161,386 results match your criteria anasarca


Isoflucypram cardiovascular toxicity in zebrafish (Danio rerio).

Authors:
Xin Chen Wenhua Li

Sci Total Environ 2021 May 6;787:147529. Epub 2021 May 6.

Engineering Research Center of Molecular Medicine of Ministry of Education, Key Laboratory of Fujian Molecular Medicine, Key Laboratory of Xiamen Marine and Gene Drugs, Key Laboratory of Precision Medicine and Molecular Diagnosis of Fujian Universities, School of Biomedical Sciences, Huaqiao University, Xiamen 361021, PR China. Electronic address:

Isoflucypram belongs to the new generation of succinate dehydrogenase inhibitor (SDHI) fungicides that are commonly used in crop fungal disease control. Evidence indicates that isoflucypram poses a potential risk to aquatic organisms. However, the effects of isoflucypram during early embryogenesis are not fully understood. Read More

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Discovery of a novel inhibitor of nitric oxide production with potential therapeutic effect on acute inflammation.

Bioorg Med Chem Lett 2021 May 12:128106. Epub 2021 May 12.

School of Pharmaceutical Science, University of South China, Hengyang 421001, China; School of Pharmacy, Lanzhou University, Lanzhou 730000, China; State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, China. Electronic address:

Inflammation as a host's excessive immune response to stimulation, is involved in the development of numerous diseases. To discover novel anti-inflammatory agents and based on our previous synthesis of marine natural product Chrysamide B, it and series of derivatives were synthesized and evaluated for their anti-inflammatory activity on inhibition of LPS-induced NO production. Then the preliminary structure-activity relationships were conducted. Read More

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Dexmedetomidine exerts a protective effect on ischemic brain injury by inhibiting the P2X7R/NLRP3/Caspase-1 signaling pathway.

Brain Res Bull 2021 May 12. Epub 2021 May 12.

Department of Neurology, Anyang People's Hospital, Anyang, Henan, 455000, China.

Dexmedetomidine (Dex) has been suggested to exert a protective function in ischemic brain injury. In this study, we aimed to elucidate the intrinsic mechanisms of Dex in regulating microglia pyroptosis in ischemic brain injury via the purinergic 2 × 7 receptor (P2 × 7R)/NLRP3/Caspase-1 signaling pathway. First, permanent middle cerebral artery occlusion (p-MCAO) rat model was established, followed by the measurement of behavioral deficit, neuronal injury, the volume of brain edema and the infarct size. Read More

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Descemet membrane endothelial keratoplasty (DMEK) in eyes with chronic ocular hypotony following glaucoma surgery.

Am J Ophthalmol 2021 May 12. Epub 2021 May 12.

Department of Ophthalmology, Rabin Medical Center, Petach Tikva, Israel; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel; Medica medical center, Tel Aviv, Israel.

Purpose: To assess the outcomes of Descemet membrane endothelial keratoplasty (DMEK) in patients with ocular hypotony following glaucoma surgery.

Design: retrospective case series.

Methods: SETTING: Multicenter retrospective case series. Read More

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Deltoid Rupture in Ankle Fractures: To Repair or Not to Repair?

Foot Ankle Clin 2021 Jun 18;26(2):361-371. Epub 2021 Apr 18.

Amsterdam University Medical Centers, Location AMC, Meibergdreef 9, Amsterdam 1105 AZ, The Netherlands. Electronic address:

The most common injury mechanism for ankle fractures with concomitant deltoid ligament injury is a supination external rotation type 4 trauma. In the acute setting, malalignment, ecchymosis, and profound edema of the affected ankle can be found. Clinical examination is a poor indicator for deltoid ligament injury. Read More

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Sodium R-lipoate and enzymatically-modified isoquercitrin suppressed IgE-independent anaphylactic reactions and stress-induced gastric ulceration in mice.

Int Immunopharmacol 2021 May 11;97:107735. Epub 2021 May 11.

Zoology Department, Faculty of Science, Ain Shams University, Cairo, Egypt.

