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Evaluation of a patient-specific algorithm for predicting distribution for convection-enhanced drug delivery into the brainstem of patients with diffuse intrinsic pontine glioma.

J Neurosurg Pediatr 2021 May 14:1-9. Epub 2021 May 14.

2Department of Neurological Surgery, Weill Medical College of Cornell University, New York, New York.

Objective: With increasing use of convection-enhanced delivery (CED) of drugs, the need for software that can predict infusion distribution has grown. In the context of a phase I clinical trial for pediatric diffuse intrinsic pontine glioma (DIPG), CED was used to administer an anti-B7H3 radiolabeled monoclonal antibody, iodine-124-labeled omburtamab. In this study, the authors retrospectively evaluated a software algorithm (iPlan Flow) for the estimation of infusate distribution based on the planned catheter trajectory, infusion parameters, and patient-specific MRI. Read More

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Metabolomic assessment of mechanisms underlying anti-renal fibrosis properties of petroleum ether extract from .

Pharm Biol 2021 Dec;59(1):565-574

Department of Pharmacy, Baotou Medical College, Inner Mongolia University of Science and Technology, Baotou, China.

Context: The petroleum ether extract (PET) of (Maxim.) Ricker (Rosaceae) has an ameliorative effect on renal fibrosis (RF).

Objective: To evaluate the antifibrotic effects of seeds PET on RF by serum metabolomics, biochemical and histopathological analyses. Read More

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December 2021

Computed tomography (CT)-defined sarcopenia and myosteatosis are prevalent in patients with neuroendocrine neoplasms (NENs) treated with peptide receptor radionuclide therapy (PRRT).

Eur J Clin Nutr 2021 May 13. Epub 2021 May 13.

Cancer Services, Royal Prince Alfred Hospital, Camperdown, NSW, Australia.

Background/objectives: Neuroendocrine neoplasms (NEN) may predispose patients to malnutrition. CT-defined sarcopenia and myosteatosis are common in other tumour types and recognized adverse prognostic factors. However, the prevalence and prognostic impact of sarcopenia and myosteatosis remain undetermined in NEN patients to date. Read More

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MRI-Visible Perivascular Spaces in the Centrum Semiovale Are Associated with Brain Amyloid Deposition in Patients with Alzheimer Disease-Related Cognitive Impairment.

AJNR Am J Neuroradiol 2021 May 13. Epub 2021 May 13.

From the Department of Nuclear Medicine (H.J.K., Y.H.R.), Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea.

Background And Purpose: The association of perivascular spaces in the centrum semiovale with amyloid accumulation among patients with Alzheimer disease-related cognitive impairment is unknown. We evaluated this association in patients with Alzheimer disease-related cognitive impairment and β-amyloid deposition, assessed with [F] florbetaben PET/CT.

Materials And Methods: MR imaging and [F] florbetaben PET/CT images of 144 patients with Alzheimer disease-related cognitive impairment were retrospectively evaluated. Read More

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Progression to Symptomatic Multiple Myeloma Predicted by Texture Analysis-Derived Parameters in Patients Without Focal Disease at F-FDG PET/CT.

Clin Lymphoma Myeloma Leuk 2021 Apr 6. Epub 2021 Apr 6.

Dipartimento di Scienze Radiologiche ed Ematologiche, Istituto di Medicina Nucleare, Università Cattolica del Sacro Cuore, Rome, Italy; Dipartimento di Diagnostica per Immagini, Radioterapia Oncologica ed Ematologia, UOC di Medicina Nucleare, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.

This retrospective study is focused on the possible clinical implications of texture analysis-derived PET parameters in patients with smoldering multiple myeloma. Several texture features are significantly associated with progression to symptomatic multiple myeloma and with a shorter time to progression. The results of this study may lead to early identification of patients who could benefit from specific therapies. Read More

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Effect of illumination level [18F]FDG-PET brain uptake in free moving mice.

PLoS One 2021 13;16(5):e0251454. Epub 2021 May 13.

