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The challenges of identifying and classifying child sexual exploitation material: Moving towards a more ecologically valid pilot study with digital forensics analysts.

Child Abuse Negl 2021 Jun 18;118:105166. Epub 2021 Jun 18.

Department of Psychology, University of Bath, UK.

Background: When child sexual exploitation material is seized, digital forensics analysts are required to manually process all "unknown" digital material by determining (a) whether a child is present in the image, and (b) whether the image is of an indecent nature (i.e., illegal). Read More

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Beyond "Meat Free Monday": A mixed method study of giving up eating meat.

Appetite 2021 Jun 18:105463. Epub 2021 Jun 18.

Department of Primary Care & Public Health, Brighton & Sussex Medical School, United Kingdom.

Increasing numbers of people are vegan, vegetarian, or reducing meat consumption. There has also been growth in campaigns such as Meat Free Monday (MFM) that encourage and support reduced meat consumption. We conducted a mixed-method exploration of the behaviour and beliefs associated with reducing or eliminating meat consumption. Read More

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A network pharmacology approach to determine the underlying mechanisms of action of Yishen Tongluo formula for the treatment of oligoasthenozoospermia.

PLoS One 2021 21;16(6):e0252906. Epub 2021 Jun 21.

Department of Reproductive Medicine, Henan Province Hospital of Traditional Chinese Medicine (The Second Affiliated Hospital of Henan University of Chinese Medicine), Zhengzhou, Henan, P. R. China.

Oligoasthenozoospermia is a complex disease caused by a variety of factors, and its incidence is increasing yearly worldwide. Yishen Tongluo formula (YSTLF), created by Professor Sun Zixue, has been used to treat oligoasthenozoospermia in clinical practice for several decades with a good therapeutic effect. However, the chemical and pharmacological profiles of YSTLF remain unclear and need to be elucidated. Read More

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Memetic Spider Monkey Optimization for Spam Review Detection Problem.

Big Data 2021 Jun 21. Epub 2021 Jun 21.

Department of Computer Science and Engineering, CHRIST (Deemed to be University), Bangalore, India.

Spider monkey optimization (SMO) algorithm imitates the spider monkey's fission-fusion social behavior. It is evident through literature that the SMO is a competitive swarm-based algorithm that is used to solve difficult real-life problems. The SMO's search process is a little bit biased by the random component that drives it with high explorative searching steps. Read More

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Are You Going to Delete Me? Latent Profiles of Post-Relationship Breakup Social Media Use and Emotional Distress.

Cyberpsychol Behav Soc Netw 2021 Jun 21. Epub 2021 Jun 21.

Children's Home and Aid, Bloomington, Illinois, USA.

When a relationship ends, former partners must make decisions about their online, often public, connections and history, which involve a complex disentangling process. We examined post-breakup behaviors including monitoring, interacting, deleting posts/photos, deleting the former partner, deleting the partner's family/friends, stopping social media (SM) use, and keeping digital possessions. Participants ( = 256) who had experienced a breakup within the last year completed an online survey. Read More

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Calls to Action (Mobilizing Information) on Cancer in Online News: Content Analysis.

J Med Internet Res 2021 Jun 21;23(6):e26019. Epub 2021 Jun 21.

Department of Communication, Faculty of Modern Languages and Communication, Universiti Putra Malaysia, Serdang, Malaysia.

Background: The health belief model explains that individual intentions and motivation of health behaviors are mostly subject to external cues to action, such as from interpersonal communications and media consumptions. The concept of mobilizing information (MI) refers to a type of mediated information that could call individuals to carry out particular health actions. Different media channels, especially digital media outlets, play an essential role as a health educator to disseminate cancer health information and persuade and mobilize cancer prevention in the community. Read More

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Fidelity of Delivery and Contextual Factors Influencing Children's Level of Engagement: Process Evaluation of the Online Remote Behavioral Intervention for Tics Trial.

