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Variation in Ontogenetic Facial Suture Fusion Patterns in Catarrhines.

Folia Primatol (Basel) 2021 Jun 23:1-8. Epub 2021 Jun 23.

Department of Biomedical Education and Anatomy, The Ohio State University College of Medicine, Columbus, Ohio, USA.

Timing of craniofacial suture fusion is important for the determination of demographics and primate ontogeny. There has been much work concerning the timing of fusion of calvarial sutures over the last century, but little comprehensive work focusing on facial sutures. Here we assess the relationships of facial suture fusion across ontogeny among select catarrhines. Read More

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Filtering in tractography using autoencoders (FINTA).

Med Image Anal 2021 Jun 7;72:102126. Epub 2021 Jun 7.

Videos & Images Theory and Analytics Laboratory (VITAL), Department of Computer Science, Université de Sherbrooke, 2500, boul. de l'Université, Sherbrooke, Québec J1K 2R1, Canada.

Current brain white matter fiber tracking techniques show a number of problems, including: generating large proportions of streamlines that do not accurately describe the underlying anatomy; extracting streamlines that are not supported by the underlying diffusion signal; and under-representing some fiber populations, among others. In this paper, we describe a novel autoencoder-based learning method to filter streamlines from diffusion MRI tractography, and hence, to obtain more reliable tractograms. Our method, dubbed FINTA (Filtering in Tractography using Autoencoders) uses raw, unlabeled tractograms to train the autoencoder, and to learn a robust representation of brain streamlines. Read More

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The effect of selected in ovo green light photostimulation periods on post-hatch broiler growth and somatotropic axis activity.

Poult Sci 2021 Apr 30;100(8):101229. Epub 2021 Apr 30.

Department of Animal Sciences, The Hebrew University of Jerusalem, Robert H. Smith Faculty of Agriculture, Food and Environment, Rehovot 76100, Israel.

Targeted in ovo green light (GL) photostimulation during the last days of broiler egg incubation increases embryonic expression of the somatotropic axis, similar to in ovo green light photostimulation from embryonic day (ED) 0 to the end of incubation. The aim of this study was to examine the effect of selected in ovo GL photostimulation periods on post-hatch broiler growth. Four hundred twenty fertile broiler eggs were divided into 7 treatment groups: the first incubated in the dark (standard conditions) as a negative control; the second incubated under monochromatic GL from ED0-ED20 (positive control); the third group incubated under monochromatic GL light from ED15-ED20; the fourth, fifth and sixth groups were incubated under monochromatic GL on ED16, ED17, and ED18, respectively; and the seventh group was incubated under monochromatic GL from ED18-ED20. Read More

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Combination chemotherapeutic and immune-therapeutic anticancer approach via anti-PD-L1 antibody conjugated albumin nanoparticles.

Int J Pharm 2021 Jun 20:120816. Epub 2021 Jun 20.

College of Pharmacy, Yeungnam University, Daehak-ro 280, Gyeongsan 38541, Republic of Korea. Electronic address:

Anticancer regimens have been substantially enriched through monoclonal antibodies targeting immune checkpoints, programmed cell death-1/programmed cell death-ligand 1 (PD-L1) and cytotoxic T-lymphocyte antigen-4. Inconsistent clinical efficacy after solo immunotherapy may be compensated by nanotechnology-driven combination therapy. We loaded human serum albumin (HSA) nanoparticles with paclitaxel (PTX) via nanoparticle albumin-bound technology and pooled them with anti-PD-L1 monoclonal antibody through a pH-sensitive linker for targeting and immune response activation. Read More

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Pumilio2 and Staufen2 selectively balance the synaptic proteome.

Cell Rep 2021 Jun;35(12):109279

Biomedical Center (BMC), Department for Cell Biology & Anatomy, Medical Faculty, Ludwig-Maximilians-University, 82152 Planegg-Martinsried, Germany. Electronic address:

Neurons have the capacity to adapt to environmental stimuli, a phenomenon termed cellular plasticity. The underlying processes are controlled by a network of RNA-binding proteins (RBPs). Their precise impact, however, is largely unknown. Read More

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Developmental Consequences of Defective ATG7-Mediated Autophagy in Humans.

