746 results match your criteria angioedema serum

What lessons can we learn? Clinical and epidemiological retrospective analysis of 267 patients with urticaria in a Brazilian tertiary center.

An Bras Dermatol 2021 May 21. Epub 2021 May 21.

Department of Dermatology, Centro Universitário Saúde ABC, Santo André, SP, Brazil.

Background: There are few epidemiological studies of urticaria, published in the indexed literature (PubMed/Medline).

Objective: The study aimed to evaluate the epidemiological and clinical data among patients with urticaria/angioedema attending a reference clinic in Brazil.

Methods: Two hundred sixty-seven patients were evaluated retrospectively considering demographic data, time course of the disease, triggering symptoms, the presence of angioedema, complementary laboratory tests including total blood count, reactive-C protein, erythrocyte sedimentation rate, IgE serum levels, and other, as necessary. Read More

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Lower IgA Levels in Chronic Spontaneous Urticaria Are Associated With Lower IgE Levels and Autoimmunity.

Front Immunol 2021 3;12:657211. Epub 2021 May 3.

Dermatological Allergology, Allergie-Centrum-Charité, Department of Dermatology and Allergy, Charité-Universitätsmedizin Berlin, Berlin, Germany.

Background: The pathogenesis of chronic spontaneous urticaria (CSU) is still insufficiently understood. Recent findings suggest that immunoglobulins, in particular IgE but also IgA, play a role in the development of CSU.

Objective: Our aim was to assess differences in clinical and laboratory markers between CSU patients with and without lower levels of serum IgA and IgE. Read More

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The Role of Interleukin 10 and 18 in Chronic Spontaneous Urticaria Pathogenesis in the Context of Angioedema Coexistence.

J Interferon Cytokine Res 2021 May;41(5):172-176

Department of Internal Medicine with Division of Allergology, Institute of Medical Sciences, University of Opole, Opole, Poland.

Chronic spontaneous urticaria (CSU) is defined using clinical symptoms as spontaneous occurrence of itchy wheals and/or angioedema for at least 6 weeks. Angioedema is underdiagnosed in CSU patients, and its presence has significant negative impact on health-related quality of life, daily activities, health care resource utilization, and work. Various cytokines have been found to be involved in pathogenesis of CSU. Read More

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Cold Agglutinins and Cryoglobulins Associate With Clinical and Laboratory Parameters of Cold Urticaria.

Front Immunol 2021 29;12:665491. Epub 2021 Apr 29.

Urticaria Center of Reference and Excellence (UCARE), University Clinic of Respiratory and Allergic Diseases Golnik, Golnik, Slovenia.

Mast cell-activating signals in cold urticaria are not yet well defined and are likely to be heterogeneous. Cold agglutinins and cryoglobulins have been described as factors possibly associated with cold urticaria, but their relevance has not been explained. We performed a single-center prospective cohort study of 35 cold urticaria patients. Read More

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Clinical experience of a specialized urticaria outpatient clinic from a Portuguese UCARE.

Eur Ann Allergy Clin Immunol 2021 May 5. Epub 2021 May 5.

Department of Immunoallergology, Hospital de Santa Maria, Centro Hospitalar Universitário Lisboa Norte EPE, Lisbon, Portugal.

Summary: Chronic urticaria (CU) is a frequent disease, with a prevalence of at least 1%. It is characterized by pruritic wheals, angioedema or both for a period longer than 6 weeks. Identify the demographic, clinical, laboratory and therapeutic profile of patients treated in a Portuguese Urticaria Center of Reference and Excellence (UCARE) and compare it with international series. Read More

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Episodic Angioedema with Hypereosinophilia (Gleich's Syndrome): A Case Report and Extensive Review of the Literature.

J Clin Med 2021 Apr 1;10(7). Epub 2021 Apr 1.

Department of Translational Medical Sciences and Center for Basic and Clinical Immunology Research (CISI), WAO Center of Excellence, University of Naples Federico II, Via S. Pansini 5, 80131 Naples, Italy.

Episodic angioedema with eosinophilia (EAE) (Gleich's syndrome) is a rare disease characterized by hypereosinophilia (up to 95 × 10 cells/L), recurrent episodes of angioedema, urticaria, weight gain, and fever, that occur at periodical intervals (usually every 3-4 weeks). The exact etiology of EAE is still unclear, but both eosinophils and abnormalities of cytokines homeostasis seem to play a pivotal role in the pathogenesis of the disease. In particular, the cyclic elevation of serum interleukin-5 before the increase in eosinophil count has been reported. Read More

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The Relation of Autologous Serum Skin Test and Autologous Plasma Skin Test Result with Various Clinical and Laboratory Findings in Patients with Chronic Spontaneous Urticaria.