J Med Internet Res 2021 Jun 21;23(6):e25470. Epub 2021 Jun 21.

Division of Psychiatry and Applied Psychology, School of Medicine, University of Nottingham, Nottingham, United Kingdom.

Background: The Online Remote Behavioral Intervention for Tics (ORBIT) study was a multicenter randomized controlled trial of a complex intervention that consisted of a web-based behavioral intervention for children and young people with tic disorders. In the first part of a two-stage process evaluation, we conducted a mixed methods study exploring the reach, dose, and fidelity of the intervention and contextual factors influencing engagement.

Objective: This study aims to explore the fidelity of delivery and contextual factors underpinning the ORBIT trial. Read More

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Integrated Bioinformatic Analysis Revealed the Regulation of Angiogenesis by Tumor Cells in Hepatocellular Carcinoma.

Biosci Rep 2021 Jun 21. Epub 2021 Jun 21.

Huashan Hospital Fudan University Department of Infectious Diseases, Shanghai, China.

Hepatocellular carcinoma (HCC) is one of the leading causes of cancer mortality, metastasis accounts for most of the cases. Angiogenesis plays an important role in cancer metastasis, but how tumor cells affect the function of endothelial cells by dictating their miRNA expression remains largely unknown.Differentially expressed miRNAs (DEMs) were identified through dataset downloaded from the Gene Expression Omnibus (GEO) database and analyzed by GEO2R. Read More

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Screening of cervical cancer-related hub genes based on comprehensive bioinformatics analysis.

Cancer Biomark 2021 Jun 12. Epub 2021 Jun 12.

Background: Since the molecular mechanisms of cervical cancer (CC) have not been completely discovered, it is of great significance to identify the hub genes and pathways of this disease to reveal the molecular mechanisms of cervical cancer.

Objective: The study aimed to identify the biological functions and prognostic value of hub genes in cervical cancer.

Methods: The gene expression data of CC patients were downloaded from the Gene Expression Omnibus (GEO) database and The Cancer Genome Atlas (TCGA) database. Read More

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Identification of immune cell infiltration pattern and related critical genes in metastatic castration-resistant prostate cancer by bioinformatics analysis.

Cancer Biomark 2021 Jun 19. Epub 2021 Jun 19.

Department of Urology, The Affiliated Suzhou Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.

Background: Metastatic castration-resistant prostate cancer (mCRPC) is the lethal stage of prostate cancer and the main cause of morbidity and mortality, which is also a potential target for immunotherapy.

Method: In this study, using the Approximate Relative Subset of RNA Transcripts (CIBERSORT) online method, we analysed the immune cell abundance ratio of each sample in the mCRPC dataset. The EdgeR (an R package) was used to classify differentially expressed genes (DEGs). Read More

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Oculomotor Behaviors and Integrative Memory Functions in the Alzheimer's Clinical Syndrome.

J Alzheimers Dis 2021 Jun 15. Epub 2021 Jun 15.

School of Psychological Sciences and Health, University of Strathclyde, Glasgow, UK.

Background: Biological information drawn from eye-tracking metrics is providing evidence regarding drivers of cognitive decline in Alzheimer's disease. In particular, pupil size has proved useful to investigate cognitive performance during online activities.

Objective: To investigate the oculomotor correlates of impaired performance of patients with mild Alzheimer's Clinical Syndrome (ACS) on a recently developed memory paradigm, namely the Short-Term Memory Binding Test (STMBT). Read More

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Measuring stress after childbirth: development and validation of the Maternal Postpartum Stress Scale.

J Reprod Infant Psychol 2021 Jun 19:1-13. Epub 2021 Jun 19.

Department of Psychology, Catholic University of Croatia, Zagreb, Croatia.

: Due to a wide range of stressors during the first postpartum year, this study aimed to develop and validate a self-report measure of stress intensity specific for postpartum.: Postpartum women (= 603) completed the Maternal Postpartum Stress Scale in a cross-sectional online study. They also filled out questionnaires on general stress, depression, and anxiety . Read More

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Psychiatric symptoms influence reward-seeking and loss-avoidance decision-making through common and distinct computational processes.