Instituto de Investigación Sanitaria Gregorio Marañón, Madrid, Spain.

In both clinical and preclinical scenarios, 2-deoxy-2[18F]fluoro-D-glucose ([18F]FDG) is the radiotracer most widely used to study brain glucose metabolism with positron emission tomography (PET). In clinical practice, there is a worldwide standardized protocol for preparing patients for [18F]FDG-PET studies, which specifies the room lighting. However, this standard is typically not observed in the preclinical field, although it is well known that animal handling affects the biodistribution of [18F]FDG. Read More

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Aortic wall segmentation in F-sodium fluoride PET/CT scans: Head-to-head comparison of artificial intelligence-based versus manual segmentation.

J Nucl Cardiol 2021 May 12. Epub 2021 May 12.

Department of Nuclear Medicine, Odense University Hospital, 5000, Odense, Denmark.

Background: We aimed to establish and test an automated AI-based method for rapid segmentation of the aortic wall in positron emission tomography/computed tomography (PET/CT) scans.

Methods: For segmentation of the wall in three sections: the arch, thoracic, and abdominal aorta, we developed a tool based on a convolutional neural network (CNN), available on the Research Consortium for Medical Image Analysis (RECOMIA) platform, capable of segmenting 100 different labels in CT images. It was tested on F-sodium fluoride PET/CT scans of 49 subjects (29 healthy controls and 20 angina pectoris patients) and compared to data obtained by manual segmentation. Read More

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Comparison between cardiac magnetic resonance stress T1 mapping and [15O]H2O positron emission tomography in patients with suspected obstructive coronary artery disease.

Eur Heart J Cardiovasc Imaging 2021 May 13. Epub 2021 May 13.

Department of Cardiology, Amsterdam University Medical Centers, Vrije Universiteit, De Boelelaan 1117, 1081 HV, Amsterdam, the Netherlands.

Aims: To compare cardiac magnetic resonance (CMR) measurement of T1 reactivity (ΔT1) with [15O]H2O positron emission tomography (PET) measurements of quantitative myocardial perfusion.

Methods And Results: Forty-three patients with suspected obstructed coronary artery disease underwent [15O]H2O PET and CMR at 1.5-T, including rest and adenosine stress T1 mapping (ShMOLLI) and late gadolinium enhancement to rule out presence of scar tissue. Read More

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Performance of 18F-DCFPyL PET/CT Imaging in Early Detection of Biochemically Recurrent Prostate Cancer: A Systematic Review and Meta-Analysis.

Front Oncol 2021 26;11:649171. Epub 2021 Apr 26.

Department of Urology, The First Affiliated Hospital of Soochow University, Suzhou, China.

Prostate-specific membrane antigen (PSMA)-targeted 2-(3-{1-carboxy-5-[(6-[18F] fluoro-pyridine-3-carbonyl)-amino]-pentyl}-ureido)-pentanedioic acid (18F-DCFPyL) positron emission tomography/computed tomography (PET/CT) has shown advantages in primary staging, restaging, and metastasis detection of prostate cancer (PCa). However, little is known about the role of 18F-DCFPyL PET/CT in biochemically recurrent prostate cancer (BRPCa). Hence, we performed a systematic review and meta-analysis to evaluate 18F-DCFPyL PET/CT as first-line imaging modality in early detection of BRPCa. Read More

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Infobuttons for Genomic Medicine: Requirements and Barriers.

Appl Clin Inform 2021 Mar 12;12(2):383-390. Epub 2021 May 12.

Genomic Medicine Institute, Geisinger, Danville, Pennsylvania, United Sates.

Objectives:  The study aimed to understand potential barriers to the adoption of health information technology projects that are released as free and open source software (FOSS).

