52,978 results match your criteria analytic study

Oral health self-care behaviours in serious mental illness: A systematic review and meta-analysis.

Acta Psychiatr Scand 2021 Apr 16. Epub 2021 Apr 16.

The Spectrum Centre for Mental Health Research, Faculty of Health & Medicine, Lancaster University, Lancaster, UK.

Aim: To understand the relationship between serious mental illness and oral health self-care behaviours using meta-analytic methods and a narrative synthesis of available literature.

Method: The review followed the Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines [PROSPERO reference: CRD42020176779]. Search terms pertaining to serious mental illness and oral health were entered into EMBASE, PsycINFO, Medline and CINAHL. Read More

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A form of muscular dystrophy associated with pathogenic variants in JAG2.

Am J Hum Genet 2021 Apr 9. Epub 2021 Apr 9.

Division of Pediatric Neurology, Department of Pediatrics, University of Florida College of Medicine, Gainesville, FL 32610, USA; Paul and Sheila Wellstone Muscular Dystrophy Center, University of Minnesota Medical School, Minneapolis, MN 55455, USA; Department of Neurology, University of Minnesota Medical School, Minneapolis, MN 55455, USA; Institute for Translational Neuroscience, University of Minnesota Medical School, Minneapolis, MN 55455, USA. Electronic address:

JAG2 encodes the Notch ligand Jagged2. The conserved Notch signaling pathway contributes to the development and homeostasis of multiple tissues, including skeletal muscle. We studied an international cohort of 23 individuals with genetically unsolved muscular dystrophy from 13 unrelated families. Read More

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Exactly solvable 1D model explains the low-energy vibrational level structure of protonated methane.

Chem Commun (Camb) 2021 Apr 16. Epub 2021 Apr 16.

Laboratory of Molecular Structure and Dynamics, Institute of Chemistry, ELTE Eötvös Loránd University, Pázmány Péter sétány 1/A, Budapest H-1117, Hungary and MTA-ELTE Complex Chemical Systems Research Group, P.O. Box 32, Budapest 112 H-1518, Hungary.

A new one-dimensional model is proposed for the low-energy vibrational quantum dynamics of CH5+ based on the motion of an effective particle confined to a 60-vertex graph Γ60 with a single edge length parameter. Within this model, the quantum states of CH5+ are obtained in analytic form and are related to combinatorial properties of Γ60. The bipartite structure of Γ60 gives a simple explanation for curious symmetries observed in numerically exact variational calculations on CH5+. Read More

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Meta-Analysis of Cognition in Parkinson's Disease Mild Cognitive Impairment and Dementia Progression.

Neuropsychol Rev 2021 Apr 16. Epub 2021 Apr 16.

Department of Neurology, University of Kentucky, Lexington, KY, USA.

Mild cognitive changes, including executive dysfunction, are seen in Parkinson's Disease (PD). Approximately 30% of individuals with PD develop Parkinson's disease dementia (PDD). Mild cognitive impairment (MCI) has been identified as a transitional state between normal cognition and dementia. Read More

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Olfactory capacity in anorexia nervosa: correlations with set-shifting ability.

Eat Weight Disord 2021 Apr 15. Epub 2021 Apr 15.

Second Department of Psychiatry, Medical School, "Attikon" University General Hospital, National and Kapodistrian University of Athens, 1 Rimini St, 12462, Athens, Greece.

Purpose: The purpose of this study is to examine olfactory capacity in adults with anorexia nervosa (AN), in terms of odor identification and odor threshold and search for possible correlations between odor identification and cognitive flexibility in this population.

Methods: Thirty-nine patients diagnosed with AN and 60 healthy participants, participated. Odor identification was assessed using the University Pennsylvania Smell Identification Test and a two alternative forced choice, ascending method with n-butanol was used to assess odor threshold. Read More

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Longitudinal Uses of the Population Assessment of Tobacco and Health Study.

Tob Regul Sci 2021 Jan;7(1):3-16

Department of Health Behavior, Roswell Park Comprehensive Cancer Center, Buffalo, NY, United States.

Objectives: The Population Assessment of Tobacco and Health (PATH) Study is a nationally representative study of the US population on tobacco use and its effects on health, with 3 waves of data collection between 2013 and 2016. Prior work described the methods of the first wave. In this paper, we describe the methods of the subsequent 2 waves and provide recommendations for how to conduct longitudinal analyses of PATH Study data. Read More

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January 2021

MetaPred: Meta-Learning for Clinical Risk Prediction with Limited Patient Electronic Health Records.

KDD 2019 Aug;2019:2487-2495

Department of Healthcare Policy and Research. Weill Cornell Medicine. Cornell University.

