2,613 results match your criteria analysis ill-defined

Clinical triage of patients on kidney replacement therapy presenting with COVID-19: an ERACODA registry analysis.

Nephrol Dial Transplant 2021 Jun 15. Epub 2021 Jun 15.

Department Internal Medicine, Division of Nephrology, Maastricht University Medical Center, Maastricht, The Netherlands.

Rationale & Objective: Patients on kidney replacement therapy (KRT) are at a very high risk of COVID-19. Triage pathway for KRT patients presenting with varying severity of COVID-19 illness remains ill-defined. We studied clinical characteristics of patients at initial and subsequent hospital presentations and its impact on patient outcomes. Read More

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Identification of macrophage related gene in colorectal cancer patients and their functional roles.

BMC Med Genomics 2021 Jun 13;14(1):159. Epub 2021 Jun 13.

Engineering Research Center for Medicine, Harbin University of Commerce, Harbin, 150076, China.

Background: Recent scientific research has enabled the identification of macrophages related-genes (MaRG), which play a key role in the control of the immune microenvironment in many human cancers. However, the functional role of MaRGs in human tumors is ill-defined. Herein, we aimed at bioinformatically exploring the molecular signatures of MaRGs in colorectal cancer. Read More

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Physiological Characteristics and Comparative Secretome Analysis of Grown on Glucose, Rice Straw, Sawdust, Wheat Grain, and MIX Substrates.

Front Microbiol 2021 25;12:636344. Epub 2021 May 25.

Institute of Vegetable, Wuhan Academy of Agricultural Sciences, Wuhan, China.

Morels ( sp.) are economically important edible macro-fungi, which can grow on various synthetic or semi-synthetic media. However, the complex nutritional metabolism and requirements of these fungi remain ill-defined. Read More

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Human immune system adaptations to simulated microgravity revealed by single-cell mass cytometry.

Sci Rep 2021 Jun 7;11(1):11872. Epub 2021 Jun 7.

Department of Anesthesiology, Perioperative, and Pain Medicine, Stanford University School of Medicine, 300 Pasteur Dr. Rm S238, Grant Bldg, Stanford, CA, 94305, USA.

Exposure to microgravity (µG) during space flights produces a state of immunosuppression, leading to increased viral shedding, which could interfere with long term missions. However, the cellular mechanisms that underlie the immunosuppressive effects of µG are ill-defined. A deep understanding of human immune adaptations to µG is a necessary first step to design data-driven interventions aimed at preserving astronauts' immune defense during short- and long-term spaceflights. Read More

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Spectral decomposition of iron-sulfur clusters.

Anal Biochem 2021 Jun 2:114269. Epub 2021 Jun 2.

Department of Chemistry, University of Alberta, 11227 Saskatchewan Drive, Edmonton AB T6G 2G2, Canada. Electronic address:

The near universal availability of UV-Visible spectrophotometers makes this instrument a highly exploited tool for the inexpensive, rapid examination of iron-sulfur clusters. Yet, the analysis of iron-sulfur cluster reconstitution experiments by UV-Vis spectroscopy is notoriously difficult due to the presence of broad, ill-defined peaks. Other types of spectroscopies, such as electron paramagnetic resonance spectroscopy and Mössbauer spectroscopy, are superior in characterizing the type of cluster present and their associated electronic transitions but require expensive, less readily available equipment. Read More

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Arterial Spin Labeling MRI for Predicting Microvascular Invasion of T1 Staging Renal Clear Cell Carcinoma Preoperatively.

Front Oncol 2021 18;11:644975. Epub 2021 May 18.

Department of Radiology, West China Hospital, Sichuan University, Chengdu, China.

Background: Microvascular invasion (MVI) is a valuable factor for T1 staging renal clear cell carcinoma (ccRCC) operation strategy decision, which is confirmed histopathologically post-operation. This study aimed to prospectively evaluate the performance of arterial spin labeling (ASL) MRI for predicting MVI of T1 staging ccRCC preoperatively.

Methods: 16 volunteers and 39 consecutive patients were enrolled. Read More

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Influenza Virus-Induced Novel miRNAs Regulate the STAT Pathway.

Viruses 2021 May 23;13(6). Epub 2021 May 23.

Allergy and Clinical Immunology Branch, Health Effects Laboratory Division, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA.

MicroRNAs (miRNAs) are essential regulators of gene expression in humans and can control pathogenesis and host-virus interactions. Notably, the role of specific host miRNAs during influenza virus infections are still ill-defined. The central goal of this study was to identify novel miRNAs and their target genes in response to influenza virus infections in airway epithelium. Read More

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Defining Telepresence as Experienced in Telehealth Encounters: A Dimensional Analysis.

J Nurs Scholarsh 2021 May 31. Epub 2021 May 31.

Upsilon, Associate Professor & Director, Florence S. Downs PhD Program in Nursing Research & Theory Development, Rory Meyers College of Nursing, and Research Associate Professor, Department of General Internal Medicine, Grossman School of Medicine, New York University, New York, NY, USA.

Purpose: Telehealth's uptake has increased substantially in recent years, with an especially large jump in 2020 due to the emergence of COVID-19. This article provides background on and explores "telepresence" in healthcare literature. Telepresence strongly impacts the patient experience, but it is poorly defined in current research. Read More

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Mobile Apps to Improve Medication Adherence in Cardiovascular Disease: Systematic Review and Meta-analysis.

