921 results match your criteria andrographis paniculata

Network pharmacology integrated with experimental validation revealed the anti-inflammatory effects of Andrographis paniculata.

Sci Rep 2021 May 7;11(1):9752. Epub 2021 May 7.

Department of Minimally Invasive Spinal Surgery, The Affiliated Hospital of Chengde Medical College, Chengde, 067000, China.

Inflammation is a key factor in the development and complications of various diseases because it has a complex pathogenesis. Andrographis paniculate (Burm. f. Read More

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Evaluation of the merit of the methanolic extract of to supplement anti-snake venom in reversing secondary hemostatic abnormalities induced venom.

3 Biotech 2021 May 21;11(5):228. Epub 2021 Apr 21.

Department of Biochemistry, Melaka Manipal Medical College (Manipal Campus), Manipal Academy of Higher Education, Manipal, Karnataka India.

Increasing evidence suggests a sizable involvement of hemotoxins in the morbidity associated with envenomation by the Indian spectacled cobra, (N.N). This study investigates the ability of Indian polyvalent anti-snake venom (ASV), methanolic extract of (MAP) and their combination in reversing the hemostatic abnormalities, viz. Read More

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Andrographis paniculata (Burm. F) Wall ex Nees: Antiviral properties.

Phytother Res 2021 Apr 30. Epub 2021 Apr 30.

Department of Stem Cell and Regenerative Medicine, Centre For Interdisciplinary Research, DY Patil Education Society (Deemed to be University) Kolhapur, Kasaba Bawada, Maharashtra, 416006, India.

Andrographis paniculata is home to a rich variety of molecules especially andrographolide and its derivatives. Clinical properties of the andrographolide are multifarious and include: analgesic, antipyretic, antiretroviral, antiproliferative, antimalarial, antithrombotic, antihyperglycemic, antiurolethial, antilesihmaniasis, hepatoprotective, immune-modulatory, protective against alcohol induced toxicity and cardioproetcive activity and anticancer activity. Andrographolide, neoandrographolide, dehydroandrographolide and several natural and synthetic derivatives of it: 14-deoxy-11,12-didehydroandrographolide and 14-deoxyandrographolide, dehydroandrographolide succinic acid monoester (DAMS), 14-ά-lipoyl andrographolide (AL-1), 14-acetyl-3,9-isopropyl-ideneandrographolide, 14-acetylandrographolide, 3,14,19-triacetylandrographolide, and 3,9-isopropyl-idene andrographolide, are shown to possess significant antiviral activity against HIV, influenza A, HBV, HCV, HPP and HSV. Read More

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Exploring combined herbal extract-loaded phytoniosomes for antimalarial and antibacterial activity against methicillin-resistant .

3 Biotech 2021 Apr 19;11(4):177. Epub 2021 Mar 19.

Department of Pharmaceutics, PSG College of Pharmacy, Coimbatore, India.

Antibiotic resistance in the context of treating malarial infections is a major challenge in India. Home remedies such as thulasi leaves (), black pepper seeds (, clove buds (), cinnamon bark (), and nilavembu whole plant powder () were taken to explore antimalarial and methicillin-resistant (MRSA) activity. Among the five extracts, the best two extracts, and extract, showed the presence of Quercetin. Read More

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(Burm. f.) Wall. ex Nees: An Updated Review of Phytochemistry, Antimicrobial Pharmacology, and Clinical Safety and Efficacy.

Life (Basel) 2021 Apr 16;11(4). Epub 2021 Apr 16.

Department of Agricultural Sciences, University of Naples Federico II, 80055 Portici, Italy.

Infectious disease (ID) is one of the top-most serious threats to human health globally, further aggravated by antimicrobial resistance and lack of novel immunization options. (Burm. f. Read More

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Effect of polysaccharide on human retinoblastoma Y79 cell proliferation and apoptosis.

Int J Ophthalmol 2021 18;14(4):497-503. Epub 2021 Apr 18.

Department of Ophthalmology, Fuling Central Hospital, Chongqing 408000, China.

Aim: To explore the effect of the () polysaccharide on the proliferation and apoptosis of human retinoblastoma (RB) Y79 cells and its mechanism.

