3,462 results match your criteria analyzing stability

[Work commitment of middle-line managers in health-care: Manageable organizational factors].

J Healthc Qual Res 2021 May 8. Epub 2021 May 8.

Unidad de Investigación, Hospital Universitario Mútua Terrassa, Fundació para la Investigación, Universidad de Barcelona, Terrasa (Barcelona), España; Laboratorio de Toxicología, Universitat Autònoma de Barcelona, Barcelona, España; Hospital Sant Jaume de Calella, Laboratori de Referència de Catalunya i Corporació de Salut del Maresme i la Selva, Barcelona, España. Electronic address:

Middle-line managers are a key element in the management of health-care organizations. Reinforcing their commitment to their job could contribute to improving the health outcomes of the population they serve.

Objective: Analyzing the work commitment of middle-line managers to the health-care organizations they work for, as well as their profile and perception of the main manageable organizational factors involved. Read More

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Quantum parameter analysis of the adsorption mechanism by freshly formed ferric hydroxide for synthetic dye and antibiotic wastewaters.

Chemosphere 2021 Apr 16;280:130577. Epub 2021 Apr 16.

School of Environmental Science and Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai, 200240, China; Shanghai Institute of Pollution Control and Ecological Security, Shanghai, 200092, China; Department of Developmental and Behavioral Pediatrics, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, 200127, PR China. Electronic address:

In this study, the adsorption effect by freshly formed ferric hydroxide (FFFH) for the removal of 47 synthetic dye and antibiotic wastewaters under different pH conditions (i.e., pH = 4, 7, and 10) was investigated. Read More

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Two 6/10-connected CuS cluster-based organic frameworks: crystal structure and proton conduction.

Dalton Trans 2021 May 10. Epub 2021 May 10.

Qinzhou Key Laboratory for Development and Application of High Performance Functional Materials, College of Petroleum and Chemical Engineering, Beibu Gulf University, Qinzhou 535011, People's Republic of China.

Nowadays, although the exploration of proton conductive materials has ranged from traditional sulfonated polymers to novel crystalline solid materials such as MOFs, COFs, and HOFs, research on crystalline cluster-based organic framework materials is very limited. Here, a pair of homologues Cu(i)-based organic framework containing a Cu12S6 cluster, [Cu12(MES)6(H2O)3]n (1) and {[Cu12(MPS)6(H2O)4]·6H2O}n (2) (H2MES = 2-mercaptoethanesulfonate acid and H2MPS = 2-mercaptoethanesulfonate acid), were hydrothermally synthesized under the same conditions and fully investigated for their proton conduction. Their structures were characterized by means of single-crystal X-ray diffraction, elemental analysis, thermogravimetric analyses, and PXRD measurements. Read More

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Stance detection with BERT embeddings for credibility analysis of information on social media.

PeerJ Comput Sci 2021 14;7:e467. Epub 2021 Apr 14.

Department of Information Systems, Arizona State University, Phoenix, AZ, United States of America.

The evolution of electronic media is a mixed blessing. Due to the easy access, low cost, and faster reach of the information, people search out and devour news from online social networks. In contrast, the increasing acceptance of social media reporting leads to the spread of fake news. Read More

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Effects of Secondary Package on Freeze-Dried Biopharmaceutical Formulation Stability during Dropping.

J Pharm Sci 2021 Apr 30. Epub 2021 Apr 30.

Zhejiang Bioray Biopharmaceutical Co., Taizhou, 317000, China.

Previously our laboratory first reported that dropping of freeze-dried monoclonal antibody (mAb) formulations could cause protein degradation and aggregation (J Pharm Sci, 2021, 1625). In this manuscript, we evaluated effects of secondary package on stability of several freeze-dried biopharmaceutical formulations during dropping. The degradation of mAb-Y during dropping with different secondary packages was determined by the sensitive particle analyzing techniques micro-flow imaging (MFI) and dynamic light scattering (DLS). Read More

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In silico explanation for the causalities of deleterious RNF213 SNPs in Moyamoya disease and insulin resistance.

Comput Biol Chem 2021 Apr 23;92:107488. Epub 2021 Apr 23.

206, Structural Biology Lab, Centre for Biomedical Research, School of Biosciences & Technology, Vellore Institute of Technology, Vellore, India. Electronic address:

Moyamoya disease (MMD), a cerebrovascular disorder caused by the RNF213 gene, is a cerebrovascular, neurological disorder leading to ischemic strokes. Our previous work suggested that RNF213 might be involved in the pro-inflammatory TNFα-mediated insulin-resistance pathway in adipocytes. Insulin resistance can lead to cerebrovascular diseases and ischemic strokes. Read More

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Cationic Dendrimers for siRNA Delivery: An Overview of Methods for In Vitro/In Vivo Characterization.

