915 results match your criteria anasarca hypoalbuminemia


Nivolumab induced systemic capillary leak syndrome as an ultra rare life-threatening phenomenon of late toxicity and intravenous immunoglobulin efficacy.

Immunotherapy 2021 May 9. Epub 2021 May 9.

The Legacy Heritage Oncology Center & Dr Larry Norton Institute, Soroka Medical Center & Ben-Gurion University, Beer-Sheva, Israel.

Systemic capillary leak syndrome (SCLS) is a life-threatening disease. It is characterized by severe capillary hyperpermeability to proteins resulting in hemoconcentration, hypoalbuminemia and hypovolemic shock. Its treatment remains supportive, and the prognosis is generally poor. Read More

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Case Report: A Rare Presentation of NSAID-Induced Secondary Membranous Nephropathy in a Pediatric Patient.

Front Pediatr 2021 23;9:670575. Epub 2021 Apr 23.

Department of Pathology, Norton Children's and University of Louisville, Louisville, KY, United States.

Membranous nephropathy (MN) is a common cause of nephrotic syndrome in adults, but it is responsible for <5% of nephrotic syndrome cases in children. MN has primary and secondary forms. Secondary MN is caused by viral infections, autoimmune diseases like lupus, or drugs. Read More

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A 41-Year-Old Woman with Excessive Fat of the Lower Body Since Puberty with Progression to Swollen Ankles and Feet Despite Caloric Restriction, Due to Lipedema and Protein-Calorie Malnutrition: A Case of Stage 3 Lipedema.

Am J Case Rep 2021 May 7;22:e930306. Epub 2021 May 7.

Private Practice, Karen L. Herbst, MD, PC, Los Angeles, CA, USA.

BACKGROUND Lipedema is a common condition that presents as excessive fat deposition in the extremities, initially sparing the trunk, ankles, and feet, and is found mainly in women, usually occurring after puberty or pregnancy. Lipedema can progress to include lipo-lymphedema of the ankles and feet. This report is of a 41-year old woman with Stage 3 lipedema and lipo-lymphedema with excessive fat of the lower body since puberty, with progression to swollen ankles and feet despite dietary caloric restriction. Read More

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A novel mutation of congenital nephrotic syndrome in a Slovenian child eventually receiving a renal transplant.

Croat Med J 2021 Apr;62(2):187-191

Rina Rus, Department of Pediatric Nephrology, University Medical Centre, Bohoričeva 20, SI 1000 Ljubljana, Slovenia,

Congenital nephrotic syndrome (CNS) is a rare disease defined as heavy proteinuria, hypoalbuminemia, hyperlipidemia, and edema presenting in the first three months of life. It is most commonly caused by mutations in the NPHS1 gene associated with nephrotic syndrome type 1, also known as Finnish-type CNS, which is inherited in an autosomal recessive manner. Symptomatic treatment with intravenous albumins, vitamins, minerals, nutritional, and hormonal supplementation and treatment of complications are mandatory. Read More

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Cryofibrinogen-associated glomerulonephritis accompanied by advanced gastric cancer.

CEN Case Rep 2021 Apr 27. Epub 2021 Apr 27.

The Second Department of Internal Medicine, University of Toyama, 2630 Sugitani, Toyama, Toyama, 930-0194, Japan.

We had a 72-year-old man with advanced gastric cancer, poorly differentiated adenocarcinoma, receiving chemotherapy with S-1 (tegafur, gimeracil, and oteracil potassium) plus oxaliplatin. Ascites developed despite remission of gastric cancer and metastasis. Given no malignant cells in ascites, leg edema, renal impairment, hypoalbuminemia, and massive proteinuria, we diagnosed as nephrotic syndrome with microscopic hematuria. Read More

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Efficacy of oral tolvaptan for severe edema and hyponatremia in a patient with refractory nephrotic syndrome.

CEN Case Rep 2021 Apr 26. Epub 2021 Apr 26.

Department of Pediatrics, Japanese Red Cross Fukuoka Hospital, Fukuoka, Japan.

