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Tunable characteristics of low-frequency bandgaps in two-dimensional multivibrator phononic crystal plates under prestrain.

Sci Rep 2021 Apr 16;11(1):8389. Epub 2021 Apr 16.

School of Mathematics and Physics, Lanzhou Jiaotong University, Lanzhou, 730070, China.

In view of the influence of variability of low-frequency noise frequency on noise prevention in real life, we present a novel two-dimensional tunable phononic crystal plate which is consisted of lead columns deposited in a silicone rubber plate with periodic holes and calculate its bandgap characteristics by finite element method. The low-frequency bandgap mechanism of the designed model is discussed simultaneously. Accordingly, the influence of geometric parameters of the phononic crystal plate on the bandgap characteristics is analyzed and the bandgap adjustability under prestretch strain is further studied. Read More

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Awareness about Vulvovaginal Aesthetics Procedures among Medical Students and Health Professionals in Saudi Arabia.

Rev Bras Ginecol Obstet 2021 Mar 15;43(3):178-184. Epub 2021 Apr 15.

Department of Clinical Sciences, Alfarabi College of Medicine, Alfarabi, Kingdom of Saudi Arabia.

Objective:  The present study aimed to explore the opinion and ethical consideration of vulvovaginal aesthetics procedures (VVAPs) among health professionals and medical students in Saudi Arabia.

Methods:  This is a cross-sectional study performed between January 2020 and April 2020. Data was collected through electronic media, WhatsApp, and emails. Read More

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Alcohol and light-polymerizing glaze effect on the physical and mechanical properties of a bisacrylate composite resin before and after immersion in chlorhexidine gluconate.

J Prosthet Dent 2021 Apr 12. Epub 2021 Apr 12.

Professor, Department of Dental Materials and Prosthodontics, Aracatuba Dental School, Sao Paulo State University (UNESP), Aracatuba, Sao Paulo, Brazil. Electronic address:

Statement Of Problem: The use of 0.12% chlorhexidine gluconate (CHX) may damage bisacrylate composite resin interim restorations, but whether they can be protected with an application of alcohol and/or the use of a glaze is unclear.

Purpose: The purpose of this in vitro study was to evaluate the effect of applying a 70% alcohol solution on the physical and mechanical properties of a bisacrylate composite resin, with and without the application of a light-polymerizing glaze subjected to 0. Read More

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Development and Practical Application of a Multiple-Criteria Decision Analysis Framework on Respiratory Inhalers: Is It Always Useful in the MOH Malaysia Medicines Formulary Listing Context?

MDM Policy Pract 2021 Jan-Jun;6(1):2381468321994063. Epub 2021 Mar 30.

Former Head of Therapeutic Drug Working Committee (TDWC) Respiratory (2014-2020), Serdang Hospital, Ministry of Health Malaysia.

The current health technology assessment used to evaluate respiratory inhalers is associated with limitations that have necessitated the development of an explicit formulary decision-making framework to ensure balance between the accessibility, value, and affordability of medicines. This study aimed to develop a multiple-criteria decision analysis (MCDA) framework, apply the framework to potential and currently listed respiratory inhalers in the Ministry of Health Medicines Formulary (MOHMF), and analyze the impacts of applying the outputs, from the perspective of listing and delisting medicines in the formulary. The overall methodology of the framework development adhered to the recommendations of the ISPOR MCDA Emerging Good Practices Task Force. Read More

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Integrating multiple blockchains to support distributed personal health records.

Health Informatics J 2021 Apr-Jun;27(2):14604582211007546

Vanderbilt University, USA.

Blockchain technologies have evolved in recent years, as have the use of personal health record (PHR) data. Initially, only the financial domain benefited from Blockchain technologies. Due to efficient distribution format and data integrity security, however, these technologies have demonstrated potential in other areas, such as PHR data in the healthcare domain. Read More

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The Value of Additional Gravity Stress Radiographs for Decision Making in the Treatment of Isolated Type B Distal Fibular Fractures.

Foot Ankle Int 2021 Apr 14:10711007211001037. Epub 2021 Apr 14.

Department of Surgery, Haaglanden Medical Centre, the Hague, the Netherlands.

Background: Prior to treatment decisions concerning isolated Weber type B ankle fractures, assessment of the stability of the ankle joint is mandatory. The gravity stress (GS) radiograph is a radiographic tool to determine stability. We hypothesized that this additional GS radiograph would lead to fewer operative treatments by applying the criterion of operative treatment when medial clear space (MCS) > superior clear space (SCS) + 2 mm on the GS radiograph, compared with the nonstressed mortise view criteria of advising operative treatment in case of MCS > SCS + 1 mm. Read More

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Extracting features from wrist vein images using fractional fourier transform for person verification.