Methods: The refined polysaccharide was obtained using techniques such as water extraction, ethanol precipitation, and decompression concentration. The inhibition effect of the polysaccharide on the proliferation of Y79 cells was detected by cell proliferation assay. Read More

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Anti-SARS-CoV-2 Activity of Extract and Its Major Component Andrographolide in Human Lung Epithelial Cells and Cytotoxicity Evaluation in Major Organ Cell Representatives.

J Nat Prod 2021 04 12;84(4):1261-1270. Epub 2021 Apr 12.

Excellent Center for Drug Discovery (ECDD), Faculty of Science, Mahidol University, Bangkok 10400, Thailand.

The coronaviruses disease 2019 (COVID-19) caused by a novel coronavirus (SARS-CoV-2) has become a major health problem, affecting more than 50 million people with over one million deaths globally. Effective antivirals are still lacking. Here, we optimized a high-content imaging platform and the plaque assay for viral output study using the legitimate model of human lung epithelial cells, Calu-3, to determine the anti-SARS-CoV-2 activity of extract and its major component, andrographolide. Read More

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Andrographis paniculata (Burm.f.) Nees: Traditional uses, phytochemistry, pharmacological properties and quality control/quality assurance.

J Ethnopharmacol 2021 Apr 6;275:114054. Epub 2021 Apr 6.

Sophisticated Analytical Instrument Facility, CSIR-Central Drug Research Institute, Lucknow, 226031, Uttar Pradesh, India. Electronic address:

Ethnopharmacological Relevance: Andrographis paniculata (Burm.f.) Nees is a medicinal herb of the Asian countries used in many traditional medicinal systems for the treatment of diarrhea, flu, leprosy, leptospirosis, malaria, rabies, upper respiratory infections, sinusitis, syphilis, tuberculosis and HIV/AIDS etc. Read More

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Enhanced anti-cancer activity of andrographis with oligomeric proanthocyanidins through activation of metabolic and ferroptosis pathways in colorectal cancer.

Sci Rep 2021 Apr 6;11(1):7548. Epub 2021 Apr 6.

Center for Gastrointestinal Research, Baylor Scott & White Research Institute and Charles A. Sammons Cancer Center, Baylor University Medical Center, Dallas, TX, USA.

The high degree of morbidity and mortality in colorectal cancer (CRC) patients is largely due to the development of chemoresistance against conventional chemotherapeutic drugs. In view of the accumulating evidence that various dietary botanicals offer a safe, inexpensive and multi-targeted treatment option, herein, we hypothesized that a combination of Andrographis paniculata and Oligomeric Proanthocyanidins (OPCs) might interact together with regard to anti-tumorigenic activity in CRC. As a result, we demonstrated the enhanced anti-cancer activity between these two botanical extracts in terms of their ability to inhibit cancer cell growth, suppress colony formation and induce apoptosis. Read More

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The Effects of Andrographolide on the Enhancement of Chondrogenesis and Osteogenesis in Human Suprapatellar Fat Pad Derived Mesenchymal Stem Cells.

Molecules 2021 Mar 24;26(7). Epub 2021 Mar 24.

Department of Pharmacy, Faculty of Pharmacy, Mahidol University, Bangkok 10400, Thailand.

Andrographolide is a labdane diterpenoid herb, which is isolated from the leaves of and widely used for its potential medical properties. However, there are no reports on the effects of andrographolide on the human suprapatellar fat pad of osteoarthritis patients. In the present study, our goal was to evaluate the innovative effects of andrographolide on viability and Tri-lineage differentiation of human mesenchymal stem cells from suprapatellar fat pad tissues. Read More

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Activities of (AS201-01) Tablet on Cox-2 and Prostaglandin Expression of Placental of Infected Mice.

Iran J Parasitol 2021 Jan-Mar;16(1):43-51

Center of Natural Product Medicine Research and Development, Institute of Tropical Disease, Universitas Airlangga, Surabaya, Indonesia.

Background: Placental malaria has ability to upregulate prostaglandin synthesis by increasing cyclooxygenase-2 (Cox-2) enzyme activity. Cox-2 and prostaglandin have a role in causing uterine contraction and therefore can cause abortion or preterm labor. Tablet AS201-01 containing the ethyl acetate fraction of was tested in vivo on pregnant mice infected with . Read More

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Hepatoprotective effect of selected isoandrographolide derivatives on steatotic HepG2 cells and High Fat Diet fed rats.