Methods:  We conducted a survey of research consortia participants engaged in genomic medicine implementation to assess perceived institutional barriers to the adoption of three systems: ClinGen electronic health record (EHR) Toolkit, DocUBuild, and MyResults.org. Read More

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Diagnostic Values of 8 Different Imaging Modalities for Preoperative Detection of Axillary Lymph Node Metastasis of Breast Cancer: A Bayesian Network Meta-analysis.

Am J Clin Oncol 2021 May 12. Epub 2021 May 12.

Department of Nuclear Medicine and Biomedical Research Institute, Pusan National University Hospital, Busan Department of Preventive Medicine, School of Medicine, Korea University, Seoul Department of Nuclear Medicine, College of Medicine, Pusan National University Department of Nuclear Medicine BioMedical Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan, Korea.

Objective: This study aimed to compare diagnostic performances of 8 different imaging modalities for preoperative detection of axillary lymph node (LN) metastasis in patients with breast cancer by performing a network meta-analysis (NMA) using direct comparison studies with 2 or more imaging techniques.

Materials And Methods: PubMed, Cochrane, and Embase were searched for the studies evaluating the performances of 8 different imaging modalities for preoperative axillary LN staging in patients with breast cancer. The NMA was performed in patient-based analyses. Read More

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Noninvasive evaluation of tumor immune microenvironment in patients with clear cell renal cell carcinoma using metabolic parameter from preoperative 2-[F]FDG PET/CT.

Eur J Nucl Med Mol Imaging 2021 May 12. Epub 2021 May 12.

Department of Nuclear Medicine, Peking University First Hospital, Beijing, 100034, China.

Purpose: Nowadays, it is necessary to explore effective biomarkers associated with tumor immune microenvironment (TIME) noninvasively. Here, we investigated whether the metabolic parameter from preoperative 2-[F]FDG PET/CT could provide information related to TIME in patients with clear cell renal cell carcinoma (ccRCC).

Methods: Ninety patients with newly diagnosed ccRCC who underwent 2-[F]FDG PET/CT prior to surgery were retrospectively reviewed. Read More

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Utility of Volumetric Metabolic Parameters on Preoperative FDG PET/CT for Predicting Tumor Lymphovascular Invasion in Non-Small Cell Lung Cancer.

AJR Am J Roentgenol 2021 May 12. Epub 2021 May 12.

Department of Nuclear Medicine, Zhongnan Hospital of Wuhan University, Wuhan University, Wuhan 430071, Hubei Province, China.

Lymphovascular invasion (LVI) is an adverse prognostic indicator in non-small cell lung cancer (NSCLC) and serves as an indication for postoperative adjuvant chemotherapy recommendation after resection. To assess the utility of clinicopathologic factors and volumetric metabolic parameters from preoperative FDG PET/CT in predicting primary tumor LVI in NSCLC. This retrospective study included 161 patients (mean age, 61. Read More

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FDG-PET for preoperative evaluation of tumor invasion in ampullary cancer: A retrospective analysis.

J Surg Oncol 2021 May 12. Epub 2021 May 12.

Department of Hepatobiliary and Pancreatic Surgery, Gunma University Graduate School of Medicine, Gunma, Japan.

Background: Tumor invasion is the most significant prognostic factor in ampullary cancer and is thus a crucial factor in decision making for treatment. Endoscopic ultrasound can be performed to evaluate tumor invasion, but its diagnostic accuracy varies depending on the endoscopist. This study aimed to assess the usefulness of fluorodeoxyglucose positron emission tomography (FDG-PET) for preoperatively predicting tumor invasion in ampullary cancer. Read More

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Indoor pet allergen exposures modify the effects of chemical air pollutants on respiratory symptoms.

Int J Tuberc Lung Dis 2021 May;25(5):350-357

Épidémiologie des maladies Allergiques et Respiratoires, Institut Pierre Louis d´Épidémiologie et de Santé Publique, Sorbonne University and Institut national de la santé et de la recherche médicale, Saint Antoine Medical School, Paris, France.