Biomed Phys Eng Express 2021 Apr 14. Epub 2021 Apr 14.

Faculty of Medical Sciences and Technologies, Islamic Azad University Science and Research Branch, Science and Research Branch, Daneshgah Blvd, Simon Bulivar Blvd, Tehran, Tehran, Tehran, 1477893855, Iran (the Islamic Republic of).

One of the major concerns is the security and protection of individuals' privacy in society. Biometric methods have been developed in recent years and they are widely used in many places and devices to protect information and assets. Wrist veins are inside the body and their pattern is unique for each person. Read More

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Qualitative and Quantitative Analysis of Tryptamines in the Poison of Incilius alvarius (Amphibia: Bufonidae).

J Anal Toxicol 2021 Apr 14. Epub 2021 Apr 14.

Institute of Forensic Medicine, Forensic Toxicology, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.

Rising numbers of psychoactive tryptamine derivatives have become available on the drug market over the last decade, making these naturally occurring or synthetically manufactured compounds highly relevant for forensic analysis. One of these compounds is 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT), a constituent of the dried poison of Incilius alvarius (Colorado River toad) which has a history of ritual and/or recreational use. Still, comprehensive and validated qualitative as well as quantitative analytical data on the psychoactive components of this poison are scarce. Read More

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Effects of SARS-CoV-2 variants on vaccine efficacy and response strategies.

Expert Rev Vaccines 2021 Apr 14:1-9. Epub 2021 Apr 14.

Institute of Biological Products, Division of Hepatitis and Enterovirus Vaccines, National Institutes for Food and Drug Control, Beijing, China.

Introduction: As the global severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic continues to spread, several variants have emerged. Variants B.1. Read More

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Quantification of Cooperativity between Metal Sites in Dinuclear Transition Metal Complexes Containing the (2-Dimethylamino)-4-(2-pyrimidinyl)pyrimidine Ligand.

Chempluschem 2021 Mar 26;86(4):622-628. Epub 2021 Mar 26.

Research Center Optimas, TU Kaiserlautern, Erwin-Schrödinger-Str. 52, 67663, Kaiserslautern, Germany.

A concept for the quantification of cooperative effects in transition-metal complexes is presented. It is demonstrated for a series of novel N,N- (mononuclear) and C,N-coordinated homo- and heterometallic binuclear complexes based on the (2-dimethylamino)-4-(2-pyrimidinyl)pyrimidine ligand, which are accessible by applying roll-over cyclometallation. These iridium-, platinum-, and palladium-containing compounds are investigated with respect to their absorption and fluorescence spectra. Read More

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Effect of different surface treatment on the repair bond strength of feldspathic porcelain.

Dent Med Probl 2021 Jan-Mar;58(1):107-113

Department of Restorative Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Background: Considering the use of silane-containing universal adhesives to enhance the repair bond strength of porcelain restorations, a question arises whether the application of these adhesives eliminates the need for a separate application of silane or not.

Objectives: This study aimed to assess the effect of various kinds of surface treatment, including hydrofluoric acid (HF) etching, the application of bis-silane and the use of universal adhesives, on the repair bond strength of feldspathic porcelain.

Material And Methods: In this experimental in vitro study, 70 porcelain disks were fabricated and divided into 7 groups (n = 10) for the following types of surface treatment: C (control group) – HF etching + silane + Porcelain Bond; HSB – HF etching + Single Bond; HSSB – HF etching + silane + Single Bond; HAB – HF etching + All Bond; HSAB – HF etching + silane + All Bond; HFB – HF etching + FuturaBond®; and HSFB – HF etching + silane + FuturaBond. Read More

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Assessment of Professionalism During the Emergency Medicine Clerkship Using the National Clinical Assessment Tool for Medical Students in Emergency Medicine.

AEM Educ Train 2021 Apr 15;5(2):e10494. Epub 2020 Jul 15.

and the Department of Emergency Medicine University of Washington Seattle WA USA.

Objectives: In 2016, a national consensus conference created the National Clinical Assessment Tool for Medical Students in Emergency Medicine (NCAT-EM), a standardized end-of-shift assessment tool. We report the first large-scale analysis of professionalism concerns collected from May 2017 through December 2018 by a multisite consortium using the NCAT-EM. Our primary objective was to characterize the nature and frequency of professionalism concerns. Read More

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Proteomic analysis of drought stress response mechanism in soybean ( L.) leaves.

