812,019 results match your criteria analysis sera

Candida albicans Biofilm Formation and Growth Optimization for Functional Studies Using Response Surface Methodology.

J Appl Microbiol 2021 Dec 4. Epub 2021 Dec 4.

Department of Microbiology, M S Ramaiah Medical College and Teaching Hospital, Bangalore-560054, Karnataka, India.

Aim: Optimization of Candida growth and biofilm formation is essential for understanding the recalcitrance of this pathogen to advance functional analysis on hospital tools and material surfaces. Optimization and quantification of biofilm have always been a challenge using the conventional One Variable at a Time (OVAT) method. The present study uses Central Composite Design-based Response Surface Methodology for optimization of conditions to induce growth and biofilm formation in Candida albicans on polystyrene microtitre plates. Read More

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December 2021

Acute kidney injury in paediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 (PIMS-TS) is not associated with progression to chronic kidney disease.

Arch Dis Child 2021 Dec 3. Epub 2021 Dec 3.

Department of Paediatric Nephrology, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK

Background: Paediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 (PIMS-TS) is a rare complication of SARS-CoV-2 associated with single or multiorgan dysfunction.

Objective: We aimed to evaluate the incidence of acute kidney injury (AKI) and risk factors for kidney dysfunction in PIMS-TS, with reporting of 6-month renal follow-up data. We also evaluated renal involvement between first and second waves of the SARS-CoV-2 pandemic in the UK, the latter attributed to the Alpha variant. Read More

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December 2021

Effect of elexacaftor-tezacaftor-ivacaftor on body weight and metabolic parameters in adults with cystic fibrosis.

J Cyst Fibros 2021 Nov 30. Epub 2021 Nov 30.

Division of Endocrinology, Metabolism, & Lipid Research, Department of Medicine, Washington University, St. Louis, Missouri, USA. Electronic address:

Background: Though weight gain has been reported in some clinical trials of CFTR modulators, the effect of elexacaftor-tezacaftor-ivacaftor on body weight, body mass index (BMI), blood pressure, lipids and glycemic control in the real-world setting remains incompletely described.

Methods: We performed a single-center, retrospective, observational analysis of the effect of elexacaftor-tezacaftor-ivacaftor on body weight and cardiometabolic parameters in 134 adult CF patients of the Washington University Adult Cystic Fibrosis Center. Body weight, BMI, and blood pressure were extracted from outpatient clinic visits for the year preceding and the period following the initiation of elexacaftor-tezacaftor-ivacaftor. Read More

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November 2021

Comparison of Elaeagnus angustifolia L. extract and quercetin on mouse model of knee osteoarthritis.

J Ayurveda Integr Med 2021 Nov 30:100529. Epub 2021 Nov 30.

Department of Biology, Central Tehran Branch, Islamic Azad University, Tehran, Iran. Electronic address:

Osteoarthritis (OA) is the most commonly observed arthritic disease causing severe pain and impairing patient's quality of life. This study aimed to investigate and compare the effect of Elaeagnus angustifolia extract and quercetin on the mouse model of knee osteoarthritis (OA). Sixty Balb-C mice were used to establish the monosodium iodoacetate (MIA) model of OA. Read More

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November 2021

Characteristics and outcomes of octogenarians with revascularized critical limb ischemia: Impact of altered cardiac function for early mortality.

J Med Vasc 2021 Oct-Dec;46(5-6):224-231. Epub 2021 Nov 5.

Vascular medicine department, groupe hospitalier Paris Saint-Joseph, Paris, France.

Objective: Patients with critical limb ischemia (CLI) present with advanced age and end-stage organ damage, in particular heart failure. The aim of the present study is to describe clinical and biological characteristics in octogenarian patients with CLI compared to their younger counterparts and to determine the peri-procedural risk and early mortality after endovascular procedure.

Methods: From November 2013 to May 2019, 315 consecutive patients were retrospectively included. Read More

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November 2021

Influencing factors of noninvasive positive pressure ventilation in the treatment of respiratory failure: a 10-year study in one single center.

Eur J Med Res 2021 Dec 3;26(1):136. Epub 2021 Dec 3.

Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.

Background: The utilization of noninvasive positive pressure ventilation (NPPV) is becoming more and more common, especially in patients with acute or chronic respiratory failure. The purpose of our study is to analyze the factors that influence the efficacy of NPPV in the treatment of respiratory failure caused by a variety of etiology.

