262,601 results match your criteria anesthetic agents


Sevoflurane versus desflurane for early postoperative vomiting after general anesthesia in hospitalized adults: A systematic review and meta-analysis of randomized controlled trials.

J Clin Anesth 2021 Jul 24;75:110464. Epub 2021 Jul 24.

Department of Diagnostic Radiology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, No.123, Ta-Pei Rd., Niao-Song Dist., Kaohsiung City 833, Taiwan. Electronic address:

Study Objective: This systematic review and meta-analysis aimed at assessing the effects of two commonly used anesthetics in general anesthesia (GA), sevoflurane and desflurane, on early postoperative vomiting (POV) in hospitalized adults.

Design: Systematic review and meta-analysis of randomized controlled trials (RCTs).

Setting: Early postoperative vomiting after GA. Read More

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Propofol-Induced Uric Acid Crystals: A Case of Cloudy Urine.

Paediatr Anaesth 2021 Jul 26. Epub 2021 Jul 26.

Department of Anesthesiology & Pediatrics, Vanderbilt University Medical Center, Monroe Carell Jr. Children's Hospital at Vanderbilt, 2200 Children's Way, Nashville, TN, 37232, USA.

Propofol is an intravenous anesthetic agent commonly used intraoperatively as well as in the intensive care unit. Known short-term effects of propofol can include apnea, hypotension, and bradycardia. In children, the rarer adverse sequelae of intravenous anesthetics have received little attention. Read More

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Update on the Mechanism and Treatment of Sevoflurane-Induced Postoperative Cognitive Dysfunction.

Front Aging Neurosci 2021 8;13:702231. Epub 2021 Jul 8.

Department of Anesthesiology, The Second Affiliated Hospital, Fujian Medical University, Quanzhou, China.

Sevoflurane is one of the most widely used anesthetics for the induction and maintenance of general anesthesia in surgical patients. Sevoflurane treatment may increase the incidence of postoperative cognitive dysfunction (POCD), and patients with POCD exhibit lower cognitive abilities than before the operation. POCD affects the lives of patients and places an additional burden on patients and their families. Read More

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Effects of fadolmidine, an α -adrenoceptor agonist, as an adjuvant to spinal bupivacaine on antinociception and motor function in rats and dogs.

Pharmacol Res Perspect 2021 Aug;9(4):e00830

Orion Corporation Orion Pharma, R&D, Turku, Finland.

α -Adrenoceptor agonists such as clonidine and dexmedetomidine are used as adjuvants to local anesthetics in regional anesthesia. Fadolmidine is an α -adrenoceptor agonist developed especially as a spinal analgesic. The current studies investigate the effects of intrathecally administered fadolmidine with a local anesthetic, bupivacaine, on antinociception and motor block in conscious rats and dogs. Read More

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Activation of Ca/Calmodulin-Dependent Protein Kinase II (CaMKII) with Lidocaine Provokes Pyroptosis of Glioblastoma Cells.

Bull Exp Biol Med 2021 Jul 24. Epub 2021 Jul 24.

Department of Anesthesiology, The Second Affiliated Hospital of Nanchang University, City, Nanchang, China.

The study examines the problem whether pyroptosis of U87-MG glioblastoma cells can result from activation of Ca/calmodulin-dependent protein kinase II (CaMKII) by a local anesthetic. Glioblastoma cells exposed to various concentrations of typical local anesthetic lidocaine demonstrated augmented cytosolic flux of Ca, while suppression of CaMKII expression with the corresponding siRNA significantly inhibited this effect in cells treated with 2 mM lidocaine. Lidocaine up-regulated the expression of mRNA caspase-3 and gasdermin GSDME proteins, whereas silencing of CaMKII gene with siRNA significantly moderated this effect. Read More

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Efficacy of Erector Spinae Plane Block for Analgesia in Thoracic Surgery: A Systematic Review and Meta-Analysis.

J Cardiothorac Vasc Anesth 2021 Jun 29. Epub 2021 Jun 29.

Department of Anesthesiology & Pain Medicine, Seoul National University Bundang Hospital, Seongnam, Korea. Electronic address:

Objective: The objective of this study was to determine whether erector spinae plane block (ESPB) can provide an effective analgesia for managing pain after thoracic surgery and compare the efficacy of ESPB with that of other regional analgesic techniques.

