456,436 results match your criteria analysis indicated

Kainate receptor modulation of glutamatergic synaptic transmission in the CA2 region of the hippocampus.

J Neurochem 2021 Jul 22. Epub 2021 Jul 22.

Laboratorio de Neurociencia Celular y Plasticidad, Departamento de Fisiología, Anatomía y Biología Celular, Universidad Pablo de Olavide, ES-41013, Sevilla, Spain.

Kainate (KA) receptors (KARs) are important modulators of synaptic transmission. We studied here the role of KARs on glutamatergic synaptic transmission in the CA2 region of the hippocampus where the actions of these receptors are unknown. We observed that KA depresses glutamatergic synaptic transmission at Schaffer collateral-CA2 synapses; an effect that was antagonized by NBQX (a KA/AMPA receptors antagonist) under condition where AMPA receptors were previously blocked. Read More

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Biomarker-Based Determination of Equiseti herba Contamination by Equisetum palustre Using HPLC-MS/MS.

Planta Med 2021 Jul 22. Epub 2021 Jul 22.

Institute of Pharmaceutical Biology, Technische Universität Braunschweig, Braunschweig, Germany.

Equiseti herba has been traditionally indicated in bacterial diseases of the efferent urinary tract or bad healing wounds in many regions worldwide. Most of the plant material used for medical purposes comes from collections of wild growing plants. The European Pharmacopoeia requires that Equiseti herba should consist of a minimum of 95% and a maximum of 5% foreign ingredients. Read More

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Combined Central Retinal Arterial and Venous Occlusions due to Leukemic Infiltration.

Retin Cases Brief Rep 2021 Sep 19. Epub 2021 Sep 19.

Department of Ophthalmology, Antwerp University Hospital, Edegem, Belgium Department of Pathology, Antwerp University Hospital, Edegem, Belgium Department of Radiology, Antwerp University Hospital, Edegem, Belgium Faculty of Health Sciences, University of Antwerp, Edegem, Belgium Name and address for correspondence: Vincent M. De La Porte, M.D. E-mail: Telephone: +32 3 821 4428, Address: Department of Ophthalmology, Antwerp University Hospital, 2650 Edegem, Belgium.

Purpose: To report combined central arterial and venous occlusions secondary to bilateral leukemic interfascicular optic nerve infiltration in a 56-year-old man. This was the sole presentation of a relapse in T/Myeloid mixed-phenotype acute leukemia after 5 months of remission.

Methods: Case report with clinical photography. Read More

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September 2021

Improvement of exhausted cerebral autoregulation in patients with idiopathic intracranial hypertension benefit of venous sinus stenting.

Physiol Meas 2021 Jul 22. Epub 2021 Jul 22.

Neurology, Beijing Tiantan Hospital, Beijing, CHINA.

Objective: Utilizing transfer function analysis to assess the cerebral autoregulation in patients with idiopathic intracranial hypertension (IIH), and to explore its improvement after venous sinus stenting.

Approach: In total, 15 consecutive IIH patients with venous sinus stenosis and 15 controls were recruited. All the patients underwent digital subtraction angiography and venous manometry. Read More

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Factors influencing under-five mortality in rural- urban Ghana: An applied survival analysis.

Soc Sci Med 2021 Jul 7;284:114185. Epub 2021 Jul 7.

Department of Economics, University of Ghana, Ghana. Electronic address:

Objectives: This paper uses a survival analysis technique to examine socio-economic and demographic factors that influence under-five mortality for rural and urban Ghana.

Method: The paper employs the Breslow Method for Ties for survival probability and uses data for the 2014 Ghana Demographic and Health Survey (GDHS). Data on some 5884 children was also generated through the interview of 4086 women aged 15-49. Read More

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Preparation and characterization of magnetic modified bone charcoal for removing Cu ions from industrial and mining wastewater.

J Environ Manage 2021 Jul 20;297:113221. Epub 2021 Jul 20.

College of Safety and Environmental Engineering, Shandong University of Science and Technology, Qingdao 266590, China; State Key Laboratory of Mining Disaster Prevention and Control Co-founded by Shandong Province and the Ministry of Science and Technology, Shandong University of Science and Technology, Qingdao 266590, China.

