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Physicians' Opinions on Anticoagulant Therapy in Patients with a Limited Life Expectancy.

Semin Thromb Hemost 2021 May 10. Epub 2021 May 10.

Department of Public Health, Erasmus University Medical Center, Rotterdam, The Netherlands.

Patients with a limited life expectancy have an increased risk of thromboembolic and bleeding complications. Anticoagulants are often continued until death, independent of their original indication. We aimed to identify the opinions of physicians about the use of anticoagulants at the end of life. Read More

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DNA metabarcoding and morphological methods show complementary patterns in the metacommunity organization of lentic epiphytic diatoms.

Sci Total Environ 2021 Apr 30;786:147410. Epub 2021 Apr 30.

Ecology Unit, University of León, Campus de Vegazana S/N, 24071 León, Spain; Institute of Environment, Natural Resources and Biodiversity, La Serna, 58, 24007 León, Spain. Electronic address:

Diatoms are important organisms in freshwater ecosystems due to their position as primary producers and therefore, analyzing their assemblages provides relevant information on ecosystem functioning. Diatoms have historically been identified based on morphological traits, which is time-consuming and requires well-trained specialists. Nevertheless, DNA barcoding offers an alternative approach to overcome some limitations of the morphological method. Read More

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Statin use for the prevention of seizure and epilepsy in the patients at risk: A systematic review and meta-analysis of cohort studies.

Epilepsy Res 2021 May 4;174:106652. Epub 2021 May 4.

Department of Neurosurgery, Qinghai Provincial People's Hospital, Xining, Qinghai, 810007, PR China. Electronic address:

Objective: Statin use for the prevention of seizure and epilepsy had been suggested but remained controversial. We sought to search existing literature to determine whether prophylactic use of statin reduced the incidence of seizure and epilepsy in the patients at risk.

Methods: Three electronic databases were thoroughly searched to identify clinical studies investigating the effects of statin use on patients at the risk of seizure or epilepsy. Read More

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Fluoride and nitrate contamination of groundwater in the Loess Plateau, China: Sources and related human health risks.

Environ Pollut 2021 May 4;286:117287. Epub 2021 May 4.

College of Natural Resources and Environment, Northwest A&F University, Yangling, Shaanxi, 712100, China. Electronic address:

Fluoride (F) and nitrate (NO) in groundwater have caused serious health problems worldwide. However, in the Chinese Loess Plateau where groundwater is the primary source of drinking water, previous studies have rarely reported the health risks from fluoride and nitrate in groundwater. Therefore, we collected 105 groundwater samples (78 from shallow aquifers and 27 from deep aquifers) from the western district of the Loess Plateau for physicochemical and isotopic analysis to investigate the sources of F and NO in groundwater and associated health risks. Read More

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Detection of chlorophyll fluorescence parameters of potato leaves based on continuous wavelet transform and spectral analysis.

Spectrochim Acta A Mol Biomol Spectrosc 2021 Apr 2;259:119768. Epub 2021 Apr 2.

Key Laboratory of Modern Precision Agriculture System Integration Research, Ministry of Education, China Agricultural University, Beijing 100083, China. Electronic address:

The tuber development and nutrient transportation of potato crops are closely related to canopy photosynthesis dynamics. Chlorophyll fluorescence parameters of photosystem II, especially the maximum quantum yield of primary photochemistry (Fv/Fm), are intrinsic indicators for plant photosynthesis. Rapid detection of Fv/Fm of leaves by spectroscopy method instead of time-consuming pulse amplitude modulation technique could help to indicate potato development dynamics and guide field management. Read More

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Comparative functional analyses of UCP1 to unravel evolution, ecophysiology and mechanisms of mammalian thermogenesis.

Comp Biochem Physiol B Biochem Mol Biol 2021 May 7:110613. Epub 2021 May 7.

Department of Molecular Biosciences, The Wenner-Gren Institute, The Arrhenius Laboratories F3, Stockholm University, SE-106 91 Stockholm, Sweden.

