382,596 results match your criteria anesthesia


Short-term Outcomes of Day-Case Stoma Closure: A Prospective, Observational Study.

Dis Colon Rectum 2021 Apr 26. Epub 2021 Apr 26.

Department of Digestive Surgery, Amiens University Hospital, Amiens, France SSPC (Simplification of Surgical Patients Care) Clinical Research Unit, University of Picardie Jules Verne, Amiens, France Department of Anaesthesia, Amiens University Hospital, Amiens, France.

Background: Elective stoma closure is a common, standardized procedure in digestive surgery.

Objective: To evaluate the feasibility of day-case surgery for elective stoma closure.

Design: A prospective, single-center, non-randomized study of consecutive patients undergoing day-case elective stoma closure. Read More

View Article and Full-Text PDF

Adult Transglottic Haemangioma with Upper Airway Obstruction: Preservation of Airway and Voice.

ORL J Otorhinolaryngol Relat Spec 2021 May 5:1-4. Epub 2021 May 5.

Department of Otorhinolaryngology-Head & Neck Surgery, Faculty of Medicine, Universiti Kebangsaan Malaysia Medical Centre, Kuala Lumpur, Malaysia.

Adult laryngeal haemangioma is normally seen in the supraglottic or glottic region. Transglottic haemangioma is unusual, and treatment with primary endolaryngeal surgical excision may lead to undesirable bleeding and poor voice outcomes. A 25-year-old female presented with hoarseness and progressive upper airway obstruction symptoms. Read More

View Article and Full-Text PDF

Coronary arterial compression testing by simultaneous balloon valvuloplasty and coronary angiography in an English bulldog with pulmonary valve stenosis.

J Vet Cardiol 2021 Apr 2;35:124-129. Epub 2021 Apr 2.

University of Chicago, Pediatric Cardiology, Chicago, IL, USA.

A 4-year-old male neutered English bulldog presented for heart murmur evaluation. Echocardiography identified severe pulmonic stenosis (an echocardiography-derived transpulmonary pressure gradient of 100 mmHg), and computed tomography confirmed the presence of an anomalous coronary artery with a prepulmonic course of the left coronary artery arising from the right coronary ostium. Before artificial pulmonic valve implantation, a coronary compression test was performed. Read More

View Article and Full-Text PDF

The Obesity Paradox in Elderly Patients Undergoing Emergency Surgery: A Nationwide Analysis.

J Surg Res 2021 May 2;265:195-203. Epub 2021 May 2.

Division of Trauma, Emergency Surgery and Surgical Critical Care, Massachusetts General Hospital, Boston, Massachusetts. Electronic address:

Background: Obesity has long been considered a risk factor for postoperative adverse events in surgery. We sought to study the impact of body mass index (BMI) on the clinical outcomes of the high-risk emergency general surgery (EGS) elderly patients.

Methods: All EGS ≥65 years old patients in the 2007-2016 ACS-NSQIP database, identified using the variables 'emergency' and 'surgspec,' were included. Read More

View Article and Full-Text PDF

Comment on: Total hip arthroplasty under continuous pericapsular nerve group block (cPENG) in a high-risk patient.

J Clin Anesth 2021 May 2;73:110301. Epub 2021 May 2.

Department of Anesthesia and Critical Care, Cork University Hospital Group, Wilton, Cork, Ireland. Electronic address:

View Article and Full-Text PDF

Liver transplantation for patients with acute-on-chronic liver failure (ACLF) in Europe: results of the ELITA/EF-CLIF collaborative study (ECLIS).

J Hepatol 2021 Apr 24. Epub 2021 Apr 24.

Department of hepatogastroenterology, Hepatology and Liver Transplantation Unit, HCL Hopital de la Croix-Rousse, Lyon, France.

Background And Aims: Liver transplantation (LT) has been proposed to be an effective salvage therapy even for the sickest patients with acute-on-chronic liver failure (ACLF). This large collaborative study was designed to address the current clinical practice and outcomes of ACLF patients wait listed (WL) for LT in Europe.

Methods: Retrospective study including 308 consecutive ACLF patients, listed in 20 centres across 8 European countries, from January 2018 to June 2019. Read More

View Article and Full-Text PDF

Repeated neonatal isoflurane exposure is associated with higher susceptibility to chronic variable stress-induced behavioural and neuro-inflammatory alterations.

Neuroscience 2021 May 2. Epub 2021 May 2.