Heavy metal water pollution is an urgent global problem to be addressed. Copper ions are common toxic heavy metal pollutants in wastewater. In order to remove the excessive copper ions in wastewater, in this study, chicken bone charcoal was modified by sodium dodecyl sulfonate and combined with magnetic nanoparticles prepared with ferric chloride hexahydrate and ferrous sulfate heptahydrate to produce a high efficiency adsorbent. Read More

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Diagnostic potential of trace metals concentration in expressed prostatic secretion and serum of patients with category IV prostatitis.

J Trace Elem Med Biol 2021 Jul 8;68:126819. Epub 2021 Jul 8.

Scientific Research Center, Guilin Medical University, Guilin, Guangxi, China; Guangxi Health Commission Key Laboratory of Disease Proteomics Research, China. Electronic address:

Background: The National Institutes of Health (NIH) category IV prostatitis is a painless prostate gland inflammation, just as its name implies, this type of prostatitis is related with inflammation of the prostate, but most men are not conscious of it. However, category IV prostatitis is fairly common in general populations and reported having indirect relationships with prostate cancer.

Method: We analyzed the concentration of zinc (Zn), copper (Cu), calcium (Ca) and magnesium (Mg) in expressed prostatic secretion (EPS) and serum of patients with category IV prostatitis and healthy controls, investigating the diagnostic potential of different metals in category IV prostatitis using a flame atomic absorption spectrometer (FAAS). Read More

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Mapping groundwater-dependent ecosystems in arid Central Asia: Implications for controlling regional land degradation.

Sci Total Environ 2021 Jul 14;797:149027. Epub 2021 Jul 14.

Eurasia Institute of Earth Sciences, Istanbul Technical University, Maslak, Istanbul 34469, Turkey.

Groundwater-dependent ecosystems (GDEs) exist all over the world, especially in water-limited regions. To achieve better water management, it is necessary to map and identify GDEs. Central Asia (CA) is one of the most arid regions in the mid-latitudes and one of the major regions with shallow groundwater tables. Read More

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Antagonizing effects of curcumin against mercury-induced autophagic death and trace elements disorder by regulating PI3K/AKT and Nrf2 pathway in the spleen.

Ecotoxicol Environ Saf 2021 Jul 19;222:112529. Epub 2021 Jul 19.

Department of Pathophysiology, College of Basic Medical Sciences, Southwest Medical University, Luzhou 646000, Sichuan Province, PR China. Electronic address:

Mercury is a naturally occurring element and highly toxic to humans even at a low dosage. Curcumin is a polyphenol found in turmeric (Curcuma longa), widely used as a treatment strategy to improve antioxidant and anti-inflammatory properties. The purpose of this study was to investigate the potential protective mechanisms of curcumin in spleen damage induced by HgCl. Read More

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A case study of flood frequency analysis by intercomparison of graphical linear log-regression method and Gumbel's analytical method in the Vaigai river basin of Tamil Nadu, India.

Chemosphere 2021 Jul 16;286(Pt 1):131571. Epub 2021 Jul 16.

Department of Chemical Engineering, Sri Sivasubramaniya Nadar College of Engineering, Chennai, 603 110, India; Centre of Excellence in Water Research (CEWAR), Sri Sivasubramaniya Nadar College of Engineering, Chennai, 603 110, India. Electronic address:

Flood Frequency Analysis (FFA) is a systematic tool used for an efficient hydraulic structures design, operation and maintenance. An effort is made to study and compare the Linear Log Regression Graphical Method (LLRGM) and Gumbel's Analytical Method (GAM) to assess the future flood magnitude for any given Return Period (RP). Twenty-four years of annual daily peak flood flow value recorded at Vaigai reservoir gauging station between the year 1995 and 2018 was used in the two methods for detailed analysis. Read More

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Hierarchical BiMoO microsphere photocatalysts modified with polypyrrole conjugated polymer for efficient decontamination of organic pollutants.

Chemosphere 2021 Jul 15;286(Pt 1):131541. Epub 2021 Jul 15.

College of Textiles & Clothing, Qingdao University, Qingdao, 266071, PR China; Collaborative Innovation Center for Eco-Textiles of Shandong Province, Qingdao, 266071, PR China.