Anaphylaxis is a life-threatening allergic reaction, for which the worldwide prevalence is rapidly increasing. The currently used synthetic antiallergic drugs have a high tendency to cause adverse effects, like gastric ulcers, in long-term use. Therefore, a great deal of attention has been given to develop new safer and more effective antiallergic agents from natural compounds that are chemically/enzymatically-modified. Read More

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Differentiation of inflammatory from degenerative changes in the sacroiliac joints by machine learning supported texture analysis.

Eur J Radiol 2021 May 11;140:109755. Epub 2021 May 11.

Institute of Diagnostic and Interventional Radiology, University Hospital Zurich, Raemistrasse 100, 8091 Zurich, Switzerland; Faculty of Medicine, University of Zurich, Switzerland.

Purpose: To compare the diagnostic performance of texture analysis (TA) against visual qualitative assessment in the differentiation of spondyloarthritis (SpA) from degenerative changes in the sacroiliac joints (SIJ).

Method: Ninety patients referred for suspected inflammatory lower back pain from the rheumatology department were retrospectively included at our university hospital institution. MRI at 3 T of the lumbar spine and SIJ was performed with oblique coronal T1-weighted (w), fluid-sensitive fat-saturated (fs) TIRM and fsT1w intravenously contrast-enhanced (CE) images. Read More

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Anthrax meningoencephalitis complicated with brain abscess - A case report.

Int J Infect Dis 2021 May 11. Epub 2021 May 11.

Carol Davila University of Medicine and Pharmacy, Bucharest, Romania; Dr Victor Babes Clinical Hospital of Infectious and Tropical Diseases, Bucharest, Romania.

Bacillus anthracis is a sporulating Gram positive rod whose main route of entry being cutaneous. Anthrax meningitis is usually fulminant and fatal. We present here a case of anthrax meningoencephalitis complicated with brain abscess successfully treated. Read More

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Facial Edema and Pancytopenia: First Features and Clues to the Etiology of Acute Kidney Injury.

Am J Med 2021 May 11. Epub 2021 May 11.

From the Thayer Firm, Osler Medical Service, Johns Hopkins Hospital; Departments of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland. Electronic address:

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The Treatment of Bone Marrow Lesions Associated with Advanced Knee Osteoarthritis: Comparing Intraosseous and Intraarticular Injections with Bone Marrow Concentrate and Platelet Products.

Pain Physician 2021 May;24(3):E279-E288

Regenexx, LLC, Des Moines, IA.

Background: Bone marrow lesions are a radiographic indication of bony pathology closely associated with advanced osteoarthritis of the adjacent joint. Injection of autologous orthobiologic products, including bone marrow concentrate and platelet-rich plasma, have demonstrated safety and efficacy in treating both advanced osteoarthritis (via intraarticular injection) and associated bone marrow lesions (via intraosseous injection). The relative efficacy of intraarticular versus intraosseous injection of orthobiologics has not been evaluated at the present time. Read More

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Functional hemispherectomy: can preoperative imaging predict outcome?

J Neurosurg Pediatr 2020 Jun 21;25(6). Epub 2020 Feb 21.

Division of Pediatric Neurosurgery, Department of Neurosurgery, Brain Institute, Miami Children's Hospital, Miami, Florida.

Objective: Although hemispherectomy is an effective treatment for children with intractable hemispheric epilepsy syndromes, as many as 40% of patients eventually develop seizure recurrence. The causes of seizure recurrence in these patients are incompletely understood. The authors sought to evaluate the efficacy of hemispherectomy at their center and determine whether contralateral MRI abnormalities can predict seizure recurrence. Read More

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A narrative review of changes in microvascular permeability after burn.

Ann Transl Med 2021 Apr;9(8):719

Burn Institute, The Fourth Medical Center of the PLA General Hospital, Beijing, China.

Objective: We aimed to review and discuss some of the latest research results related to post-burn pathophysiological changes and provide some clues for future study.

Background: Burns are one of the most common and serious traumas and consist of a series of pathophysiological changes of thermal injury. Accompanied by thermal damage to skin and soft tissues, inflammatory mediators are released in large quantities. Read More

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Observation of the impact of the eight-step process combined with the four-track crossover quality control applied to patients with glioma surgery: a randomised trial.

Ann Transl Med 2021 Apr;9(8):696

Department of Neurosurgery, The First Affiliated Hospital of Soochow University, Suzhou, China.