Eur J Pharmacol 2021 May 20;899:174056. Epub 2021 Mar 20.

Department of Plant Biology & Biotechnology, Loyola College, Chennai, Tamil Nadu, 600034, India.

Non-alcoholic Fatty Liver Disease (NAFLD) is one of the growing epidemics of the globe. This study was aimed to evaluate the anti-NAFLD effect of selected IAN derivatives using in silico, in vitro and in vivo models. In silico tools viz. Read More

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Analgesic and Antipyretic Activities of Ethyl Acetate Fraction Tablet of in Animal Models.

Evid Based Complement Alternat Med 2021 8;2021:8848797. Epub 2021 Mar 8.

Center of Natural Product Medicine Research and Development, Institute of Tropical Disease, Universitas Airlangga, Surabaya 60115, Indonesia.

Objectives: To determine the analgesic and antipyretic activities of a tablet derived from ethyl acetate fraction (AS201-01) in animal models.

Methods: The tablet derived from AS201-01 contains an equivalent of 35 mg andrographolide per tablet. Analgesic activity was determined using an acetic acid-induced writhing test on adult male mice. Read More

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Ethnobotany, Pharmacological activities and Bioavailability studies of "King of Bitter" (Kalmegh): A Review (2010-2020).

Comb Chem High Throughput Screen 2021 Mar 10. Epub 2021 Mar 10.

Department of Pharmaceutical Chemistry, Shivalik College of Pharmacy, Nangal, 140126, Punjab. India.

Background: Andrographis paniculata, commonly known as "Kalmegh", is an annual herbaceous plant from family Acanthaceae. The whole plant of A. paniculata has explored for multiple pharmacological activities and is scientifically recognized by in-vivo and in-vitro studies. Read More

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Therapeutic Journey of Andrographis paniculata (Burm.f.) Nees from Natural to Synthetic and Nanoformulations.

Mini Rev Med Chem 2021 Mar 15. Epub 2021 Mar 15.

Department of Pharmaceutical Chemistry, Shivalik College of Pharmacy, Nangal, 140126, Punjab. India.

Andrographis paniculata (Burm.f.) Nees (Acanthaceae) is a herbaceous plant and commonly called 'King of Bitters'. Read More

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Biochar amendment reduced the risk associated with metal uptake and improved metabolite content in medicinal herbs.

Physiol Plant 2021 Mar 13. Epub 2021 Mar 13.

Upper Assam Advisory Centre, Tea Research Association, Dikom, Dibrugarh, Assam, India.

Contaminations of heavy metals such as lead (Pb) and cadmium (Cd) in medicinal plants (MPs) not only restrict their safe consumption due to health hazards but also lower their productivity. Biochar amendments in the soil are supposed to immobilize the toxic metals, improve the soil quality and agricultural productivity. However, the impact of biochar on growth attributes, metal accumulation, pharmacologically active compounds of MPs, and health risk is less explored. Read More

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Isolation of 4-hydroxy 3-methyl 2-butenyl 4-diphosphate reductase () gene of methyl erythritol diphosphate (MEP) pathway, analysis and differential tissue specific expression in (Burm. f) Nees.

Physiol Mol Biol Plants 2021 Feb 19;27(2):223-235. Epub 2021 Feb 19.

Centre for Plant Molecular Biology (CPMB), Osmania University, Hyderabad, Telangana 500007 India.

The full length 4-hydroxy 3-methyl 2-butenyl 4-diphosphate reductase () gene of MEP pathway was isolated for the first time The ORF with 1404 bp flanked by 100 bp 5'UTR and 235 bp 3'UTR encoding 467 amino acids (NCBI accession number: MK503970) and cloned in pET 102, transformed and expressed in BL21. The protein physico-chemical properties, secondary and tertiary structure were analyzed. The Ramachandran plot showed 93. Read More

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February 2021

Application of virus-induced gene silencing in Andrographis paniculata, an economically important medicinal plant.

Protoplasma 2021 Mar 11. Epub 2021 Mar 11.

Plant Biotechnology, Council of Scientific and Industrial Research-Central Institute of Medicinal and Aromatic Plants, Lucknow, 226015, India.