To effectively degrade organic pollutants in wastewater, visible-light-driven BiMoO/PPy hierarchical heterogeneous photocatalysts were prepared through a solvothermal method and the following in-situ chemical oxidation polymerization. Compared with pristine BiMoO photocatalyst, the composite photocatalysts exhibited dramatically improved photocatalytic activity and photostability towards the degradation of methylene blue dye and tetracycline antibiotic. BiMoO/PPy-80 sample achieved the highest photocatalytic degradation rates for methylene blue dye (93. Read More

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Cross-domain associations between mathematical and narrative abilities in preschool-aged children.

J Exp Child Psychol 2021 Jul 19;212:105233. Epub 2021 Jul 19.

Crane Center for Early Childhood Research and Policy, The Ohio State University, Columbus, OH 43201, USA.

Both mathematical and narrative abilities are considered critical dimensions of children's kindergarten readiness skills and are emphasized in developmental standards and readiness assessments during the prekindergarten period. Yet, despite considerable opportunities available to educators to leverage potential cross-domain associations in their instruction, little is known about how component math skills are associated with narrative skills. The current study extends prior theoretical and empirical work on cross-domain associations by examining the extent to which component math skills, constituting a kindergarten readiness assessment battery, are associated with narrative comprehension skills in children aged 4-6 years. Read More

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Two newly isolated GVI lineage infectious bronchitis viruses in China show unique molecular and pathogenicity characteristics.

Infect Genet Evol 2021 Jul 19:105006. Epub 2021 Jul 19.

Key Laboratory of Animal Epidemiology of the Ministry of Agriculture, College of Veterinary Medicine, China Agricultural University, Beijing 100193, China. Electronic address:

During 2016 to 2020, GVI-1 type infectious bronchitis virus (IBV) strains were sporadically reported across China, indicating a new epidemic trend of the virus. Here we investigated the molecular characteristics and pathogenicity of two newly isolated GVI-1 type IBV virus strains (CK/CH/TJ1904 and CK/CH/NP2011) from infected chicken farms in China. Genetic evolution analysis of the S1 gene showed the highest homology with the GVI-1 representative strain, TC07-2. Read More

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Genome-wide DNA arrays profiling unravels the genetic structure of Iranian sheep and pattern of admixture with worldwide coarse-wool sheep breeds.

Genomics 2021 Jul 19. Epub 2021 Jul 19.

Department of Animal Science, Faculty of Agriculture, Shahid Bahonar University of Kerman, PB 76169-133 Kerman, Iran. Electronic address:

Archaeological and genetic evidence show that sheep were originally domesticated in area around the North of Zagros mountains, North-west of Iran. The Persian plateau exhibits a variety of native sheep breeds with a common characteristic of coarse-wool production. Therefore, knowledge about the genetic structure and diversity of Iranian sheep and genetic connections with other sheep breeds is of great interest. Read More

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Pregnancy influences the selection of appropriate reference genes in mouse tissue: Determination of appropriate reference genes for quantitative reverse transcription PCR studies in tissues from the female mouse reproductive axis.

Gene 2021 Jul 19:145855. Epub 2021 Jul 19.

University of Westminster, School of Life Sciences, 115 New Cavendish Street, London, W1W 6UW, United Kingdom. Electronic address:

Selecting stably expressed reference genes which are not affected by physiological or pathophysiological conditions is crucial for reliable quantification in gene expression studies. This study examined the expression stability of a panel of twelve reference genes in tissues from the female mouse reproductive axis and the uterus. Gene expression studies were carried out using reverse transcriptase quantitative polymerase chain reaction (RT-qPCR). Read More

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Molecular cloning and biochemical characterization of a new coumarin glycosyltransferase CtUGT1 from Cistanche tubulosa.

Fitoterapia 2021 Jul 19:104995. Epub 2021 Jul 19.

Modern Research Center for Traditional Chinese Medicine, School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100029, People's Republic of China. Electronic address:

UDP-glycosyltransferases (UGTs) are an important and functionally diverse family of enzymes involved in secondary metabolite biosynthesis. Coumarin is one of the most common skeletons of natural products with candidate pharmacological activities. However, to date, many reported GTs from plants mainly recognized flavonoids as sugar acceptors. Read More

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Promising potential of boron compounds against Glioblastoma: In Vitro antioxidant, anti-inflammatory and anticancer studies.

