands and Germany (abbreviated as Europe). When funding was discontinued, the international group of investigators continued to work together as the Bipolar Collaborative Network (BCN), publishing so far 87 peer-reviewed manuscripts. On the 25th year anniversary of its founding, publication of a brief summary of some of the major findings appeared appropriate. Read More

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Rhizome Extract Inhibits Glutamate-Induced Toxicity in HT-22 Mouse Hippocampal Neuronal Cells and Extends Longevity in .

Biology (Basel) 2021 Mar 26;10(4). Epub 2021 Mar 26.

Natural Products for Neuroprotection and Anti-Ageing Research Unit, Chulalongkorn University, Bangkok 10330, Thailand.

Wall. ex Baker (KP) or "Kra-chai-dam" has been shown to exhibit several pharmacological effects including anti-inflammation, antimicrobial, and sexual-enhancing activity. The objectives of this study included an investigation of the effect of KP rhizome extract against glutamate-induced toxicity in mouse hippocampal HT-22 neuronal cells, determination of the underlying mechanism of neuroprotection, and an evaluation of the effect of KP extract on the longevity of . Read More

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The 35th Anniversary of the Discovery of EPR Effect: A New Wave of Nanomedicines for Tumor-Targeted Drug Delivery-Personal Remarks and Future Prospects.

Authors:
Hiroshi Maeda

J Pers Med 2021 Mar 22;11(3). Epub 2021 Mar 22.

BioDynamics Research Foundation, Kumamoto 862-0954, Japan.

This Special Issue on the enhanced permeability and retention (EPR) effect commemorates the 35th anniversary of its discovery, the original 1986 Matsumura and Maeda finding being published in as a new concept in cancer chemotherapy. My review here describes the history and heterogeneity of the EPR effect, which involves defective tumor blood vessels and blood flow. We reported that restoring obstructed tumor blood flow overcomes impaired drug delivery, leading to improved EPR effects. Read More

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Green Natural Rubber Composites Reinforced with Black/White Rice Husk Ashes: Effects of Reinforcing Agent on Film's Mechanical and Dielectric Properties.

Polymers (Basel) 2021 Mar 13;13(6). Epub 2021 Mar 13.

Bio-Circular-Green-Economy Technology & Engineering Center, BCGeTEC, Department of Chemical Engineering, Faculty of Engineering, Chulalongkorn University, Bangkok 10330, Thailand.

Green natural rubber (NR) composites reinforced with black rice husk ash (BRHA)/white rice husk ash (WRHA), using alginate as a thickening and dispersing agent and crosslinking by CaCl, was developed to improve mechanical, chemical and dielectric properties of NR-based films by using a latex aqueous microdispersion process. A maximum of 100 per hundred rubbers (phr) of rice husk ashes (RHAs) could be integrated in NR matrix without phase separation. Mechanical properties of the composite films were considerably enhanced, compared to the neat NR film. Read More

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The role of pharmacy in the management of cardiometabolic risk, metabolic syndrome and related diseases in severe mental illness: a mixed-methods systematic literature review.

Syst Rev 2021 Mar 31;10(1):92. Epub 2021 Mar 31.

School of Life and Health Sciences, Aston University, Birmingham, B4 7ET, UK.

Background: Individuals with severe mental illness, e.g. schizophrenia have up to a 20% shortened life expectancy compared to the general population. Read More

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Mucosal immunoglobulins of teleost fish: a decade of advances.

Dev Comp Immunol 2021 Mar 27:104079. Epub 2021 Mar 27.

Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA. Electronic address:

Immunoglobulins (Igs) are complex glycoproteins that play critical functions in innate and adaptive immunity of all jawed vertebrates. Given the unique characteristics of mucosal barriers, secretory Igs (sIgs) have specialized to maintain homeostasis and keep pathogens at bay at mucosal tissues from fish to mammals. In teleost fish, the three main IgH isotypes, IgM, IgD and IgT/Z can be found in different proportions at the mucosal secretions of the skin, gills, gut, nasal, buccal, and pharyngeal mucosae. Read More

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Bilingualism is a long-term cognitively challenging experience that modulates metabolite concentrations in the healthy brain.

Sci Rep 2021 Mar 29;11(1):7090. Epub 2021 Mar 29.