Department of Anaesthesiology and Operating Theatre Services, Xiangya Hospital of Central South University, Changsha city, Hunan Province, PR China; Teaching and Research Section of Anesthesia and Critical Care Medicine, Xiangya Hospital of Central South University, Changsha city, Hunan Province, PR China. Electronic address:

Numerous studies have reported that prolonged or multiple exposures to anaesthetics in early life lead to detrimental effects on brain function, most having focused on neurocognitive function, and relatively few on long term neuropsychiatric performance. The present study investigated the impact of repeated neonatal isoflurane exposure on chronic variable stress (CVS)-induced psychiatric and behavioural outcomes together with CVS-related neuronal activity and neuro-inflammatory reactivity in relevant brain circuits. In the present study, C57BL/6J mice received either three exposures to isoflurane at postnatal days 7, 8, and 9 or a control exposure. Read More

View Article and Full-Text PDF

Anterior insula regulates brain network transitions that gate conscious access.

Cell Rep 2021 May;35(5):109081

Department of Anesthesiology, University of Michigan Medical School, Ann Arbor, MI 48109, USA; Center for Consciousness Science, University of Michigan Medical School, Ann Arbor, MI 48109, USA; Neuroscience Graduate Program, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address:

Conscious access to sensory information is likely gated at an intermediate site between primary sensory and transmodal association cortices, but the structure responsible remains unknown. We perform functional neuroimaging to determine the neural correlates of conscious access using a volitional mental imagery task, a report paradigm not confounded by motor behavior. Titrating propofol to loss of behavioral responsiveness in healthy volunteers creates dysfunction of the anterior insular cortex (AIC) in association with an impairment of dynamic transitions of default-mode and dorsal attention networks. Read More

View Article and Full-Text PDF

Dexamethasone and Surgical-Site Infection.

N Engl J Med 2021 05;384(18):1731-1741

From Royal Perth Hospital (T.B.C., P.C., K.M.H.), the University of Western Australia (T.B.C., E.O., K.M.H.), Murdoch University (K.M.H.), and Fiona Stanley Hospital (E.O.), Perth, and the Alfred Hospital (P.S.M., A.C.C., L.A.B.), Monash University (T.B.C., P.S.M., A.B.F., A.C.C., L.A.B., K.L., C.M.), the University of Melbourne (K.L., D.S.), and Royal Melbourne Hospital (K.L.), Melbourne, VIC - all in Australia; the Chinese University of Hong Kong, Hong Kong (M.T.V.C.); and Auckland City Hospital and the University of Auckland - both in Auckland, New Zealand (T.G.S.).

Background: The glucocorticoid dexamethasone prevents nausea and vomiting after surgery, but there is concern that it may increase the risk of surgical-site infection.

Methods: In this pragmatic, international, noninferiority trial, we randomly assigned 8880 adult patients who were undergoing nonurgent, noncardiac surgery of at least 2 hours' duration, with a skin incision length longer than 5 cm and a postoperative overnight hospital stay, to receive 8 mg of intravenous dexamethasone or matching placebo while under anesthesia. Randomization was stratified according to diabetes status and trial center. Read More

View Article and Full-Text PDF

Long-term changes in self-reported sleep quality and risk of chronic musculoskeletal pain: The HUNT Study.

J Sleep Res 2021 May 5:e13354. Epub 2021 May 5.

Department of Public Health and Nursing, Norwegian University of Science and Technology (NTNU), Trondheim, Norway.

We examined the association between long-term (~10 years) changes in self-reported sleep quality and risk of any chronic musculoskeletal pain and chronic widespread pain. The study comprised data on 6,033 people who participated in three consecutive surveys in the Norwegian HUNT Study (1995-1997, 2006-2008 and 2017-2019) and who were without chronic musculoskeletal pain at the first two surveys. We used a modified Poisson regression model to calculate adjusted risk ratios for chronic pain at follow-up (2017-2019) associated with categories of poor and good sleep quality reported in 1995-1997 and 2006-2008. Read More

View Article and Full-Text PDF

The role and significance of angiotensin-converting enzyme 2 peptides in the treatment of coronavirus disease 2019.

J Clin Lab Anal 2021 May 5:e23789. Epub 2021 May 5.

Key Laboratory of Molecular Medicine, Huzhou Central Hospital, Affiliated Central Hospital HuZhou University, Huzhou, China.