Background: At present, surgery is the main treatment for patients with glioma, but there are certain risks in the operation. The traction and stress reaction of related brain tissue during surgery can cause complications such as cerebral edema, which adversely affects the prognosis of patients. The purpose of the present study was to explore the effect of an eight-step process combined with four-track quality control applied to patients undergoing glioma surgery. Read More

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Perilesional edema in brain metastases as predictive factor of response to systemic therapy in non-small cell lung cancer patients: a preliminary study.

Ann Transl Med 2021 Apr;9(8):648

Neuro-Oncology Unit, Hospital Universitari de Bellvitge-ICO L'Hospitalet (IDIBELL), Barcelona, Spain.

Background: The significance of upfront systemic therapies as an alternative to whole brain radiotherapy (WBRT) for multiple brain metastases (BM) is debatable. Our purpose is to investigate if peritumoral edema could predict the intracranial response to systemic chemotherapy (chemo) in patients with advanced non-squamous non-small cell lung cancer (non-SQ-NSCLC) and synchronous multiple BM.

Methods: In this observational cohort study, we evaluated the outcome of 28 patients with multiple BM (≥3) treated with chemo based on cisplatin/carboplatin plus pemetrexed (chemo, group A, n=17) or WBRT plus subsequent chemo (group B, n=11). Read More

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An MSCT-based radiomics nomogram combined with clinical factors can identify Crohn's disease and ulcerative colitis.

Ann Transl Med 2021 Apr;9(7):572

Department of Radiology, Qilu Hospital (Qingdao), Cheeloo College of Medicine, Shandong University, Qingdao, China.

Background: We established and evaluated a radiomics nomogram based on multislice computed tomography (MSCT) arterial phase contrast-enhanced images to distinguish between Crohn's disease (CD) and ulcerative colitis (UC) objectively, quantitatively, and reproducibly.

Methods: MSCT arterial phase-enhancement images of 165 lesions (99 CD, 66 UC) in 87 patients with inflammatory bowel disease (IBD) confirmed by endoscopy or surgical pathology were retrospectively analyzed. A total of 132 lesions (80%) were selected as the training cohort and 33 lesions (20%) as the test cohort. Read More

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Mycophenolate suppresses inflammation by inhibiting prostaglandin synthases: a study of molecular and experimental drug repurposing.

PeerJ 2021 30;9:e11360. Epub 2021 Apr 30.

Department of Biomedical Sciences, College of Veterinary Medicine, King Faisal University, Al-Ahsa, Saudi Arabia.

Mycophenolate mofetil is an established anti-proliferative and immune-suppressive agent that minimizes the proliferation of inflammatory cells by interfering with nucleic acid synthesis. Herein, we report our discovery of the prostaglandin inhibiting properties of MMF, which offers new applications for the drug in the treatment of inflammatory diseases. The estimated values of ICMMF, ICMMF, and ICMMF were 5. Read More

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Glibenclamide Advantage in Treating Edema After Intracerebral Hemorrhage (GATE-ICH): Study Protocol for a Multicenter Randomized, Controlled, Assessor-Blinded Trial.

Front Neurol 2021 27;12:656520. Epub 2021 Apr 27.

Department of Neurology, Xijing Hospital, Fourth Military Medical University (Air Force Medical University), Xi'an, China.

Brain edema after acute intracerebral hemorrhage (ICH) plays a critical role in the secondary injury of ICH and may heighten the potential for a poor outcome. This trial aims to explore the efficacy of small doses of oral glibenclamide in perihematomal edema (PHE) and the prognosis of patients with ICH. The GATE-ICH trial is a multicenter randomized, controlled, assessor-blinded trial. Read More

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Salvianolic acid A alleviated inflammatory response mediated by microglia through inhibiting the activation of TLR2/4 in acute cerebral ischemia-reperfusion.

Phytomedicine 2021 Apr 15:153569. Epub 2021 Apr 15.

Second Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou 310053, People's Republic of China; Department of Pharmacy, Zhejiang Chinese Medical University, Hangzhou 310053, People's Republic of China. Electronic address:

Background: Toll-like receptor 2 and Toll-like receptor 4 (TLR2/4) on microglia have been found as important regulators in the inflammatory response during cerebral ischemia/reperfusion (I/R). In China, traditional Chinese medicine Salvia miltiorrhiza (danshen) and its some components are considered to be effective in rescuing cerebral I/R injury through clinical practice.