Tolvaptan (TLV) is a vasopressin V2 receptor antagonist that increases free water excretion. However, there are few reports of the use of TLV in pediatric patients with nephrotic syndrome (NS). The efficacy of TLV for the management of edema and hyponatremia in a 12-year-old boy with refractory NS is demonstrated. Read More

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Advances in the Starling Principle and Microvascular Fluid Exchange; Consequences and Implications for Fluid Therapy.

Front Vet Sci 2021 6;8:623671. Epub 2021 Apr 6.

Department of Bioengineering, Imperial College London, London, United Kingdom.

Ernest Starling first presented a hypothesis about the absorption of tissue fluid to the plasma within tissue capillaries in 1896. In this Chapter we trace the evolution of Starling's hypothesis to a principle and an equation, and then look in more detail at the extension of the Starling principle in recent years. In 2012 Thomas Woodcock and his son proposed that experience and experimental observations surrounding clinical practices involving the administration of intravenous fluids were better explained by the revised Starling principle. Read More

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Podocyte Sphingolipid Signaling in Nephrotic Syndrome.

Cell Physiol Biochem 2021 Apr;55(S4):13-34

Department of Pharmacology and Toxicology, School of Medicine, Virginia Commonwealth University, Richmond, VA, USA,

Podocytes play a vital role in the pathogenesis of nephrotic syndrome (NS), which is clinically characterized by heavy proteinuria, hypoalbuminemia, hyperlipidemia, and peripheral edema. The pathogenesis of NS has evolved through several hypotheses ranging from immune dysregulation theory and increased glomerular permeability theory to the current concept of podocytopathy. Podocytopathy is characterized by dysfunction or depletion of podocytes, which may be caused by unknown permeability factor, genetic disorders, drugs, infections, systemic disorders, and hyperfiltration. Read More

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Immunotactoid glomerulonephritis in a patient with cold agglutinins: causal association or mere coincidence?

CEN Case Rep 2021 Apr 13. Epub 2021 Apr 13.

Department of Nephrology, Yokosuka Kyosai Hospital, 1-16 Yonegahamadori, Yokosuka, Kanagawa, 238-8558, Japan.

We report a case of immunotactoid glomerulonephritis (ITG) in a patient with cold agglutinins. An 86-year-old Japanese male with a history of hypertension, dyslipidemia, and gastric malignancy presented to our hospital for the evaluation of proteinuria and hematuria. He had an elevated blood pressure of 200/77 mmHg and edema of the lower extremities. Read More

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Spontaneous Bacterial Peritonitis in an Adult Patient with Minimal Change Disease.

Am J Case Rep 2021 Apr 13;22:e930677. Epub 2021 Apr 13.

Department of Internal Medicine, HANSUNG Union Internal Medicine Clinic and Dialysis Center, Daegu, South Korea.

BACKGROUND Pediatric patients with nephrotic syndrome have a high risk of developing spontaneous bacterial peritonitis (SBP). However, SBP in adults with nephrotic syndrome is very rare. We report a case of SBP induced by Escherichia coli in a 60-year-old male patient on immunosuppressive therapy for the treatment of minimal change disease (MCD). Read More

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[Idiopathic systemic capillary leak syndrome: 2 cases with misleading presentation].

Rev Med Interne 2021 Apr 9. Epub 2021 Apr 9.

Service de médecine interne, hôpital de la Timone, AP-HM, 264, rue Saint-Pierre, 13005 Marseille, France; Université d'Aix-Marseille, Marseille, France.

Introduction: Idiopathic systemic capillary leak syndrome (ISCLS) also known as Clarkson syndrome is a rare and sudden life-threatening entity. Three consecutive phases are described. A first non-specific prodromal phase often manifests as "flu-like" symptoms and precedes capillary leak phase with major hypovolemic and distributive shock leading to serious and frequent multiorgan dysfunction syndrome (MODS). Read More

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Toceranib phosphate-associated nephrotic syndrome in a dog: a case report.

BMC Vet Res 2021 Apr 7;17(1):146. Epub 2021 Apr 7.

Department of Veterinary Medicine and Surgery, College of Veterinary Medicine, University of Missouri, 900 East Campus Drive, Columbia, MO, 65211, USA.