N Engl J Med 2021 Jun;384(25):2406-2417

From the Wellcome Centre for Mitochondrial Research, (J.J.C., M.O., N.M.-L., A.M.S., A.P., R.M., R.W.T.), the Translational and Clinical Research Institute (J.J.C, M.O., T.M.P., A.M.S., A.P., R.M., R.W.T.), and the NHS Highly Specialised Service for Rare Mitochondrial Disorders of Adults and Children (A.M.S., R.M., R.W.T.), Newcastle University, Newcastle Upon Tyne, and the Institute of Child Health, Department of Molecular Neuroscience, University College London Institute of Neurology (D.Z., M.R.), the Division of Genetics and Molecular Medicine, Guy's Hospital, King's College London School of Medicine (I.A.B.), and the Clinical Genetics Unit, Guy's and St. Thomas' NHS Foundation Trust (C.D.), London - all in the United Kingdom; Institut Universitaire de Recherche Clinique and Laboratoire de Génétique Moléculaire, University of Montpellier and Centre Hospitalier Universitaire (CHU) de Montpellier (C.G., S.S., L.L., M.K.), Departments of Neuroradiology (N.L.) and Pediatric Neurology (P.M., F.R.) and Reference Center for Neuromuscular Diseases Atlantic-Occitania-Caribbean (AOC) (P.M., F.R.), CHU de Montpellier, and Laboratoire de Physiologie et Médecine Expérimentale du Cœur et des Muscles (PhyMedExp), INSERM, CNRS, University of Montpellier (P.M., F.R.), Montpellier, and the Institute for Integrative Biology of the Cell (I2BC), Université Paris-Saclay, Alternative Energies and Atomic Energy Commission (CEA), CNRS Gif-sur-Yvette (F.P.-P., A.D.) - all in France; the Translational Stem Cell Biology and Metabolism Program, Research Programs Unit, and the Department of Anatomy, Faculty of Medicine, University of Helsinki, Helsinki (F.S., T.G.M.); Radiation Oncology, Albert Einstein College of Medicine, New York (N.M.-L.); the Institute of Medical Genetics, University of Zurich, Zurich, Switzerland (A.B., S.A.-B., A.R.); Hertie Institute for Clinical Brain Research and Center of Neurology, and the German Center for Neurodegenerative Diseases, University of Tübingen, Tübingen, Germany (S.R., L.S., M.S.); the Departments of Genetics (H.S.A., F.S.A.) and Neuroscience (S.A.), King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia; and the Dr. John T. Macdonald Foundation, Department of Human Genetics, and John P. Hussman Institute for Human Genomics, Miller School of Medicine, University of Miami, Miami (S.Z.).

Background: Autophagy is the major intracellular degradation route in mammalian cells. Systemic ablation of core autophagy-related () genes in mice leads to embryonic or perinatal lethality, and conditional models show neurodegeneration. Impaired autophagy has been associated with a range of complex human diseases, yet congenital autophagy disorders are rare. Read More

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Antimicrobial treatment of Corynebacterium striatum invasive infections: a systematic review.

Rev Inst Med Trop Sao Paulo 2021 18;63:e49. Epub 2021 Jun 18.

University of Priština, School of Medicine, Department of Infectious Diseases, Pristina, Serbia.

The aim of this study was to establish an evidence-based guideline for the antibiotic treatment of Corynebacterium striatum infections. Several electronic databases were systematically searched for clinical trials, observational studies or individual cases on patients of any age and gender with systemic inflammatory response syndrome, harboring C. striatum isolated from body fluids or tissues in which it is not normally present. Read More

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The history, importance and anatomy of the specimen that validated the giant Purussaurus brasiliensis Barbosa-Rodrigues 1892 (Crocodylia: Caimaninae).

An Acad Bras Cienc 2021 16;93(suppl 2):e20200369. Epub 2021 Jun 16.

Universidade Federal do Acre, Laboratório de Pesquisas Paleontológicas, Rodovia BR 364, Km 04, Distrito Industrial, 69915-900 Rio Branco, AC, Brazil.

The Solimões Formation is a southwest geological unit of the Brazilian Amazon, being well-known for the Cenozoic giant eusuchian fossils. Among the eight species of Crocodylia described for this formation, the alligatoroid Purussaurus brasiliensis is the best known worldwide due to its enormous size. The holotype was described in 1892 by Barbosa-Rodrigues, composed by a right hemimandible. Read More

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LAMP3 deficiency affects surfactant homeostasis in mice.

PLoS Genet 2021 Jun 23;17(6):e1009619. Epub 2021 Jun 23.

Institute of Biochemistry, Christian-Albrechts-University Kiel, Kiel, Germany.