Ann Dermatol 2020 Aug 30;32(4):280-288. Epub 2020 Jun 30.

Department of Dermatology, Hallym University Dongtan Sacred Heart Hospital, Hwaseong, Korea.

Background: Despite the autologous serum skin test (ASST) and autologous plasma skin test (APST) is widely used test accessing whether a patient with chronic spontaneous urticaria (CSU) has autoreactivity or not, the clinician often encounter difficulty making correlation between the test result and clinical implications.

Objective: This study was aimed to find any clinical and laboratory findings related to the ASST and APST response. Agreement and correlation between the two tests was also analyzed. Read More

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Episodic angioedema with eosinophilia (Gleich's syndrome) associated with urticarial vasculitis: a coincidence or a novel clinical entity?

Braz J Med Biol Res 2021 19;54(6):e10745. Epub 2021 Apr 19.

Departamento de Medicina, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, SP, Brasil.

Episodic angioedema with eosinophilia (EAE) is a rare condition characterized by recurrent attacks of angioedema and urticaria accompanied by a marked elevation of peripheral eosinophil count. We report the case of a young female patient diagnosed with EAE associated with urticarial vasculitis. A 40-year-old female patient was admitted to our institution due to recurrent episodes of cheek and eyelid angioedema in the previous year. Read More

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Proprotein Convertase Is the Highest-Level Activator of the Alternative Complement Pathway in the Blood.

J Immunol 2021 May 15;206(9):2198-2205. Epub 2021 Apr 15.

Institute of Enzymology, Research Centre for Natural Sciences, Budapest, Hungary;

Factor D (FD) is an essential element of the alternative pathway of the complement system, and it circulates predominantly in cleaved, activated form in the blood. In resting blood, mannose-binding lectin-associated serine protease 3 (MASP-3) is the exclusive activator of pro-FD. Similarly to FD, MASP-3 also circulates mainly in the active form. Read More

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A Comparative Study of Sex Distribution, Autoimmunity, Blood, and Inflammatory Parameters in Chronic Spontaneous Urticaria with Angioedema and Chronic Histaminergic Angioedema.

J Allergy Clin Immunol Pract 2021 Jun 5;9(6):2284-2292. Epub 2021 Apr 5.

Department of Allergy and Clinical Immunology, Clínica Universidad de Navarra, Pamplona, Spain; Instituto de Investigación Sanitaria de Navarra (IdiSNA), Pamplona, Spain; RETIC de Asma, Reacciones Adversas y Alérgicas (ARADYAL), Madrid, Spain. Electronic address:

Background: Recurrent idiopathic histaminergic angioedema is currently classified as a subtype of angioedema, as well as a subtype of chronic spontaneous urticaria (CSU), based on the fact that both are mast cell-mediated and respond to the same treatments.

Objective: In the present work, we sought to verify whether chronic histaminergic angioedema (CHA) is an entity distinct from CSU or represents a CSU subtype that lacks hives.

Methods: We performed a prospective study comparing 68 CHA patients, angioedema without hives, with 63 CSU patients, with hives and angioedema, from whom we collected demographic and clinical data, as well as blood and serum markers. Read More

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A case of hand urticaria, lip angioedema, and oropharyngeal pruritus induced by Japanese radish through IgE-mediated immediate allergic reaction.

Allergy Asthma Clin Immunol 2021 Mar 31;17(1):36. Epub 2021 Mar 31.

Department of Respiratory Medicine, Juntendo University Faculty of Medicine and Graduate School of Medicine, 3-1-3 Hongo, Bunkyo-ku, Tokyo, 113-8431, Japan.

Background: Although Japanese radish (Raphanus sativus L.) is a common Japanese ingredient, there are few reports of IgE-mediated immediate food allergy caused by Japanese radish.

Case Presentation: A 48-year-old woman developed urticarial lesions on her hands after grating Japanese radish and also developed lip edema and oral itching when she ate a salad composed of raw Japanese radishes. Read More

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A case of episodic angioedema with eosinophilia in an elderly woman with primary biliary cholangitis.