Kalmegh [Andrographis paniculata (Burm.f.) Wall. Read More

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A review on extraction techniques and therapeutic value of polar bioactives from Asian medicinal herbs: Case study on and .

Saudi Pharm J 2021 Feb 7;29(2):143-165. Epub 2021 Jan 7.

Institute of Bioproduct Development, Universiti Teknologi Malaysia, 81310 Johor Bahru, Johor, Malaysia.

Medicinal plants have gained much interest in the prevention and treatment of common human disease such as cold and fever, hypertension and postpartum. Bioactive compounds from medicinal plants were synthesised using effective extraction methods which have important roles in the pharmaceutical product development. (OA), (EL) and (AP) are among popular medicinal herbs in Southeast Asia. Read More

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February 2021

Chemical constituents and their biological activities from Taunggyi (Shan state) medicinal plants.

Heliyon 2021 Feb 11;7(2):e06173. Epub 2021 Feb 11.

Department of Chemistry, Faculty of Science and Technology, Universitas Airlangga, Komplek Kampus C UNAIR, Jl. Mulyorejo, Surabaya, Indonesia.

Medicinal plants are essential aspects of readily available primary healthcare remedies. Phytochemical constituents of medicinal plants cover a broad variety of chemical fields to explore medicines. This review highlights selected empirical data on traditional uses, phytochemistry, and pharmacological properties of Taunggyi medicinal plants, , and . Read More

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February 2021

Andrographolide upregulates protein quality control mechanisms in cell and mouse through upregulation of mTORC1 function.

Biochim Biophys Acta Gen Subj 2021 Jun 25;1865(6):129885. Epub 2021 Feb 25.

Division of Molecular Medicine, Bose Institute, P1/12 CIT Scheme VIIM, Kolkata 700054, India. Electronic address:

Background: Heat shock response (HSR), a component of cellular protein quality control mechanisms, is defective in different neurodegenerative conditions such as Parkinson's disease (PD). Forced upregulation of heat shock factor 1 (HSF1), an HSR master regulator, showed therapeutic promise in PD models. Many of the reported small-molecule HSF1 activators have limited functions. Read More

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Anticancer potential of andrographolide from Andrographis paniculata (Burm.f.) Nees and its mechanisms of action.

J Ethnopharmacol 2021 May 18;272:113936. Epub 2021 Feb 18.

Human Genetics Laboratory, Department of Biosciences, Jamia Millia Islamia, New Delhi, 110025, India.

Ethnopharmacological Relevance: Synthetic drugs used for cancer treatment have side effects that may be immunosupressive, can cause liver, kidney and cardiac toxicity, and infertility and ovarian failure, among others. Thus, herbal drugs could be used in the cancer treatment as an adjuvant therapy. Andrographis paniculata (Burm. Read More

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Andrographis paniculata (Burm.f.) Nees and its major constituent andrographolide as potential antiviral agents.

J Ethnopharmacol 2021 May 18;272:113954. Epub 2021 Feb 18.

State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, 999078, China. Electronic address:

Ethnopharmacological Relevance: Andrographis paniculata (Burm.f.) Nees is widely used all over the world, especially in subtropical regions such as India, Thailand, Vietnam, and China. Read More

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A tablet derived from complements dihydroartemisinin-piperaquine treatment of malaria in pregnant mice.

J Basic Clin Physiol Pharmacol 2021 Feb 11. Epub 2021 Feb 11.

Natural Product Medicine Research and Development, Institute of Tropical Disease, Universitas Airlangga, C Campus Universitas Airlangga, Surabaya, Indonesia.

Objectives: The use of standard antimalarial drugs, such as dihydroartemisinin-piperaquine (DHP) for the treatment of malaria during pregnancy is limited due to the risk of teratogenicity. The alternative is therefore required although few exist. Here we show a phytopharmaceutical drug derived from (AS201-01), which is effective as herbal antimalarial both and and may be a suitable alternative when used in complementary treatment with DHP. Read More

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February 2021

Andrographolide, an Antioxidant, Counteracts Paraquat- Induced Mutagenesis in Mammalian Cells.

Asian Pac J Cancer Prev 2021 Feb 1;22(S1):3-8. Epub 2021 Feb 1.

Laboratory of Pharmacology, Chulabhorn Research Institute, Bangkok 10210, Thailand.