Lysosome-associated membrane glycoprotein 3 (LAMP3) is a type I transmembrane protein of the LAMP protein family with a cell-type-specific expression in alveolar type II cells in mice and hitherto unknown function. In type II pneumocytes, LAMP3 is localized in lamellar bodies, secretory organelles releasing pulmonary surfactant into the extracellular space to lower surface tension at the air/liquid interface. The physiological function of LAMP3, however, remains enigmatic. Read More

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Exploring the distribution of statistical feature parameters for natural sound textures.

PLoS One 2021 23;16(6):e0238960. Epub 2021 Jun 23.

Dept. of Neuroscience, City University of Hong Kong, Hong Kong, Hong Kong.

Sounds like "running water" and "buzzing bees" are classes of sounds which are a collective result of many similar acoustic events and are known as "sound textures". A recent psychoacoustic study using sound textures has reported that natural sounding textures can be synthesized from white noise by imposing statistical features such as marginals and correlations computed from the outputs of cochlear models responding to the textures. The outputs being the envelopes of bandpass filter responses, the 'cochlear envelope'. Read More

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Interleukin-6 is an activator of pituitary stem cells upon local damage, a competence quenched in the aging gland.

Proc Natl Acad Sci U S A 2021 Jun;118(25)

Laboratory of Tissue Plasticity in Health and Disease, Cluster of Stem Cell and Developmental Biology, Department of Development and Regeneration, Leuven Stem Cell Institute, Katholieke Universiteit Leuven, 3000 Leuven, Belgium;

Stem cells in the adult pituitary are quiescent yet show acute activation upon tissue injury. The molecular mechanisms underlying this reaction are completely unknown. We applied single-cell transcriptomics to start unraveling the acute pituitary stem cell activation process as occurring upon targeted endocrine cell-ablation damage. Read More

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Inter-Patient Atrial Flutter Classification Using FFT-Based Features and a Low-Variance Stacking Classifier.

IEEE Trans Biomed Eng 2021 Jun 23;PP. Epub 2021 Jun 23.

Objective: Atrial Flutter (AFL) is a supraventricular tachyarrhythmia typically arising from a macroreentry circuit that can have variable atrial anatomy. It is often treated by catheter ablation, the success of which depends upon the correct determination of the electroanatomic circuit, generally through invasive electrophysiological (EP) study. We hypothesized that machine learning (ML) methods applied to the diagnostic 12-lead surface electrocardiogram (ECG) could determine the specific circuit prior to any invasive EP study. Read More

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Thymic Immunosuppressive Pentapeptide (TIPP) Showed Anticancer Activity in Breast Cancer and Chronic Myeloid Leukemia Both In Vitro and In Vivo.

Protein Pept Lett 2021 Jun 22. Epub 2021 Jun 22.

Key Laboratory of Chemical Biology (Ministry of Education), Institute of Biochemical and Biotechnological Drug, School of Pharmaceutical Sciences, Shandong University, No.44 Wenhuaxi Road, Jinan 250012, China.

Aim: Being the common cause and major burden of deaths globally, timely management of cancer is crucial.

Background: Thymic immunosuppressive pentapeptide (TIPP) is a novel pentapeptide originally obtained from calf thymic immunosuppressive extract. Previously, TIPP has been proved to suppress the allergic and inflammatory responses in allergic mice via blocking MAP kinases/NF-κB signaling pathways. Read More

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High irisin and low BDNF levels in aqueous humor of high myopia.

Adv Clin Exp Med 2021 Jun 23. Epub 2021 Jun 23.

Department of Ophthalmology, Peking University People's Hospital, China.

Background: The pathogenesis of myopia remains unclear. Both genetic and environmental factors play a role in the disease progression. Reasons including reduced physical activity (PA) and low-grade intraocular inflammation may be involved in the development of myopia. Read More

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Digest: Taxonomically Inclusive and Quantitative Tests for Convergence.

Laura E Hunter

Evolution 2021 Jun 23. Epub 2021 Jun 23.

Department of Organismal Biology and Anatomy, University of Chicago.

How common is morphological convergence, and can the cause of convergence be traced to simple ecological categories like diet? Tamagnini et al. (2021) use phylogenetic comparative methods and simple morphological data from a large number of Carnivora taxa to investigate whether diet causes convergence in their craniomandibular complex. They find that convergence is less prevalent than expected and that this outcome is likely caused by a complex interplay between biomechanics, ecology, and morphology. Read More

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LncRNA Quantification from Extracellular Vesicles Isolated from Blood Plasma or Conditioned Media.

