893,437 results match your criteria animals observed

Metabolic benefits of novel histamine H receptor ligands in the model of excessive eating: The importance of intrinsic activity and pharmacokinetic properties.

Biomed Pharmacother 2021 Jul 26;142:111952. Epub 2021 Jul 26.

Department of Pharmacological Screening, Jagiellonian University, Medical College, Medyczna 9, PL 30-688 Cracow, Poland. Electronic address:

Aims: One of the therapeutic approaches in the treatment of obesity is the use of histamine H receptor ligands. Histamine plays a significant role in eating behavior because it causes a loss of appetite and is considered to be a satiety signal released during food intake.

Material And Methods: Histamine ligands were selected based on the preliminary studies which included determination of intrinsic activity and selected pharmacokinetic parameters. Read More

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Telocytes and their structural relationships with surrounding cell types in the skin of silky fowl by immunohistochemistrical, transmission electron microscopical and morphometric analysis.

Poult Sci 2021 Jun 29;100(9):101367. Epub 2021 Jun 29.

College of Life Science and Engineering, Foshan University, Foshan 528231, China; College of Animal Science and Technology, Jiangxi Agricultural University, Nanchang 330045, China. Electronic address:

Telocytes (TCs), a novel type of interstitial cells, were identified in various animals. Since TCs have not observed in avian skin, hence, we carried out immunohistochemistrical and transmission electron microscopical studies in the skin of the silky fowl to investigate the TCs. TCs appear as CD34, c-Kit, and PDGFRα immunopositive. Read More

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Photobiomodulation for the aging brain.

Ageing Res Rev 2021 Jul 26:101415. Epub 2021 Jul 26.

Núcleo de Pesquisas Tecnológicas, Universidade de Mogi das Cruzes, Mogi das Cruzes, SP, Brazil; Centro Universitário UNIFAMINAS (UNIFAMINAS), Muriaé, MG, Brazil; Hospital do Câncer de Muriaé, Fundação Cristiano Varella (FCV), Muriaé, MG, Brazil. Electronic address:

Longevity is one of the great triumphs of humanity. Worldwide, the elderly is the fastest growing segment of the population. As a consequence, the number of cases of age-related cognitive decline and neurological diseases associated with aging, such as Alzheimer's and Parkinson's, has been increasing. Read More

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Differential white spot syndrome virus-binding proteins in two hemocyte subpopulations of Chinese shrimp (Fenneropenaeus chinensis).

Dev Comp Immunol 2021 Jul 26:104215. Epub 2021 Jul 26.

Laboratory of Pathology and Immunology of Aquatic Animals, KLMME, Ocean University of China, Qingdao, 266003, China; Laboratory for Marine Fisheries Science and Food Production Processes, Qingdao National Laboratory for Marine Science and Technology, Qingdao, 266071, China.

A number of white spot syndrome virus (WSSV)-binding proteins have been identified previously in the hemocytes of Fenneropenaeus chinensis. In order to further investigate the differential WSSV-binding proteins in hemocyte subpopulations, granular hemocytes and hyalinocytes were sorted from WSSV-infected shrimp by immunomagnetic bead (IMB) method. The results of ELISA and immuno-dot blot assay showed that the WSSV-binding activity of granular hemocytes proteins was much stronger than that of hyalinocytes proteins. Read More

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Comparative evaluation of clinical findings and prognostic outcome parameters in hospitalized, critically ill neonatal foals and crias.

J Vet Emerg Crit Care (San Antonio) 2021 Jul 29. Epub 2021 Jul 29.

Department of Clinical Sciences, Cummings School of Veterinary Medicine at Tufts University, North Grafton, Massachusetts.

Objective: Species-related differences in the prevalence, manifestation, and outcome of neonatal illness may impact management practices of neonatal intensive care. The study aimed to elucidate similarities between disease manifestations and mortality risks of critically ill (CI) neonatal crias and foals admitted to the same referral center.

Design: A comparative, retrospective cohort evaluation of two species (camelid and equine). Read More

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Volume reduction without neuronal loss in the primate pulvinar complex following striate cortex lesions.

Brain Struct Funct 2021 Jul 29. Epub 2021 Jul 29.

Department of Physiology and Neuroscience Program, Biomedicine Discovery Institute, Monash University, Melbourne, VIC, 3800, Australia.