Food Sci Nutr 2021 Apr 7;9(4):2010-2020. Epub 2021 Feb 7.

Agriculture institute Iranian Research Organization of Science and Technology Tehran Iran.

Knowledge of the physiological and molecular mechanisms of drought responses is fundamental for developing genetically drought tolerant and high yielding crops. To understand molecular mechanism of drought tolerance of soybean ( L.), we compared leaf proteome patterns of in two genotypes GN-3074 (drought tolerant) and GN-2032 (drought-sensitive) under drought stress during vegetative stage. Read More

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Applying TS-DBN model into sports behavior recognition with deep learning approach.

J Supercomput 2021 Apr 6:1-17. Epub 2021 Apr 6.

Institute of Physical Education, Shandong University, Jinan, China.

The purposes are to automatically collect information about human sports behavior from massive video data and provide an explicit recognition and analysis of body movements. The analysis of multi-scale input data, the improvement of spatiotemporal Deep Belief Network (DBN), and the different pooling strategies are regarded as the focuses to improve the belief networks in deep learning (DL). Moreover, a human sports behavior recognition model is proposed based on particular spatio-temporal features. Read More

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Artificial intelligence applications in restorative dentistry: A systematic review.

J Prosthet Dent 2021 Apr 9. Epub 2021 Apr 9.

Assistant Professor, J. Mike Walker '66 Department of Mechanical Engineering, Texas A&M University, College Station, Texas.

Statement Of Problem: Artificial intelligence (AI) applications are increasing in restorative procedures. However, the current development and performance of AI in restorative dentistry applications has not yet been systematically documented and analyzed.

Purpose: The purpose of this systematic review was to identify and evaluate the ability of AI models in restorative dentistry to diagnose dental caries and vertical tooth fracture, detect tooth preparation margins, and predict restoration failure. Read More

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The Role of Cerebrospinal Fluid Dynamics in Normal Pressure Hydrocephalus Diagnosis and Shunt Prognostication.

Acta Neurochir Suppl 2021 ;131:359-363

Division of Neurosurgery, Department of Clinical Neuroscience, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK.

Background: Over the years, there have been several reports and trials of the resistance to cerebrospinal fluid (CSF) outflow (Rout) in normal pressure hydrocephalus (NPH). This work aimed to revisit the utility of testing CSF circulation in a large population of patients clinically presenting with NPH.

Materials And Methods: We retrospectively analyzed the data of 369 NPH patients-either shunted or with endoscopic third ventriculostomy (ETV)-in Cambridge between 1992 and 2018. Read More

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January 2021

Renal cell carcinomas with tubulopapillary architecture and oncocytic cells: Molecular analysis of 39 difficult tumors to classify.

Ann Diagn Pathol 2021 Mar 31;52:151734. Epub 2021 Mar 31.

Department of Pathology, Charles University in Prague, Faculty of Medicine in Plzeň, Pilsen, Czech Republic. Electronic address:

So-called oncocytic papillary renal cell carcinoma (OPRCC) is a poorly defined variant of papillary renal cell carcinoma. Since its first description, several studies were published with conflicting results, and thus precise definition is lacking. A cohort of 39 PRCCs composed of oncocytic cells were analyzed. Read More

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Retention forces between primary and secondary CAD/CAM manufactured telescopic crowns: an in vitro comparison of common material combinations.

Clin Oral Investig 2021 Apr 8. Epub 2021 Apr 8.

Section for Digital Implant- and Reconstructive Dentistry [DIRecD], Department of Reconstructive Dentistry and Gerodontology, School of Dental Medicine, University of Bern, Freiburgstrasse 7, 3010, Bern, Switzerland.

Objectives: To analyze the retention forces between primary and secondary telescopic crowns milled from various materials and to compare them with the retention forces between cast telescopic crowns made of precious metal alloys.

Materials And Methods: Primary and secondary crowns (N = 60; n = 10 per group) were fabricated using various material combinations (1: zirconia [ZIR]/polyether ether ketone [PEEK]; 2: titanium grade IV [TI]/PEEK; 3: PEEK/PEEK; 4: non-precious alloy [NPA]/PEEK; 5:NPA/NPA), while precious alloy (PA) was used for the control group (6: PA/PA). The retention forces at 10, 1000, 5000, and 10,000 connection and disconnection cycles and the relative weights were analyzed, applying nonparametric repeated measures ANOVA and post hoc Mann-Whitney and Wilcoxon signed-rank tests (α < 0. Read More

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Preliminary Exploration of Setting the Disease Severity Score in the Nutritional Risk Screening of Patients with Severe Novel Coronavirus Pneumonia by Applying NRS2002.