Methods Mol Biol 2021 ;2282:209-244

Molecular Biology and Nanotechnology Laboratory (MolBNL@UniTs), Department of Engineering and Architecture, University of Trieste, Trieste, Italy.

This chapter reviews the different techniques for analyzing the chemical-physical properties, transfection efficiency, cytotoxicity, and stability of covalent cationic dendrimers (CCDs) and self-assembled cationic dendrons (ACDs) for siRNA delivery in the presence and absence of their nucleic cargos. On the basis of the reported examples, a standard essential set of techniques is described for each step of a siRNA/nanovector (NV) complex characterization process: (1) analysis of the basic chemical-physical properties of the NV per se; (2) characterization of the morphology, size, strength, and stability of the siRNA/NV ensemble; (3) characterization and quantification of the cellular uptake and release of the siRNA fragment; (4) in vitro and (5) in vivo experiments for the evaluation of the corresponding gene silencing activity; and (6) assessment of the intrinsic toxicity of the NV and the siRNA/NV complex. Read More

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January 2021

Three-Dimensional Unified Motion Control of a Robotic Standing Wheelchair for Rehabilitation Purposes.

Sensors (Basel) 2021 Apr 27;21(9). Epub 2021 Apr 27.

Departamento de Eléctrica y Electrónica, Universidad de las Fuerzas Armadas-ESPE, Sangolquí 171103, Ecuador.

Technological advances in recent years have shown interest in the development of robots in the medical field. The integration of robotic systems in areas of assistance and rehabilitation improves the user's quality of life. In this context, this article presents a proposal for the unified control of a robotic standing wheelchair. Read More

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Apoferritin/Vandetanib Association Is Long-Term Stable But Does Not Improve Pharmacological Properties of Vandetanib.

Int J Mol Sci 2021 Apr 20;22(8). Epub 2021 Apr 20.

Department of Biochemistry, Faculty of Science, Charles University, Albertov 6, 128 00 Prague 2, Czech Republic.

A tyrosine kinase inhibitor, vandetanib (Van), is an anticancer drug affecting the signaling of VEGFR, EGFR and RET protooncogenes. Van is primarily used for the treatment of advanced or metastatic medullary thyroid cancer; however, its usage is significantly limited by side effects, particularly cardiotoxicity. One approach to minimize them is the encapsulation or binding of Van in- or onto a suitable carrier, allowing targeted delivery to tumor tissue. Read More

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Stiff Landings, Core Stability, and Dynamic Knee Valgus: A Systematic Review on Documented Anterior Cruciate Ligament Ruptures in Male and Female Athletes.

Int J Environ Res Public Health 2021 Apr 6;18(7). Epub 2021 Apr 6.

Shriners Hospital for Children-Philadelphia, Philadelphia, PA 19140, USA.

Anterior cruciate ligament (ACL) injuries are the most common ligament injury of the knee, accounting for between 100,000 and 200,000 injuries among athletes per year. ACL injuries occur via contact and non-contact mechanisms, with the former being more common in males and the later being more common in females. These injuries typically require surgical repair and have relatively high re-rupture rates, resulting in a significant psychological burden for these individuals and long rehabilitation times. Read More

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Characterizing the Rheological and Bread-Making Properties of Wheat Flour Treated by "Gluten Friendly" Technology.

Foods 2021 Apr 1;10(4). Epub 2021 Apr 1.

Department of Agriculture, Food, Natural resources and Engineering (DAFNE), University of Foggia, 71122 Foggia, Italy.

After discovering an innovative technology for the reshaping of gluten proteins-the "Gluten Friendly" system-that confers to wheat flour some unprecedented characteristics, such as reduced epitope antigenicity and a positive modulation of the gut microbiota, its effects on the production and quality of bread have been studied. Mainly, we have investigated the chemical, rheological and pasting properties of Gluten Friendly Flour (GFF) and of control flour (CF) with the aim of analyzing and interpreting potential differences. Furthermore, the bread made from GFF and CF was evaluated in terms of microstructure properties and sensory quality. Read More

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A Novel Method for Estimating and Balancing the Second Harmonic Error of Cylindrical Fused Silica Resonators.

Micromachines (Basel) 2021 Apr 1;12(4). Epub 2021 Apr 1.