Brown adipose tissue (BAT), present in many placental mammals, provides adaptive nonshivering thermogenesis (NST) for body temperature regulation and has facilitated survival in diverse thermal niches on our planet. Intriguingly, several key details on the molecular mechanisms of NST and their potential ecophysiological adaptations are still unknown. Comparative studies at the whole animal level are unpragmatic, due to the diversity and complexity of thermoregulation among different species. Read More

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Longer Operative Time Associated with Prolonged Length of Stay, Non-Home Discharge and Transfusion Requirement after Anterior Cervical Discectomy and Fusion: an Analysis of 24,593 Cases.

Spine J 2021 May 7. Epub 2021 May 7.

Department of Orthopaedic Surgery, Cleveland Clinic Foundation, 9500 Euclid Ave, Cleveland, OH, USA; Center for Spine Health, Cleveland Clinic Foundation, 9500 Euclid Ave, Cleveland, OH, USA.

Background: Prolonged operative time of single-level ACDF has been associated with adverse postoperative outcomes. The current literature does not contain a comprehensive quantitative description of these associations PURPOSE: This study characterized the associations between single-level anterior cervical discectomy and fusion(ACDF) operative time and 1)30-day postoperative healthcare utilization, and 2)the incidence of local wound complications, need for transfusion and mechanical ventilation.

Design/setting: Retrospective database analysis PATIENT SAMPLE: The American College of Surgeons National Surgical Quality Improvement Program(ACS-NSQIP) database was queried for single-level ACDF cases(2012-2018) using current procedural terminology codes. Read More

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Association between ß-Blockers and Outcomes in HFpEF - Current Insights from the SwedeHF Registry.

J Card Fail 2021 May 7. Epub 2021 May 7.

Division of Cardiology, Department of Medicine, Karolinska Institutet, Stockholm, Swede; Heart and Vascular Theme, Karolinska University Hospital, Stockholm, Sweden.

Background: ß-blockers have an uncertain effect in heart failure with a preserved ejection fraction of 50% or higher (HFpEF).

Methods: We included patients with HFpEF from the Swedish Heart Failure Registry (SwedeHF) enrolled from 2011 through 2018. In a 2:1 propensity-score matched analysis (β-blocker use versus no-use), we assessed the primary outcome first HF hospitalization, the co-primary outcome cardiovascular (CV) death, and the secondary outcomes all-cause hospitalization and all-cause death. Read More

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Histogram parameters derived from T1 and T2 weighted images correlate with tumor infiltrating lymphocytes and tumor-stroma ratio in head and neck squamous cell cancer.

Magn Reson Imaging 2021 May 7. Epub 2021 May 7.

Department of Diagnostic and Interventional Radiology, University of Magdeburg, Germany.

Purpose: The present study used histogram analysis values derived from T1- and T2- weighted (w) images to elucidate possible associations with Tumor-infiltrating lymphocytes (TIL) and Vimentin expression in head and neck squamous cell cancer (HNSCC).

Materials And Methods: Overall, 28 patients (n = 8 female patient, 28.6%) with primary HNSCC of different localizations were involved in the study. Read More

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Efficacy and safety of voclosporin versus placebo for lupus nephritis (AURORA 1): a double-blind, randomised, multicentre, placebo-controlled, phase 3 trial.

Lancet 2021 May 7. Epub 2021 May 7.

Research, Aurinia Pharmaceuticals, Victoria, BC, Canada. Electronic address:

Background: Voclosporin, a novel calcineurin inhibitor approved for the treatment of adults with lupus nephritis, improved complete renal response rates in patients with lupus nephritis in a phase 2 trial. This study aimed to evaluate the efficacy and safety of voclosporin for the treatment of lupus nephritis.

Methods: This multicentre, double-blind, randomised phase 3 trial was done in 142 hospitals and clinics across 27 countries. Read More

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Benzodiazepine Use in Opioid Maintenance Treatment Programme: Risks and Clinical Outcomes.

Acta Med Port 2021 Mar 1;34(3):209-216. Epub 2021 Mar 1.