Since the end of 2019, coronavirus disease 2019 (COVID-19) caused by the novel coronavirus (2019-nCoV) posed a serious threat to human health and life. Therefore, the discovery of drugs that can effectively prevent and treat COVID-19 is urgently warranted. In this article, the role and significance of angiotensin-converting enzyme 2 in drug development and the treatment of COVID-19 are discussed. Read More

View Article and Full-Text PDF

Isoflurane Suppresses Hippocampal High-frequency Ripples by Differentially Modulating Pyramidal Neurons and Interneurons in Mice.

Anesthesiology 2021 May 5. Epub 2021 May 5.

Background: Isoflurane can induce anterograde amnesia. Hippocampal ripples are high-frequency oscillatory events occurring in the local field potentials of cornu ammonis 1 involved in memory processes. The authors hypothesized that isoflurane suppresses hippocampal ripples at a subanesthetic concentration by modulating the excitability of cornu ammonis 1 neurons. Read More

View Article and Full-Text PDF

Absorbable Hemostatic Pack Effect After Primary Incisor Extraction: A Pilot Study and Introduction of a Novel Scale to Assess Post-Operative Bleeding.

J Clin Pediatr Dent 2021 Apr;45(2):67-73

Objectives: This pilot study compared hemostatic pack (HP) application with no intervention following extraction of maxillary primary incisors in healthy children for effect on bleeding time and influence of patient or tooth variables utilizing a novel scale for assessment of bleeding following extraction.

Study Design: A novel scale was created to assess bleeding after extraction. This scale was utilized in a randomized, split mouth study of healthy children ages 2-7 years old requiring extraction of at least 2 primary maxillary incisors under general anesthesia. Read More

View Article and Full-Text PDF

Computer-assisted Individualized Hemodynamic Management Reduces Intraoperative Hypotension in Intermediate- and High-risk Surgery: A Randomized Controlled Trial.

Anesthesiology 2021 May 5. Epub 2021 May 5.

Background: Individualized hemodynamic management during surgery relies on accurate titration of vasopressors and fluids. In this context, computer systems have been developed to assist anesthesia providers in delivering these interventions. This study tested the hypothesis that computer-assisted individualized hemodynamic management could reduce intraoperative hypotension in patients undergoing intermediate- to high-risk surgery. Read More

View Article and Full-Text PDF

Association of chorioamnionitis with failed conversion of epidural labor analgesia to cesarean delivery anesthesia: A retrospective cohort study.

PLoS One 2021 5;16(5):e0250596. Epub 2021 May 5.

Department of Anesthesiology, Juntendo University Hospital, Hongo, Bunkyo-ku, Tokyo, Japan.

Aim: This study aimed to examine the association between clinically diagnosed chorioamnionitis and failed conversion of epidural labor analgesia to cesarean delivery anesthesia.

Methods: This retrospective, single-center cohort study, conducted in a university hospital, enrolled term parturients undergoing emergency cesarean section after induction of epidural labor analgesia between September 2015 and May 2019. For the purpose of this study, all cases were re-examined to ensure that they fulfilled the criteria of chorioamnionitis, regardless of the actual indication for cesarean section proposed by obstetricians at the time of application. Read More

View Article and Full-Text PDF

Epidemiology and reporting characteristics of preclinical systematic reviews.

PLoS Biol 2021 May 5;19(5):e3001177. Epub 2021 May 5.

Clinical Epidemiology Program, Blueprint Translational Research Group, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.

In an effort to better utilize published evidence obtained from animal experiments, systematic reviews of preclinical studies are increasingly more common-along with the methods and tools to appraise them (e.g., SYstematic Review Center for Laboratory animal Experimentation [SYRCLE's] risk of bias tool). Read More

View Article and Full-Text PDF

Thromboembolic Complications of Vascular Catheters Used for Pediatric Continuous Renal Replacement Therapy: Prevalence in a Single-Center, Retrospective Cohort.

Pediatr Crit Care Med 2021 May 4. Epub 2021 May 4.

Department of Perioperative Medicine and Intensive Care, Karolinska University Hospital, Huddinge, Stockholm, Sweden. Department of Physiology and Pharmacology, Section of Anaesthesia and Intensive Care, Karolinska Institutet, Stockholm, Sweden. Department of Pediatric Perioperative Medicine and Intensive Care, Astrid Lindgren Children's Hospital, Karolinska University Hospital, Stockholm, Sweden. Department of Clinical Science Intervention and Technology (CLINTEC), Karolinska Institutet, Stockholm, Sweden.