Psychiatry Clin Neurosci 2021 Jun 20. Epub 2021 Jun 20.

Department of Psychological and Cognitive Sciences, Graduate School of Informatics, Nagoya University.

Aim: Psychiatric symptoms are often accompanied by impairments in decision-making to attain rewards and avoid losses. However, due to the complex nature of mental disorders (e.g. Read More

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Towards Transparency in the Selection of Published Health Utility Inputs in Cost-Utility Analyses: The Health Utility Application Tool (HAT).

Pharmacoeconomics 2021 Jun 21. Epub 2021 Jun 21.

Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada.

Background: Evaluating the relevance of published health utilities to the context of a cost-utility analysis (CUA) remains an essential, yet often overlooked, task.

Objective: The objective of this study was to provide guidance on this process through the development of the Health utility Application Tool (HAT).

Methods: We conducted semi-structured telephone interviews with Canadian stakeholders from reimbursement bodies, academia, and the pharmaceutical industry to identify current practices and perspectives of the application of the health utility literature to CUAs. Read More

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Examining the Effects of Social Determinants of Health on COVID-19 Related Stress, Family's Stress and Discord, and Personal Diagnosis of COVID-19.

J Affect Disord Rep 2021 Jun 16:100183. Epub 2021 Jun 16.

Julius L. Chambers Biomedical Biotechnology Research Institute, North Carolina Central University, Durham, NC 27707, USA.

Background: COVID-19 is a significant threat to people's mental health and social well-being. The research examined the effects of social determinants of health on COVID-19 related stress, family's stress and discord, and personal diagnosis of COVID-19.

Methods: In November 2020, the data collection was conducted from 97 counties in North Carolina ( = 1500). Read More

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Humanizing the ICU Patient: A Qualitative Exploration of Behaviors Experienced by Patients, Caregivers, and ICU Staff.

Crit Care Explor 2021 Jun 15;3(6):e0463. Epub 2021 Jun 15.

Division of Pulmonary Critical Care and Sleep Medicine, Department of Medicine, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell Health, Hempstead, NY.

Objectives: To understand how patients and family members experience dehumanizing or humanizing treatment when in the ICU.

Design: Qualitative study included web-based focus groups and open-ended surveys posted to ICU patient/family social media boards. Focus groups were audio recorded and transcribed. Read More

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In-text citation's frequencies-based recommendations of relevant research papers.

PeerJ Comput Sci 2021 4;7:e524. Epub 2021 Jun 4.

Information Systems Department, College of Computer and Information Sciences, Princess Nourah Bint Abdulrahman University, Riyadh, Saudi Arabia.

From the past half of a century, identification of the relevant documents is deemed an active area of research due to the rapid increase of data on the web. The traditional models to retrieve relevant documents are based on bibliographic information such as Bibliographic coupling, Co-citations, and Direct citations. However, in the recent past, the scientific community has started to employ textual features to improve existing models' accuracy. Read More

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The contemporary trends and geographic variation in premature mortality due to heart failure from 1999 to 2018 in the United States.

Int J Cardiol Heart Vasc 2021 Jun 7;34:100812. Epub 2021 Jun 7.

The Department of Medicine, Division of Cardiology Saint Louis University Hospital, MO, USA.

Objectives: We aimed to examine the contemporary trends and regional variations in premature mortality due to heart failure across the U.S. from 1999 to 2018. Read More

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COVID-19 pandemic and lockdown stress consequences in people with and without Irritable Bowel Syndrome.

Ethics Med Public Health 2021 Sep 24;18:100660. Epub 2021 Mar 24.

INSERM U-987, Pathophysiology and Clinical Pharmacology of pain, Ambroise-Paré Hospital, 92100 Boulogne-Billancourt, France.

