12,972 results match your criteria analytic model

Incorporating oxygenation levels in analytical DNA-damage models - quantifying the oxygen fixation mechanism.

Phys Med Biol 2021 Jun 15. Epub 2021 Jun 15.

CRUK/MRC Oxford Institute for Radiation Oncology, University of Oxford, Oxford, Oxfordshire, UNITED KINGDOM OF GREAT BRITAIN AND NORTHERN IRELAND.

Purpose: To develop a framework to include oxygenation effects in radiation therapy treatment planning which is valid for all modalities, energy spectra and oxygen levels. The framework is based on predicting the difference in DNA--damage resulting from ionising radiation at variable oxygenation levels.

Methods: Oxygen fixation is treated as a statistical process in a simplified model of complex and simple damage. Read More

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A population-based psychometric analysis of the insomnia severity index in black women with and without a history of cancer.

J Sleep Res 2021 Jun 14:e13421. Epub 2021 Jun 14.

Slone Epidemiology Center at Boston University, Boston, MA, USA.

Black women are under-represented in insomnia research. Further, cancer treatments increase the risk of late effects, thus affecting the sleep of psychologically and medically vulnerable cancer survivors. The Insomnia Severity Index (ISI) is widely used, but has not been researched in black women, and research in cancer survivors is limited. Read More

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Efficacy and safety of autologous chondrocyte implantation for osteochondral defects of the talus: a systematic review and meta-analysis.

Arch Orthop Trauma Surg 2021 Jun 14. Epub 2021 Jun 14.

Department of Orthopaedics, Ruijin Hospital, School of Medicine, Shanghai Jiaotong University, No, 999 Xiwang Road, Jiading District, Shanghai, 201801, China.

Introduction: Studies have reported various effects of autologous chondrocyte implantation (ACI) on osteochondral defects of the talus. Therefore, to assess the effectiveness of ACI for osteochondral defects of the talus, we used the meta-analytic approach.

Materials And Methods: Electronic databases PubMed, Embase, and the Cochrane Library were systematically searched to identify eligible studies from their inception until November 2020. Read More

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Propensity-score-based meta-analytic predictive prior for incorporating real-world and historical data.

Stat Med 2021 Jun 14. Epub 2021 Jun 14.

Statistical and Quantitative Sciences, Takeda Pharmaceuticals, Cambridge, Massachusetts, USA.

As the availability of real-world data sources (eg, EHRs, claims data, registries) and historical data has rapidly surged in recent years, there is an increasing interest and need from investigators and health authorities to leverage all available information to reduce patient burden and accelerate both drug development and regulatory decision making. Bayesian meta-analytic approaches are a popular historical borrowing method that has been developed to leverage such data using robust hierarchical models. The model structure accounts for various degrees of between-trial heterogeneity, resulting in adaptively discounting the external information in the case of data conflict. Read More

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Economic and clinical burden of comorbidities among patients with acromegaly.

Growth Horm IGF Res 2021 Apr 30;59:101389. Epub 2021 Apr 30.

Department of Clinical Pharmacy, University of Colorado Anschutz Medical Campus, Aurora, CO, United States of America.

Objective: Acromegaly is a rare, pituitary hormonal disorder that requires improved awareness worldwide. The objective of this analysis was to quantify the clinical and economic burden of comorbidities for patients with acromegaly and examine the influence of biochemical control on these outcomes.

Study Design: Markov cohort decision analytic model consisting of two states, including alive (with and without comorbidity) and dead. Read More

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Deep learning for discovering pathological continuum of crypts and evaluating therapeutic effects: An implication for in vivo preclinical study.

PLoS One 2021 14;16(6):e0252429. Epub 2021 Jun 14.

Global Computational Biology and Digital Sciences, Boehringer Ingelheim Pharmaceuticals, Ridgefield, Connecticut, United States of America.

Applying deep learning to the field of preclinical in vivo studies is a new and exciting prospect with the potential to unlock decades worth of underutilized data. As a proof of concept, we performed a feasibility study on a colitis model treated with Sulfasalazine, a drug used in therapeutic care of inflammatory bowel disease. We aimed to evaluate the colonic mucosa improvement associated with the recovery response of the crypts, a complex histologic structure reflecting tissue homeostasis and repair in response to inflammation. Read More

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MacEmerg Podcast: A Novel Initiative to Connect a Distributed Community of Practice.