Drug Addiction Treatment Centre. Agualva-Cacém. Cacém. Portugal.

Introduction: The co-association of benzodiazepines and opioids is associated with an increased risk of overdose, death, and poorer psychosocial prognosis. The aim of this study is to characterize the prevalence, pattern of use, and primary clinical outcomes in benzodiazepines users in a public opioid maintenance treatment unit.

Material And Methods: We conducted a cross-sectional study involving 236 patients treated with opioid substitutes (methadone and buprenorphine). Read More

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[Early Detection of COVID-19 in Portugal: Use of Clinical Records].

Acta Med Port 2021 Mar 1;34(3):176-184. Epub 2021 Mar 1.

Departamento de Epidemiologia. Instituto Nacional de Saúde Doutor Ricardo Jorge. Lisboa. Portugal.

Introduction: Syndromic surveillance allows early detection of changes in the population's morbidity pattern. The aim of this study is to evaluate the usefulness of indicators related to access to healthcare services, in COVID-19 surveillance.

Material And Methods: A time series analysis was performed using the weekly incidence rate of COVID-19 in Mainland Portugal, between weeks 14/2020 (March 30 to April 5) and 25/2020 (June 15 to 21), and six indicators: 1) COVID-19 consultations in primary healthcare; 2) number of COVID-19 emergency department visits; 3) number of emergency department visits due to viral pneumonia; 4) number of hospitalizations due to viral pneumonia; 5) proportion of emergency department visits due to viral pneumonia; and 6) proportion of hospitalizations for viral pneumonia. Read More

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Development a LC-MS/MS method to simultaneous quantitative analysis macromolecular pharmaceutical adjuvant 2-hydroxypropyl-β-cyclodextrin and active pharmaceutical ingredients butylphthalide in rat plasma.

J Sep Sci 2021 May 10. Epub 2021 May 10.

School of Pharmacy, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang, 110016, P. R. China.

Hydroxypropyl-β-cyclodextrin, possessing higher water solubility and lower hemolytic, was widely used as solubilizer and excipient. It had also been reported that hydroxypropyl-β-cyclodextrin has the activity of regulating lipid homeostatic. In order to further understand the metabolism, the primary focus was to establish a quantitative method for hydroxypropyl-β-cyclodextrin. Read More

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Symptom scores in the diagnosis of paediatric cow's milk protein allergy: a systematic review.

Pediatr Allergy Immunol 2021 May 10. Epub 2021 May 10.

Exeter Test Group, University of Exeter, Medical School, University of Exeter, Exeter, UK.

Background: Cow's milk protein allergy (CMPA) is an immune-mediated allergic response to proteins in milk that is common in infants. Broad CMPA symptoms make diagnosis a challenge, particularly in primary care. Symptom scores may improve a clinician's awareness of symptoms, indicating a need for further testing. Read More

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Peak atrial longitudinal strain is predictive of atrial fibrillation in patients with chronic obstructive pulmonary disease and coronary artery disease.

Echocardiography 2021 May 10. Epub 2021 May 10.

UO Cardiologia, Azienda Ospedaliero Universitaria di Ferrara, Ferrara, Italy.

Background: The peak atrial longitudinal strain (PALS) has been validated in the prediction of atrial fibrillation (AF) in the general population. If this finding can be applied to patients with chronic obstructive pulmonary disease (COPD) and concomitant coronary artery disease (CAD) is unknown.

Methods And Results: We analyzed two different study populations of patients with COPD and acute CAD in SCAP trial (Clinical trial. Read More

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Recent developments of HDAC inhibitors: Emerging indications and novel molecules.

Br J Clin Pharmacol 2021 May 10. Epub 2021 May 10.

Department of Neuroscience, Functional Pharmacology, Uppsala University, Uppsala, Sweden.