Methods: From May 2011 to April 2020, patients treated with NPPV during hospitalization in the First Affiliated Hospital of Soochow University were enrolled. Read More

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December 2021

Nonthyroidal illness syndrome (NTIS) in severe COVID-19 patients: role of T3 on the Na/K pump gene expression and on hydroelectrolytic equilibrium.

J Transl Med 2021 Dec 3;19(1):491. Epub 2021 Dec 3.

Department of Clinical and Surgical Translational Medicine, Sapienza University, Rome, Italy.

Background: Nonthyroidal Illness Syndrome (NTIS) can be detected in many critical illnesses. Recently, we demonstrated that this condition is frequently observed in COVID-19 patients too and it is correlated with the severity the disease. However, the exact mechanism through which thyroid hormones influence the course of COVID-19, as well as that of many other critical illnesses, is not clear yet and treatment with T4, T3 or a combination of both is still controversial. Read More

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December 2021

Syndecan-1, an indicator of endothelial glycocalyx degradation, predicts outcome of patients admitted to an ICU with COVID-19.

Mol Med 2021 Dec 3;27(1):151. Epub 2021 Dec 3.

Department of Clinical Laboratory, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, 100730, People's Republic of China.

Background: We investigated the feasibility of two biomarkers of endothelial damage (Syndecan-1 and thrombomodulin) in coronavirus disease 2019 (COVID-19), and their association with inflammation, coagulopathy, and mortality.

Methods: The records of 49 COVID-19 patients who were admitted to an intensive care unit (ICU) in Wuhan, China between February and April 2020 were examined. Demographic, clinical, and laboratory data, and outcomes were compared between survivors and non-survivors COVID-19 patients, and between patients with high and low serum Syndecan-1 levels. Read More

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December 2021

Treating Full Depth Cartilage Defects with Intraosseous Infiltration of Plasma Rich in Growth Factors: An Experimental Study in Rabbits.

Cartilage 2021 Dec 3:19476035211057246. Epub 2021 Dec 3.

Bioregenerative Medicine and Applied Surgery Research Group, Department of Animal Medicine and Surgery, CEU Cardenal Herrera University, CEU Universities, Valencia, Spain.

Objective: Intraarticular (IA) administration of platelet-rich plasma (PRP) has been proposed as a new strategy to halt osteoarthritis (OA) progression. In patients with severe OA, its potential is limited because it is unable to reach the subchondral bone, so a new strategy is needed, and intraosseous (IO) infiltration has been suggested. The purpose is to assess the impact of IA together with IO infiltration of plasma rich in growth factors (PRGF) in serum hyaluronic acid (HA) and type II collagen cleavage neoepitope (C2C) levels. Read More

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December 2021

[Effects of oral manganese supplementation with different compounds on the manganese whole blood and serum concentrations of broodmares and their suckling foals].

Tierarztl Prax Ausg G Grosstiere Nutztiere 2021 Dec 3;49(6):392-402. Epub 2021 Dec 3.

Institut für Tierernährung, Ernährungsschäden und Diätetik, Universität Leipzig.

Objective: This study aimed to examine the effects of an oral supplementation on manganese (Mn) concentrations in the blood of lactating warm-blood broodmares. Furthermore, the potential relationship between Mn supply of the lactating mare and its suckling foal was investigated.

Material And Methods: During the 90-day trial, lactating mares were divided into 3 groups and daily received a daily dose of either a placebo (n = 11) or a Mn supplement of 560 mg Mn as Mn sulfate (n = 11) or Mn chelate (n = 11) in addition to the Mn intake from the basal ration (hay ad libitum, total mixed ration: Mn intake ~ 100 mg/kg dry matter). Read More

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December 2021

In Vitro and In Vivo Antiglycation Effects of Connarus ruber Extract.

Planta Med 2021 Dec 3. Epub 2021 Dec 3.

Research Institute for Human Health Science, Konan University, Kobe, Hyogo, Japan.

Accumulation of advanced glycation end products (AGEs) of the Maillard reaction has been implicated in the pathogenesis of diabetes and its complications. has been used as a folk remedy for several diseases, including diabetes; however, its underlying mechanism has not yet been investigated. This study investigated the effects of extract against glycation on collagen-linked AGEs and streptozotocin-induced diabetic rats (STZ-DM rats) . Read More

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December 2021

Structural modulation of gut microbiota during alleviation of experimental passive Heymann nephritis in rats by a traditional Chinese herbal formula.

Biomed Pharmacother 2021 Nov 30;145:112475. Epub 2021 Nov 30.

Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100193, China. Electronic address:

Background: Jianpi-Qushi-Heluo formula (JQHF) has been used to treat idiopathic membranous nephropathy (IMN) in hospitals for many years.