In recent years, large amounts of health data, such as patient Electronic Health Records (EHR), are becoming readily available. This provides an unprecedented opportunity for knowledge discovery and data mining algorithms to dig insights from them, which can, later on, be helpful to the improvement of the quality of care delivery. Predictive modeling of clinical risks, including in-hospital mortality, hospital readmission, chronic disease onset, condition exacerbation, etc. Read More

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Deep-learning and MR images to target hypoxic habitats with evofosfamide in preclinical models of sarcoma.

Theranostics 2021 11;11(11):5313-5329. Epub 2021 Mar 11.

Department of Cancer Physiology, Moffitt Cancer Center, Tampa, US.

Hypoxic regions (habitats) within tumors are heterogeneously distributed and can be widely variant. Hypoxic habitats are generally pan-therapy resistant. For this reason, hypoxia-activated prodrugs (HAPs) have been developed to target these resistant volumes. Read More

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Patients are unaware of clinical recommendations and resources.

Prim Care Diabetes 2021 Apr 12. Epub 2021 Apr 12.

Department of Family and Preventive Medicine, School of Medicine, Emory University, Atlanta, GA, USA. Electronic address:

Aims: The Emory Family Medicine Clinic (EFMC) sought to identify perceptions of recent patient-provider communications for patients with diabetes, factors influencing patient compliance with clinical recommendations, and patients' desire for additional resources to facilitate diabetes management.

Methods: Four focus group discussions were held June-August 2018 (3-9 participants each, 21 total). EFMC patients with uncontrolled diabetes received a phone invitation. Read More

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Assessing the Value of Echocardiography in the Absence of Randomized Trials: How Analytic Techniques from Causal Inference Can Fill the Gap.

J Am Soc Echocardiogr 2021 Apr 12. Epub 2021 Apr 12.

Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.

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Sex Differences in Cardiovascular Outcomes in CKD: Findings From the CRIC Study.

Am J Kidney Dis 2021 Apr 12. Epub 2021 Apr 12.

Department of Medicine, University of Illinois at Chicago, Chicago, IL. Electronic address:

Rationale & Objective: Cardiovascular events are less common in women than men in general populations; however, studies in chronic kidney disease (CKD) are less conclusive. We evaluated sex-related differences in cardiovascular events and death in adults with CKD.

Study Design: Prospective cohort study. Read More

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Patterns of Media Use, Strength of Belief in COVID-19 Conspiracy Theories, and the Prevention of COVID-19 from March to July 2020 in the US.

J Med Internet Res 2021 Apr 8. Epub 2021 Apr 8.

Annnenberg Public Policy Center, University of Pennsylvania, 202 S. 36th ST, Philadelphia, US.

Background: Holding conspiracy beliefs regarding the coronavirus pandemic in the US has been associated with reductions in both actions to prevent the spread of the infection (e.g., mask wearing) and intentions to accept a vaccine when one becomes available. Read More

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Difference in HIV testing behavior by injection status, among users of illicit drugs.

AIDS Care 2021 Apr 15:1-8. Epub 2021 Apr 15.

Division of Social Solutions and Services Research, The Nathan S. Kline Institute for Psychiatric Research, Orangeburg, NY, USA.

Human Immunodeficiency Virus (HIV) infection remains prevalent among the marginalized and drug using population in the United States. Testing for HIV is an important and cost-effective way to reduce HIV prevalence. Our objective was to determine if there is a difference in the number of HIV testing by injection status among users of illicit drugs and if a person's social network characteristics is a contributing factor. Read More

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A Meta-analysis of University STEM Summer Bridge Program Effectiveness.

CBE Life Sci Educ 2021 Jun;20(2):ar21

Department of Psychological Sciences, Rice University, Houston, TX 77005.

University science, technology, engineering, and math (STEM) summer bridge programs provide incoming STEM university students additional course work and preparation before they begin their studies. These programs are designed to reduce attrition and increase the diversity of students pursuing STEM majors and STEM career paths. A meta-analysis of 16 STEM summer bridge programs was conducted. Read More

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Comparison of plasma total solids concentration as measured by refractometry and plasma total protein concentration as measured by biuret assay in pet rabbits and ferrets.

J Am Vet Med Assoc 2021 May;258(9):977-982

Objective: To determine the agreement between plasma total solids (TS) concentration as measured by refractometry and plasma total protein (TP) concentration as measured by biuret assay in pet rabbits and ferrets.

Sample: 253 and 146 blood samples from 146 and 121 ferrets and rabbits, respectively, with results of CBC and plasma biochemical analyses.

Procedures: Data were collected from medical records regarding plasma TS and TP concentrations, PCV, plasma biochemical values, plasma appearance, and patient signalment. Read More

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Time-to-event analysis in economic evaluations: a comparison of modelling methods to assess the cost-effectiveness of transplanting a marginal quality kidney.

Health Econ Rev 2021 Apr 15;11(1):13. Epub 2021 Apr 15.