The histone deacetylase (HDAC) enzymes, a class of epigenetic regulators, are historically well-established as attractive therapeutic targets. During investigation of trends within clinical trials, we have identified a high number of clinical trials involving HDAC inhibitors, prompting us to further evaluate the current status of this class of therapeutic agents. In total, we have identified 32 agents with HDAC-inhibiting properties, of which 29 were found to interact with the HDAC enzymes as their primary therapeutic target. Read More

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Self-reported medication adherence among patients with diabetes or hypertension, Médecins Sans Frontières Shatila refugee camp, Beirut, Lebanon: A mixed-methods study.

PLoS One 2021 10;16(5):e0251316. Epub 2021 May 10.

Department of Global Health, University of Washington, Seattle, Washington, United States of America.

Introduction: Low adherence to medications, specifically in patients with Diabetes (DM) and Hypertension (HTN), and more so in refugee settings, remains a major challenge to achieving optimum clinical control in these patients. We aimed at determining the self-reported medication adherence prevalence and its predictors and exploring reasons for low adherence among these patients.

Methods: A mixed-methods study was conducted at Médecins Sans Frontières non-communicable diseases primary care center in the Shatila refugee camp in Beirut, Lebanon in October 2018. Read More

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Association between early intensive care or coronary care unit admission and post-discharge performance of activities of daily living in patients with acute decompensated heart failure.

PLoS One 2021 10;16(5):e0251505. Epub 2021 May 10.

Department of Healthcare Management Research Center, Chiba University Hospital, Chiba, Japan.

The management of acute decompensated heart failure often requires intensive care. However, the effects of early intensive care unit/coronary care unit admission on activities of daily living (ADL) in acute decompensated heart failure patients have not been precisely evaluated. Thus, we retrospectively assessed the association between early intensive care unit admission and post-discharge ADL performance in these patients. Read More

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Long-term outcome of 177Lu-PSMA-617 radioligand therapy in heavily pre-treated metastatic castration-resistant prostate cancer patients.

PLoS One 2021 10;16(5):e0251375. Epub 2021 May 10.

Department of Nuclear Medicine, Thyroid Clinic, AIIMS, Ansari Nagar, New Delhi, India.

Objective: Investigators have extensively explored the short-term safety and efficacy data on 177Lu-PSMA-617 radioligand therapy (RLT) in mCRPC patients. However, scarce literature is reported on the long-term outcome of these patients. The current goal of this study is focused on the long-term outcome of mCRPC patients treated with 177Lu-PSMA-617 RLT. Read More

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Insights on biology student motivations and challenges when reading and analyzing primary literature.

PLoS One 2021 10;16(5):e0251275. Epub 2021 May 10.

Department of Biology, University of North Georgia, Dahlonega, Georgia, United States of America.

Reading primary literature is a popular classroom practice that exposes students to the process of science. However, the analysis of primary literature can be taxing and time-consuming for students. For this reason, it is important to determine the source of student challenges and what motivates them to read primary literature. Read More

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Predictors for inpatient mortality during the first wave of the SARS-CoV-2 pandemic: A retrospective analysis.

PLoS One 2021 10;16(5):e0251262. Epub 2021 May 10.

White Plains Hospital, White Plains, New York, United States of America.

Background: The coronavirus disease 2019 (COVID-19) pandemic overwhelmed healthcare systems, highlighting the need to better understand predictors of mortality and the impact of medical interventions.

Methods: This retrospective cohort study examined data from every patient who tested positive for COVID-19 and was admitted to White Plains Hospital between March 9, 2020, and June 3, 2020. We used binomial logistic regression to analyze data for all patients, and propensity score matching for those treated with hydroxychloroquine and convalescent plasma (CP). Read More

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Patient compliance with NHS 111 advice: Analysis of adult call and ED attendance data 2013-2017.

PLoS One 2021 10;16(5):e0251362. Epub 2021 May 10.

School of Health and Related Research (ScHARR), University of Sheffield, Sheffield, United Kingdom.