Indoor volatile organic compound (VOC) levels, which are generally correlated with each other, may have an additive or synergistic effect on health. VOC synergy with allergens is a suspected mechanism affecting respiration. To determine the effect of exposure to interactions between VOCs and allergens on respiratory symptoms in individuals aged ≥15 years. Read More

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Serosurvey and associated risk factors of anti-Toxocara spp. antibodies in bovines from slaughterhouses of southeastern Brazil.

Parasit Vectors 2021 May 11;14(1):250. Epub 2021 May 11.

Graduate College in Animal Sciences, University of Western São Paulo (UNOESTE), Rodovia Raposo Tavares km 572-Bairro Limoeiro, Presidente Prudente, São Paulo, 19050-920, Brazil.

Background: Toxocariasis, caused by a nematode species of the genus Toxocara, has been described as one of the most prevalent zoonotic helminthiases worldwide. Human transmission may occur by ingesting Toxocara spp. larvae from raw or undercooked meat or organs; however, no comprehensive serosurvey study has been conducted to date investigating the role of cattle as paratenic hosts. Read More

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An immunoinformatics approach for the design of a multi-epitope vaccine targeting super antigen TSST-1 of Staphylococcus aureus.

J Genet Eng Biotechnol 2021 May 11;19(1):69. Epub 2021 May 11.

Department of Biotechnology, Vignan's Foundation for Science, Technology and Research (Deemed to be University), Vadlamudi, Guntur - District, Andhra Pradesh, 522 213, India.

Background: TSST-1 is a secretory and pyrogenic superantigen that is being responsible for staphylococcal mediated food poisoning and associated clinical manifestations. It is one of the main targets for the construction of vaccine candidates against Staphylococcus aureus. Most of the vaccines have met failure due to adverse reactions and toxicity reported during late clinical studies. Read More

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Automated ictal EEG source imaging: A retrospective, blinded clinical validation study.

Clin Neurophysiol 2021 Apr 27. Epub 2021 Apr 27.

Department of Clinical Neurophysiology, Danish Epilepsy Centre, Visby Allé 5, 4293 Dianalund, Denmark; Department of Clinical Neurophysiology, Aarhus University Hospital, Palle Juul-Jensens Blvd., 8200 Aarhus, Denmark. Electronic address:

Objective: EEG source imaging (ESI) is a validated tool in the multimodal workup of patients with drug resistant focal epilepsy. However, it requires special expertise and it is underutilized. To circumvent this, automated analysis pipelines have been developed and validated for the interictal discharges. Read More

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Validation of amyloid PET positivity thresholds in centiloids: a multisite PET study approach.

Alzheimers Res Ther 2021 May 10;13(1):99. Epub 2021 May 10.

Helen Wills Neuroscience Institute, University of California Berkeley, Berkeley, CA, USA.

Background: Inconsistent positivity thresholds, image analysis pipelines, and quantitative outcomes are key challenges of multisite studies using more than one β-amyloid (Aβ) radiotracer in positron emission tomography (PET). Variability related to these factors contributes to disagreement and lack of replicability in research and clinical trials. To address these problems and promote Aβ PET harmonization, we used [F]florbetaben (FBB) and [F]florbetapir (FBP) data from the Alzheimer's Disease Neuroimaging Initiative (ADNI) to derive (1) standardized Centiloid (CL) transformations and (2) internally consistent positivity thresholds based on separate young control samples. Read More

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Automatic magnetic projection for one-step separation of mixed plastics using ring magnets.

Sci Total Environ 2021 Apr 21;786:147217. Epub 2021 Apr 21.

State Key Lab of Fluid Power Transmission and Control, School of Mechanical Engineering, Zhejiang University, Hangzhou, China; Key Laboratory of 3D Printing Process and Equipment of Zhejiang Province, School of Mechanical Engineering, Zhejiang University, Hangzhou, China; Jiangsu Jianghuai Magnetic Industry Co., Ltd., Xuyi 211700, China. Electronic address:

Magnetic projection, a novel separation method proposed recently, can separate multiple mixed materials in an efficient and low-cost way. Although promising, existing magnetic projection method cannot achieve the automatic feeding of mixed materials, which limits its applications. To address this challenge, ring magnets were used to replace conventional square magnets in this research. Read More

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Towards point-of-care diagnosis of Alzheimer's disease: Multi-analyte based portable chemiresistive platform for simultaneous detection of β-amyloid (1-40) and (1-42) in plasma.