Hypothesis/purpose: Here we examined the effect of Salvianolic acid A (SAA), a monomer compound in the water extract of Salvia miltiorrhiza, on TLR2/4 of microglia and its mediated inflammatory injury during cerebral I/R in vivo and in vitro. Read More

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A comparative study of chemical constituents and safety of Thai herbal medicated oil formula and traditional medicated oil.

J Complement Integr Med 2021 May 13. Epub 2021 May 13.

Department of Pharmacology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.

Objectives: Medicated oil has been traditionally used as an analgesic medicine to relieve pain by applying to the skin over painful muscles, and has been established in The National List of Essential Medicines (2556 B.E.). Read More

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First report of fatal baylisascariasis-induced acute pancreatitis in a giant panda.

Parasitol Int 2021 May 10:102380. Epub 2021 May 10.

Sichuan Key Laboratory of Conservation Biology for Endangered Wildlife, Chengdu Research Base of Giant Panda Breeding, Sich3uan Academy of Giant Panda, Chengdu, Sichuan, China.

A wild adult male giant panda that was rescued from a nature reserve in Sichuan Province, China, has died. The panda had been in poor physical condition: it was wheezing and had increased serum amylase. A pathological examination was performed in order to determine the cause of death. Read More

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Risk of acute lung injury after esophagectomy.

Semin Thorac Cardiovasc Surg 2021 May 10. Epub 2021 May 10.

Division of Thoracic Surgery, Department of Surgery, Affiliated Hospital of Qingdao University, Qingdao, China; Surgery, Health management center, Affiliated Hospital of Qingdao University, Qingdao, China.

To develop a new approach for identifying acute lung injury (ALI) in surgical ward setting and to assess incidence rate, clinical outcomes, and risk factors for ALI cases after esophagectomy. We also compare the degree of lung injury between operative and non-operative sides. Consecutive esophageal cancer patients (n=1022) who underwent esophagectomy from Dec 2012 to Nov 2018 in our hospital were studied. Read More

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Targeting Sphingosine-1-Phosphate Signaling in Immune-Mediated Diseases: Beyond Multiple Sclerosis.

Drugs 2021 May 13. Epub 2021 May 13.

San Diego VA Medical Center (SDVAMC), San Diego, CA, USA.

Sphingosine-1-phosphate (S1P) is a bioactive lipid metabolite that exerts its actions by engaging 5 G-protein-coupled receptors (S1PR1-S1PR5). S1P receptors are involved in several cellular and physiological events, including lymphocyte/hematopoietic cell trafficking. An S1P gradient (low in tissues, high in blood), maintained by synthetic and degradative enzymes, regulates lymphocyte trafficking. Read More

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Comparison of Central Macular Fluid Volume With Central Subfield Thickness in Patients With Diabetic Macular Edema Using Optical Coherence Tomography Angiography.

JAMA Ophthalmol 2021 May 13. Epub 2021 May 13.

Casey Eye Institute, Oregon Health & Science University, Portland.

Importance: Diabetic macular edema (DME) is the predominant cause of visual impairment in patients with type 1 or 2 diabetes. Automated fluid volume measurements using optical coherence tomography (OCT) may improve the diagnostic accuracy of DME screening.

Objective: To assess the diagnostic accuracy of an automated central macular fluid volume (CMFV) quantification using OCT for DME. Read More

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Sacral dural arteriovenous fistula supplied by bilateral lateral sacral arteries: case report and literature review.

Br J Neurosurg 2021 May 13:1-4. Epub 2021 May 13.

Department of Neurosurgery, West China Hospital of Sichuan University, Chengdu, PR China.

Sacral dural arteriovenous fistulas (DAVFs) with bilateral arterial supplies are extremely rare. To date, only two cases with arterial supply from bilateral lateral sacral arteries (LSAs) were reported. We report a rare case of sacral DAVF with arterial supply from bilateral LSAs. Read More

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Real-world effectiveness and tolerability of Zelesse cream® for treating vulvovaginitis in adult women: an observational, prospective study.

J Int Med Res 2021 May;49(5):3000605211013226

Medical Department, ITF Research Pharma S.L.U., Madrid, Spain.