Lesions in the primary visual cortex (V1) cause extensive retrograde degeneration in the lateral geniculate nucleus, but it remains unclear whether they also trigger any neuronal loss in other subcortical visual centers. The inferior (IPul) and lateral (LPul) pulvinar nuclei have been regarded as part of the pathways that convey visual information to both V1 and extrastriate cortex. Here, we apply stereological analysis techniques to NeuN-stained sections of marmoset brain, in order to investigate whether the volume of these nuclei, and the number of neurons they comprise, change following unilateral long-term V1 lesions. Read More

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The effect of balneotherapy on the oxidative system and changes in anxiety behavior, enhanced by low doses of radon.

Int J Radiat Biol 2021 Jul 29:1-9. Epub 2021 Jul 29.

Faculty of Medicine, Javakhishvili Tbilisi State University, Tbilisi, Georgia.

Purpose: The aim of our research was to study the effect of radon hormesis balneotherapy using natural thermal waters of Tskaltubo spring, practically, its effect on oxidant and antioxidant systems and anxiety reactions in rats. Radon is a natural gas with radioactive properties, which can have a hermetic effect when used in small doses. Radon was used to activate antioxidant mechanisms in rats, which resulted an anxiolytic effect and positively enhanced the effect of balneotherapy. Read More

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Urinary bladder augmentation with acellular biologic scaffold-A preclinical study in a large animal model.

J Biomed Mater Res B Appl Biomater 2021 Jul 29. Epub 2021 Jul 29.

Chair of Urology and Andrology, Department of Regenerative Medicine, Cell and Tissue Bank, Nicolaus Copernicus University in Torun, Ludwik Rydygier Medical College in Bydgoszcz, Bydgoszcz, Poland.

Current strategies in urinary bladder augmentation include use of gastrointestinal segments, however, the technique is associated with inevitable complications. An acellular biologic scaffold seems to be a promising option for urinary bladder augmentation. The aim of this study was to evaluate the utility of bladder acellular matrix (BAM) for reconstruction of clinically significant large urinary bladder wall defects in a long-term porcine model. Read More

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Tiny golden angle ultrashort echo-time lung imaging in mice.

NMR Biomed 2021 Jul 28:e4591. Epub 2021 Jul 28.

Department of Internal Medicine II, Ulm University Medical Centre, Ulm, Germany.

Imaging the lung parenchyma with MRI is particularly difficult in small animals due to the high respiratory and heart rates, and ultrashort T2* at high magnetic field strength caused by the high susceptibilities induced by the air-tissue interfaces. In this study, a 2D ultrashort echo-time (UTE) technique was combined with tiny golden angle (tyGA) ordering. Data were acquired continuously at 11. Read More

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First direct human-to-cat transmission of the SARS-CoV-2 B.1.1.7 variant.

Aust Vet J 2021 Jul 29. Epub 2021 Jul 29.

DESAM Institute, Near East University, Nicosia, 99138, Cyprus.

A highly transmissible severe acute respiratory coronavirus 2 (SARS-CoV-2) caused the coronavirus diseases 2019 (COVID-19) pandemic, which resulted the highest morbidity and mortality rates among SARS-CoV and MERS-CoV. SARS-CoV-2 B.1. Read More

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Molecular Survey of Tick-Borne Pathogens Reveals Diversity and Novel Organisms With Veterinary and Public Health Significance in Wildlife From a National Nature Reserve of China.

Front Vet Sci 2021 12;8:682963. Epub 2021 Jul 12.

State Key Laboratory of Veterinary Etiological Biology, Key Laboratory of Veterinary Parasitology of Gansu Province, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China.

Wildlife is involved in the maintenance and transmission of various tick-borne pathogens. The objective of the present study was to determine the occurrence and diversity of tick-borne pathogens in free-ranging wild animals collected from Tangjiahe National Nature Reserve of China. Blood or liver samples from 13 wild animals (5 takin, 3 Himalayan goral, 3 Reeves' muntjac, 1 forest musk deer, and 1 wild boar) were collected and screened for piroplasm, spp. Read More

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Focal Palatitis (Previously Focal Palatine Erosions) in Captive Cheetahs ().

Front Vet Sci 2021 12;8:682150. Epub 2021 Jul 12.

Institute of Mammal Research, Department of Zoology and Entomology, Faculty of Natural and Agricultural Sciences, University of Pretoria, Pretoria, South Africa.