Paraquat (1,1'-dimethyl, 4,4'-bipyridinium dichloride; PQ), a commonly used herbicide worldwide, is both toxic and mutagenic. The mutagenic effect of PQ stems from its ability to redox-cycle, generating oxidative stress and subsequently oxidative DNA damage, which miscodes when replication is attempted. Andrographolide (AP1), the major constituent in the leaves of the herbaceous plant Andrographis paniculata, is a diterpenoid with reported antioxidant activity. Read More

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February 2021

Influence of a Polyherbal Mixture in Dairy Calves: Growth Performance and Gene Expression.

Front Vet Sci 2020 26;7:623710. Epub 2021 Jan 26.

Centro Universitario UAEM Amecameca, Universidad Autónoma del Estado de México, Amecameca, Mexico.

A polyherbal feed mixture containing (, and ) was evaluated in growing calves through blood chemistry, blood biometry, and gene expression during the pre-ruminant to weaning period. Forty Holstein calves (initial BW 45.6 ± 3. Read More

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January 2021

Polyphenolic-rich extracts of mitigate hyperglycemia via attenuating β-cell dysfunction, pro-inflammatory cytokines and oxidative stress in alloxan-induced diabetic Wistar albino rat.

J Diabetes Metab Disord 2020 Dec 15;19(2):1543-1556. Epub 2020 Nov 15.

College of Science, Department of Chemical Sciences, Biochemistry Unit, Afe Babalola University, P.M.B. 5454, Ado-Ekiti, Ekiti State Nigeria.

Background: This study sought to investigate anti-hyperglycemic potentials of free and bound phenolic-rich extracts of () leaves, commonly called "king of the bitter", a plant locally employed in folkloric alternative medicine

Method: In vitro antioxidant potentials such as total phenolic and flavonoid contents were evaluated in addition to phosphomolybdenum reducing total antioxidant activity in bound and free polyphenol-rich extracts of Also, following induction of diabetes through a single intraperitoneal injection of freshly prepared alloxan monohydrate (150 mg/kg body weight, b.w), diabetic rats were divided into seven (7) treatment groups with six rats each ( = 6) i.e. Read More

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December 2020

Genomic Characterization of WRKY Transcription Factors Related to Andrographolide Biosynthesis in .

Front Genet 2020 18;11:601689. Epub 2021 Jan 18.

Joint Laboratory for Translational Cancer Research of Chinese Medicine of the Ministry of Education of the People's Republic of China, International Institute for Translational Chinese Medicine, School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, China.

Andrographolide, which is enriched in the leaves of , has been known as "natural antibiotic" due to its pharmacological activities such as anti-inflammatory, antimicrobial and antioxidant effects. Several key enzymes in andrographolide biosynthetic pathway have been studied since the genome sequences were released, but its regulatory mechanism remains unknown. WRKY transcription factors proteins have been reported to regulate plant secondary metabolism, development as well as biotic and abiotic stresses. Read More

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January 2021

In silico docking analysis revealed the potential of phytochemicals present in and , used in Ayurveda medicine in inhibiting SARS-CoV-2.

3 Biotech 2021 Feb 11;11(2):44. Epub 2021 Jan 11.

Department of Plant Pathology, College of Agriculture, University of Agricultural Sciences, GKVK, Bangalore, Karnataka 560065 India.

The 2 (SARS-CoV-2) has resulted in outbreak of global pandemic, fatal pneumonia in human referred as Coronavirus Disease-2019 (Covid-19). Ayurveda, the age old practice of treating human ailments in India, can be considered against SARS-CoV-2. Attempt was made to provide preliminary evidences for interaction of 35 phytochemicals from two plants ( and used in Ayurveda with SARS-CoV-2 proteins (open & closed state S protein, 3CLpro, PLpro and RdRp) through in silico docking analysis. Read More

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February 2021

The coronavirus disease 2019 main protease inhibitor from (Burm. f) Ness.

J Adv Pharm Technol Res 2020 Oct-Dec;11(4):157-162. Epub 2020 Oct 10.

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Universitas Airlangga, Surabaya, Indonesia.

The coronavirus disease 2019 (COVID-19) pandemic has attracted worldwide attention. (Burm. f) Ness (AP) is naturally used to treat various diseases, including infectious diseases. Read More

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October 2020