Objective: To assess the efficacy, acceptability, and tolerability of a vaginal cream based on plant extracts for treating signs and symptoms of vulvovaginitis (VV) (Zelesse cream®), either as monotherapy (non-infectious VV) or adjuvant to antimicrobial therapy (infectious VV).

Methods: This prospective, observational, multicenter study included women who attended outpatient offices for VV. The severity of signs (vaginal discharge, erythema, and edema) and symptoms (pruritus, burning, and dysuria) was assessed before and after 15±5 days of daily treatment with Zelesse cream on a 4-point scale (18-point global score). Read More

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Inhibition of exosome release augments neuroinflammation following intracerebral hemorrhage.

FASEB J 2021 Jun;35(6):e21617

Department of Neurology, Tianjin Neurological Institute, Tianjin Medical University General Hospital, Tianjin, China.

Intracerebral hemorrhage (ICH) is a severe stroke subtype without effective pharmacological treatment. Following ICH, peripheral leukocytes infiltrate into the brain and contribute to neuroinflammation and brain edema. However, the intercellular machinery controlling the initiation and propagation of leukocyte infiltration remains elusive. Read More

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Sweet Syndrome with Perifollicular Involvement due to Koebnerization from Facial Hair Plucking.

J Cutan Pathol 2021 May 12. Epub 2021 May 12.

Department of Dermatology, UMass Memorial Health Care, University of Massachusetts Medical School, Worcester, Massachusetts, USA.

Sweet Syndrome (SS), also known as acute febrile neutrophilic dermatosis, is an uncommon skin eruption characterized by fever, leukocytosis, and tender erythematous papules, nodules, and plaques. Histopathologically, SS lesions are characterized by marked superficial papillary edema with a dense neutrophilic infiltrate. SS is known to demonstrate both the Koebner phenomenon and pathergy. Read More

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Development of a PCR Lateral Flow Assay for Rapid Detection of Bacillus anthracis, the Causative Agent of Anthrax.

Mol Biotechnol 2021 May 12. Epub 2021 May 12.

Bioprocess Technology Division, Defence Research and Development Establishment, Jhansi Road, Gwalior, 474002, India.

Bacillus anthracis, the causative agent of anthrax is one of the most potent listed biological warfare agents. The conventional microbiological methods of its detection are labor intensive and time consuming, whereas molecular assays are fast, sensitive and specific. PCR is one of the most reliable diagnostic tools in molecular biology. Read More

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The Mitochondrial mitoNEET Ligand NL-1 Is Protective in a Murine Model of Transient Cerebral Ischemic Stroke.

Pharm Res 2021 May 12. Epub 2021 May 12.

Department of Pharmaceutical Sciences, School of Pharmacy, West Virginia University, 1 Medical Center Drive, Morgantown, West Virginia, 26506, USA.

Purpose: Therapeutic strategies to treat ischemic stroke are limited due to the heterogeneity of cerebral ischemic injury and the mechanisms that contribute to the cell death. Since oxidative stress is one of the primary mechanisms that cause brain injury post-stroke, we hypothesized that therapeutic targets that modulate mitochondrial function could protect against reperfusion-injury after cerebral ischemia, with the focus here on a mitochondrial protein, mitoNEET, that modulates cellular bioenergetics.

Method: In this study, we evaluated the pharmacology of the mitoNEET ligand NL-1 in an in vivo therapeutic role for NL-1 in a C57Bl/6 murine model of ischemic stroke. Read More

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Infliximab prevents systemic bone loss and suppresses tendon inflammation in a collagen-induced arthritis rat model.

Inflammopharmacology 2021 May 12. Epub 2021 May 12.

Department of Clinical Pharmacology, School of Medicine, Aristotle University of Thessaloniki, University Campus, 54124, Thessaloniki, Greece.

Reduced Bone Mineral Density (BMD) and tendon abnormalities, such as tenosynovitis and enthesitis, are prevalent comorbidities in patients with rheumatoid arthritis (RA). The aim of the present study was to investigate the effect of chronic treatment with infliximab on BMD and tendon inflammation in an animal model of inflammatory arthritis. Collagen-Induced Arthritis (CIA) was induced in rats, followed by long-term intraperitoneal administration of infliximab. Read More

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