Background: While all resources have been mobilized to fight COVID-19, this study aimed to analyze the consequences of lockdown and pandemic stress in participants with and without Irritable Bowel Syndrome (IBS).

Methodology: An online survey was proposed to people with or without IBS during the exponential phase of the pandemic in France. The questionnaire included questions about socio-demographic data, conditions of confinement, activities carried out, IBS characteristics, measurement of stress level, consequences on sleep, fatigue, anxiety and depression, and quality of life (both perceived non-specific and specific for IBS). Read More

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September 2021

A comprehensive review on global contributions and recognition of pharmacy professionals amidst COVID-19 pandemic: moving from present to future.

Futur J Pharm Sci 2021 11;7(1):119. Epub 2021 Jun 11.

Department of Pharmacy, University of Chittagong, Chittagong, 4331 Bangladesh.

Background: COVID-19, a respiratory tract infection caused by SARS-CoV-2, is a burning question worldwide as it gives rise to a pandemic situation. No specific medications are still recommended for COVID-19; however, healthcare support is crucial for ameliorating the disease condition. Pharmacists are the frontline fighters who are responsible for providing healthcare support to the COVID-19 infected patients around the world. Read More

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Lameness in Beef Cattle: A Cross-Sectional Descriptive Survey of On-Farm Practices and Approaches.

Front Vet Sci 2021 4;8:657299. Epub 2021 Jun 4.

Department of Livestock and One Health, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Neston, United Kingdom.

Cattle lameness is a concern to the United Kingdom (UK) cattle industry, negatively impacting upon welfare and production. Previous work involving one small study ( = 21) has identified that some UK beef farmers underestimate lameness prevalence, but also that farmers vary in their perception of the impact of lameness. Knowledge and skills of farmers were identified as a potential concern, and farmer-reported barriers were identified. Read More

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Potential and Challenges of Community-Based Surveillance in Animal Health: A Pilot Study Among Equine Owners in Switzerland.

Front Vet Sci 2021 4;8:641448. Epub 2021 Jun 4.

Veterinary Public Health Institute, Vetsuisse Faculty, University of Bern, Bern, Switzerland.

Animal owners' potential to observe and report clinical signs, as the persons with the closest contact to their animals, is an often neglected source of information in surveillance. Allowing community members other than health care professionals, such as animal owners, to report health events can contribute to close current surveillance gaps and enhance early detection. In the present study, we tested a community-based surveillance (CBS) approach in the equine community in Switzerland. Read More

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A Concise and Geometrically Exact Planar Beam Model for Arbitrarily Large Elastic Deformation Dynamics.

Front Robot AI 2020 25;7:609478. Epub 2021 May 25.

Chair of Automatic Control Engineering (LSR), Department of Electrical and Computer Engineering, Technical University of Munich (TUM), Munich, Germany.

The potential of large elastic deformations in control applications, e.g., robotic manipulation, is not yet fully exploited, especially in dynamic contexts. Read More

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Strategies in Primary Care to Face the SARS-CoV-2 / COVID-19 Pandemic: An Online Survey.

Front Med (Lausanne) 2021 2;8:613537. Epub 2021 Jun 2.

Department of General Practice and Primary Care, Center for Psychosocial Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Primary care plays a key role in pandemics like the SARS-CoV-2 pandemic in 2020. We aimed to investigate the challenges faced and the solutions implemented in primary care. One hundred and twenty-one general practitioners in Germany completed the online survey. Read More

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The Role of Self-Efficacy and Injunctive Norms in Helping Older Adults Decide to Stay Home During the COVID-19 Pandemic.

Front Public Health 2021 4;9:660813. Epub 2021 Jun 4.

Department of Applied Health Science, School of Public Health, Indiana University, Bloomington, IN, United States.

