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Synthesis of C-Labelled ω-Hydroxy Carboxylic Acids of the General Formula HO C-(CH ) -CH OH or HO C-(CH ) - CH OH (n = 12, 16, 20, 28).

J Labelled Comp Radiopharm 2021 Jun 22. Epub 2021 Jun 22.

University Koblenz - Landau, Institute of Integrated Natural Sciences, Koblenz, Germany.

C-labelled ω-hydroxy-carboxylic acids HO C-(CH ) -CH OH or HO C-(CH ) - CH OH (n = 12, 16, 20, 28) with C labels selectively introduced either at the carboxy group or at the primary alcohol function at the end of the hydrocarbon chain have been synthesized. Different synthetic strategies had to be applied depending on the position of the label, the chain length of the respective synthetic target and due to economic considerations. C-labels in general were introduced by nucleophilic substitution of a suitable leaving group with labelled potassium cyanide and subsequent hydrolysis of the nitriles to produce the corresponding labelled carboxy functions which may also be reduced to give the labelled primary alcohol group. Read More

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Validation of BRCA testing on cytologic samples of high-grade serous carcinoma.

Cancer Cytopathol 2021 Jun 22. Epub 2021 Jun 22.

Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.

Background: Testing for BRCA1/2 gene alterations in patients with high-grade serous carcinoma (HGSC) is a critical determinant of treatment eligibility for poly(adenosine diphosphate-ribose) polymerase inhibitors in addition to providing vital information for genetic counselling. Many patients present with effusions necessitating therapeutic drainage, and this makes cytologic specimens (CySs) the initial diagnostic material for HGSC, often before histologic sampling. Initiating somatic BRCA testing on a CyS allows the BRCA status to be determined sooner, and this affects clinical management. Read More

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Hematologic safety of palbociclib in combination with endocrine therapy in patients with benign ethnic neutropenia and advanced breast cancer.

Cancer 2021 Jun 22. Epub 2021 Jun 22.

Georgetown Lombardi Comprehensive Cancer Center, MedStar Georgetown University Hospital, Washington, District of Columbia.

Background: Cyclin-dependent kinase 4/6 (CDK4/6) inhibitors, including palbociclib, are approved to treat hormone receptor (HR)-positive/human epidermal growth factor receptor 2 (HER2)-negative advanced breast cancer (ABC) and are associated with hematologic toxicity. African American women, who are underrepresented in CDK4/6 inhibitor clinical trials, may experience worse neutropenia because of benign ethnic neutropenia. The authors specifically investigated the hematologic safety of palbociclib in African American women with HR-positive/HER2-negative ABC. Read More

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OCT Application for Sterile Corneal Graft Screening in the Eye Bank.

Klin Monbl Augenheilkd 2021 Jun 22;238(6):688-692. Epub 2021 Jun 22.

Department of Ophthalmology, Saarland University Medical Center (UKS), Homburg/Saar, Germany.

Background And Objective: Sterile donor tomography enables the detection of corneal tissues with refractive anomalies. The aim of this study was to determine the curvature and thickness of donor corneas to support proper selection in the eye bank.

Methods: 704 donor corneas (Klaus Faber Center, LIONS Eye Bank Saar-Lor-Lux, Trier/Westpfalz, in Homburg/Saar) were measured using the anterior segment optical coherence tomograph (AS-OCT) CASIA 2 (Tomey Corp. Read More

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Relationship between clinical signs and hormonal analytical findings in bitches with lactatio sine graviditate.

Tierarztl Prax Ausg K Kleintiere Heimtiere 2021 Jun 22;49(3):174-182. Epub 2021 Jun 22.

Department of Obstetrics, Gynecology, and Andrology of Large and Small Animals, Justus Liebig University.

Objective: Lactatio sine graviditate of the bitch can become clinically relevant in particularly severe manifestations. The aim of the study was to relate the hormone pattern consisting of progesterone (P4), estradiol 17β (E2) and prolactin to the time of occurrence of lactatio sine graviditate in the course of metoestrus and anoestrus as well as to its symptomatology.

Material And Methods: Sixty-eight bitches with apparent lactatio sine graviditate were divided into 3 groups according to their cycle status. Read More

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Prevalence and risk factors of undiagnosed diabetes mellitus among gastroenterological patients: a HbA1c-based single center experience.

Z Gastroenterol 2021 Jun 22. Epub 2021 Jun 22.

I. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Background: Diabetes mellitus is a major risk factor for microvascular disease, leading to chronic kidney injury or cardiovascular disease, but there is a tremendous proportion of patients worldwide who suffer from undiagnosed diabetes. Until now, little is known about the prevalence of undiagnosed diabetes in gastroenterology inpatients.

Objective: To improve detection of undiagnosed diabetes, a routine screening procedure for gastroenterology inpatients, based on hemoglobin A1c (HbA1c) and fasting plasma glucose (FPG) measurement, was established. Read More

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[Methodical investigation of mineral and trace element concentrations in equine feces with special consideration of the sampling location].

Tierarztl Prax Ausg G Grosstiere Nutztiere 2021 Jun 22;49(3):178-188. Epub 2021 Jun 22.

Klinik für Pferde, Freie Universität Berlin.

Objective: Objective measurements of the mineral supply in horses are rarely performed. As a result, incorrect elements or an improper amount of elements are provided. The analysis of feces could represent a novel method to evaluate the nutritive supply. Read More

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The usefulness of the RSTC medical questionnaire in pre-participation health risk assessment of recreational scuba divers in Hong Kong.

Diving Hyperb Med 2021 Jun;51(2):173-181

Department of Global Health, Stellenbosch University, Cape Town, South Africa.

Introduction: The current practice in Hong Kong is to have potential recreational divers complete a Recreational Scuba Training Council self-declared medical statement (RSTC form) prior to participation in diving. There are no reports in the literature on the usefulness of the Chinese version of the form.

Methods: The Professional Association of Diving Instructors (PADI) RSTC form (Chinese version) was completed by 117 research participants who were then individually interviewed (without examination) to establish whether relevant information was not captured by the form. Read More

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Ultrasonographic 3D Evaluation in the Diagnosis of Bladder Endometriosis: A Prospective Comparative Diagnostic Accuracy Study.

Gynecol Obstet Invest 2021 Jun 22:1-8. Epub 2021 Jun 22.

Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DiNOGMI), University of Genova, Genova, Italy.

Objective: The use of three-dimensional (3D) transvaginal ultrasonography (TVS) has been investigated for the diagnosis of deep endometriosis (DE). This study aimed to evaluate if 3D reconstructions improve the performance of TVS) in assessing the presence and characteristics of bladder endometriosis (BE).

Design: This was a single-center comparative diagnostic accuracy study. Read More

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Ordered multi-path propagation for vessel centerline extraction.

Phys Med Biol 2021 Jun 22. Epub 2021 Jun 22.

School of Optics and Photonics, Beijing Institute of Technology, NO.5 Zhongguancun south street, Beijing, 100081, CHINA.

Vessel centerline extraction from x-ray angiography (XRA) images is essential for vessel structure analysis in the diagnosis of coronary artery disease. However, complete and continuous centerline extraction remains a challenging task due to image noise, poor contrast, and complexity of vessel structure. Thus, an iterative multi-path search framework for automatic vessel centerline extraction is proposed. Read More

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Summary and analysis of Russian and international requirements for the safe management of very low level radioactive waste and production waste containing very low active radionuclides.

J Radiol Prot 2021 Jun 22. Epub 2021 Jun 22.

Burnasyan SRC-FMBC, FMBA Rossii, Moskva, Moskva, RUSSIAN FEDERATION.

Purpose: This article gives an overview of Russian legislation and international recommendations on the safe management regulation of the accumulated very low level RW, provides the comparison of Russian and international criteria for RW attribution to this or that class and also the existing radiation safety requirements. This article also deals with the difficulties in management of production waste containing radionuclides.

Method: Criteria and standards were selected from international (ICRP and IAEA publications) and Russian (Federal Law on Management of Radioactive Waste, Government Decree on Radioactive Waste Classification, The Basic Sanitary Rules of Radiation Safety) documents for comparative analysis. Read More

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Early Cerebrovascular Ultrasonography as a Predictor of Hemorrhagic Transformation After Thrombectomy.

J Stroke Cerebrovasc Dis 2021 Jun 18;30(8):105922. Epub 2021 Jun 18.

Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal; Faculdade de Medicina da Universidade de Coimbra, Coimbra, Portugal.

Objectives: To determine the predictive value of early transcranial color-coded sonography (TCCS) for intracranial hemorrhage (ICH) in patients with large artery occlusion (LAO) stroke of carotid circulation, who were submitted to endovascular therapy (EVT) with successful reperfusion.