Design: Systematic review and meta-analysis of randomized controlled trials.

Setting: PubMed, EMBASE, CENTRAL, CINAHL, Scopus, and Web of Science were searched. Read More

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Comparative study of the anaesthetic efficacy of 4% articaine versus 2% lidocaine with adrenaline during extraction of mandibular molars using an inferior alveolar nerve blocking technique.

Br J Oral Maxillofac Surg 2020 Sep 17. Epub 2020 Sep 17.

Department of Oral & Maxillofacial Surgery Institute of Dental Sciences, Bareilly, UP 243006, India. Electronic address:

Various anaesthetic agents have been used in dentistry for the extraction of teeth. The most commonly used local anaesthetic agent is lidocaine hydrochloride. Recently, articaine hydrochloride came into existence because of its versatile properties and longer duration of action. Read More

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September 2020

The Effects of Ketamine on the Gut Microbiome on CD1 Mice.

Comp Med 2021 Jul 23. Epub 2021 Jul 23.

The intestinal microbiota of an organism can significantly alter outcome data in otherwise identical experiments. Occasionally,animals may require sedation or anesthesia for scientific or health-related purposes, and certain anesthetics, suchas ketamine, can profoundly affect the gastrointestinal system. While many factors can alter the gut microbiome (GM), theeffects of anesthetics on the composition or diversity of the GM have not been established. Read More

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Breast Cancer and Anaesthesia: Genetic Influence.

Int J Mol Sci 2021 Jul 17;22(14). Epub 2021 Jul 17.

Department of Anaesthesiology, Virgen de la Victoria University Hospital, 29010 Malaga, Spain.

Breast cancer is the leading cause of mortality in women. It is a heterogeneous disease with a high degree of inter-subject variability even in patients with the same type of tumor, with individualized medicine having acquired significant relevance in this field. The clinical and morphological heterogeneity of the different types of breast tumors has led to a diversity of staging and classification systems. Read More

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-Acetylcysteine Added to Local Anesthesia Reduces Scar Area and Width in Early Wound Healing-An Animal Model Study.

Int J Mol Sci 2021 Jul 14;22(14). Epub 2021 Jul 14.

Department of Methodology, Medial University of Warsaw, 02-091 Warsaw, Poland.

The aim of the study was to evaluate if a pre-incisional -acetylcysteine (NAC) treatment altered the process of wound healing in a rat model. The dorsal skin of 24 Sprague-Dawley rats was incised in six locations. Before the incisions were made, skin was injected either with lidocaine and epinephrine (one side) or with these agents supplemented with 0. Read More

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Impact of anesthesia on static and dynamic functional connectivity in mice.

Neuroimage 2021 Jul 20;241:118413. Epub 2021 Jul 20.

Jikei University School of Medicine, 3-25-8 Nishishinbashi, Minato City, Tokyo 105-8461, Japan; Riken, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan.

A few studies have compared the static functional connectivity between awake and lightly anesthetized states in rodents by resting-state fMRI. However, impact of light anesthesia on static and dynamic fluctuations in functional connectivity has not been fully understood. Here, we developed a resting-state fMRI protocol to perform awake and anesthetized functional MRI in the same mice. Read More

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Comparison of standing stability with different doses in epidural fentanyl among post-cesarean delivery women: a prospective trial.

Braz J Anesthesiol 2021 Jul 19. Epub 2021 Jul 19.

The Hospital for Sick Children, Department of Anesthesia and Pain Medicine, Toronto, Canada.

Background: The study purpose was to determine the safety and efficacy of different doses of epidural fentanyl plus local anesthetics on ambulation for patients who had elective cesarean delivery.

Methods: A prospective study at a single community hospital used posturography to compute Sway area for assessment of standing stability [ISRCTN14517337]. Continuous epidural infusion of 0. Read More

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Association of dexmedetomidine with recovery room and hospital discharge times: a retrospective cohort analysis.

Paediatr Anaesth 2021 Jul 22. Epub 2021 Jul 22.

Department of Anesthesiology, Pharmacology & Therapeutics, University of British Columbia, Vancouver, BC, Canada.