Biosens Bioelectron 2021 May 4;186:113294. Epub 2021 May 4.

Department of Electrical Engineering, Indian Institute of Technology Hyderabad, 502285, India. Electronic address:

Label-free simultaneous detection of Alzheimer's disease (AD) specific biomarkers Aβ40 and Aβ42 peptides on a single platform using polypyrrole nanoparticle-based chemiresistive biosensors is reported here. The proposed interdigitated-microelectrode based inexpensive multisensor-platform can concurrently detect Aβ40 and Aβ42 in spiked-plasma in the range of 10 - 10 g/mL (with LoDs being 5.71 and 9. Read More

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Identification of a novel pegivirus in pet cats (Felis silvestris catus) in Japan.

Virus Res 2021 May 7:198452. Epub 2021 May 7.

Division of Virology, Department of Infection and Immunity, Jichi Medical University School of Medicine, Shimotsuke, Tochigi 329-0498, Japan. Electronic address:

We report a novel pegivirus in pet cats (Felis silvestris catus) in Japan. This virus was only 39.7-51. Read More

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Change in CAIDE Dementia Risk Score and neuroimaging biomarkers during a 2-year multidomain lifestyle randomized controlled trial: results of a post-hoc subgroup analysis.

J Gerontol A Biol Sci Med Sci 2021 May 10. Epub 2021 May 10.

Institute of Clinical Medicine/Neurology, University of Eastern Finland, Kuopio, Finland.

The CAIDE (Cardiovascular Risk Factors, Aging and Dementia) Risk Score is a validated tool estimating dementia risk. It was previously associated with imaging biomarkers. However, associations between dementia risk scores (including CAIDE) and dementia-related biomarkers have not been studied in the context of an intervention. Read More

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Cardiac perfusion by positron emission tomography.

Clin Physiol Funct Imaging 2021 May 9. Epub 2021 May 9.

Heart Center, Turku University Hospital, Turku, Finland.

Myocardial perfusion imaging (MPI) with positron emission tomography (PET) is an established tool for evaluation of obstructive coronary artery disease (CAD). The contemporary 3-dimensional scanner technology and the state-of-the-art MPI radionuclide tracers and pharmacological stress agents, as well as the cutting-edge image reconstruction techniques and data analysis software have all enabled accurate, reliable, and reproducible quantification of absolute myocardial blood flow (MBF), and henceforth calculation of myocardial flow reserve (MFR) in several clinical scenarios. In patients with suspected coronary artery disease, both absolute stress MBF and MFR can identify myocardial territories subtended by epicardial coronary arteries with hemodynamically significant stenosis, as defined by invasive coronary fractional flow reserve measurement. Read More

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The End of the Partnership With a Guide Dog: Emotional Responses, Effects on Quality of Life and Relationships With Subsequent Dogs.

Front Vet Sci 2021 22;8:543463. Epub 2021 Apr 22.

Institute of Veterinary, Animal and Biomedical Sciences, Massey University, Palmerston North, New Zealand.

Guide dogs are mobility aids that facilitate independent travel of people who are blind or visually impaired. Additional benefits imparted to the guide dog handler include companionship, and increased: social-function, self-esteem and confidence. Some evidence shows that the end of the guide dog partnership can result in reduced mobility, and may have profound psychosocial effects on the handler due to feelings of bereavement and loss of self-esteem. Read More

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Application of Artificial Neural Network to Preoperative F-FDG PET/CT for Predicting Pathological Nodal Involvement in Non-small-cell Lung Cancer Patients.

Front Med (Lausanne) 2021 22;8:664529. Epub 2021 Apr 22.