Materials And Methods: Retrospective study evaluating a cohort of consecutive stroke patients with LAO of the carotid circulation that were recanalyzed with EVT. We measured angle-corrected peak systolic velocities, end-diastolic velocities and mean flow velocities (PSV, EDV and MFV) of the symptomatic and asymptomatic middle cerebral artery (MCA). Read More

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Cost Burden and Cost-Effective Analysis of the Nationwide Implementation of the Quality in Acute Stroke Care Protocol in Australia.

J Stroke Cerebrovasc Dis 2021 Jun 19;30(8):105931. Epub 2021 Jun 19.

School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia. Electronic address:

Objectives: The Quality in Acute Stroke Care (QASC) protocol is a multidisciplinary approach to implement evidence-based treatment after acute stroke that reduces death and disability. This study sought to evaluate the cost-effectiveness of implementing the QASC protocol across Australia, from a healthcare and a societal perspective.

Materials And Methods: A decision-analytic model was constructed to reflect one-year outcomes post-stroke, aligned with the stroke severity categories of the modified Rankin scale (mRS). Read More

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The risk of depression and anxiety in patients with familial mediterranean fever - a cross-sectional study.

J Affect Disord 2021 Jun 6;292:695-699. Epub 2021 Jun 6.

Division of Psychiatry, Barzilai Medical Center, Ashkelon, Israel.

Background: Familial Mediterranean Fever (FMF) is an autosomal recessive autoinflammatory disease associated with various systemic comorbidities. Recent research regarding the association with depression and anxiety has yielded conflicting results. The current study aims were to examine whether such an association exists using big data analysis methodology. Read More

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Serum cortisol as a predictor for posttraumatic stress disorder symptoms in post-myocardial infarction patients.

J Affect Disord 2021 Jun 5;292:687-694. Epub 2021 Jun 5.

Department of Consultation-Liaison Psychiatry and Psychosomatic Medicine, University Hospital Zurich, and University of Zurich, Zurich, Switzerland.

Background: After an acute myocardial infarction (MI), patients may develop posttraumatic stress disorder (PTSD). There is evidence for alterations in the hypothalamic-pituitary-adrenal axis in PTSD. An association between patients` cortisol level after experiencing an MI and subsequent PTSD symptoms has not been investigated yet. Read More

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Mammographic density and prognosis in primary breast cancer patients.

Breast 2021 Jun 17;59:51-57. Epub 2021 Jun 17.

Department of Gynecology and Obstetrics, Erlangen University Hospital, Comprehensive Cancer Center, European Metropolitan Area Erlangen-Nuremberg (CCC ER-EMN), Friedrich Alexander University of Erlangen-Nuremberg, Erlangen, Germany.

Purpose: Mammographic density (MD) is one of the strongest risk factors for breast cancer (BC). However, the influence of MD on the BC prognosis is unclear. The objective of this study was therefore to investigate whether percentage MD (PMD) is associated with a difference in disease-free or overall survival in primary BC patients. Read More

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Identifying genetic risk variants associated with noise-induced hearing loss based on a novel strategy for evaluating individual susceptibility.

Hear Res 2021 Jun 6;407:108281. Epub 2021 Jun 6.

Department of Otolaryngology-Head and Neck Surgery, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, 600 Yishan Road, Shanghai 200233, China; Otolaryngology Institute of Shanghai Jiao Tong University, Shanghai 200233, China; Shanghai Key Laboratory of Sleep Disordered Breathing, Shanghai 200233, China.

Background: The overall genetic profile for noise-induced hearing loss (NIHL) remains elusive. Herein we proposed a novel machine learning (ML) based strategy to evaluate individual susceptibility to NIHL and identify the underlying genetic risk variants based on a subsample of participants with extreme phenotypes.

Methods: Five features (age, sex, cumulative noise exposure [CNE], smoking, and alcohol drinking status) of 5,539 shipbuilding workers from large cross-sectional surveys were included in four ML classification models to predict their hearing levels. Read More

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Paternal inheritance predicts earlier cardiovascular event onset in patients with familial hypercholesterolemia.

Atherosclerosis 2021 Jun 11;329:9-13. Epub 2021 Jun 11.

Genetic Dyslipidemias Clinic of the Montreal Clinical Research Institute, Québec, Canada; Department of Medicine, Divisions of Experimental Medicine and Medical Biochemistry, McGill University, Québec, Canada. Electronic address:

Background And Aims: Familial hypercholesterolemia (FH) is a genetic disease, with an autosomal codominant inheritance, predisposing to premature atherosclerotic cardiovascular disease (ASCVD). Paternal or maternal inheritance of the FH-causing mutation may affect the FH phenotype in offspring, but the effect of the genetic transmission on cardiovascular disease risk remains to be established. The aim of the present study is to compare the incidence of cardiovascular events between patients with maternal vs paternal inheritance of familial hypercholesterolemia. Read More

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Fast mesh data augmentation via Chebyshev polynomial of spectral filtering.