Background: Dexmedetomidine is a useful anesthetic adjunct, increasingly popular during pediatric surgery and procedural sedation. Its half-life of 2-3 hours might prolong recovery and discharge times when compared with an un-supplemented propofol anesthetic. This may create an additional burden in a busy post-anesthetic care unit (PACU). Read More

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The Effect of Preoperative Anxiety and Pain Sensitivity on Preoperative Hemodynamics, Propofol Consumption, and Postoperative Recovery and Pain in Endoscopic Ultrasonography.

Pain Ther 2021 Jul 22. Epub 2021 Jul 22.

Department of Anaesthesiology and Reanimation, Faculty of Medicine, Istanbul Medeniyet University, Goztepe Prof. Dr. Suleyman Yalcın Sehir Hastanesi, Dr. Erkin Cad., Kadikoy, 34722, Istanbul, Turkey.

Introduction: The present study investigates how preoperative anxiety and pain sensitivity affect the consumption of anesthetics, time elapsed until the desired sedation level is achieved, preoperative hemodynamics, postoperative recovery time, and postoperative pain.

Methods: The present study includes 80 ASA 1-2 patients aged between 20 and 65 who were scheduled for endoscopic ultrasonography (EUS) under sedation. Patients were instructed to fill out the Spielberger State-Trait Anxiety Inventory (STAI) and Pain Sensitivity Questionnaire (PSQ) before the procedure. Read More

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Genetic variation of rs12918566 affects GRIN2A expression and is associated with spontaneous movement response during sevoflurane anesthesia induction.

Brain Behav 2021 Jul 21:e02165. Epub 2021 Jul 21.

Department of Anesthesiology, Third Xiangya Hospital of Central South University, Changsha, China.

N-methyl-D-aspartate (NMDA) receptors mediate excitatory neurotransmission in the nervous system and are preferentially inhibited by general anesthetics such as sevoflurane. Spontaneous movement is a common complication during sevoflurane anesthesia induction and seriously affects operations. In this study, we investigated the relationship between NMDA polymorphisms and spontaneous movement during sevoflurane induction. Read More

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Important reminder: nitrous oxide (NO) as a cause of functional vitamin B deficiency.

BMJ Case Rep 2021 Jul 21;14(7). Epub 2021 Jul 21.

Internal Medicine, Hurley Medical Center, Flint, Michigan, USA

A 32-year-old woman who misused multiple substances, including nitrous oxide (NO), sought medical advice after she subacutely developed bilateral lower extremity weakness without a sensory level but with ataxia-her significant other developed similar symptoms with vitamin B deficiency due to NO intake. Laboratory results revealed macrocytic anaemia despite normal B and folate levels, with serum markers pointing towards functional cobalamin deficiency. Spinal MRIs and cerebrospinal fluid analysis were unremarkable. Read More

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HTX-011 effectively reduces postoperative pain intensity and opioid use in the elderly.

Pain Manag 2021 Jul 21. Epub 2021 Jul 21.

University of Utah College of Pharmacy, 30 South 2000 East, Salt Lake City, UT 84112, USA.

HTX-011 (ZYNRELEF™) is an extended-release, dual-acting local anesthetic containing bupivacaine and meloxicam. In bunionectomy and herniorrhaphy studies, HTX-011 resulted in less postoperative pain and less opioid consumption versus bupivacaine HCl. Here we evaluate HTX-011 in patients aged ≥65 years. Read More

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The histamine H receptor antagonist hydroxyzine enhances sevoflurane and propofol anesthesia: A quantitative EEG study.

Clin Neurophysiol 2021 Jun 24;132(9):2054-2061. Epub 2021 Jun 24.

Department of Anesthesiology and Resuscitology, Shinshu University School of Medicine, Japan.

Objective: The aim of this study was to determine the anesthesia-promoting effects of hydroxyzine on electroencephalograms during sevoflurane anesthesia and during propofol anesthesia.

Methods: We analyzed 40 patients scheduled for elective surgery under sevoflurane anesthesia (n = 20) or propofol anesthesia (n = 20). Anesthesia was adjusted at a bispectral index value of 50-60, and then 0. Read More

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Cancer-Associated Fibroblasts Modulate Transcriptional Signatures Involved in Proliferation, Differentiation and Metastasis in Head and Neck Squamous Cell Carcinoma.

Cancers (Basel) 2021 Jul 4;13(13). Epub 2021 Jul 4.

Division of Cell Biology, Department of Biomedical and Clinical Sciences, Linköping University, 58185 Linköping, Sweden.