Background: Nephrotic syndrome (NS) is rare in dogs and is characterized by concurrent clinical findings of proteinuria, hyperlipidemia, hypoalbuminemia, and edema. NS has been reported in humans receiving tyrosine kinase inhibitors (TKI) and in dogs receiving masitinib. This is the first report of NS in a dog receiving toceranib phosphate. Read More

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The Consequence of Excessive Consumption of Cow's Milk: Protein-Losing Enteropathy with Anasarca in the Course of Iron Deficiency Anemia-Case Reports and a Literature Review.

Nutrients 2021 Mar 3;13(3). Epub 2021 Mar 3.

Department of Pediatrics, Allergology and Gastroenterology, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University, 87-100 Toruń, Poland.

Cow's milk is a key component of a child's diet. While the consumption of even trace amounts can result in allergy to its proteins and/or hypolactasia, excessive cow's milk consumption can result in numerous health complications, including iron deficiency, due to the diet being improperly balanced. Although the incidence of iron deficiency has declined, it remains the most widespread nutritional deficiency globally and the most common cause of anemia. Read More

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An unusual disease mimicking congenital nephrotic syndrome: Questions.

Pediatr Nephrol 2021 Mar 31. Epub 2021 Mar 31.

Department of Pediatric Nephrology, Marmara University School of Medicine, İstanbul, Turkey.

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An unusual disease mimicking congenital nephrotic syndrome: Answers.

Pediatr Nephrol 2021 Mar 31. Epub 2021 Mar 31.

Department of Pediatric Nephrology, Marmara University School of Medicine, İstanbul, Turkey.

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Minimal Change Disease After Elective Surgical Abortion: A Case Report.

Am J Case Rep 2021 Mar 27;22:e930292. Epub 2021 Mar 27.

Division of Nephrology, Maimonides Medical Center, Brooklyn, NY, USA.

BACKGROUND Pregnancy causes a physiological increase in renal blood flow and glomerular filtration rate, which leads to a transient increase in urinary protein excretion. Up to 300 mg/d proteinuria is known to occur in pregnancy due to physiological changes. Proteinuria of greater than 3 g/d is categorized as being within the nephrotic range, and the most common cause of nephrotic range proteinuria in the later stages of pregnancy is preeclampsia. Read More

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A case of episodic angioedema with eosinophilia in an elderly woman with primary biliary cholangitis.

Clin J Gastroenterol 2021 Mar 10. Epub 2021 Mar 10.

Department of Gastroenterology and Medicine, Faculty of Medicine, Fukuoka University, 7-45-1 Nanakuma, Jonan-ku, Fukuoka, 814-0180, Japan.

We present the case of a 56-year-old woman diagnosed with primary biliary cholangitis (PBC). She has continuously taken 600 mg/day of ursodeoxycholic acid. Edema of the lower limbs manifested on July 20, 20XX; after 2 weeks, she manifested rapid weight gain and nettle rash on the limbs and trunk. Read More

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The effect of tetrastarch solution for capillary leak syndrome following allogeneic hematopoietic stem cell transplantation: A report of 2 cases.

Hematol Rep 2021 Mar 5;13(1):8750. Epub 2021 Mar 5.

Divisions of Hematology/Oncology, Department of Pediatrics, Chang Gung Children's Hospital, Chang Gung University, Taoyuan.

Capillary leak syndrome (CLS) is a severe complication of allogeneic hematopoietic stem cell transplantation (HSCT) characterized by weight gain, generalized edema, hypotension, and hypoalbuminemia. The primary pathogenesis is injury of the capillary endothelium resulting in a loss of intravascular fluid into the interstitial space. Treatment is limited to vascular endothelial growth factor withdrawal and systemic corticosteroids. Read More

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Cytomegalovirus ileitis with protein-losing enteropathy in an immunocompetent adult.

Clin J Gastroenterol 2021 Mar 20. Epub 2021 Mar 20.

Department of Gastroenterology, Toranomon Hospital, 2-2-2 Toranomon, Minato-ku, Tokyo, 105-8470, Japan.