Int J Gen Med 2021 31;14:1167-1172. Epub 2021 Mar 31.

First Department of Pulmonary and Critical Care Medicine, Yan'an Hospital of Kunming City/Yan'an Hospital Affiliated to Kunming Medical University, Yunnan, 650000, People's Republic of China.

Objective: This study was designed to explore the impact of different scoring settings of disease severity on the accuracy of screening by NRS2002.

Methods: Patients with severe COVID-19 who were admitted to our hospital from January 26, 2020, to March 16, 2020, were enrolled in this study. The basic data, the scores of the NRS2002 score sheet, and the serum prealbumin (PAB) level when these patients were admitted were collected, and the reflection of NRS2002 scores under different disease severity score settings to abnormal patients was analyzed. Read More

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Expectations of citizens from the government in response to COVID-19 pandemic: a cross-sectional study in Iran.

BMC Public Health 2021 04 8;21(1):686. Epub 2021 Apr 8.

Health Policy Research Center, Institute of Health, Shiraz University of Medical Sciences, Shiraz, Fars, Iran.

Background: The government is the main body in charge of controlling epidemics; hence, expectations from the intention and capacities of the government would affect the flexibility and behaviors of citizens. Given the severity of COVID-19 pandemic and the urgent need for cooperation of people in the prevention and combat processes, understanding the public perspectives would be crucial and instructive. This study aimed to explore such perspectives towards the current pandemic among the Iranian. Read More

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[Effect of subpressure on the bonding strength of resin to polycrystalline particulates modified zirconia ceramic].

Zhonghua Kou Qiang Yi Xue Za Zhi 2021 Apr;56(4):342-348

Institute of Dental Research, Capital Medical University School of Stomatology, Beijing 100050, China.

To explore the effect of subpressure on the bonding strength of resin to polycrystalline particulates modified zirconia ceramic. One hundred and twenty pre-sintered zirconia discs were prepared and divided into the control group, the sandblasting group and the 30, 50, 70 s acid etching group (24 per group) by the random number table method. There was no additional treatment in the control group and sandblasting group before sinering. Read More

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Reprogramming enriches for somatic cell clones with small scale mutations in cancer-associated genes.

Mol Ther 2021 Apr 5. Epub 2021 Apr 5.

Leibniz Research Laboratories for Biotechnology and Artificial Organs (LEBAO), Department of Cardiothoracic-, Transplantation and Vascular Surgery, REBIRTH - Research Center for Translational Regenerative Medicine, Hannover Medical School, 30625 Hannover, Germany; Biomedical Research in Endstage and Obstructive Lung Disease (BREATH), Member of the German Center for Lung Research (DZL), 30625 Hannover, Germany. Electronic address:

Cellular therapies based on induced pluripotent stem cells (iPSCs) come out of age and an increasing number of clinical trials applying iPSC-based transplants are ongoing or in preparation. Recent studies, however, demonstrated a high number of small scale mutations in iPSCs. Although, the mutational load in iPSCs seems to be largely derived from their parental cells, it is still unknown whether reprogramming may enrich for individual mutations that could lead to loss of functionality and tumor formation from iPSC derivatives. Read More

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Are radiomics features universally applicable to different organs?

Cancer Imaging 2021 Apr 7;21(1):31. Epub 2021 Apr 7.

Center for Neuroscience Imaging Research, Institute for Basic Science (IBS), Suwon, 16419, South Korea.

Background: Many studies have successfully identified radiomics features reflecting macroscale tumor features and tumor microenvironment for various organs. There is an increased interest in applying these radiomics features found in a given organ to other organs. Here, we explored whether common radiomics features could be identified over target organs in vastly different environments. Read More

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Long-term oncologic result of laparoscopic versus open gastrectomy for gastric cancer: a propensity score matching analysis.

World J Surg Oncol 2021 Apr 7;19(1):101. Epub 2021 Apr 7.

Division of General Surgery, Department of Surgery, Tri-Service General Hospital, National Defense Medical Center, 325 Chenggong Rd Sec 2, Nei-hu, 114, Taipei, Taiwan.