Purpose: Elucidating the protective effect and exploring the potential mechanism of JQHF against IMN.

Methods: Passive Heymann nephritis (PHN) was induced in rats by a single tail vein injection of anti-Fx1A antiserum. Read More

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November 2021

Rapid detection of miRNA via development of consecutive adenines (polyA)-based electrochemical biosensors.

Biosens Bioelectron 2021 Nov 26;198:113830. Epub 2021 Nov 26.

School of Biomedical Engineering, Health Science Center, Shenzhen University, Shenzhen, 518037, PR China.

Herein, we report rapid electrochemical detection of miRNA let-7a based on a DNA probe consisting of a polyA and Fc-co-labeled harpin structure (the polyA-H probe). The polyA-H probe could be facilely immobilized on Au surfaces through the interactions between polyA and Au, followed by its pre-hybridization with a single strand (S1). The probe's surface density could be optimized for minimizing steric hindrance via changing the polyA block length. Read More

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November 2021

Relative Ratios of Human Seasonal Coronavirus Antibodies Predict the Efficiency of Cross-Neutralization of SARS-CoV-2 Spike Binding to ACE2.

EBioMedicine 2021 Nov 29;74:103700. Epub 2021 Nov 29.

Department of Biochemistry, Microbiology & Immunology, Faculty of Medicine, University of Ottawa, Canada; University of Ottawa Centre for Infection, Immunity and Inflammation (CI3). Electronic address:

Background: Antibodies raised against human seasonal coronaviruses (sCoVs), which are responsible for the common cold, are known to cross-react with SARS-CoV-2 antigens. This prompts questions about their protective role against SARS-CoV-2 infections and COVID-19 severity. However, the relationship between sCoVs exposure and SARS-CoV-2 correlates of protection are not clearly identified. Read More

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November 2021

Factors predicting neuro-endocrine recovery following transsphenoidal surgery in pituitary apoplexy patients.

World Neurosurg 2021 Nov 30. Epub 2021 Nov 30.

Division of Neurosurgery, Department of Surgery, Songklanagarind Hospital, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla, 90110, Thailand.

Background: Pituitary apoplexy is a rare clinical syndrome. Only a few studies have examined factors associated with recovery of neuro-endocrine functions following transsphenoidal surgery. This study aimed to identify factors associated with neuro-endocrine recovery following surgery for pituitary apoplexy. Read More

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November 2021

Fetal and Maternal Inflammatory Response in the Setting of Maternal Intrapartum Fever with and without Clinical and Histological Chorioamnionitis.

Am J Obstet Gynecol MFM 2021 Nov 30:100539. Epub 2021 Nov 30.

Richmond University Medical Center, Department of Obstetrics and Gynecology, Staten Island, New York; New York Medical College, Department of Obstetrics and Gynecology, Valhalla, New York. Electronic address:

Background: Both infectious and noninfectious causes of maternal fever have been linked to adverse neonatal outcomes including low Apgar scores, respiratory distress, hypotonia, and neonatal seizures. Even in the absence of infection, the occurrence of intrapartum fever is a strong risk factor for long-term neonatal developmental outcomes, including encephalopathy, cerebral palsy, and neonatal death.

Objective: The primary objective of this study was to compare intrapartum and postpartum maternal and fetal umbilical cord serum levels of RANTES, IFN-ɣ, IL-1 beta, IL-2, IL-4, IL-6, IL-8, IL-10, IL-13, and TNF-α between non-febrile patients, febrile patients without clinical chorioamnionitis, and febrile patient with clinical chorioamnionitis. Read More

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November 2021

Bu-shen-zhu-yun decoction inhibits granulosa cell apoptosis in rat polycystic ovary syndrome through estrogen receptor α-mediated PI3K/AKT/mTOR pathway.

J Ethnopharmacol 2021 Nov 30:114862. Epub 2021 Nov 30.

Department of Gynecology, Jiangsu Provincial Hospital, Nanjing 210029, Jiangsu, China. Electronic address:

Ethnopharmacological Relevance: Bu-shen-zhu-yun decoction (BSZYD) is a traditional chinese herbal prescription is widely used in the treatment of infertility.

Aim Of The Study: We aimed to elucidate the impact of a traditional herbal prescription BSZYD on polycystic ovary syndrome (PCOS).

Materials And Methods: The candidate active compounds in BSZYD and their putative targets were investigated by bioinformatics analysis. Read More

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November 2021

Study on collateral circulation level and prognosis of acute ischemic stroke by 4D CTA-CTP integrated technology and serum S100B.