Centro de Ciencia Cognitiva, Facultad de Lenguas y Educación, Universidad Antonio de Nebrija, Calle de Sta. Cruz de Marcenado, 27, 28015, Madrid, Spain.

Cognitively demanding experiences, including complex skill acquisition and processing, have been shown to induce brain adaptations, at least at the macroscopic level, e.g. on brain volume and/or functional connectivity. Read More

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Introduction to the 25th anniversary issue.

Urol Oncol 2021 Mar 25. Epub 2021 Mar 25.

Department of Urology, The Mount Sinai Medical Center, New York, NY 10029.

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A decade of rotavirus vaccination in Africa - Saving lives and changing the face of diarrhoeal diseases: Report of the 12 African Rotavirus Symposium.

Vaccine 2021 Mar 25. Epub 2021 Mar 25.

Diarrhoeal Pathogens Research Unit, Department of Virology, Sefako Makgatho Health Sciences University, Medunsa 0204, Pretoria, South Africa; Enteric and Diarrhoeal Diseases Programme, Global Health, Bill & Melinda Gates Foundation, Seattle, WA, USA.

The African Rotavirus Network organised the 12 African Rotavirus Symposium (ARS) from 30 July to 1 August 2019 in Johannesburg, South Africa. The symposium theme "A decade of rotavirus vaccination in Africa - Saving lives and changing the face of diarrhoeal diseases", included sessions aimed at sharing ideas and expertise on prevention and control of diarrhoeal disease in Africa. Inter alia, the delegates reviewed global and regional epidemiological trends on rotavirus diarrhoea, progress and experiences on rotavirus vaccine introduction, including vaccine safety monitoring and impact in Africa, scientific advances in developing newer rotavirus vaccines, surveillance and research on other diarrhoeal pathogens, and providing an enabling environment for networking. Read More

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Lessons learned in the collection of convalescent plasma during the COVID-19 pandemic.

Vox Sang 2021 Mar 27. Epub 2021 Mar 27.

Unit Transfusion Medicine, Sanquin Blood Supply Foundation, Amsterdam, Netherlands.

Background: The lack of definitive treatment or preventative options for COVID-19 led many clinicians early on to consider convalescent plasma (CCP) as potentially therapeutic. Regulators, blood centres and hospitals worldwide worked quickly to get CCP to the bedside. Although response was admirable, several areas have been identified to help improve future pandemic management. Read More

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[Statement for the rights of the elderly].

Geriatr Psychol Neuropsychiatr Vieil 2021 Mar;19(1):9-19

Commission Âge Droits Liberté (SFGG), Conseil Scientifique Fédération 3977 contre les maltraitances.

The SFGG (French Society of geriatrics and gerontology) stands up against ageism and fights it in all its forms of expression. The SFGG warns about the persistence of age discrimination and the emergence of new forms of ageism alongside traditional stereotypes. The SFGG has taken a position on the occasion of the 70th anniversary of the Universal Declaration of Human Rights in December 2018. Read More

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The 25th Anniversary of Laser Vision Correction in the United States.

Authors:
Stephen N Joffe

Clin Ophthalmol 2021 17;15:1163-1172. Epub 2021 Mar 17.

History of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA.

Laser Vision Correction (LVC) is an elective, self-pay and safe surgical procedure to correct myopia and hyperopia. Since FDA approval 25 years ago, there have been a progression of technological improvements leading to better outcomes and LVC is now one of the safest surgical procedures. With a potential pool of 50 million patients, 6000 trained ophthalmic surgeons regularly treating in over 1000 centers of which 65% are physician owned. Read More

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Over 40 years with jumping spiders: on the 70th birthday of Wanda Wesołowska.

Zootaxa 2020 Dec 30;4899(1):zootaxa.4899.1.3. Epub 2020 Dec 30.

Institute of Biology and Earth Sciences, Pomeranian University in Słupsk, Arciszewskiego 22b, 76-200 Słupsk, Poland.

Professor Wanda Wesołowska (maiden name Nowysz)-an internationally recognised expert in the taxonomy of jumping spiders (Araneae: Salticidae)-was born in Włocławek (Central Poland) on 11 August 1950. Wanda spent her youth and received her primary and secondary education in Szczecin (NW Poland). After finishing school in 1968, she entered the Adam Mickiewicz University in Poznań, where she studied biology. Read More

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December 2020