Symptomatic cytomegalovirus (CMV) infection in immunocompetent hosts has traditionally been considered to have a benign, self-limited course, and those who need intensive therapy are rare. Moreover, there are few reports of CMV infection with protein-losing enteropathy (PLE). We present an immunocompetent 74-year-old woman with CMV ileitis with PLE, which was diagnosed due to severe hypoalbuminemia and edema of the lower extremities. Read More

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Clinical features resembling subcutaneous insulin resistance observed in a patient with type 2 diabetes and severe COVID-19-associated pneumonia: a case report.

Diabetol Int 2021 Mar 1:1-6. Epub 2021 Mar 1.

Department of Endocrinology and Diabetes, School of Medicine, Saitama Medical University, 38 Morohongo, Moroyamamachi, Iruma-gun, Saitama, 350-0495 Japan.

We report the case of a 52-year-old hyperglycemic woman with type 2 diabetes and severe coronavirus disease 2019 (COVID-19)-associated pneumonia, possibly involving the subcutaneous insulin resistance (SIR) syndrome. After admission for pneumonia, her average daily blood glucose (BG) levels remained at 300-400 mg/dL, although the required dosage of subcutaneous insulin markedly increased (~ 150 units/day; ~ 2.63 units/kg/day). Read More

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[Four cases of nephrotic syndrome with TRPC6 gene variations and literature review].

Zhonghua Er Ke Za Zhi 2021 Mar;59(3):223-227

Department of Nephrology and Rheumatology, Children's Hospital of Shanghai, Children's Hospital of Shanghai Jiao Tong University, Shanghai 200062, China.

To investigate the clinical characteristics, treatment and prognosis of TRPC6 variation induced children with steroid-resistant nephrotic syndrome (SRNS). Clinical data of four patients with nephrotic syndrome carrying TRPC6 variations, who were admitted to the Department of Nephrology and Rheumatology, Children's Hospital of Shanghai from Jan. 2017 to Dec. Read More

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Tacrolimus-induced epilepsy with primary membranous nephropathy: A case report.

Medicine (Baltimore) 2021 Mar;100(9):e24989

Institute of Nephrology, Zhong Da Hospital, Southeast University School of Medicine, Nanjing.

Rationale: Tacrolimus-associated neurologic disorders can be found in some cases, mainly in organ transplantation patients. However, epilepsy induced by tacrolimus in primary membranous nephropathy (PMN) patient is scare.

Patient Concerns: A 63-year-old man experienced 1-year history of foamy urine, and edema of lower extremity. Read More

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Nutrition Therapy in Critically Ill Overweight Elderly Patient with Heart Failure, Myocardial Infarction, Pneumonia, and Chronic Kidney Disease.

J Nutr Sci Vitaminol (Tokyo) 2020 ;66(Supplement):S25-S31

Department of Nutritional Science, Faculty of Medicine, Hasanuddin University.

Overweight or obesity will increase the risk of morbidity and mortality from cardiovascular disease. In older people, the risk is higher, but also paradoxically associated with lower mortality rates. Overweight patients vary in body composition and when it coupled with limited reliable sources to make caloric requirements estimation will make nutrition therapy extremely challenging. Read More

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January 2020

Novel Case Report: A Previously Reported, but Pathophysiologically Unexplained, Association Between Collagenous Colitis and Protein-Losing Enteropathy May Be Explained by an Undetected Link with Collagenous Duodenitis.

Dig Dis Sci 2021 Feb 4. Epub 2021 Feb 4.

Division of Gastroenterology, Department of Internal Medicine, William Beaumont Hospital at Royal Oak, 3535 W. Thirteen Mile Rd, Royal Oak, MI, 48073, USA.

Collagenous colitis (CC) is associated with non-bloody, watery diarrhea, which is pathophysiologically reasonable because normal colonic absorption (or excretion) of water and electrolytes can be blocked by the abnormally thick collagen layer in CC. However, CC has also been associated with six previous cases of protein-losing enteropathy (PLE), with no pathophysiologic explanation. The colon does not normally absorb (or excrete) amino acids/proteins, which is primarily the function of the small bowel. Read More

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February 2021

Secondary Kwashiorkor Disease in a Patient with Gastric Bypass Surgery and Short Gut Syndrome.