AEM Educ Train 2021 Jul 25;5(3):e10550. Epub 2020 Nov 25.

and the Royal College of Physicians and Surgeons of Canada Emergency Medicine Training Program McMaster University Burlington Ontario Canada.

Background: Regional knowledge dissemination and information sharing is a challenge among physically divided groups of physicians. Many staff and resident physicians do not have easy access to share clinical and medical education and research information with each other in an academic setting. Our divisions of emergency medicine could benefit from a novel approach aimed at improving overall connection and collaborative engagement. Read More

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Noncontact Knee Ligament Injury Prevention Screening in Netball: A Clinical Commentary with Clinical Practice Suggestions for Community-Level Players.

Nicholas C Clark

Int J Sports Phys Ther 2021 Jun 1;16(3):911-929. Epub 2021 Jun 1.

University of Essex.

Netball is a predominantly female team court-sport which is played worldwide. Netball is becoming more popular in the United States following its countrywide introduction to schools and community centers. A unique characteristic of netball is the footwork rule which restricts players to a one-step landing after catching the ball. Read More

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State-Level Evaluation of Washington's State Innovation Models (SIM) Initiative.

J Health Care Poor Underserved 2021 ;32(2):862-891

The Washington State Innovation Models (SIM) $65 million Test Award from the Center for Medicare & Medicaid Services' Innovation Center is a statewide intervention expected to improve population health, quality of care, and cost growth through four initiatives: 1) regional accountable communities of health linking health and social services to address local needs; 2) a practice transformation support hub; 3) four value-based payment reform pilot projects mainly in state employee and Medicaid populations; and 4) data and analytic infrastructure development to support system transformation with common measures. We develop a conceptual model based on diffusion theory and apply the RE-AIM evaluation framework (Reach, Effectiveness, Adoption, Implementation, and Maintenance) to structure our evaluation. We find that in three years (2016-2018), SIM built the infrastructure for system transformation and increased Washington's readiness for health system change in the next decade. Read More

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January 2021

Cost effectiveness of typhoid vaccination in India.

Vaccine 2021 Jun 10. Epub 2021 Jun 10.

Department of Community Medicine and School of Public Health, Postgraduate Institute of Medical Education and Research, Chandigarh 160012, India. Electronic address:

Introduction: World Health Organization has prequalified the use of typhoid conjugate vaccine (TCV) in children over six months of age in typhoid endemic countries. We assessed the cost-effectiveness of introducing TCV separately for urban and rural areas of India.

Methods: A decision analytic model was developed, using a societal perspective, to compare long-term costs and outcomes (3% discount rate) in a new-born cohort of 100,000 children immunized with or without TCV. Read More

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Improving Hospital Based Medical Procurement Decisions with Health Technology Assessment and Multi-Criteria Decision Analysis.

Inquiry 2021 Jan-Dec;58:469580211022911

The First Affiliated Hospital of University of Sciences and Technology of China, Hefei, P.R. China.

This research proposes a new medical procurement decision-making tool named Evaluation of Medical Technology Procurement (EMTP), which combines Mini-health Technology Assessment (Mini HTA) with the analytic hierarchy process (AHP), as well as the intuitionistic linguistic multi-criteria group decision model for multi-criteria decision analysis (MCDA). This tool was applied to a medical device procurement decision in a large provincial general hospital with more than 5000 beds in China as a case study. Specifically, the AHP evaluation framework is first established to determine the evaluation dimensions and criteria. Read More

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The Use of Decision Analytic Modeling in the Evaluation of Surgical Innovations: A Scoping Review.

Value Health 2021 Jun 25;24(6):884-900. Epub 2021 Feb 25.

Department of Operating Rooms, Radboud University Medical Center, Radboud Institute for Health Sciences, Nijmegen, The Netherlands; Department for Health Evidence, Radboud University Medical Center, Radboud Institute for Health Sciences, Nijmegen, The Netherlands.

Objectives: The main objective of this review was to map how decision analytic models are used in surgical innovation (in which research phase, with what aim) and to understand how challenges related to the assessment of surgical interventions are incorporated.

Methods: We systematically searched PubMed, Embase, and the Cochrane Library for studies published in 2018. We included original articles using a decision analytic model to compare surgical strategies. Read More

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Quantitative detection of aflatoxin B using quantum dots-based immunoassay in a recyclable gravity-driven microfluidic chip.