Clin J Gastroenterol 2021 Jun 10;14(3):836-841. Epub 2021 Mar 10.

Department of Gastroenterology and Medicine, Faculty of Medicine, Fukuoka University, 7-45-1 Nanakuma, Jonan-ku, Fukuoka, 814-0180, Japan.

We present the case of a 56-year-old woman diagnosed with primary biliary cholangitis (PBC). She has continuously taken 600 mg/day of ursodeoxycholic acid. Edema of the lower limbs manifested on July 20, 20XX; after 2 weeks, she manifested rapid weight gain and nettle rash on the limbs and trunk. Read More

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Elevated MRGPRX2 Levels Related to Disease Severity in Patients With Chronic Spontaneous Urticaria.

Allergy Asthma Immunol Res 2021 May;13(3):498-506

Department of Allergy and Clinical Immunology, Ajou University School of Medicine, Suwon, Korea.

Mas-related G-protein coupled receptor-X2 (MRGPRX2), a receptor on mast cells, basophils, and eosinophils associated with immunoglobulin E (IgE)-independent degranulation, has been reported to be highly expressed on cutaneous mast cells in patients with severe chronic spontaneous urticaria (CSU). We sought to investigate whether MRGPRX2 levels in the sera from CSU patients differ from those in healthy control subjects and to evaluate the clinical utility of MRGPRX2 levels in CSU patients. Severe CSU was defined as urticaria activity score over 7 days (UAS7) ≥ 28. Read More

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Evaluation of serum levels of C-reactive protein, D-Dimer and Autologous Serum Skin Test in patients with Chronic Spontaneous Urticaria in a Brazilian tertiary center : a cross-sectional study.

An Bras Dermatol 2021 Mar-Apr;96(2):148-154. Epub 2021 Feb 1.

Department of Dermatology, Faculdade de Medicina do ABC, Santo André, SP, Brazil.

Background: The pathophysiology of urticaria is still poorly understood. Recent studies demonstrate that the activation of coagulation is correlated with the clinical activity of Chronic Spontaneous Urticaria. Coagulation and inflammation are strongly linked. Read More

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Allergy: Is Aquacultured Fish a Safe and Alternative Food to Wild-Capture Fisheries for -Sensitized Patients?

Biology (Basel) 2021 Feb 2;10(2). Epub 2021 Feb 2.

Polypheno Academic Spin Off, University of Bari "A. Moro", 70124 Bari, Italy.

Background: ( infection, in humans, causes a series of clinical manifestations affecting the gastro-intestinal tract known as Anisakiasis/Anisakidosis. Patients may also present allergic manifestations such as hives and/or angioedema and even anaphylactic shock. The aim of this study was to investigate whether aquacultured fish could be considered -free food and constitute a safe, alternative, wild-capture fish food for Gastro-Allergic Anisakiasis (GAA)-sensitized subjects. Read More

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February 2021

CME suggestions for pediatricians, allergists, and dermatologists, directed by an online survey on urticaria knowledge.

Allergol Immunopathol (Madr) 2021 2;49(1):87-94. Epub 2021 Jan 2.

Pediatrics Division, Hospital con Especialidades Juan María Salvatierra, La Paz Baja California Sur, Mexico.

Background: The Mexican Guidelines for the diagnosis and treatment of urticaria have been published. Just before their launch, physicians' knowledge was explored relating to key issues of the guidelines.

Objective: The aim of this study was to investigate the opinion of medical specialists concerning urticaria management. Read More

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January 2021

Successful Long-Term Control of the Syndrome of Episodic Angioedema With Eosinophilia (Gleich Syndrome) With Low-Dose Imatinib Mesylate and Prednisone.

J Investig Med High Impact Case Rep 2021 Jan-Dec;9:2324709620987691

Mayo Clinic, Rochester, MN, USA.

The syndrome of episodic angioedema with eosinophilia, first reported over 40 years ago, is a hypereosinophilic disorder that, uniquely, is not associated with end-organ pathology. However, patients develop a constellation of symptoms that include angioedema, urticaria, fatigue, and fever. Episodes are accompanied by massive hypereosinophilia and weight gain. Read More

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January 2021

Short-term Prophylaxis for Delivery in Pregnant Women with Hereditary Angioedema with Normal C1-Inhibitor.

Rev Bras Ginecol Obstet 2020 Dec 21;42(12):845-848. Epub 2020 Dec 21.