Australian Centre for Health Services Innovation (AusHSI) and Centre for Healthcare Transformation, Queensland University of Technology (QUT), 60 Musk Ave, Kelvin Grove, QLD, 4059, Australia.

Background: Economic-evaluations using decision analytic models such as Markov-models (MM), and discrete-event-simulations (DES) are high value adds in allocating resources. The choice of modelling method is critical because an inappropriate model yields results that could lead to flawed decision making. The aim of this study was to compare cost-effectiveness when MM and DES were used to model results of transplanting a lower-quality kidney versus remaining waitlisted for a kidney. Read More

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Revealing Conformational Transition Dynamics of Photosynthetic Proteins in Single-Molecule Electrical Circuits.

J Phys Chem Lett 2021 Apr 15:3853-3859. Epub 2021 Apr 15.

Beijing National Laboratory for Molecular Sciences State Key Laboratory for Structural Chemistry of Unstable and Stable Species, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, P. R. China.

The function of proteins depends on their structural flexibility and conformational change. By utilizing silicon-nanowire-based single-molecule electrical circuits, here we present a label-free real-time measurement method that can directly monitor conformational changes of a photosynthetic LH1-RC complex, reaching the ultimate goal of analytic chemistry. These results manifest that the conformation of the LH1-RC complex vibrates among four conformations with strong temperature dependence. Read More

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Reliability of Coronary Artery Calcium Severity Assessment on Non-Electrocardiogram-Gated CT: A Meta-Analysis.

Korean J Radiol 2021 Apr 1. Epub 2021 Apr 1.

Department of Radiology, Research Institute of Radiological Science, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.

Objective: The purpose of this meta-analysis was to investigate the pooled agreements of the coronary artery calcium (CAC) severities assessed by electrocardiogram (ECG)-gated and non-ECG-gated CT and evaluate the impact of the scan parameters.

Materials And Methods: PubMed, EMBASE, and the Cochrane library were systematically searched. A modified Quality Assessment of Diagnostic Accuracy Studies-2 tool was used to evaluate the quality of the studies. Read More

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Relationship between work-family conflict and turnover intention in nurses: A meta-analytic review.

J Adv Nurs 2021 Apr 14. Epub 2021 Apr 14.

Brunel University London, Uxbridge, UK.

Aim: This meta-analytic review aimed to synthesize and analyse studies that explored the relationship between nurses' work-family conflicts and turnover intentions.

Design: This meta-analytical review was conducted according to the Joanna Briggs Institute guidelines and PRISMA checklist.

Data Sources: A total of 191 (k = 14) publications published between 2005 and 2019 in English, including grey literature on turnover intention and work-family conflict, were retrieved from PubMed, PsycINFO, Web of Science, ProQuest and Scopus databases. Read More

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Social Cognition in Paediatric Traumatic Brain Injury: A Systematic Review and Meta-analysis.

Neuropsychol Rev 2021 Apr 15. Epub 2021 Apr 15.

Department of Psychology and Counselling, School of Psychology & Public Health, La Trobe University, Bundoora, VIC, 3086, Australia.

Recent evidence suggests social cognitive deficits may be among the most profound and disabling consequences of childhood traumatic brain injury (TBI); however, it is only over the last decade that this area has received increasing research attention. This study aims to systematically review all studies reporting on the effects of childhood TBI on social cognition. Meta-analytic techniques were employed to determine the magnitude of social cognitive deficits in childhood TBI. Read More

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Correlation between the burden of family caregivers and health status of people with diabetes mellitus.

J Public Health Res 2021 Apr 14;10(2). Epub 2021 Apr 14.

School of Nursing, Faculty of Medicine, Universitas Brawijaya, Malang.

Background: Family caregivers play an important role in providing long-term care for people with diabetes mellitus because it is a chronic disease that requires critical attention. This increases the burden of family caregivers which affects the health status of people with this disease. Therefore, the aim of this study is to determine the correlation between the burden of family caregivers and the health status of people with diabetes mellitus. Read More

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Evaluation of Hematocrit in Adults with Dengue by a Laboratory Information System.

J Trop Med 2021 27;2021:8852031. Epub 2021 Mar 27.

Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand.

The implementation of a laboratory information system (LIS) at the Hospital for Tropical Diseases in Thailand provides valuable medical resources, particularly for dengue. Hematocrit (Hct), which is often derived from hemoglobin (Hgb), is important in the diagnosis and management of dengue. This study aimed to evaluate the Hct value obtained from the LIS automated analyzer. Read More

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Stigma and psychological distress among pediatric participants in the FD/MAS Alliance Patient Registry.

Amanda Konradi

BMC Pediatr 2021 Apr 14;21(1):173. Epub 2021 Apr 14.

Department of Sociology, Loyola University Maryland, 4501 North Charles St., Baltimore, MD, 20210, USA.