Biosens Bioelectron 2021 Jun 2;190:113394. Epub 2021 Jun 2.

Guangdong Provincial Key Laboratory of Microbial Safety and Health, State Key Laboratory of Applied Microbiology Southern China, Institute of Microbiology, Guangdong Academy of Sciences, Guangzhou, China; School of Biology and Biological Engineering, South China University of Technology, Guangzhou, China. Electronic address:

To achieve rapid and sensitive detection of aflatoxin B (AFB), we developed a polydimethylsiloxane gravity-driven cyclic microfluidic chip using the two-signal mode strategy. The structural design of the chip, together with the two-wavelength quantum dot ratio fluorescence, effectively eliminates the influence of environmental factors, improves the signal stability, and ensures that the final detection result positively correlates with the target concentration. Moreover, the theoretical analysis performed for the established physical model of the three-dimensional reaction interface inside the chip confirmed the improved reaction rate of immune adsorption in the microfluidic strategy. Read More

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Assessment and management of soil erosion in the hilltop mining dominated catchment using GIS integrated RUSLE model.

J Environ Manage 2021 Jun 9;294:112987. Epub 2021 Jun 9.

Central Soil Salinity Research Institute, Canning, South 24-Paragana, West Bengal, India. Electronic address:

The Saranda forest region, which is well known for its biodiversity in India, is now confronted by rapid socio-economic development, particularly the hilltop mining activities. Hilltop mining areas of this region have always been responsible for producing excessive soil erosion in the associated river basin. This erosion phenomenon becomes hazardous during the rainy season, thereby contributing to various environmental problems, and consequently, necessitating soil erosion control planning in the Saranda forest. Read More

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Cost Effectiveness of an Electrocardiographic Deep Learning Algorithm to Detect Asymptomatic Left Ventricular Dysfunction.

Mayo Clin Proc 2021 Jun 8. Epub 2021 Jun 8.

Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN.

Objective: To evaluate the cost-effectiveness of an artificial intelligence electrocardiogram (AI-ECG) algorithm under various clinical and cost scenarios when used for universal screening at age 65.

Patients And Methods: We used decision analytic modeling to perform a cost-effectiveness analysis of the use of AI-ECG to screen for asymptomatic left ventricular dysfunction (ALVD) once at age 65 compared with no screening. This screening consisted of an initial screening decision tree and subsequent construction of a Markov model. Read More

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Field-Dependent Dehydration and Optimal Ionic Escape Paths for CN Membranes.

J Phys Chem B 2021 Jun 11. Epub 2021 Jun 11.

Department of Physics, Lancaster University, Lancaster LA1 4YB, United Kingdom.

Most analytic theories describing electrostatically driven ion transport through water-filled nanopores assume that the corresponding permeation barriers are bias-independent. While this assumption may hold for sufficiently wide pores under infinitely small bias, transport through subnanometer pores under finite bias is difficult to interpret analytically. Given recent advances in subnanometer pore fabrication and the rapid progress in detailed computer simulations, it is important to identify and understand the specific field-induced phenomena arising during ion transport. Read More

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The ecological dynamics of the coronavirus epidemics during transmission from outside sources when is successfully managed below one.

R Soc Open Sci 2021 Jun 9;8(6):202234. Epub 2021 Jun 9.

Center for Ecological and Evolutionary Synthesis (CEES), Department of Biosciences and Faculty of Mathematics and Natural Sciences, University of Oslo, PO Box 1032 Blindern, 316 Oslo, Norway.

Since COVID-19 spread globally in early 2020 and was declared a pandemic by the World Health Organization (WHO) in March, many countries are managing the local epidemics effectively through intervention measures that limit transmission. The challenges of immigration of new infections into regions and asymptomatic infections remain. Standard deterministic compartmental models are inappropriate for sub- or peri-critical epidemics (reproductive number close to or less than one), so individual-based models are often used by simulating transmission from an infected person to others. Read More

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DNA-Helix Inspired Wire Routing in Cylindrical Structures and Its Application to Flexible Surgical Devices.

Soft Robot 2021 Jun 9. Epub 2021 Jun 9.

School of Electrical Engineering, Hanyang University, Ansan, Republic of Korea.