College of Advanced Interdisciplinary Studies, National University of Defense Technology, Changsha 410073, China.

The cylindrical resonator gyroscope (CRG) is a type of Coriolis vibratory gyroscope which measures the angular velocity or angle through the precession of the elastic wave of the cylindrical resonator. The cylindrical fused silica resonator is an essential component of the CRG, the symmetry of which determines the bias drift and vibration stability of the gyroscope. The manufacturing errors breaking the symmetry of the resonator are usually described by Fourier series, and most studies are only focusing on analyzing and reducing the fourth harmonic error, the main error source of bias drift. Read More

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Potential risk analysis and experience summarization of unstable factors of cranial fixation devices in neurosurgical operations: three-case reports and systematic review.

Chin Neurosurg J 2021 Apr 28;7(1):25. Epub 2021 Apr 28.

Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.

Background: The use of cranial fixation devices in neurosurgery is very common, which is considered to be an important auxiliary method for many craniotomies. However, previous studies have reported complications of using cranial fixation devices, including brain tissue, nerve and blood vessel damage, scalp laceration, subcutaneous hematoma, etc. Some of the complications are serious and even potentially fatal, and the causes of which may be related to the incorrect use of cranial fixation devices. Read More

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Investigation of Phosphorylation-Induced Folding of an Intrinsically Disordered Protein by Coarse-Grained Molecular Dynamics.

J Chem Theory Comput 2021 May 28;17(5):3203-3220. Epub 2021 Apr 28.

Baker Laboratory of Chemistry and Chemical Biology, Cornell University, Ithaca, New York 14853-1301, United States.

Apart from being the most common mechanism of regulating protein function and transmitting signals throughout the cell, phosphorylation has an ability to induce disorder-to-order transition in an intrinsically disordered protein. In particular, it was shown that folding of the intrinsically disordered protein, eIF4E-binding protein isoform 2 (4E-BP2), can be induced by multisite phosphorylation. Here, the principles that govern the folding of phosphorylated 4E-BP2 (pT37pT46 4E-BP2) are investigated by analyzing canonical and replica exchange molecular dynamics trajectories, generated with the coarse-grained united-residue force field, in terms of local and global motions and the time dependence of formation of contacts between Cs of selected pairs of residues. Read More

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Developmental validations of a self-developed 39 AIM-InDel panel and its forensic efficiency evaluations in the Shaanxi Han population.

Int J Legal Med 2021 Apr 27. Epub 2021 Apr 27.

Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University, Xi'an, 710004, China.

Most of insertion/deletion polymorphisms are diallelic molecular markers characterized as small amplicon sizes, high inter-population diversities, and low mutation rates, which make them the promising genetic markers in biogeographic ancestor inference field. The developmental validations of a 39 ancestry informative marker-insertion/deletion (AIM-InDel) panel and the genetic polymorphic investigations of this panel were performed in the Shaanxi Han population of China. The developmental validation included the optimizations of PCR-related indicators, repeatability, reproducibility, precision, accuracy, sensitivity, species specificity, stability of the panel, and the abilities in analyzing degraded, casework, and mixture samples, and the present results demonstrated that this 39 AIM-InDel panel was robust, sensitive, and accurate. Read More

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A meta-analysis of the influence of the external conditions on the biosensor receptor layer component stability.

Acta Biochim Pol 2021 Apr 27. Epub 2021 Apr 27.

Department of Computer Science and Automatics, University of Bielsko-Biala, 43-309 Bielsko-Biala, Poland.

The manuscript presented here contains meta-analysis of the influence of the external conditions on the biosensor receptor layer component stability. The novelty of this paper is due to compilation and comparison of studies, based on proposed collective analyses. The presented meta-analysis allows to increase the precision and accuracy of the results by combining and co-analyzing data from five smaller experiments. Read More

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Study on the SEIQR model and applying the epidemiological rates of COVID-19 epidemic spread in Saudi Arabia.

Infect Dis Model 2021 18;6:678-692. Epub 2021 Apr 18.

Science and Technology Unit (STU), Umm Al-Qura University, Makkah, Saudi Arabia.

This article attempts to establish a mathematical epidemic model for the outbreak of the new COVID-19 coronavirus. A new consideration for evaluating and controlling the COVID-19 outbreak will be constructed based on the SEIQR Pandemic Model. In this paper, the real data of COVID-19 spread in Saudi Arabia has been used for the mathematical model and dynamic analyses. Read More

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Coupling the dual isotopes of water (δH and δO) and nitrate (δN and δO): A new framework for classifying current and legacy groundwater pollution.