Neurochem Int 2021 Jul 19;149:105137. Epub 2021 Jul 19.

Centre for Host-Microbiome Interactions, Faculty of Dentistry, Oral & Craniofacial Sciences, King's College London, London, SE1 9RT, UK; Science for Life Laboratory, KTH - Royal Institute of Technology, Stockholm, SE-17121, Sweden. Electronic address:

Glioblastoma (GB) is the most common and aggressive primary malignant astrocytoma correlated with poor patient survival. There are no curative treatments for GB, and it becomes resistant to chemotherapy, radiation therapy, and immunotherapy. Resistance in GB cells is closely related to their states of redox imbalance, and the role of reactive oxygen species and its impact on cancer cell survival is still far from elucidation. Read More

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Spatiotemporal variations, health risks, pollution status and possible sources of dissolved trace metal(loid)s in the Karasu River, Turkey.

Environ Res 2021 Jul 19:111733. Epub 2021 Jul 19.

East Mediterranean Transitional Zone Agricultural Research of Institute, Kahramanmaraş, Turkey.

The Karasu River is the main tributary of the Euphrates River, which is the longest river in Southwest Asia. Domestic and industrial wastewater discharges, agricultural practices and mining activities in the basin can cause potential toxic metal pollution in the Karasu River. However, very little is known about the levels of dissolved trace metal(loid)s (TMs) in the river. Read More

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In-depth bioinformatic study of the cadherin 5 interactome in patients with thoracic aortic aneurysm unveils 8 novel biomarkers.

Eur J Cardiothorac Surg 2021 Jul 19. Epub 2021 Jul 19.

Department of Surgery and Cancer, Imperial College London, St Mary's Hospital, London, UK.

Objectives: Thoracic aortic aneurysm (TAA) is characterized by the dilation of the aorta and is associated with poor prognosis if not diagnosed and treated early. In this context, the identification of biomarkers regarding the TAA diagnosis, monitoring and prognosis is crucial. The purpose of the current study was to investigate the differential gene expression profile of the cadherin 5 (CDH5 or VE-Cadherin) gene network in patients with TAA, to propose novel biomarkers. Read More

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Association between ANGPTL3, 4, and 8 and lipid and glucose metabolism markers in patients with diabetes.

PLoS One 2021 22;16(7):e0255147. Epub 2021 Jul 22.

Department of Endocrinology and Metabolism, Yokohama City University School of Medicine, Yokohama, Japan.

Lipid management, especially with respect to triglyceride (TG) metabolism, in patients with diabetes is not sufficient with current therapeutic agents, and new approaches for improvement are needed. Members of the angiopoietin-like protein (ANGPTL) family, specifically ANGPTL3, 4, and 8, have been reported as factors that inhibit lipoprotein lipase (LPL) activity and affect TGs. The present study investigated the association between lipid and glucose metabolism markers and the mechanism by which these proteins affect lipid metabolism. Read More

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Association between antenatal corticosteroid use and perinatal mortality among preterm births in hospitals in Tanzania.

PLoS One 2021 22;16(7):e0254916. Epub 2021 Jul 22.

Owerko Centre at the Alberta Children's Hospital Research Institute and Departments of Pediatrics and Community Health Sciences, University of Calgary, Calgary, Canada.

Objectives: The primary aims of this study were to investigate if exposure to antenatal corticosteroids (ACS) was associated with lower rates of perinatal mortality (primary outcome) and other adverse perinatal outcomes (i.e., stillbirth, early neonatal mortality, APGAR score of < 7 at 5 mins, neonatal sepsis and respiratory distress syndrome) in preterm infants in hospitals in Tanzania. Read More

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Association of GSTP1 Ile105Val polymorphism with the risk of coronary heart disease: An updated meta-analysis.

PLoS One 2021 22;16(7):e0254738. Epub 2021 Jul 22.

Department of Disinfection and Pest Control, Wuhan Centers for Disease Prevention and Control, Wuhan, Hubei, China.