Cancer-associated fibroblasts (CAFs) are known to increase tumor growth and to stimulate invasion and metastasis. Increasing evidence suggests that CAFs mediate response to various treatments. HNSCC cell lines were co-cultured with their patient-matched CAFs in 2D and 3D in vitro models, and the tumor cell gene expression profiles were investigated by cDNA microarray and qRT-PCR. Read More

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Transversus Abdominis Plane Block Versus Intraperitoneal Local Anesthetics in Bariatric Surgery: A Systematic Review and Network Meta-analysis.

Obes Surg 2021 Jul 19. Epub 2021 Jul 19.

Department of Anesthesiology, Faculty of Medicine, University of Malaya, 50603, Kuala Lumpur, Malaysia.

Background: Transversus abdominis plane (TAP) block and intraperitoneal local anesthetics (IPLA) are widely investigated techniques that potentially improve analgesia after bariatric surgery. The analgesic efficacy of TAP block has been shown in previous studies, but the performance of TAP block can be difficult in patients with obesity. We performed a systematic review and meta-analysis to compare the analgesic efficacy of TAP block and IPLA. Read More

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Analgesic effect of perineural local anesthetics, steroids, and conventional medical management for trauma and compression-related peripheral neuropathic pain: a retrospective cohort study.

Pain Rep 2021 Jul-Aug;6(2):e945. Epub 2021 Jul 13.

Department of Physical Therapy and Surgery, Graduate Department of Rehabilitation Science and Institute of Health Policy, Management and Evaluation and Institute of Medical Science, University of Toronto, Toronto, ON, Canada.

Introduction: Trauma and compression are common causes of peripheral neuropathic pain (NP) refractory to conventional medical management (CMM). The role of perineural interventions in relieving this type of pain is unclear.

Objectives: The objectives of this retrospective study were to determine the analgesic benefits of adding a combination of perineural local anesthetic and steroids (LA-S) to CMM compared with CMM alone in patients who had moderate-to-severe refractory NP after trauma to the ankle and the foot. Read More

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The Effects of Sevoflurane vs. Propofol for Inflammatory Responses in Patients Undergoing Lung Resection: A Meta-Analysis of Randomized Controlled Trials.

Front Surg 2021 2;8:692734. Epub 2021 Jul 2.

Department of Anesthesiology and Perioperative Medicine, Henan University People's Hospital, Henan Provincial People's Hospital, Zhengzhou, China.

Inflammatory cytokines are increased during one-lung ventilation in patients undergoing lung resection, and this increase can be fatal. Propofol and sevoflurane are the main anesthetics used for these patients. Unfortunately, there is no consensus on the best choice of an anesthetic agent concerning an inflammatory response in patients undergoing lung resection. Read More

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Effect of Intravenous Dexmedetomidine on Spinal Anesthesia.

Cureus 2021 Jun 17;13(6):e15708. Epub 2021 Jun 17.

Anaesthesiology, ACS Medical College Hospital, Chennai, IND.

Background Subarachnoid block (SAB) with hyperbaric bupivacaine is routinely administered for abdominal and lower limb surgeries. Various agents have been used intrathecally as adjuvants to local anesthetic to increase efficacy and prolong the duration of SAB, among which opioids and α2 agonists are most commonly used. Intravenously administered dexmedetomidine has also been shown to prolong the duration of sensory and motor blockade obtained with subarachnoid block. Read More

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Volatile Versus Intravenous Anesthetics in Cardiac Anesthesia: a Narrative Review.

Curr Anesthesiol Rep 2021 Jul 10:1-9. Epub 2021 Jul 10.

Department of Anesthesiology and Intensive Care Medicine, University Hospital and Medical Faculty, Cologne University, Albertus-Magnus-Platz, 50923 Cologne, Germany.

Purpose Of The Review: The present review addresses clinicians and gives an overview about the experimental rationale for pharmacological conditioning associated with volatile anesthetics, opioids, and propofol; the current clinical data; and the technical considerations regarding the clinical routine in cardiac anesthesia.

Recent Findings: Volatile anesthetics have been standard of care for general anesthesia for cardiac surgery, especially while using cardiopulmonary bypass. The 2019 published MYRIAD trial was not able to show a difference in mortality or cardiac biomarkers for volatile anesthetics compared to total intravenous anesthesia (TIVA), raising the question of equivalence with respect to patient outcome. Read More

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