Environ Res Lett 2021 Mar;16(4):1-45008

Pacific Ecological Systems Division, Center for Public Health and Environmental Assessment, Office of Research and Development, US Environmental Protection Agency, Corvallis, OR, United States of America.

Nitrate contamination of groundwater is a concern globally, particularly in agricultural regions where decades of fertilizer nitrogen (N) use has led to a legacy of N accumulation in soils and groundwater. Linkages between current management practices and groundwater nitrate dynamics are often confounded by the legacy effect, and other processes unrelated to management. A coupled analysis of dual stable isotopes of water (δHO = δH and δO) and nitrate (δNO = δN and δO) can be a powerful approach to identify sources and processes responsible for groundwater pollution. Read More

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Gold nanostar as an ultrasensitive colorimetric probe for picomolar detection of lead ion.

Anal Chim Acta 2021 May 12;1160:338380. Epub 2021 Mar 12.

Department of Pharmacy, University of South China, Henyang, 421001, China.

The sensitivity for analytes of interest is vital for environment protection and food safety. Here, we propose an extremely sensitive assay toward Pb by using gold nanostars (GNSs) as probes based on the catalytic activity of Pb on etching gold atoms after being reduced in the presence of 2-mercaptoethanol (2-ME) and sodium thiosulfate. GNSs were prepared by using 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid as both the reducing and capping agents, enabling high stability and sensitivity for quantitation of Pb. Read More

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[Effects of Land Use Changes on Soil Fungal Community Structure and Function in the Riparian Wetland Along the Downstream of the Songhua River].

Huan Jing Ke Xue 2021 May;42(5):2531-2540

College of Environmental Science and Engineering, China West Normal University, Nanchong 637002, China.

The aim of this study was to provide a reference for wetland resource management and ecological restoration by analyzing the influence of land use changes on the soil fungal community and its function and to identify the potential natural restoration ability of degraded riverside wetlands in the Songhua River. In July 2018, soil fungi in a natural wetland, paddy field, sand mining slash, and restoration wetland along the downstream of the Songhua River were amplified by PCR. PCR products were sequenced using the Illumina MiSeq PE300 high-throughput sequencing platform. Read More

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Nanoemulsified Butenafine for Enhanced Performance against Experimental Cutaneous Leishmaniasis.

J Immunol Res 2021 31;2021:8828750. Epub 2021 Mar 31.

Institute of Biosciences, São Paulo State University (UNESP), São Vicente, Praça Infante Dom Henrique, s/n, 11330-900 São Vicente, SP, Brazil.

The production of ergosterol lipid involves the activity of different enzymes and is a crucial event for the membrane homeostasis. Such enzymes can be blocked by azoles and allylamines drugs, such as the antifungal butenafine chloride. This drug was active on parasites that cause cutaneous and visceral leishmaniasis. Read More

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Influence of Glutaraldehyde's Molecular Transformations on Spectroscopic Investigations of Its Conjugation with Amine-Modified FeO Microparticles in the Reaction Medium.

Langmuir 2021 May 20;37(17):5242-5251. Epub 2021 Apr 20.

Department of Physics, Southern Illinois University, 1245 Lincoln Dr., Neckers 483-A, Carbondale, Illinois 62901, United States.

Glutaraldehyde (GA) is a widely used cross-linking agent in biological research due to its superior characteristics, such as high reactivity toward proteins, high stability, and cost-effectiveness. In this regard, analyzing spectral changes initiated by various molecular forms and transformations of GA in a reaction medium and its reaction with surface functional-modified solid spheres is vital for a successful bioconjugation process targeting the biomolecules of interest. In this work, we present Fourier transform-infrared (FT-IR), Raman, and UV-visible spectroscopic analyses of glutaraldehyde-modified FeO microparticles (magnetic beads) to confirm the conjugation between GA and magnetic beads. Read More

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Antiaromaticity-aromaticity transition of cyclo[16]carbon upon metal encapsulation.

Phys Chem Chem Phys 2021 Apr 31;23(14):8817-8824. Epub 2021 Mar 31.

Department of Chemistry, Renmin University of China, 100872 Beijing, P. R. China.

In contrast to aromatic compounds with particular stability, antiaromatic compounds are usually less stable due to their high reactivity and unfavorable formation energies. Cyclo[16]carbon (C) is a carbon ring molecule with a dual antiaromatic character. In this study, we demonstrate that C can be transformed into highly aromatic molecules upon metal encapsulation. Read More

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Fluorescent Ensemble Sensors and Arrays Based on Surfactant Aggregates Encapsulating Pyrene-Derived Fluorophores for Differentiation Applications.