Methods Mol Biol 2021 ;2348:285-304

Molecular Oncology and Embryology Laboratory, Human Anatomy Unit, Faculty of Medicine and Health Sciences, University of Barcelona, IDIBAPS, Barcelona, Spain.

During the last years, the study of extracellular vesicles (EVs) and its cargo has gained interest in the scientific media. EVs have been found in all biofluids and it is postulated that all cells are capable to secrete a wide variety of these vesicles, which play a key role in different cell-to-cell communication processes as well as in the microenvironment modulation. In the EV cargo, DNA, protein, and RNA molecules can be found, including long noncoding RNAs (lncRNAs). Read More

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January 2021

SIRM-SIC appropriateness criteria for the use of Cardiac Computed Tomography. Part 1: Congenital heart diseases, primary prevention, risk assessment before surgery, suspected CAD in symptomatic patients, plaque and epicardial adipose tissue characterization, and functional assessment of stenosis.

Radiol Med 2021 Jun 23. Epub 2021 Jun 23.

Cardiothoracovascular Department, Azienda Ospedaliero Universitaria Careggi, Florence, Italy.

In the past 20 years, Cardiac Computed Tomography (CCT) has become a pivotal technique for the noninvasive diagnostic work-up of coronary and cardiac diseases. Continuous technical and methodological improvements, combined with fast growing scientific evidence, have progressively expanded the clinical role of CCT. Recent large multicenter randomized clinical trials documented the high prognostic value of CCT and its capability to increase the cost-effectiveness of the management of patients with suspected CAD. Read More

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DNAzyme Cleavage of CAG Repeat RNA in Polyglutamine Diseases.

Neurotherapeutics 2021 Jun 23. Epub 2021 Jun 23.

Department of Neurology, Neuroscience Program, Houston Methodist Research Institute, Houston, TX, USA.

CAG repeat expansion is the genetic cause of nine incurable polyglutamine (polyQ) diseases with neurodegenerative features. Silencing repeat RNA holds great therapeutic value. Here, we developed a repeat-based RNA-cleaving DNAzyme that catalyzes the destruction of expanded CAG repeat RNA of six polyQ diseases with high potency. Read More

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Comments on: Mechanisms of action of the erector spinae plane (ESP) block: a narrative review (Letter #2).

Can J Anaesth 2021 Jun 23. Epub 2021 Jun 23.

Department of Innovation in Medical Education, Division of Clinical and Functional Anatomy, University of Ottawa, Ottawa, ON, Canada.

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Reply: The heterogeneity of endometriotic lesions could be explained by their progesterone resistance.

Hum Reprod 2021 Jun 23. Epub 2021 Jun 23.

Department of Obstetrics and Gynecology, The University of Melbourne and Gynecology Research Centre, Royal Women's Hospital, Melbourne, Victoria, Australia.

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The effects of orthopedic pathological conditions and systemic diseases on the prevalence of hip osteoarthritis in Modern African- and European-Americans.

Homo 2021 Jun 23. Epub 2021 Jun 23.

Department of Physical Therapy, Movement & Rehabilitation Sciences, Northeastern University, Boston, MA, USA.

Osteoarthritis (OA) is a leading cause of disability among aging adults. In the U.S. Read More

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A comparative digital morphometric study of nasofrontal region in metopic and non-metopic cranial series.

Anthropol Anz 2021 Jun 23. Epub 2021 Jun 23.

Department of Anatomy and Histology, Medical University of Sofia, Sofia, Bulgaria.

This study aimed to compare the nasofrontal region in metopic and non-metopic cranial series and to assess whether the persistent metopic suture is related to a specific morphology of this part of the cranium. For the purpose of the study, a total of 159 dry crania (control series n = 90 and metopic one n = 69) of contemporary adult males were scanned with a laser scanner. Digital morphometry was accomplished by recording the three-dimensional coordinates of eleven landmarks, 3 bilateral and 5 in the mid-sagittal plane, characterizing the nasofrontal region. Read More

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Sexual dimorphism of lumbar lordosis and lumbar spine mobility during the period of progressive development.

Anthropol Anz 2021 Jun 23. Epub 2021 Jun 23.

Department of Biology and Anatomy, Poznan University of Physical Education, Królowej Jadwigi 27/39, 61-871 Poznań, Poland.