Unità Operativa Complessa (UOC) di Medicina Nucleare, Dipartimento di Diagnostica per Immagini, Radioterapia Oncologica ed Ematologia, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.

To evaluate the performance of artificial neural networks (aNN) applied to preoperative F-FDG PET/CT for predicting nodal involvement in non-small-cell lung cancer (NSCLC) patients. We retrospectively analyzed data from 540 clinically resectable NSCLC patients (333 M; 67.4 ± 9 years) undergone preoperative F-FDG PET/CT and pulmonary resection with hilo-mediastinal lymphadenectomy. Read More

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The Heterogeneous Metabolic Patterns of Ganglia in Ga-PSMA, C-choline, and F-FDG PET/CT in Prostate Cancer Patients.

Front Oncol 2021 23;11:666308. Epub 2021 Apr 23.

Department of Nuclear Medicine, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.

Purpose: Studies have indicated that PSMA-positive ganglia represent a diagnostic pitfall for nuclear medicine physicians. No studies have described choline and FDG uptake in ganglia, which may be a source of misdiagnosis. Herein, we described the percentage and uptake pattern of Ga-PSMA, C-choline and F-FDG PET/CT in ganglia and evaluated the heterogeneous metabolic patterns of ganglia to differentiate from lymph node metastases (LNM). Read More

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The Clinical Accuracy and Risk Stratification in End of Therapy F-FDG PET/CT in Burkitt Lymphoma.

Front Oncol 2021 21;11:625436. Epub 2021 Apr 21.

Sun Yat-sen University Cancer Center (SYSUCC), Guangzhou, China.

Purpose: Burkitt lymphoma (BL) is an invasive lymphoma subtype with FDG avid at F-FDG PET/CT, but there is currently no validated criterion in treatment evaluation and prognosis prediction. The aim of this study was to analyze the clinical accuracy of F-FDG PET/CT in Burkitt lymphoma in end of therapy PET/CT (EOT-PET) to assess the treatment response in BL and conduct a survival analysis with different Deauville 5-point score (DS) cutoff values.

Materials And Methods: A total of 189 patients were retrospectively included: 97 underwent baseline PET/CT and all underwent EOT-PET. Read More

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High-Efficiency Cationic Labeling Algorithm of Macroaggregated Albumin with Gallium.

Nucl Med Mol Imaging 2021 Apr 10;55(2):79-85. Epub 2021 Feb 10.

Education and Research Hospital, Department of Nuclear Medicine, Pamukkale University, Denizli, Turkey.

Purpose: The generator product radionuclide gallium-68(Ga) is widely used for PET/CT imaging agents and the Ga-labeled MAA is an attractive alternative to Tc-labeled MAA. Using a commercially available MAA labeling kit for Tc, we presented a reliable synthesis protocol with a highly efficient, organic solvent-free cationic method in GMP conditions in the Scintomics automated synthesis unit.

Methods: The labeling process was performed by incubating for 7 min at 90 C in the borax vial containing the generator product GaCl MAA-HEPES eluted from the PSH cartridge with 1. Read More

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Differentiating between Primary Central Nervous System Lymphoma and Glioblastoma: The Diagnostic Value of Combining F-Fluorodeoxyglucose Positron Emission Tomography with Arterial Spin Labeling.

Neurol Med Chir (Tokyo) 2021 May 8. Epub 2021 May 8.

Department of Neurosurgery, Akita University Graduate School of Medicine.

Using conventional magnetic resonance imaging (MRI) methods, the differentiation of primary central nervous system lymphoma (PCNSL) and glioblastoma (GBM) is often difficult due to overlapping imaging characteristics. This study aimed to evaluate the diagnostic value of combining F-fluorodeoxyglucose positron emission tomography (FDG-PET) with arterial spin labeling (ASL) for differentiating PCNSL from GBM. In all, 20 patients with PCNSL and 55 with GBM were retrospectively examined. Read More

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