Am J Case Rep 2021 Feb 4;22:e928468. Epub 2021 Feb 4.

Department of Internal Medicine and Pediatrics, University of California Los Angeles (UCLA), Los Angeles, CA, USA.

BACKGROUND Kwashiorkor disease is a subtype of severe acute protein malnutrition characterized by peripheral edema associated with hypoalbuminemia and ascites. It can result from both protein deficiency and protein loss. In resource-poor countries, the disease often is caused by inadequate dietary intake, but in resource-rich countries, it can be seen as a rare complication of severe malabsorption. Read More

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February 2021

Capillary leak syndrome and disseminated intravascular coagulation after kidney transplantation in a patient with hereditary angioedema - A case report.

Anesth Pain Med (Seoul) 2021 Jan 27;16(1):75-80. Epub 2021 Jan 27.

Department of Anesthesiology and Pain Medicine, Chosun University Hospital, Gwangju, Korea.

Background: Hereditary angioedema (HAE) is a rare disease caused by the deficiency of C1 esterase inhibitor. HAE has a risk of life-threatening complications such as capillary leak syndrome (CLS) and disseminated intravascular coagulation (DIC).

Case: A 42-year-old male patient with HAE presented for deceased-donor kidney transplantation. Read More

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January 2021

Diagnosis and Management of Ménétrier Disease in Children: A Case Series Review.

Pediatr Gastroenterol Hepatol Nutr 2021 Jan 8;24(1):109-117. Epub 2021 Jan 8.

KidZ Health Castle, Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel, Brussels, Belgium.

Purpose: Ménétrier disease (MD) was first described in 1888, and 50 cases have been reported until now. We aimed to discuss the etiology, diagnostics, and management of MD in children.

Methods: We searched for case reports published from 2014 till 2019 in English using PubMed. Read More

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January 2021

Primary intestinal lymphangiectasia in an adult patient: A case report and review of literature.

World J Gastroenterol 2020 Dec 8;26(48):7707-7718. Epub 2020 Dec 8.

Department of Internal Medicine, General Hospital Oberndorf, Teaching Hospital of the Paracelsus Medical University Salzburg, Oberndorf 5110, Austria.

Background: Primary intestinal lymphangiectasia (PIL), first described in 1961, is a rare disorder of unknown etiology resulting in protein-losing enteropathy. The disease is characterized by dilatation and leakage of intestinal lymph vessels leading to hypoalbuminemia, hypogammaglobulinemia, and lymphopenia. Since the severity and location of lymph vessels being affected can vary considerably, the range of associated symptoms is wide from mild lower-limb edema to generalized edema, abdominal and/or pleural effusion, and recurrent diarrhea, among others. Read More

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December 2020

Conceptual Approach to Body Fluids and Edema, Education Determines Clinical Outcomes in Nephrotic Syndrome Management.

Iran J Kidney Dis 2021 Jan;1(1):69-72

Division of General Internal Medicine, Department of Medicine, Toronto General Hospital, Toronto, ON, Canada.

The objective of our paper is to reemphasize the importance of critical thinking in clinical practice and education in the field of internal medicine using the example of edema. We provide an in-depth and interactive investigation of physiological concepts as a foundation for the understanding of body fluid dynamics. Four fundamental concepts described are the hydrostatic and oncotic pressure gradients, capillary permeability, and lymphatic drainage. Read More

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January 2021

Clinicopathologic characteristics, pathology, and prognosis of 77 dogs with focal segmental glomerulosclerosis.

J Vet Intern Med 2020 Sep 7;34(5):1948-1956. Epub 2020 Jul 7.

Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, Ohio, USA.

Background: Focal segmental glomerulosclerosis (FSGS) is a common cause of nonimmune complex glomerulopathy and the prognosis and clinicopathologic findings associated with this condition have not been described in dogs.

Objective: To characterize the presentation and identify clinical factors associated with the survival of dogs with FSGS.

Animals: Seventy-seven dogs diagnosed with FSGS based on evaluation of renal biopsy samples submitted to the International Veterinary Renal Pathology Service. Read More

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September 2020