Neural Netw 2021 Jun 9;143:198-208. Epub 2021 Jun 9.

Department of Biomedical Engineering, National University of Singapore, Singapore; Institute of Data Science, National University of Singapore, Singapore; The N.1 Institute for Health, National University of Singapore, Singapore; The Johns Hopkins University, MD, USA. Electronic address:

Deep neural networks have recently been recognized as one of the powerful learning techniques in computer vision and medical image analysis. Trained deep neural networks need to be generalizable to new data that are not seen before. In practice, there is often insufficient training data available, which can be solved via data augmentation. Read More

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Intra-scanner repeatability of quantitative imaging features in a 3D printed semi-anthropomorphic CT phantom.

Eur J Radiol 2021 Jun 9;141:109818. Epub 2021 Jun 9.

Department of Radiology, Charité - Universitätsmedizin Berlin, Germany; Berlin Institute of Health, Berlin, Germany.

Objectives: Radiomics has shown to provide novel diagnostic and predictive disease information based on quantitative image features in study settings. However, limited data yielded contradictory results and important questions regarding the validity of the methods remain to be answered. The purpose of this study was to evaluate how clinical imaging techniques affect the stability of radiomics features by using 3D printed anthropomorphic CT phantom to test for repeatability and reproducibility of quantitative parameters. Read More

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Feasibility of using an automated analysis of formulation effort in patients' spoken seizure descriptions in the differential diagnosis of epileptic and nonepileptic seizures.

Seizure 2021 Jun 13;91:141-145. Epub 2021 Jun 13.

Academic Neurology Unit, University of Sheffield, Royal Hallamshire Hospital, Sheffield, United Kingdom.

Objective: There are three common causes of Transient Loss of Consciousness (TLOC), syncope, epileptic and psychogenic nonepileptic seizures (PNES). Many individuals who have experienced TLOC initially receive an incorrect diagnosis and inappropriate treatment. Whereas syncope can be distinguished relatively easily with a small number of "yes"/"no" questions, the differentiation of the other two causes of TLOC is more challenging. Read More

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Ictal gamma-band interactions localize ictogenic nodes of the epileptic network in focal cortical dysplasia.

Clin Neurophysiol 2021 May 26;132(8):1927-1936. Epub 2021 May 26.

Department of Physiology, Second Faculty of Medicine, Charles University, Prague, Czech Republic; Department of Developmental Epileptology, Institute of Physiology, Czech Academy of Sciences, Prague, Czech Republic. Electronic address:

Objective: Epilepsy surgery fails in > 30% of patients with focal cortical dysplasia (FCD). The seizure persistence after surgery can be attributed to the inability to precisely localize the tissue with an endogenous potential to generate seizures. In this study, we aimed to identify the critical components of the epileptic network that were actively involved in seizure genesis. Read More

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The effects of transcranial direct current stimulation on upper-limb function post-stroke: A meta-analysis of multiple-session studies.

Clin Neurophysiol 2021 Jun 11;132(8):1897-1918. Epub 2021 Jun 11.

REVAL Research Institute, Hasselt University, Diepenbeek, Belgium; Movement Control & Neuroplasticity Research Group, Department of Movement Sciences, Group Biomedical Sciences, KU Leuven, Heverlee, Belgium. Electronic address:

Objective: To systematically review how patient characteristics and/or transcranial direct current stimulation (tDCS) parameters influence tDCS effectiveness in respect to upper limb function post-stroke.

Methods: Three electronic databases were searched for sham-controlled randomised trials using the Fugl-Meyer Assessment for upper extremity as outcome measure. A meta-analysis and nine subgroup-analyses were performed to identify which tDCS parameters yielded the greatest impact on upper limb function recovery in stroke patients. Read More

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Applying Spike-density component analysis for high-accuracy auditory event-related potentials in children.

Clin Neurophysiol 2021 May 29;132(8):1887-1896. Epub 2021 May 29.

Center for Music in the Brain, Department of Clinical Medicine, Aarhus University and Royal Academy of Music, Aarhus/Aalborg, Universitetsbyen 3, 8000 Aarhus C, Denmark; Department of Education, Psychology, Communication, University of Bari Aldo Moro, Italy.