Focal palatine erosion (FPE) is a misleading term that is used in the literature to describe inflammatory lesions associated with depressions of the palatal mucosa in cheetah. Cheetahs have large cheek teeth and these depressions are formed to accommodate them. Previously FPE was only described as a mandibular molar tooth malocclusion on the hard palate due to suspected rotation and super eruption of the mandibular molar teeth of cheetahs aged 18 months and older. Read More

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Precocious puberty in male wild boars: a possible explanation for the dramatic population increase in Germany and Europe.

PeerJ 2021 20;9:e11798. Epub 2021 Jul 20.

Institute for Anatomy, University of Veterinary Medicine Hannover Foundation, Hannover, Germany.

Background: The wild boar population in Europe is steadily growing, one of the reasons for this increase probably being the high reproductive potential of this large mammal. Population management is important to stabilise wild boar numbers and a great deal of attention is focusing on the reasons, which might contribute to the high reproductive rates. Understanding the timing of puberty attainment provides information required for proper management practices. Read More

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Sex Differences in Exercise-Training-Related Functional and Morphological Adaptation of Rat Gracilis Muscle Arterioles.

Front Physiol 2021 12;12:685664. Epub 2021 Jul 12.

Department of Obstetrics and Gynecology, Semmelweis University, Budapest, Hungary.

Background: The cardiovascular effects of training have been widely investigated; however, few studies have addressed sex differences in arteriolar adaptation. In the current study, we examined the adaptation of the gracilis arterioles of male and female rats in response to intensive training.

Methods: Wistar rats were divided into four groups: male exercise (ME) and female exercise (FE) animals that underwent a 12-week intensive swim-training program (5 days/week, 200 min/day); and male control (MC) and female control (FC) animals that were placed in water for 5 min daily. Read More

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Atherosclerosis Impairs Naive CD4 T-Cell Responses via Disruption of Glycolysis.

Arterioscler Thromb Vasc Biol 2021 Jul 29:ATVBAHA120314189. Epub 2021 Jul 29.

Division of Inflammation Biology, La Jolla Institute for Immunology, CA (D.E.G., L.E.P., R.W., D.J.A., C.C.H.).

Objective: CD4 T cells are important regulators of atherosclerotic progression. The metabolic profile of CD4 T cells controls their signaling and function, but how atherosclerosis affects T-cell metabolism is unknown. Here, we sought to determine the impact of atherosclerosis on CD4 T-cell metabolism and the contribution of such alterations to atheroprogression. Read More

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Expression and prognostic significance of vascular endothelial growth factor-A (VEGF-A) and its receptor in canine prostate cancer.

Prostate 2021 Jul 28. Epub 2021 Jul 28.

Department of Veterinary Surgery and Anesthesiology, School of Veterinary Medicine and Animal Science, São Paulo State University-UNESP, Botucatu, Sao Paulo, Brazil.

Background: Vascular endothelial growth factor-A (VEGF-A) and its receptor, VEGF receptor-2 (VEGFR-2), represent a complex family of angiogenic molecules consisting of different ligands and receptors. Due to the importance of VEGF-A/VEGFR-2 signaling in tumor proliferation and angiogenesis, this study aimed to evaluate the protein and gene expression levels of VEGF-A and VEGFR-2 in canine prostate cancer (PC).

Methods: We analyzed VEGF-A and VEGFR-2 expression in 87 PC samples by immunohistochemistry and quantitative-polymerase chain reaction. Read More

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Molecular epidemiology of aspergillosis in Magellanic penguins and susceptibility patterns of clinical isolates.

Med Mycol 2021 Jul 28. Epub 2021 Jul 28.

Microbiology and Parasitology Post-Graduate Program, Institute of Biology, Federal University of Pelotas, Pelotas, Rio Grande do Sul, Brazil.

Aspergillus section Fumigati is reported in up to 99% of aspergillosis cases in penguins. So far, no data regarding molecular epidemiology and azole resistance are available for A. fumigatus isolates collected from Magellanic penguins. Read More

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Fluoroquinolone resistance in non-typhoidal isolated from slaughtered pigs in Thailand.

J Med Microbiol 2021 Jul;70(7)

Japan-Thailand Research Collaboration Center for Infectious Diseases, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan.