Background: Stigma, both enacted and internalized, is part of the illness experience of many chronic conditions / diseases and has been found to increase psychological distress, lower self-esteem, and impact social engagement lowering quality of life (QOL). Stigma among pediatric patients is of particular concern due to its potential impact on identity formation. Using patient data from the online FD/MAS Alliance Patient Registry (FDMASAPR), this study seeks to 1) determine levels of enacted and self-stigma in a pediatric population of fibrous dysplasia (FD) / McCune Albright syndrome (MAS) patients and 2) to explore the relationship between stigma and anxiety and depression. Read More

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Phase I dose-escalation oncology trials with sequential multiple schedules.

BMC Med Res Methodol 2021 Apr 14;21(1):69. Epub 2021 Apr 14.

Department of Medical Statistics, University Medical Center Göttingen, Göttingen, Germany.

Background: Conventional methods for phase I dose-escalation trials in oncology are based on a single treatment schedule only. More recently, however, multiple schedules are more frequently investigated in the same trial.

Methods: Here, we consider sequential phase I trials, where the trial proceeds with a new schedule (e. Read More

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Risk Factors for Infection and Revision Surgery following Patellar Tendon and Quadriceps Tendon Repairs: An Analysis of 3,442 Patients.

J Knee Surg 2021 Apr 14. Epub 2021 Apr 14.

Department of Orthopaedic Surgery, University of Virginia, Charlottesville, Virginia.

Disruption of the extensor mechanism is debilitating with surgical repair being the accepted treatment. The incidence of infection and reoperation after extensor mechanism repair are not well reported in the literature. Thus, the objective of the current study was to (1) determine the incidence of surgical site infection and reoperation within 1 year of primary extensor mechanism repair and (2) identify independent risk factors for infection and reoperation following patellar and quadriceps tendon repair. Read More

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Describing Droplet Motion on Surface-Textured Ratchet Tracks with an Inverted Double Pendulum Model.

Langmuir 2021 Apr 14. Epub 2021 Apr 14.

Mechanical Engineering Department, Bilkent University, Ankara 06800, Turkey.

We describe the motion of a droplet on a textured ratchet track using a nonlinear resonator model. A textured ratchet track is composed of a semicircular pillar array that induces a net surface tension local gradient on a droplet placed on it. When a vertical vibration is applied, hysteresis is overcome, and the droplet moves toward the local lower energy barrier; however, due to the repetitive structure of texture, it keeps moving until the end of the track. Read More

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Bayesian semiparametric meta-analytic-predictive prior for historical control borrowing in clinical trials.

Stat Med 2021 Apr 13. Epub 2021 Apr 13.

Takeda Pharmaceuticals, Cambridge, Massachusetts, USA.

When designing a clinical trial, borrowing historical control information can provide a more efficient approach by reducing the necessary control arm sample size while still yielding increased power. Several Bayesian methods for incorporating historical information via a prior distribution have been proposed, for example, (modified) power prior, (robust) meta-analytic predictive prior. When utilizing historical control borrowing, the prior parameter(s) must be specified to determine the magnitude of borrowing before the current data are observed. Read More

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Does your past define you? How weight histories are associated with child eating-disorder psychopathology.

Eat Weight Disord 2021 Apr 13. Epub 2021 Apr 13.

Department of Psychiatry, Yale School of Medicine, 301 Cedar Street, New Haven, CT, 06519, USA.

Purpose: To examine how parents' and adolescents' weight histories were associated with parents' approach to eating/weight-related parenting and children's eating-disorder behaviors.

Methods: Participants were 502 parents (69.3% mothers, 30. Read More

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Patient Electronic Health Record Portal Use and Patient-Centered Outcomes in CKD.

Kidney Med 2021 Mar-Apr;3(2):231-240.e1. Epub 2021 Feb 9.

University of Michigan, Ann Arbor, MI.

Rationale & Objective: Electronic health record portals are increasingly emphasized in chronic kidney disease (CKD). However, associations of portal use with clinical and patient-centered outcomes remain unknown.

Study Design: Cross-sectional survey (April 2015 to March 2018). Read More

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February 2021

Detection of pathogenic bacteria by magneto-immunoassays: a review.

Eugen Gheorghiu

J Biomed Res 2020 Dec 25:1-7. Epub 2020 Dec 25.

International Centre of Biodynamics, Bucharest 060101, Romania.

Magnetic particle-based immunoassays are widely used in microbiology-related assays for both microbial capture, separation, analysis, and detection. Besides facilitating sample operation, the implementation of micro-to-nanometer scale magnetic beads as a solid support potentially shortens the incubation time (for magnetic immuno capture) from several hours to less than an hour. Analytical technologies based on magnetic beads offer a rapid, effective and inexpensive way to separate and concentrate the target analytes prior to detection. Read More

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December 2020