Objective: Overlapping neurophysiological signals are the main obstacle preventing from using cortical auditory event-related potentials (AEPs) in clinical settings. Children AEPs are particularly affected by this problem, as their cerebral cortex is still maturing. To overcome this problem, we applied a new version of Spike-density Component Analysis (SCA), an analysis method recently developed, to isolate with high accuracy the neural components of auditory responses of 8-year-old children. Read More

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Valorization of groundnut shell via pyrolysis: Product distribution, thermodynamic analysis, kinetic estimation, and artificial neural network modeling.

Chemosphere 2021 Jun 15;283:131162. Epub 2021 Jun 15.

Department of Chemical Engineering, Khalifa University, P.O. Box 127788, Abu Dhabi, United Arab Emirates. Electronic address:

Pyrolysis of agricultural biomass is a promising technique for producing renewable energy and effectively managing solid waste. In this study, groundnut shell (GNS) was processed at 500 °C in an inert gas atmosphere with a gas flow rate and a heating rate of 10 mL/min and 10 °C/min, respectively, in a custom-designed fluidized bed pyrolytic-reactor. Under optimal operating conditions, the GNS-derived pyrolytic-oil yield was 62. Read More

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COVID-19 and the surge of child marriages: A phenomenon in Nusa Tenggara Barat, Indonesia07.

Authors:
Maila D H Rahiem

Child Abuse Negl 2021 Jun 17;118:105168. Epub 2021 Jun 17.

Department of Early Childhood Education, UIN Syarif Hidayatullah Jakarta, Indonesia. Electronic address:

Background: Worldwide, there has been a massive increase in child marriages following the COVID-19 crisis. In Indonesia, too, this figure has risen with Indonesia ranked amongst ten countries with the highest rates of child marriage in the world. One of the Indonesian provinces with a high incidence of child marriage cases is in Nusa Tenggara Barat (NTB). Read More

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Virtual pedagogical strategies and HESI student outcomes in response to COVID-19.

Nurse Educ Today 2021 Jun 17;104:105019. Epub 2021 Jun 17.

Adjunct Faculty, College of DuPage, 425 Fawell Blvd., Glen Ellyn, IL 60137, United States of America.

Background: To maintain curricular integrity in response to COVID-19, nurse educators are increasingly required to transition from traditional (face-to-face) to virtual pedagogy.

Objectives: The purpose of this analysis was to compare the HESI scores based on a traditional pedagogy with the HESI scores following implementation of virtual pedagogy during Spring 2020.

Methods: Student (n = 115; 81% female; mean age = 25. Read More

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Native LC-MS for capturing quality attributes of biopharmaceuticals on the intact protein level.

Curr Opin Biotechnol 2021 Jun 18;71:32-40. Epub 2021 Jun 18.

NIBRT - The National Institute for Bioprocessing Research and Training, Foster Avenue, Mount Merrion, Blackrock, Co. Dublin, A94 X099, Ireland; School of Chemical and Bioprocess Engineering, University College Dublin, Belfield, Dublin 4, D04 V1W8, Ireland. Electronic address:

Intact protein analysis by means of mass spectrometry has become a well-established method for the characterization of biotherapeutics. However, due to the highly complex nature of recombinant proteins, prior chromatographic separation is inevitable for a comprehensive analysis. In recent years, progress in coupling a variety of liquid chromatography-based native separation modes such as size exclusion, ion exchange and hydrophobic interaction chromatography to mass spectrometry (native LC-MS) has been reported, therefore allowing for rapid assessment of molecular mass and deep characterization of the heterogeneity of complex, recombinantly produced therapeutic proteins. Read More

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Estimation of komatsuna freshness using visible and near-infrared spectroscopy based on the interpretation of NMR metabolomics analysis.

Food Chem 2021 Jun 16;364:130381. Epub 2021 Jun 16.

Food Research Institute, National Agriculture and Food Research Organization (NARO), Tsukuba, Ibaraki 305-8642, Japan. Electronic address:

The objective of this study was to explore the potentiality and mechanism of visible and near-infrared (Vis-NIR) spectroscopy in estimating the freshness of komatsuna. We monitored the cumulative CO production of komatsuna stored under different conditions as a freshness indicator and measured the Vis-NIR spectra of komatsuna as the predictor. Using the informative wavelengths (IW) selected using the stepwise selectivity ratio method, we constructed an accurate freshness prediction model through PLSR analysis. Read More

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