In general wire-driven continuum robot mechanisms, the wires are used to control the motion of the devices attached at the distal end. The slack and taut wire is one of the challenging issues to solve in flexible mechanism. This phenomenon becomes worse when the continuum robot is inserted into the natural orifices of the human body, which inherently have uncertain curvilinear geometries consisting of multiple curvatures. Read More

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Social synchronization during joint attention in children with autism spectrum disorder.

Autism Res 2021 Jun 9. Epub 2021 Jun 9.

School of Psychological and Cognitive Sciences & Beijing Key Laboratory of Behavior and Mental Health, Peking University, Beijing, China.

We explored the social synchronization of gaze-shift behaviors when responding to joint attention in children with autism spectrum disorder (ASD). Forty-one children aged 5 to 8 with ASD and 43 typically developing (TD) children watched a video to complete the response to joint attention (RJA) tasks, during which their gaze data were collected. The synchronization of gaze-shift behaviors between children and the female model in the video was measured with the cross-recurrence quantification analysis (CRQA). Read More

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Going deep into schizophrenia with artificial intelligence.

Schizophr Res 2021 Jun 5. Epub 2021 Jun 5.

Department of Electrical Engineering, University of Chile, Santiago, Chile.

Despite years of research, the mechanisms governing the onset, relapse, symptomatology, and treatment of schizophrenia (SZ) remain elusive. The lack of appropriate analytic tools to deal with the heterogeneity and complexity of SZ may be one of the reasons behind this situation. Deep learning, a subfield of artificial intelligence (AI) inspired by the nervous system, has recently provided an accessible way of modeling and analyzing complex, high-dimensional, nonlinear systems. Read More

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A Systematic Review and Quality Appraisal of Applications of Direct Instruction with Children with Autism Spectrum Disorder.

Perspect Behav Sci 2021 Jun 1:1-22. Epub 2021 Jun 1.

May Institute, Inc., Simmons University, 41 Pacella Park Drive, Randolph, MA 02368 USA.

Developed by Siegfried ("Zig") Engelmann and colleagues, direct instruction (DI) has been recognized as an effective and replicable teaching model for decades. Although rooted in many principles of learning that behavior analysts utilize in daily practice, DI is not a common a component of behavior analytic services for learners with autism spectrum disorder (ASD). This may be attributed to behavior analysts' unfamiliarity with research evaluating the efficacy of DI with learners with ASD. Read More

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Polycentric or monocentric, which kind of spatial structure is better for promoting the green economy? Evidence from Chinese urban agglomerations.

Environ Sci Pollut Res Int 2021 Jun 6. Epub 2021 Jun 6.

Guangxi Institute of Finance and Economics, Guangxi University of Finance and Economics, Nanning, China.

The green economy has gained worldwide attention, especially in the urban agglomerations where population and economic activities are highly concentrated. However, what kind of urban agglomeration spatial structure is more conducive to promoting the green economy? No clear conclusions have been made. To bridge this gap, by employing the data of 16 urban agglomerations in China in 2003-2017 and a comprehensive analytic framework including dynamic panel threshold model, this paper studies the impact of urban agglomeration spatial structure on the green economy and the three subsystems of green economy to shed light on which kind of urban agglomeration spatial structure better drives the green economy. Read More

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Learning from imbalanced COVID-19 chest X-ray (CXR) medical imaging data.

Methods 2021 Jun 4. Epub 2021 Jun 4.

Division of Engineering Science, Faculty of Applied Science and Engineering, University of Toronto, Toronto, Canada. Electronic address:

The trendy task of digital medical image analysis has been continually evolving. It has been an area of prominent and growing importance from both research and deployment perspectives. Nonetheless, it is necessary to realize that the use of algorithms, methodology, as well as the source of medical image data, must be strictly scrutinized. Read More

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Early health economic analysis of 1.5T MRI-guided radiotherapy for localized prostate cancer: Decision analytic modelling.

Radiother Oncol 2021 Jun 2. Epub 2021 Jun 2.

Utrecht University, The Netherlands.

Background And Purpose: 1.5 Tesla magnetic resonance imaging radiotherapy linear accelerator (MR-Linac) is gaining interest for treatment of localized prostate cancer. Clinical evidence is lacking and it therefore remains uncertain whether MR-Linac is cost-effective. Read More

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Two dimensionless parameters and a mechanical analogue for the HKB model of motor coordination.

J F Cass S J Hogan

Biol Cybern 2021 Jun 5. Epub 2021 Jun 5.

Department of Engineering Mathematics, University of Bristol, Bristol, BS8 1UB, UK.