Background: Numerous case-control studies have investigated the association between GSTP1 Ile105Val polymorphism and CHD risk, but the results from published studies were inconclusive. The present meta-analysis was performed to derive a more precise estimation.

Methods: PubMed, EMBASE, and Web of Science database searches were conducted to retrieve relevant articles. Read More

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An association analysis between hypertension, dementia, and depression and the phases of pre-sarcopenia to sarcopenia: A cross-sectional analysis.

PLoS One 2021 22;16(7):e0252784. Epub 2021 Jul 22.

Center for Community-Based Healthcare Research and Education (CoHRE), Shimane University, Shimane, Japan.

Sarcopenia is intricately related to aging associated diseases, such as neuropsychiatric disorders, oral status, and chronic diseases. Dementia and depression are interconnected and also related to sarcopenia. The preliminary shift from robust to sarcopenia (i. Read More

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Fact-Checking of Health Information: The Effect of Media Literacy, Metacognition and Health Information Exposure.

J Health Commun 2021 Jul 22:1-10. Epub 2021 Jul 22.

Department of Educational Psychology, College of Education, Washington State University, Pullman, Washington, USA.

With the rampant circulation of health information, concerns for the information quality are growing. Thereby, scholars are calling for media literacy as an educative means to cultivate fact-checking behavior among information consumers. Focusing on the critical role of metacognition for education effectiveness, this study examined the underlying mechanism that is conducive to the success of media literacy in the context of health information consumption. Read More

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Septic Arthritis of the Acromioclavicular Joint: A Single-Center, 11-Year Retrospective Review.

Orthopedics 2021 Jul-Aug;44(4):e493-e497. Epub 2021 Jul 1.

Septic arthritis of the smaller acromioclavicular joint is uncommon, with only a few reports and case series available in the literature. The aim of this outcomes analysis was to determine the prevalence of shoulder girdle septic arthritis within the authors' institution, with a particular focus on describing the authors' experience with acromioclavicular joint septic arthritis. A retrospective outcomes analysis was conducted of patients admitted to a single tertiary referral center from 2008 to 2018 with acromioclavicular joint septic arthritis. Read More

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Confronting behaviour in palliative care: a qualitative study of the lived experience of nursing staff.

Int J Palliat Nurs 2021 Jul;27(5):245-253

Professor of Psycho-oncology, Olivia Newton-John Cancer Wellness and Research Centre, Melbourne, Australia; School of Psychology and Public Health, La Trobe University, Melbourne, Australia.

Background: Little research examines the extent and impact of aggressive or uncomfortable 'confronting behaviour' experienced by palliative care nurses, despite palliative wards being an emotionally labile environment.

Methods: Qualitative data on nurses' experiences of confrontation were collected from 17 palliative care nurses at a major metropolitan hospital via a focus group and individual interviews. Data were analysed using inductive thematic analysis. Read More

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Inverse Hydrogen-Bonding Change Between the Protonated Retinal Schiff Base and Water Molecules upon Photoisomerization in Heliorhodopsin 48C12.

J Phys Chem B 2021 Jul 22. Epub 2021 Jul 22.

Department of Life Science and Applied Chemistry, Nagoya Institute of Technology, Showa-ku, Nagoya 466-8555, Japan.

Heliorhodopsin (HeR) is a new class of the rhodopsin family discovered in 2018 through functional metagenomic analysis (named 48C12). Similar to typical microbial rhodopsins, HeR possesses seven transmembrane (TM) α-helices and an all--retinal covalently bonded to the lysine residue on TM7 via a protonated Schiff base. Remarkably, the HeR membrane topology is inverted compared with that of typical microbial rhodopsins. Read More

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Association of dexmedetomidine with recovery room and hospital discharge times: a retrospective cohort analysis.

Paediatr Anaesth 2021 Jul 22. Epub 2021 Jul 22.

Department of Anesthesiology, Pharmacology & Therapeutics, University of British Columbia, Vancouver, BC, Canada.

Background: Dexmedetomidine is a useful anesthetic adjunct, increasingly popular during pediatric surgery and procedural sedation. Its half-life of 2-3 hours might prolong recovery and discharge times when compared with an un-supplemented propofol anesthetic. This may create an additional burden in a busy post-anesthetic care unit (PACU). Read More

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