Adv Healthc Mater 2021 Jun 24:e2100229. Epub 2021 Jun 24.
UCD Centre for Biomedical Engineering, School of Mechanical and Materials Engineering, University College Dublin, Dublin, D04 V1W8, Ireland.
Medical devices, such as silicone-based prostheses designed for soft tissue implantation, often induce a suboptimal foreign-body response which results in a hardened avascular fibrotic capsule around the device, often leading to patient discomfort or implant failure. Here, it is proposed that additive manufacturing techniques can be used to deposit durable coatings with multiscale porosity on soft tissue implant surfaces to promote optimal tissue integration. Specifically, the "liquid rope coil effect", is exploited via direct ink writing, to create a controlled macro open-pore architecture, including over highly curved surfaces, while adapting atomizing spray deposition of a silicone ink to create a microporous texture. Read More