The emergence and spread of non-typhoidal (NTS) serovars resistant to fluoroquinolones and third- and higher-generation cephalosporins is a matter of great concern. Antimicrobial-resistant NTS is increasingly being discovered in humans, animals, food animals, food products, and agricultural environments. Pigs are considered a major reservoir of antimicrobial-resistant spp. Read More

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Assessment of qualitative and quantitative parameters of healthy thyroid gland in adult horses by magnetic resonance imaging.

Anat Histol Embryol 2021 Jul 28. Epub 2021 Jul 28.

Department of Animal Reproduction and Veterinary Radiology, São Paulo State University (UNESP), Botucatu, Brazil.

In humans and pets, magnetic resonance imaging (MRI) provides important adjunctive anatomic information about the thyroid and its adjacent structures. To the best of our knowledge, however, no studies have been reported regarding the use of MRI for thyroid evaluation in horses. The aim of this study was to obtain qualitative and quantitative parameters of healthy thyroid gland in adult horses by MRI. Read More

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Dense Polytetrafluoroethylene Membrane versus Titanium Mesh in Vertical Ridge Augmentation: Clinical and Histological Results of a Split-mouth Prospective Study.

J Contemp Dent Pract 2021 May 1;22(5):465-472. Epub 2021 May 1.

Department of Periodontology, Maxillofacial Surgery and Odontostomatology Unit, Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico, University of Milan, Milan, Italy.

Aim And Objective: The aim of the present split-mouth prospective study was to evaluate clinically and histologically the bone regeneration obtained following preprosthetic vertical bone augmentation performed with titanium-reinforced dense polytetrafluoroethylene membrane (d-PM) compared to titanium mesh (TM).

Materials And Methods: Healthy adult patients presenting with bilateral partial edentulism in the posterior mandible requiring vertical ridge augmentation for implant placement purposes were consecutively included. One side of the mandible was randomly assigned to the use of d-PM, the other to TM. Read More

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Pemphigus foliaceus in Arabian oryx ().

Vet Pathol 2021 Jul 28:3009858211030532. Epub 2021 Jul 28.

National Zoological Garden, South African National Biodiversity Institute, Pretoria, South Africa.

Pemphigus foliaceus (PF) is an autoimmune acantholytic skin disease described in humans, dogs, cats, horses, goats, and sheep. From 2003 to 2016, six Arabian oryx () at the National Zoological Garden in Pretoria, South Africa, developed progressive, bilaterally symmetrical, hyperkeratotic skin lesions and pustules consistent with PF. Lesions were similar to those observed in domestic animals and primarily affected the pinnae, face and nasal planum, distal legs, and tail tip. Read More

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Doxycycline pharmacokinetics in geese.

J Vet Pharmacol Ther 2021 Jul 27. Epub 2021 Jul 27.

Department of Veterinary Sciences, University of Pisa, Pisa, Italy.

The study aims to describe the pharmacokinetics of doxycycline after a single intravenous and oral dose (20 mg/kg) in geese. In addition, two multiple-dose simulations have been performed to investigate the predicted plasma concentration after either a 10 or 20 mg/kg daily administration repeated consecutively for 5 days. Ten geese were enrolled in a two-phase cross-over study with a washout period of two weeks. Read More

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Influence of the dental topical application of a nisin-biogel in the oral microbiome of dogs: a pilot study.

PeerJ 2021 14;9:e11626. Epub 2021 Jul 14.

CIISA - Centro de Investigação Interdisciplinar em Sanidade Animal, Faculdade de Medicina Veterinária, Universidade de Lisboa, Lisboa, Portugal.

Periodontal disease (PD) is one of the most widespread inflammatory diseases in dogs. This disease is initiated by a polymicrobial biofilm in the teeth surface (dental plaque), leading to a local inflammatory response, with gingivitis and/or several degrees of periodontitis. For instance, the prevention of bacterial dental plaque formation and its removal are essential steps in PD control. Read More

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One health pathogen surveillance demonstrated the dissemination of gut pathogens within the two coastal regions associated with intensive farming.

Gut Pathog 2021 23;13:47. Epub 2021 Jul 23.

Center for Microbial Ecology and Technology (CMET), Ghent University, Coupure Links 653, Gent, 9000 Belgium.

Background: Intensive aquaculture farming has caused significant degradation of coastal wetlands and has been proposed as a reservoir for pathogenic spp.

Results: Gut pathogens including spp., spp. Read More

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Ketone bodies - causes and effects of their increased presence in cows' body fluids: A review.