The widely cited Haken-Kelso-Bunz (HKB) model of motor coordination is used in an enormous range of applications. In this paper, we show analytically that the weakly damped, weakly coupled HKB model of two oscillators depends on only two dimensionless parameters; the ratio of the linear damping coefficient and the linear coupling coefficient and the ratio of the combined nonlinear damping coefficients and the combined nonlinear coupling coefficients. We illustrate our results with a mechanical analogue. Read More

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The Analytic Identification of Variance Component Models Common to Behavior Genetics.

Behav Genet 2021 Jun 4. Epub 2021 Jun 4.

Department of Psychology and Human Development, Vanderbilt University, Nashville, TN, 37203, USA.

Many behavior genetics models follow the same general structure. We describe this general structure and analytically derive simple criteria for its identification. In particular, we find that variance components can be uniquely estimated whenever the relatedness matrices that define the components are linearly independent (i. Read More

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Assessment of potential strain injury to rectus capitis posterior minor muscles during whiplash type distortions of the cervical spine.

J Osteopath Med 2021 Jun 4. Epub 2021 Jun 4.

Department of Osteopathic Manipulative Medicine, Michigan State University, East Lansing, MI, USA.

Context: Whiplash type injuries resulting from a rear end motor vehicle accident (REMVA) are thought to be caused by excessive loading and displacement of structural components of the cervical spine. On impact, the seat propels the driver's torso forward relative to the head, resulting in forced flexion of the occipitoatlantal (OA) joint, accompanied by forced stretching of the rectus capitis posterior minor (RCPm) muscles. Flexion of the OA joint and stretching of the RCPm muscles continues to increase until the vehicle's headrest strikes the back of the driver's head. Read More

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Lenvatinib versus sorafenib for first-line treatment of unresectable hepatocellular carcinoma: patient-reported outcomes from a randomised, open-label, non-inferiority, phase 3 trial.

Lancet Gastroenterol Hepatol 2021 Jun 1. Epub 2021 Jun 1.

FSBSI N N Blokhin Russian Cancer Research Center, Moscow, Russia.

Background: Hepatocellular carcinoma is the third-leading cause of cancer-related death worldwide. Preservation of health-related quality of life (HRQOL) during treatment is an important therapeutic goal. The aim of this study was to evaluate the effect of treatment with lenvatinib versus sorafenib on HRQOL. Read More

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Dissect the immunity using cytokine profiling and NF-kB target gene analysis in systemic inflammatory minipig model.

PLoS One 2021 4;16(6):e0252947. Epub 2021 Jun 4.

Animal Model Research Group, Korea Institute of Toxicology, Jeongeup, Jeollabuk-do, Republic of Korea.

Minipigs have remarkably similar physiology to humans, therefore, they it can be a good animal model for inflammation study. Thus, the conventional (serum chemistry, histopathology) and novel analytic tools [immune cell identification in tissue, cytokine level in peripheral blood mononuclear cells (PBMC) and serum, NF-kB target gene analysis in tissue] were applied to determine inflammation in Chicago Miniature Swine (CMS) minipig. Lipopolysaccharide (LPS)-induced acute systemic inflammation caused liver and kidney damage in serum chemistry and histopathology. Read More

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Editorial Perspective: Psychosis risk in adolescence - outcomes, comorbidity, and antipsychotics.

J Child Psychol Psychiatry 2021 Jun 4. Epub 2021 Jun 4.

Department of Neuroscience, University of Turin, Turin, Italy.

Research on Clinical High-Risk for Psychosis (CHR-P) has led to a vigorous change in the field of early detection in psychiatry and is gradually expanding its focus toward early development. The Annual Research Review on psychosis risk in adolescents (Journal of Child Psychology and Psychiatry, 62, 2020 and 657) offers a wide-angle meta-analytical picture of such emerging trends in all areas relevant to CHR-P Research, that is, detection, prognosis, and intervention. This editorial perspective is meant to expand the clinical and conceptual reach of these meta-analytic findings in relation to (a) the influence of age on transition rate and scalability of the early detection model across the child-adolescent vs adult periods; (b) potential latent heterogeneity of the pathogenetic trajectories leading to CHR-P as suggested by comorbid psychopathologies; (c) controversial (or at least problematic) prognostic significance of antipsychotic exposure in CHR-P subjects, especially in children and adolescents. Read More

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