Microvasc Res 2021 Nov 30:104270. Epub 2021 Nov 30.

Department of Radiology, Shanghai Pudong New Area Gongli Hospital, No. 219 Miaopu Road, Pudong New Area, Shanghai 200135, China. Electronic address:

Objective: To evaluate the cerebral collateral circulation in patients with acute ischemic stroke (AIS) by Four-dimensional CT angiography-CT perfusion (4D CTA-CTP)-integrated technology, and to explore the feasibility of predicting the prognosis of patients with AIS by using cerebral collateral circulation and serum S100B protein concentration.

Methods: Thirty-two patients with anterior circulation AIS who underwent 4D CTA-CTP were retrospectively analysed. The level of cerebral collateral circulation was assessed by multi-phase CT angiography (mCTA) scores and regional leptomeningeal collateral (rLMC) scores. Read More

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November 2021

Association of both prenatal and early childhood multiple metals exposure with neurodevelopment in infant: A prospective cohort study.

Environ Res 2021 Nov 30:112450. Epub 2021 Nov 30.

Center for Genomic and Personalized Medicine, Guangxi Key Laboratory for Genomic and Personalized Medicine, Guangxi Collaborative Innovation Center for Genomic and Personalized Medicine, Guangxi Medical University, 530021, Nanning, Guangxi, China; Department of Public Health, School of Medicine, Guangxi University of Science and Technology, Liuzhou, 545006, Guangxi, China; Department of Occupational Health and Environmental Health, School of Public Health, Guangxi Medical University, 530021, Nanning, Guangxi, China. Electronic address:

Background: Impaired neurodevelopment of children has become a growing public concern; however, the associations between metals exposure and neurocognitive function have remained largely unknown.

Objectives: We systematically evaluated the associations of multiple metals exposure during pregnancy and childhood on the neurodevelopment of children aged 2-3 years.

Methods: We measured 22 metals in the serum and urine among703 mother-child pairs from the Guangxi Birth Cohort Study. Read More

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November 2021

Is Preoperative Serum Albumin Predictive of Adverse Surgical Outcomes in Maxillofacial Fracture Repair?

J Oral Maxillofac Surg 2021 Nov 4. Epub 2021 Nov 4.

Associate Professor, Oral & Maxillofacial Surgery, Massachusetts General Hospital and Harvard School of Dental Medicine, Boston, MA. Electronic address:

Purpose: Malnutrition has been recognized as a predictor of postoperative adverse outcomes across many surgical subspecialties. The purpose of this study was to evaluate the relationship between serum albumin and adverse outcomes in patients undergoing operative repair of maxillofacial fractures.

Methods: The authors utilized the 2011 to 2018 American College of Surgeons National Surgical Quality Improvement Program (ACS-NSQIP) databases to identify patients with facial fractures undergoing operative repair. Read More

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November 2021

Anti-Chi3L1 antibody suppresses lung tumor growth and metastasis through inhibition of M2 polarization.

Mol Oncol 2021 Dec 3. Epub 2021 Dec 3.

College of Pharmacy and Medical Research Center, Chungbuk National University, 194-31, Osongsaengmyeong 1-ro, Osong-eup, Cheongju-si Chungbuk, 28160, Republic of Korea.

Chitinase 3 like 1 (Chi3L1) is associated with various biological processes, such as inflammation, tissue repair, proliferation, cell survival, invasion and extracellular matrix remodeling. Recent studies indicated that Chi3L1 is critical for cancer development and metastasis. In this study, we demonstrate that Chi3L1 serum and tissue levels were significantly increased in lung cancer patients compared to controls. Read More

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December 2021

Time-course changes in liver functional reserve after successful sofosbuvir/velpatasvir treatment in patients with decompensated cirrhosis.

Hepatol Res 2021 Dec 3. Epub 2021 Dec 3.

Department of Gastroenterology and Hepatology, Yamaguchi University Graduate School of Medicine, Ube, Japan.

Aim: Direct-acting antivirals (DAAs) are currently available even for patients with decompensated cirrhosis. Reportedly, hepatic functional reserve improved in the short term after achievement of sustained virologic response (SVR). We aimed to clarify the outcomes after achievement of SVR in patients with decompensated cirrhosis who were treated by DAAs in real-world clinical practice. Read More

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December 2021

Efficacy of a Third BNT162b2 mRNA COVID-19 Vaccine Dose in Patients with CLL who Failed Standard Two-dose Vaccination.

Blood 2021 Dec 3. Epub 2021 Dec 3.