Objectives: Pediatric venous thromboembolic events are commonly associated with in situ central venous catheters. The risk for severe venous thromboembolism increases if a larger portion of the vessel lumen is occupied by the central venous catheter. A functioning vascular catheter is required when the continuous renal replacement therapy is used in critically ill children. Read More

View Article and Full-Text PDF

Evaluation of analgesic interaction between morphine, maropitant and dexmedetomidine in dogs undergoing ovariohysterectomy.

N Z Vet J 2021 May 5:1-27. Epub 2021 May 5.

School of Veterinary Science, Massey University, Palmerston North, New Zealand.

Aims: To compare the analgesic effect of morphine combined with maropitant and/or dexmedetomidine to morphine alone given at a higher dose, and to evaluate the pharmacokinetics of the drug combinations, in dogs undergoing ovariohysterectomy (OHE).

Methods: Forty client owned-dogs were randomised into four treatment groups (n=10 per group) each to receive a different analgesic protocol. After premedication with I/M acepromazine anaesthesia was induced with propofol to effect and maintained with isoflurane in 100% oxygen delivered via a circle system. Read More

View Article and Full-Text PDF

An Entrustable Professional Activities Model for Assessment of Undergraduate Competence in Anesthesia and Surgery: Performance of the Assessment Scheme and the Impact of Assessment Timing and Variation in Structure of Teaching Activities on Student Outcomes.

J Vet Med Educ 2021 May 4:e20200109. Epub 2021 May 4.

An entrustable professional activity (EPA) model was used to assess the anesthesia and surgery competence of year 4 students during elective neutering procedures over 3 academic years (cohort A, cohort B, and cohort C). Two competence thresholds were defined by an expert panel, the minimum acceptable standard (MAS) and the standard expected at the start of final-year rotations (SFR). The assessment scheme performed as expected, and the median level of supervision achieved by students either matched or exceeded the SFR for all EPAs except one, which matched the MAS. Read More

View Article and Full-Text PDF

[Training in reconstructive surgery in sub-Saharan Africa : the « 2nd Chance » model].

Rev Med Suisse 2021 May;17(737):885-888

Association 2nd Chance, Rue Ferdinand-Hodler 7, 1207 Genève.

Based in Geneva since 2010, 2 Chance's mission is the development of reconstructive surgery care in resource-limited countries with a focus on sub-Saharan Africa, through teaching and advocacy activities. We develop the surgical management of patients on the one hand, providing training for African surgical teams. On the other hand, we support surgical procedures for patients, in the areas of reconstructive surgery, giant goiters, obstetric fistulas and anesthesia so that quality care is guaranteed for the long term. Read More

View Article and Full-Text PDF

Yentl syndrome and the ICU.

Intensive Care Med 2021 May 5. Epub 2021 May 5.

University Faculty of Medicine, Intensive Care Unit of the Shaare Zedek Medical Medical Centre and 2Hebrew, Jerusalem, Israel.

View Article and Full-Text PDF

Factors associated with quality of dreams during general anesthesia: a prospective observational study.

J Anesth 2021 May 5. Epub 2021 May 5.

Department of Anesthesiology, Wakayama Medical University, 811-1 Kimiidera, Wakayama, 641-8509, Japan.

Patients frequently report having dreams during general anesthesia, and the dreams are often reported to be pleasant dreams. However, factors associated with the quality of dreams during general anesthesia have not been clarified. The aim of this study was to determine the relationships between the quality of dreams during general anesthesia and perioperative factors. Read More

View Article and Full-Text PDF

Experience of cardiac implantable electronic device lead removal from a South African tertiary referral centre.

Cardiovasc J Afr 2021 Apr 19;32:1-5. Epub 2021 Apr 19.

Division of Cardiology, Department of Medicine, Faculty of Health Sciences, University of Cape Town; Cardiac Clinic, Groote Schuur Hospital, Cape Town, South Africa.

Background: The rate of cardiac implantable electronic device (CIED) implantation in low- and middle-income countries is increasing. Patients recieving these devices are frequently older and with multiple co-morbidities, which may later lead to complications requiring CIED removal. CIED removals are associated with life-threatening complications. Read More

View Article and Full-Text PDF

Challenging paediatric coarctation cases treated with a hybrid approach: five-year follow up.

Cardiovasc J Afr 2021 May 4;32:1-4. Epub 2021 May 4.