Universidade Federal do Paraná, Curitiba, PR, Brazil.

Objective:  To verify the efficacy of short-term prophylaxis for vaginal or cesarean section childbirth with plasma-derived C1-inhibitor concentrate in pregnant women. They should have hereditary angioedema (HAE) and normal plasma C1-inhibitor.

Methods:  Case report of pregnant women diagnosed with HAE with normal C1-inhibitor who had been treated with intravenous C1-inhibitor concentrate for prophylaxis of angioedema attacks when hospitalized for delivery. Read More

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December 2020

MRGPRX2 is critical for clozapine induced pseudo-allergic reactions.

Immunopharmacol Immunotoxicol 2021 Feb 17;43(1):77-84. Epub 2020 Dec 17.

School of Pharmacy, Xi'an Jiaotong University, Xi'an, China.

Background: Clozapine is one of the most widely used second-generation antipsychotics in clinic. However, allergy-like symptoms such as rash and angioedema have been reported frequently, and the mechanism is still not clear. Mas-related G protein-coupled receptor X2 (MRGPRX2) expressed on mast cells is a crucial receptor for drug induced pseudo-allergic reactions. Read More

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February 2021

Refractory chronic urticaria in adults: clinical characterization and predictors of severity.

Allergy Asthma Clin Immunol 2020 Nov 11;16(1):97. Epub 2020 Nov 11.

Allergy and Clinical Immunology Departement, Centro Hospitalar E Universitário de Coimbra, Coimbra, Portugal.

Background: Chronic urticaria (CU) is defined as recurrent urticaria lasting for more than 6 weeks.

Objectives: We aimed to characterize the phenotypes of patients with CU refractory to standard dose anti-H1 antihistamine treatment and search for clinical predictors of poor disease control.

Methods: Retrospective collection of data regarding clinical characteristics, comorbidities, treatment, and disease control of all adult refractory CU patients presenting to the Allergy and Immunology Department during 1 year. Read More

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November 2020

Hereditary angioedema: a disease seldom diagnosed by pediatricians.

J Pediatr (Rio J) 2021 Mar-Apr;97 Suppl 1:S10-S16. Epub 2020 Nov 30.

Faculdade de Medicina de São José do Rio Preto, Departamento de Pediatria e Cirurgia Pediátrica, São José do Rio Preto, SP, Brazil.

Objectives: To describe the hereditary angioedema to improve awareness of this condition and reduce diagnostic delay.

Data Sources: Relevant articles in the MEDLINE database through PubMed.

Data Synthesis: Hereditary angioedema is rare and has an autosomal dominant pattern of inheritance. Read More

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Novel SERPING1 gene mutations and clinical experience of type 1 hereditary angioedema from North India.

Pediatr Allergy Immunol 2021 Apr 5;32(3):599-611. Epub 2020 Dec 5.

Allergy Immunology Unit, Department of Paediatrics, Advanced Paediatrics Centre, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Background: There is paucity of literature on long-term follow-up of patients with hereditary angioedema (HAE) from developing countries.

Objective: This study was carried out to analyze the clinical manifestations, laboratory features, and genetic profile of 32 patients (21 male and 11 female) from 23 families diagnosed with HAE between January 1996 and December 2019.

Methods: Data were retrieved from medical records of Paediatric Immunodeficiency Clinic, Postgraduate Institute of Medical Education and Research, Chandigarh, India. Read More

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Drug Induced Cutaneous Manifestations due to Treatment of Gastrointestinal Disorders.

Curr Drug Metab 2021 ;22(2):99-107

Faculty of Medicine, University of Belgrade, Belgrade, Serbia.

Cutaneous manifestations due to drugs used in the treatment of gastrointestinal disorders are multiple and common. Adequate diagnosis is of great importance, bearing in mind that the therapeutic regimen depends on its diagnosis. In this review, we provided an overview of the most common drug-induced skin lesions with a detailed explanation of the disease course, presentation and treatment, having in mind that in recent years, novel therapeutic modalities have been introduced in the treatment of various gastrointestinal disorders, and that incidence of cutaneous adverse reactions has been on the rise. Read More

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January 2021

Antiphospholipid antibodies may be associated with uveitis.

Eur J Ophthalmol 2020 Nov 4:1120672120968729. Epub 2020 Nov 4.

Clinical Immunology, Angioedema and Allergy Unit, Center for Autoimmune Diseases, Sheba Medical Center, Tel Hashomer, Israel.