Piotr Guliński

Vet World 2021 Jun 11;14(6):1492-1503. Epub 2021 Jun 11.

Institute of Animal Production and Fisheries, Siedlce University of Natural Sciences and Humanities, 08-110 Siedlce, ul. Prusa 14, Poland.

Ketosis is the most common metabolic disease in high-performance dairy cows during the first 6-8 weeks of lactation. Its main symptoms include an excessive amount of so-called ketone bodies in a cow's body fluids. Ketone bodies consist of β-hydroxybutyric acid (βHBA), acetoacetic acid, and acetone. Read More

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Allele and genotype frequencies of the gene polymorphism associated with canine degenerative myelopathy in Belgian Malinois dogs in Greece.

Vet World 2021 Jun 9;14(6):1472-1479. Epub 2021 Jun 9.

School of Animal Biosciences, Department of Animal Science, Laboratory of Animal Breeding and Husbandry, Agricultural University of Athens, Athens, Greece.

Background And Aim: Canine degenerative myelopathy (CDM) is an adult-onset fatal disorder associated with a point mutation of the superoxide dismutase 1 () gene (). This study aimed to determine the allele and genotype frequencies of this mutation in a group of Belgian Malinois dogs in Greece.

Materials And Methods: Samples (n=72) of whole blood were collected from 72 purebred dogs of the Hellenic Armed Forces; these samples were processed for DNA isolation, polymerase chain reaction, and digestion with the restriction endonuclease . Read More

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Pirfenidone ameliorates silica-induced lung inflammation and fibrosis in mice by inhibiting the secretion of interleukin-17A.

Acta Pharmacol Sin 2021 Jul 27. Epub 2021 Jul 27.

State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Beijing, 100005, China.

Silicosis is a global occupational disease characterized by lung dysfunction, pulmonary inflammation, and fibrosis, for which there is a lack of effective drugs. Pirfenidone has been shown to exert anti-inflammatory and anti-fibrotic properties in the lung. However, whether and how pirfenidone is effective against silicosis remains unknown. Read More

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Illegal fishing with electrofishing devices in the Po river basin, Emilia Romagna, Italy.

Sci Rep 2021 Jul 27;11(1):15270. Epub 2021 Jul 27.

Department of Comparative Biomedicine and Food Science, University of Padua, Legnaro, Italy.

Electric fishing is an illegal hunting method, unfortunately widely used by poachers to paralyze fish and to catch many animals in a short time. In Italy, it is authorized only for scientific and conservative purposes. Between 2014 and 2018, the Ferrara section of the Experimental Zooprophylactic Institute of Lombardy and Emilia Romagna, Italy, received nine cases of potentially illegal electric fishing in Po river and its tributary rivers. Read More

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Comparison between three dosages of intramuscular alfaxalone and a ketamine-dexmedetomidine-midazolam-tramadol combination in golden-headed lion tamarins (Leontopithecus chrysomelas).

Vet Anaesth Analg 2021 Jun 26. Epub 2021 Jun 26.

Veterinary Medical Center, Oregon Zoo, Portland, OR, USA.

Objectives: To characterize the cardiopulmonary and anesthetic effects of alfaxalone at three dose rates in comparison with a ketamine-dexmedetomidine-midazolam-tramadol combination (KDMT) for immobilization of golden-headed lion tamarins (GHLTs) (Leontopithecus chrysomelas) undergoing vasectomy.

Study Design: Prospective clinical trial.

Animals: A total of 19 healthy, male, wild-caught GHLTs. Read More

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Determination of genetic effects and functional SNPs of bovine HTR1B gene on milk fatty acid traits.

BMC Genomics 2021 Jul 27;22(1):575. Epub 2021 Jul 27.

Department of Animal Genetics, Breeding and Reproduction, College of Animal Science and Technology, Key Laboratory of Animal Genetics, Breeding and Reproduction of Ministry of Agriculture and Rural Affairs, National Engineering Laboratory for Animal Breeding, China Agricultural University, Beijing, 100193, China.

Background: Our previous genome-wide association study (GWAS) on milk fatty acid traits in Chinese Holstein cows revealed, the SNP, BTB-01556197, was significantly associated with C10:0 at genome-wide level (P = 0.0239). It was located in the down-stream of 5-hydroxytryptamine receptor 1B (HTR1B) gene that has been shown to play an important role in the regulation of fatty acid oxidation. Read More

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