Background: Laparoscopic gastrectomy is an acceptable procedure for early-stage gastric cancer; however, most patients are diagnosed at an advanced stage and older age in Taiwan. The feasibility and safety of applying laparoscopic gastrectomy in daily practice remain unclear. This study aimed to examine the short- and long-term outcomes of laparoscopic gastrectomy versus open procedures. Read More

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CO and N O emissions and microbial community structure from fields that include salt-affected soils.

J Environ Qual 2021 Apr 7. Epub 2021 Apr 7.

Distinguished Professor, Agronomy, Horticulture, and Plant Science, South Dakota State University, Brookings, SD.

Although salinity and sodicity are world-wide problems, information on greenhouse gas emissions from agricultural salt-affected soils is scarce. The CO -C and N O-N emissions were quantified from three zones intertwined within a single Northern Great Plains USA field, a highly productive zone (EC = 0.4 dS m ; SAR = 1. Read More

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Impact of overweight/obesity on clinical outcomes after reduction for intussusception in children.

Pediatr Surg Int 2021 Apr 7. Epub 2021 Apr 7.

Department of Neonatal Gastrointestinal Surgery, Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing, 400014, China.

Purpose: Childhood obesity is a worsening epidemic. Little is known about the impact of overweight and obesity (OV-OB) on clinical outcomes after reduction for intussusception in children. The aim of this study was to compare clinical outcomes after primarily air enema reduction for intussusception in grouped OV-OB (body mass index-for-age percentile ≥ 85) pediatric patients compared with no OV-OB patients. Read More

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ADHESION TO TREATMENT BY CHILDREN WITH CONGENITAL HYPOTHYROIDISM: KNOWLEDGE OF CAREGIVERS IN BAHIA STATE, BRAZIL.

Rev Paul Pediatr 2021 2;39:e2020074. Epub 2021 Apr 2.

Universidade Federal da Bahia, Salvador, BA, Brazil.

Objective: To investigate knowledge of caregivers of children with congenital hypothyroidism (CH), followed in a public reference service, as well as their associations with treatment adherence.

Methods: Exploratory, descriptive, cross-sectional study with convenience sample. Medical records of 158 patients diagnosed with congenital hypothyroidism were analyzed, and data were evaluated by applying a previously prepared questionnaire to caregivers from 2014 to 2016. Read More

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Insight into Canary Island pine physiology provided by stable isotope patterns of water and plant tissues along an altitudinal gradient.

Tree Physiol 2021 Apr 6. Epub 2021 Apr 6.

Swiss Federal Institute for Forest, Snow and Landscape Research WSL, 8903 Birmensdorf, Switzerland.

The Canary Islands, an archipelago east of Morocco's Atlantic coast, present steep altitudinal gradients covering various climatic zones from hot deserts to subalpine Mediterranean, passing through fog-influenced cloud forests. Unlike the majority of the Canarian flora, Pinus canariensis grow along most of these gradients, allowing the study of plant functioning in contrasting ecosystems. Here we assess the water sources (precipitation, fog) of P. Read More

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Impact of the new definition of pulmonary hypertension according to world symposium of pulmonary hypertension 2018 on diagnosis of post-capillary pulmonary hypertension.

Int J Cardiol 2021 Apr 3. Epub 2021 Apr 3.

Department of Internal Medicine, Respiratory Medicine and Ventilatory Support, Medical Mission Hospital, Central Clinic Würzburg, Academic Teaching Hospital of the Julius Maximilian University of Würzburg, Würzburg, Germany.

Background: The World Symposium on Pulmonary Hypertension (WSPH) in 2018 recommended new definitions of pulmonary hypertension (PH). We investigated the impact of the updated definition on prevalence of PH due to left heart disease (PH-LHD).

Methods: The data of right heart catheterizations in patients with suspected PH-LHD between January 2008 and July 2015 was retrospectively analyzed applying different definitions. Read More

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Data, data flows, and model specifications for linking multi-level contribution margin accounting with multi-level fixed-charge problems.

Data Brief 2021 Apr 5;35:106931. Epub 2021 Mar 5.

Department of Business and Economics, Neu-Ulm University of Applied Sciences (HNU), Wileystr. 1, 89231 Neu-Ulm, Germany.

This article describes the data, data flows, and spreadsheet implementations for linking multi-level contribution margin accounting as a subsystem in cost accounting with several versions of a multi-level fixed-charge problem (MLFCP), the latter based on the optimization approach in operations research. This linkage can reveal previously hidden optimization potentials within the framework of multi-level contribution margin accounting, thus providing better information for decision making in companies and other organizations. For the data, plausible fictitious values have been assumed taking into consideration the calculation principles in cost accounting where applicable. Read More

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