: The objective of this paper is to present possible differences in spondylometric dimorphic characteristics of lumbar spine in the period of progressive development. : The research material included 24,517 individuals of both sexes aged from 3 to 25. Individuals that showed abnormal structure of the motor system and individuals reporting pain in the joints of the spine were excluded. Read More

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Twelve-month Outcomes of the LuX-Valve for Transcatheter Treatment of Severe Tricuspid Regurgitation.

EuroIntervention 2021 Jun 23. Epub 2021 Jun 23.

Department of Ultrasound, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan, China.

Background: Severe functional tricuspid regurgitation is associated with adverse clinical outcomes. Conventional surgical risk for patients with advanced tricuspid regurgitation stage is high, alternative approaches are therefore required.

Aims: The purpose of this study was to investigate the feasibility, technical details, and mid-term outcomes of implantation of a novel radial force-independent orthotopic transcatheter tricuspid valve-LuX-Valve in patients with severe functional tricuspid regurgitation. Read More

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Cystic lymph node metastasis of papillary thyroid cancer. Clinical facts.

Minerva Surg 2021 Jun 23. Epub 2021 Jun 23.

Department of Endocrine Surgery, Schoen Clinic, Hamburg, Germany.

Background: The therapy planning for cystic cervical lesions is dizzying. Although it is mostly a benign disease, it can also be a cystic lymph node metastasis with the origin of papillary thyroid cancer (PTC).

Methods: Included were all patients with histological confirmed PTC, who underwent a thyroid resection from January 2012 to December 2017 (n=680). Read More

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The contribution of TFPIα to the hemostatic response to injury in mice.

J Thromb Haemost 2021 Jun 23. Epub 2021 Jun 23.

Department of Medicine, Perelman School of Medicine, University of Pennsylvania.

Background: TFPI is an essential regulator of coagulation, limiting thrombin generation and preventing thrombosis. In humans and mice, TFPIα is the sole isoform present in platelets.

Objective: Here we asked whether TFPIα, because of its release from platelets at sites of injury, has a unique role in limiting the hemostatic response. Read More

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Vestibular contributions to the Romberg test: Testing semicircular canal and otolith function.

Eur J Neurol 2021 Jun 23. Epub 2021 Jun 23.

School of Psychology, University of Sydney, Sydney, NSW, Australia.

Normal stance relies on three sensory inputs: vision, proprioception and vestibular function. The Romberg test, trying to stand with feet together and eyes closed, is familiar to every medical student as a test of distal proprioceptive impairment. It remains the best known of Romberg's many remarkable contributions to clinical neurology. Read More

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Wiad Lek 2021 ;74(6):1382-1388


Objective: The aim: The study focuses on the morphometric features specification concerning the structural components of the hemomicrocirculatory bed of the perivulnar region of the cecum in rabbits when suturing a wound defect with synthetic polyfilament surgical suture Vicryl.

Patients And Methods: Materials and methods: The research was carried out on rabbits (n = 30: 5 animals made up the control group and 25 animals made up the experimental group) and included surgery based on the method of surgical intervention on the large intestine patented by the authors, which was performed in the conditions of the operating room at the Department of Clinical Anatomy and Operative Surgery. When determining the main morphometric parameters, we took biopsy specimens of the cecum and used paraffin and epoxy resin embedding considering the generally accepted methods. Read More

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Severe, protracted anaphylaxis with hypovolemic shock after sublingual misoprostol administration.

J Obstet Gynaecol 2021 Jun 23:1-2. Epub 2021 Jun 23.

Department of Obstetrics and Gynecology, Clinical Hospital "Sveti Duh", Zagreb, Croatia.

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Association between the IL-1A, IL-1B and IL-1R polymorphisms and lymphoma.

Nucleosides Nucleotides Nucleic Acids 2021 Jun 23:1-13. Epub 2021 Jun 23.

Department of Human Anatomy and Cell Science, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada.

We investigate the impact of IL-1A, IL-1B and IL-1R1 polymorphism on lymphoma. This study consisted of 155 Non-Hodgkin's lymphoma (NHL) patients 55 Hodgkin's lymphoma (HL) patients and 150 healthy individuals. PCR-RFLP method and ARMS PCR were used for genotyping of IL-1A rs3783553, IL-1B rs3917356, rs16944, IL-1R1 rs10490571 and IL-1A rs3783550 polymorphism. Read More

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