ACS Appl Mater Interfaces 2021 Apr 19;13(16):18395-18412. Epub 2021 Apr 19.

Key Laboratory of Applied Surface and Colloids Chemistry of Ministry of Education, School of Chemistry and Chemical Engineering, Shaanxi Normal University, Xi'an 710119, PR China.

Surfactant assemblies have drawn great attention in fabricating fluorescent sensors as they can provide advantages such as easy preparation, low cost, aqueous detection, high fluorescence stability, high sensitivity to external stimuli, etc. We have devoted the past few years to fluorescent cross-reactive sensors and arrays that are advantageous in differentiating similar analytes and analyzing mixed samples. In this Spotlight on Applications, we introduce our recent advances in developing surfactant assembly-based fluorescent sensors and arrays for discrimination applications. Read More

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The Role of Human Centromeric RNA in Chromosome Stability.

Front Mol Biosci 2021 31;8:642732. Epub 2021 Mar 31.

Greehey Children's Cancer Research Institute, Department of Molecular Medicine, University of Texas Health Science Center at San Antonio, San Antonio, TX, United States.

Chromosome instability is a hallmark of cancer and is caused by inaccurate segregation of chromosomes. One cellular structure used to avoid this fate is the kinetochore, which binds to the centromere on the chromosome. Human centromeres are poorly understood, since sequencing and analyzing repeated alpha-satellite DNA regions, which can span a few megabases at the centromere, are particularly difficult. Read More

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Instrumentally assessed gait quality is more relevant than gait endurance and velocity to explain patient-reported walking ability in early-stage multiple sclerosis.

Eur J Neurol 2021 Apr 17. Epub 2021 Apr 17.

IRCSS Fondazione Don Carlo Gnocchi, Milan, Italy.

Background And Purpose: People with multiple sclerosis (PwMS) often report walking limitations even when the gold standard Expanded Disability Status Scale (EDSS) indicates normal walking endurance/autonomy. The present multicenter study on early-stage PwMS aims at analyzing which aspects are associated with patient-reported walking limitations measured with the 12-item Multiple Sclerosis Walking Scale (MSWS-12).

Methods: Eighty-two PwMS (EDSS ≤ 2. Read More

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The influence of awareness campaigns on the spread of an infectious disease: a qualitative analysis of a fractional epidemic model.

Model Earth Syst Environ 2021 Apr 8:1-9. Epub 2021 Apr 8.

Department of Mathematics, Faculty of Sciences and Technology, Cadi Ayyad University, B.P. 549, C.P. 40.000 Marrakesh, Morocco.

Mass-media coverage is one of the most widely used government strategies on influencing public opinion in times of crisis. Awareness campaigns are highly influential tools to expand healthy behavior practices among individuals during epidemics and pandemics. Mathematical modeling has become an important tool in analyzing the effects of media awareness on the spread of infectious diseases. Read More

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Functional Movement Screen Detected Asymmetry & Normative Values Among College-Aged Students.

Int J Sports Phys Ther 2021 Apr 1;16(2):450-458. Epub 2021 Apr 1.

Texas A&M Central Texas.

Background: The Functional Movement Screen (FMS™) is a popular test used by sports medicine professionals to identify dysfunctional movement patterns by analyzing mobility and stability during prescribed movements. Although the FMS™ has been a popular topic of research in recent years, normative data and asymmetries in college-aged students have not been established through research.

Purpose: The objective was to determine normative FMS™ scores, report frequency counts for FMS™ asymmetries, and determine if the number of sports seasons and number of different sports an individual participated in during high school varied between university students that showed FMS™ identified asymmetries. Read More

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NLRP7 deubiquitination by USP10 promotes tumor progression and tumor-associated macrophage polarization in colorectal cancer.

J Exp Clin Cancer Res 2021 Apr 10;40(1):126. Epub 2021 Apr 10.

Endoscopy Center, Zhongshan Hospital of Fudan University, 180 Fenglin Road, Shanghai, 20032, People's Republic of China.

Background: NOD-like receptors affect multiple stages of cancer progression in many malignancies. NACHT, LRR, and PYD domain-containing protein 7 (NLRP7) is a member of the NOD-like receptor family, although its role in tumorigenesis remains unclear. By analyzing clinical samples, we found that NLRP7 protein levels were upregulated in colorectal cancer (CRC). Read More

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