Purpose: To evaluate the prevalence of a spectrum of autoantibodies in adult patients with non-infectious uveitis compared to healthy controls.

Methods: This is a case-control study conducted in a tertiary referral center. Serum positivity to auto-antibodies directed at membranous phospholipids (aPL), nuclear antigens, and cytoplasmic (ANCA) antigens were assessed in sera from 63 non-infectious uveitis patients, and 78 healthy controls. Read More

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November 2020

Safety implications of combining ACE inhibitors with thiazides for the treatment of hypertensive patients.

Expert Opin Drug Saf 2020 Dec;19(12):1577-1583

Department of Medical and Surgical Sciences, University of Bologna , Bologna, Italy.

Introduction: ACE-inhibitors (ACEI) and diuretics are the typical first-line antihypertensive drugs with complementary mechanisms of action. The present paper is summarizing the evidence supporting the efficacy of their combination in a broad range of hypertensive patients.

Areas Covered: This source of data is different trials investigating the use of ACEI and diuretics in different populations of patients. Read More

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December 2020

Interleukin 17 receptor A haplotype analysis in chronic spontaneous urticaria: A preliminary study.

J Cosmet Dermatol 2021 Apr 12;20(4):1331-1342. Epub 2020 Oct 12.

Dermatology, Venereology and Andrology Department, Faculty of Medicine, Suez Canal University, Ismailia, Egypt.

Background: Chronic spontaneous urticaria (CSU) is a distressing skin disease. Family clustering and heterogeneity in the onset and progression indicate that susceptibility to CSU is a complex trait. In this study, we performed haplotype analysis for one of the key player gene, IL17RA, for CSU to test the association with disease susceptibility and severity. Read More

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Chronic spontaneous urticaria and angioedema in a patient with autoimmune thyroid disease resolved after thyroidectomy.

Auris Nasus Larynx 2020 Sep 5. Epub 2020 Sep 5.

Department of Clinical Immunology and Pulmology, General Hospital "Sveti Duh", Zagreb, Croatia.

The link between chronic urticaria and accompanying thyroid disease is still not understood, with current treatment focusing on antihistamines and levothyroxine. A 35-year-old female patient presented with chronic idiopathic urticaria and facial angioedema for 9 months prior to evaluation. Oral corticosteroid therapy, antihistamines, leukotriene-antagonists, selenium, and omalizumab were all administered, with the disease relapsing within several days, accompanied with facial angioedema of varying severity. Read More

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September 2020

Orthognathic Surgery in Hereditary Angioedema With Normal C1 Inhibitor: A Clinical Response to Concentrated C1 Inhibitor Against Angioedema Attack.

J Oral Maxillofac Surg 2021 02 7;79(2):463-470. Epub 2020 Aug 7.

Professor, Department of Oral and Maxillofacial Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

Hereditary angioedema (HAE) is a rare autosomal dominant disorder characterized by episodes of localized swelling, often of life-threatening severity. HAE due to C1 inhibitor (C1-INH) deficiency is common and is divided into types 1 and 2, but HAE with normal C1-INH is exceedingly rare. Herein, we describe the case of a patient with HAE with normal C1-INH undergoing orthognathic surgery. Read More

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February 2021

Eosinophilia Associated With CD3CD4 T Cells: Characterization and Outcome of a Single-Center Cohort of 26 Patients.

Front Immunol 2020 11;11:1765. Epub 2020 Aug 11.

Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium.

Lymphocytic variant hypereosinophilic syndrome is characterized by marked over-production of eosinophilopoietic factor(s) by dysregulated T cells leading to eosinophil expansion. In most cases, these T cells are clonal and express a CD3CD4 phenotype. As this is a rare disorder, presenting manifestations, disease course, treatment responses, and outcome are not well-characterized. Read More

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The effect of vitamin D add-on therapy on the improvement of quality of life and clinical symptoms of patients with chronic spontaneous urticaria.

Asian Pac J Allergy Immunol 2020 Aug 23. Epub 2020 Aug 23.

Allergy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.

Background: Chronic urticaria is a common distressing allergic skin disorder. Immune dysregulation, histamine release and mast cell degranulation are suggested as its underlying mechanisms.

Objective: Add-on therapy of vitamin D was evaluated in patients with chronic spontaneous urticaria to determine the quality of life and urticaria severity score. Read More

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