Sheba Medical Center, Tel Hashomer, Ramat Gan, Israel.

Patients with chronic lymphocytic leukemia (CLL) have an impaired antibody response to COVID-19 vaccination. Here, we evaluated the antibody response to a third BNT162b2 mRNA vaccine in patients with CLL/small lymphocytic lymphoma (SLL) who failed to achieve a humoral response after standard two-dose vaccination regimen. Anti-SARS-CoV-2S and neutralizing antibodies were measured 3 weeks after administration of the third dose. Read More

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December 2021

Analysis of Outcomes in COVID-19 Patients With Varying Degrees of Hyperlipasemia.

Pancreas 2021 Oct;50(9):1310-1313

Division of Gastroenterology & Hepatology, Renaissance School of Medicine at Stony Brook University, Stony Brook.

Objectives: Coronavirus disease 2019 (COVID-19) patients may have varying degrees of hyperlipasemia. The aim was to compare outcomes among different levels of hyperlipasemia in patients with COVID-19.

Methods: This is a retrospective study examining outcomes among hospitalized COVID-19 patients with a lipase <3× upper limit of normal (ULN), asymptomatic hyperlipasemia (>3× ULN), secondary pancreatitis (typical respiratory COVID-19 symptoms and found to have pancreatitis), and primary pancreatitis (presenting with pancreatitis). Read More

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October 2021

Salivary C-Reactive Protein and Mean Platelet Volume in the Diagnosis and Follow-Up of Community-Acquired Pneumonia in Infants.

Pediatr Allergy Immunol Pulmonol 2021 Dec 2. Epub 2021 Dec 2.

Departments of Pediatrics and Neonatology, Faculty of Medicine, Helwan University, Helwan, Egypt.

Community-acquired pneumonia (CAP) in infants is a major cause of morbidity and mortality, especially in developing countries. Increased salivary C-reactive protein (CRP) levels have been demonstrated in neonatal pneumonia and other diseases. We investigated the applicability of CRP and mean platelet volume (MPV) in the diagnosis and follow-up of CAP in infants. Read More

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December 2021

Longevity of anti-spike and anti-nucleocapsid antibodies after COVID-19 in solid organ transplant recipients compared to immunocompetent controls.

Am J Transplant 2021 Dec 3. Epub 2021 Dec 3.

Department of Microbiology and Immunology, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

Solid organ transplant recipients (SOTRs) are on lifelong immunosuppression, which may interfere with adaptive immunity to COVID-19. The data on dynamics and duration of antibody response in SOTRs are limited. This longitudinal study examined the longevity of both anti-spike (S)- and anti-nucleocapsid (N)-specific IgG-antibodies after COVID-19 in SOTRs compared to matched immunocompetent persons. Read More

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December 2021

Global differences in vitamin D status and dietary intake: a review of the data.

Kevin D Cashman

Endocr Connect 2021 Dec 1. Epub 2021 Dec 1.

K Cashman, School of Food and Nutritional Sciences, Univ Coll Cork, Cork, Ireland.

Background: Internationally, concern has been repeatedly raised about the little notable progress in the collection, analysis and use of population micronutrient status and deficiency data globally. The need for representative status and intake data for vitamin D has been highlighted as a research priority for well over a decade.

Aim And Methods: A narrative review which aims to provide a summary and assessment of vitamin D nutritional status data globally. Read More

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December 2021

Anemia and its predictors among adult non-dialysis chronic kidney disease patients at Southern Ethiopia: a cross-sectional study.

Curr Med Res Opin 2021 Dec 3:1-22. Epub 2021 Dec 3.

Department of Hematology & Immunohematology, School of Biomedical and Laboratory Sciences, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.

Background: Anemia is an adverse outcome and common complication in chronic kidney disease patients. This is usually associated with iron deficiency, inflammation, and blood loss. However, little is known about the prevalence of anemia and its predictors among chronic kidney disease patients in Southern Ethiopia. Read More

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December 2021

Utilizing reclassification to explore characteristics and prognosis of KDIGO AKI subgroups: a retrospective analysis of a multicenter prospective cohort study.

Ren Fail 2021 Dec;43(1):1569-1576

Medical Intensive Care Unit, Peking Union Medical College Hospital, Beijing, China.

Background: Acute kidney injury (AKI) is widespread in the intensive care unit (ICU) and affects patient prognosis. According to Kidney Disease: Improving Global Outcomes (KDIGO) guidelines, the absolute and relative increases of serum creatinine (Scr) are classified into the same stage. Whether the prognosis of the two types of patients is similar in the ICU remains unclear. Read More

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December 2021