Pediatric Cardiology Division, Pediatric Department, Cairo University, Cairo, Egypt.

Two paediatric patients suffering from recurrent coarctation after native coarctation surgery were scheduled for cardiac catheterisation in a hybrid setting by the age of two and three years. Through a right anterior mini-thoracotomy, unmounted stents were successfully placed in the coarctant segment. One-year follow up did not show echocardiographic improvement but the patients were controlled on medical therapy. Read More

View Article and Full-Text PDF

Exogenous insulin-like growth factor 1 attenuates sevoflurane anesthesia-induced cognitive dysfunction in aged rats.

J Neurophysiol 2021 May 5. Epub 2021 May 5.

the First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, China.

Sevoflurane anesthesia is correlated with the generation of postoperative cognitive dysfunction. Insulin-like growth factor 1 (IGF-1) has important function in the nervous system development. Intravenously injected IGF-1 is reported to successfully pass the blood-brain barrier and perform neuroprotection effect in the brain. Read More

View Article and Full-Text PDF

Lipid nanoparticles loaded with butamben and designed to improve anesthesia at inflamed tissues.

Biomater Sci 2021 May;9(9):3378-3389

Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas - UNICAMP, Campinas, São Paulo, Brazil.

The most frequently used local anesthetics (LA) for local infiltration have an ionizable amine in the range of pH 7.6-8.9. Read More

View Article and Full-Text PDF

Analysis of mRNA‑lncRNA and mRNA‑lncRNA-pathway co‑expression networks based on WGCNA in developing pediatric sepsis.

Bioengineered 2021 Dec;12(1):1457-1470

General ICU, Zhengzhou Key Laboratory of Sepsis, Henan Engineering Research Center for Critical Care Medicine, the First Affiliated Hospital of Zhengzhou University, Henan Key Laboratory of Critical Care Medicine, Zhengzhou, China.

Pediatric sepsis is a great threat to death worldwide. However, the pathogenesis has not been clearly understood until now in sepsis. This study identified differentially expressed mRNAs and lncRNAs based on Gene Expression Omnibus (GEO) database. Read More

View Article and Full-Text PDF
December 2021

Changes of cerebral oxygenation indices measured by near infrared time-resolved spectroscopy during spinal anesthesia for cesarean section: Simultaneous measurement with cerebral blood flow.

J Obstet Gynaecol Res 2021 May 4. Epub 2021 May 4.

Department of Anesthesiology and Critical Care Medicine, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan.

Aim: To measure the changes in cerebral oxygenation indices by near infrared time-resolved spectroscopy and the cerebral blood flow simultaneously after spinal anesthesia for cesarean section.

Methods: This prospective observational study was conducted for 25 pregnant women scheduled for elective cesarean section under spinal anesthesia. During a period of 15 min after spinal anesthesia, cerebral oxygenation (ScO ), and the total cerebral hemoglobin concentration (tHb) were measured using near infrared time-resolved spectroscopy and mean cerebral blood flow velocity (Vm) was measured using transcranial Doppler ultrasonography. Read More

View Article and Full-Text PDF

A Practical and Ethical Toolkit for Last-Minute Refusal of Anaesthetic in Children.

Paediatr Anaesth 2021 May 4. Epub 2021 May 4.

Children's Bioethics Centre, Royal Children's Hospital, Melbourne, Australia.

Children's fear of a procedure, including the anaesthetic is a common issue that operating theatre staff face. This fear is generally mitigated by pre-aesthetic preparation and information sharing. Last minute refusal of a procedure creates unique difficulties for the anaesthetist and proceduralist. Read More

View Article and Full-Text PDF

Methods for dose quantification in continuous renal replacement therapy: towards a more precise approach.

Artif Organs 2021 May 5. Epub 2021 May 5.

Department of Health Sciences, Section of Anaesthesiology, Intensive Care and Pain Medicine, University of Florence, Italy.

Periodic dose assessment is quintessential for dynamic dose adjustment and quality control of continuous renal replacement therapy (CRRT) in critically ill patients with acute kidney injury (AKI). The flows-based methods to estimate dose are easy and reproducible methods to quantify (estimate)CRRT dose at the bedside. In particular, quantification of effluent flow and, mainly, the current dose (adjusted for dialysate, replacement, blood flows and net ultrafiltration) is routinely used in clinical practice. Read More

View Article and Full-Text PDF