Because older adults are at elevated risk of COVID-19-related adverse health outcomes, and staying at home is an effective strategy to avoid unnecessary exposures, the current formative study used the Reasoned Action Approach (RAA) to identify the beliefs underlying older adults' decision to stay home for the next month. The participants (weighted = 206, age 65-94) for the current study were selected from a nationally representative online survey of US adults from April 10-20, 2020. We used multiple linear regression to estimate the relative contribution of the four RAA global constructs (instrumental attitude, injunctive norms, descriptive norms, and self-efficacy) in explaining intention to stay home after controlling for demographic covariates. Read More

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Attitudes Toward and Use of Prostate-Specific Antigen Testing Among Urologists and General Practitioners in Germany: A Survey.

Front Oncol 2021 4;11:691197. Epub 2021 Jun 4.

University Hospital for Urology, Klinikum Oldenburg, Department of Human Medicine, School of Medicine and Health Sciences, Carl von Ossietzky University Oldenburg, Oldenburg, Germany.

Background: In 2020, around 1.4 million new prostate cancer (PCa) cases were recorded worldwide. Early detection of PCa by prostate-specific antigen (PSA) screening remains debated, leading to different specialist-specific recommendations in PCa guidelines. Read More

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Reliability of Chinese web-based ocular surface disease index questionnaire in dry eye patients: a randomized, crossover study.

Int J Ophthalmol 2021 18;14(6):834-843. Epub 2021 Jun 18.

Department of Ophthalmology, He Eye Specialists Hospital, Shenyang 110034, Liaoning Province, China.

Aim: To assess the reliability of web-based version of ocular surface disease index in Chinese (C-OSDI) on clinically diagnosed dry eye disease (DE) patients.

Methods: A total of 254 Chinese participants (51% male, 129/254; mean age: 27.90±9. Read More

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Retrospective study of factors associated with progression and remission/regression of diabetic kidney disease-hypomagnesemia was associated with progression and elevated serum alanine aminotransferase levels were associated with remission or regression.

Diabetol Int 2021 Jul 2;12(3):268-276. Epub 2021 Jan 2.

Department of Medicine, Nerima General Hospital, 1-24-1 Asahigaoka, Nerima-ku, Tokyo, 176-8530 Japan.

Aim: This study was aimed at retrospectively investigating some common clinical factors, including the serum level of magnesium (Mg), associated with progression and remission/regression of diabetic kidney disease (DKD).

Methods: The subjects were 690 Japanese patients with type 2 diabetes mellitus who were receiving treatment with oral antidiabetic drugs other than SGLT2 inhibitors. Routine clinical data were collected on the first and last day of the observation period. Read More

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Remote Musculoskeletal Consultations: A Survey of General Practitioner Registrars' Level of Confidence, Acceptability, and Management.

Cureus 2021 May 18;13(5):e15084. Epub 2021 May 18.

Physical Medicine and Rehabilitation, Centre for Musculoskeletal Medicine, Royal Orthopaedic Hospital, Birmingham, GBR.

Background and objective The coronavirus disease 2019 (COVID-19) pandemic has accelerated the shift towards remote consultations in the medical field, including musculoskeletal (MSK) appointments. General practitioner (GP) registrars are now routinely conducting many MSK consultations remotely; however, very little is known of their level of confidence and satisfaction regarding this new and evolving scenario, or how this may impact patient management of patients. In this study, we aimed to understand GP registrars' level of confidence and satisfaction with respect to remote MSK consultations, and the perceived impact on patient management. Read More

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Intimate partner violence among Arab women before and during the COVID-19 lockdown.

J Egypt Public Health Assoc 2021 Dec 16;96:15. Epub 2021 Jun 16.

Department of Family Health, High Institute of Public Health, Alexandria University, Alexandria, Egypt.

Introduction: Intimate partner violence (IPV) remains a serious human rights violation and an important health concern during the ongoing COVID-19 pandemic. The study aims to estimate the proportion of IPV among adult Arab women before and during the COVID-19 lockdown and to identify its possible predictors during the lockdown.

Methods: A cross-sectional study was conducted between April and June 2020 using an online questionnaire. Read More

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December 2021