The NHS 111 telephone advice and triage service is a vital part of the management of urgent and emergency care (UEC) services in England. Demand for NHS 111 advice has increased since its introduction in 2013, and the service is of particular importance in light of the current pandemic and resulting increased demand for emergency care. Currently, little is known about the effectiveness of NHS 111 in terms of the appropriateness of the advice given, or about the compliance of patients with that advice. Read More

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Parenting interventions to promote early child development in the first three years of life: A global systematic review and meta-analysis.

PLoS Med 2021 May 10;18(5):e1003602. Epub 2021 May 10.

Department of Global Health and Population, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, United States of America.

Background: Parents are the primary caregivers of young children. Responsive parent-child relationships and parental support for learning during the earliest years of life are crucial for promoting early child development (ECD). We conducted a global systematic review and meta-analysis to evaluate the effectiveness of parenting interventions on ECD and parenting outcomes. Read More

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A clinical study protocol for COVID-19 rehabilitation with herbal medicine and cardiorespiratory exercise.

JMIR Res Protoc 2021 Apr 12. Epub 2021 Apr 12.

Centre for Health and Exercise Science Research, Hong Kong Baptist University, Hong Kong Baptist UniversityKowloon Tong, Kowloon, HK.

Background: Recent studies revealed that most discharged patients with COVID-19 suffered ongoing symptoms months later. Rehabilitation interventions can help address the consequences of COVID-19. These include medically, physically, cognitively and psychologically related problems. Read More

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Attitudes and beliefs of parents about routine childhood vaccination in Greece.

Hum Vaccin Immunother 2021 May 10:1-7. Epub 2021 May 10.

Department of Paediatrics, Medical School, University of Patras, Patras, Greece.

Vaccine hesitancy remains one of the 10 major global threats as per the WHO report in 2019. The aim of the present study is to assess attitudes and perceptions of vaccine hesitant parents in Greece with a view to implementing strategies to increase vaccine uptake. A cross-sectional questionnaire-based prospective survey was conducted between September 2019 and June 2020 on parents of children attending primary education in the city of Patras in Western Greece. Read More

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Clinical and pathological analysis of renal biopsies of elderly patients in Northeast China: a single-center study.

Ren Fail 2021 Dec;43(1):851-859

The Department of Nephropathy, The Second Hospital of Jilin University, Changchun, China.

Purpose: To identify the clinical characteristics, histopathological features, and prognosis of kidney disease in a large cohort of elderly patients from Northeast China.

Methods: We retrospectively analyzed the renal disease spectrum in 7,122 patients who underwent renal biopsies at the Second Hospital of Jilin University from 2006 to 2020. Patients were grouped according to age: below 60 years (non-elderly group,  = 5923) and at least 60 years (elderly group,  = 1199). Read More

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December 2021

Biomarkers as a Prognostic Factor in COPD Exacerbation: A Cohort Study.

COPD 2021 May 10:1-14. Epub 2021 May 10.

Internal Medicine Department, Medical School, University of Antioquia, Medellín, Colombia.

The acute exacerbations of COPD (AECOPD) are one of the main causes of hospitalization and morbimortality in the adult population. There are not many tools available to predict the clinical course of these patients during exacerbations. Our goal was to estimate the clinical utility of C Reactive Protein (CRP), Mean Platelet Volume (MPV), eosinophil count and neutrophil/lymphocyte ratio (NLR) as in-hospital prognostic factors in patients with AECOPD. Read More

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Head and Neck Cancer in a Rural U.S. Population: Quality of Life, Coping, Health Care Literacy, and Access to Services.

Am J Speech Lang Pathol 2021 May 10:1-18. Epub 2021 May 10.

Department of Communication Sciences and Disorders, Loma Linda University, CA.

Purpose The aim of this study was to explore the beliefs, access, and motivations of individuals with head and neck cancer (HNC) living in a rural community in the United States, regarding their speech and swallowing deficits. Method A convenience sample of nine patient participants with HNC and nine caregiver participants completed in-depth, semistructured interviews regarding their experiences with HNC diagnosis and treatment. The researchers utilized a thematic networks approach to analyze the qualitative data obtained. Read More

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