J Med Internet Res 2021 May 25;23(5):e24190. Epub 2021 May 25.

Institute of Clinical Sciences, University of Birmingham, Birmingham, United Kingdom.

Background: Adherence rates of preventative medication for cardiovascular disease (CVD) have been reported as 57%, and approximately 9% of all CVD events in Europe are attributable to poor medication adherence. Mobile health technologies, particularly mobile apps, have the potential to improve medication adherence and clinical outcomes.

Objective: The objective of this study is to assess the effects of mobile health care apps on medication adherence and health-related outcomes in patients with CVD. Read More

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Morphologic Spectrum of Lymphadenopathy in Adult-onset Immunodeficiency (Anti-interferon-γ Autoantibodies).

Am J Surg Pathol 2021 May 20. Epub 2021 May 20.

Departments of Pathology Infectious Disease, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan Department of Pathology and Laboratory Medicine, Taichung Veterans General Hospital School of Medicine, Chung Shan Medical University, Taichung Department of Pathology, National Taiwan University Hospital, Taipei Department of Pathology, Ditmanson Medical Foundation Chia-Yi Christian Hospital, Chiayi Department of Pathology, E-DA Hospital, I-Shou University Department of Pathology, Kaohsiung Medical University Hospital Department of Pathology, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan Babina Diagnostics, Imphal, Manipur, India Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX.

Adult-onset immunodeficiency syndrome (AOIS) caused by anti-interferon-γ autoantibodies is an emerging disease. Affected patients present typically with systemic lymphadenopathy, fatigue, and fever. We studied 36 biopsy specimens, 31 lymph nodes, and 5 extranodal sites, of AOIS confirmed by serum autoantibody or QuantiFERON-TB Gold In-Tube assay. Read More

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Different approaches to the analysis of causes of death during the COVID-19 epidemic.

Eur Rev Med Pharmacol Sci 2021 May;25(9):3610-3613

Epidemiological Department, Azienda Zero, Veneto Region, Italy.

Objective: The aim of the study is to assess the impact of the COVID-19 pandemic on causes of mortality through multiple methodological approaches.

Materials And Methods: The causes of mortality in the Veneto region (Italy) during the first epidemic wave, March-April 2020, were compared with the corresponding months of the previous two years. Both the underlying cause of death (UCOD), and all diseases reported in the death certificate (multiple causes of death) were investigated; a further analysis was carried out through a simulation where the UCOD was selected after substituting ICD-10 codes for COVID with unspecified pneumonia. Read More

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Harmonizing Formula Prescription Patterns in Patients With Chronic Kidney Disease: A Population-Based Cross-Sectional Study.

Front Pharmacol 2021 29;12:573145. Epub 2021 Apr 29.

Division of Nephrology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.

Harmonizing formulas are associated with beneficial renal outcomes in chronic kidney disease (CKD), but the therapeutic mechanisms are unclear. The study aims to explore the associations of intentions and independent factors with harmonizing formulas prescriptions for patients with CKD. We conducted a population-based cross-sectional study to explore factors associated with harmonizing formulas prescription. Read More

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New Spin on LIGO-Virgo Binary Black Holes.

Phys Rev Lett 2021 Apr;126(17):171103

TAPIR, California Institute of Technology, Pasadena, California 91125, USA.

Gravitational waves from binary black holes have the potential to yield information on both of the intrinsic parameters that characterize the compact objects: their masses and spins. While the component masses are usually resolvable, the component spins have proven difficult to measure. This limitation stems in great part from our choice to inquire about the spins of the most and least massive objects in each binary, a question that becomes ill defined when the masses are equal. Read More

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Bioinformatics-Based Analysis of the lncRNA-miRNA-mRNA Network and TF Regulatory Network to Explore the Regulation Mechanism in Spinal Cord Ischemia/Reperfusion Injury.

Front Genet 2021 27;12:650180. Epub 2021 Apr 27.

Department of Anesthesiology, The First Hospital of China Medical University, Shenyang, China.

Background: Spinal cord ischemia/reperfusion injury (SCII) is a catastrophic complication involved with cardiovascular, spine, and thoracic surgeries and can lead to paraplegia. Nevertheless, the molecular mechanism of SCII remain ill-defined.

Methods: Expression profiling (GSE138966) data were obtained from GEO database. Read More

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The gene: An appraisal.

Keith Baverstock

Prog Biophys Mol Biol 2021 May 9. Epub 2021 May 9.

Department of Environmental and Biological Sciences, University of Eastern Finland, Kuopio Campus, Kuopio, Finland. Electronic address:

The gene can be described as the foundational concept of modern biology. As such, it has spilled over into daily discourse, yet it is acknowledged among biologists to be ill-defined. Here, following a short history of the gene, I analyse critically its role in inheritance, evolution, development, and morphogenesis. Read More

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Assessment of Magnet status and Textbook Outcomes among medicare beneficiaries undergoing hepato-pancreatic surgery for cancer.

J Surg Oncol 2021 May 7. Epub 2021 May 7.

Department of Surgery, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA.

Background: The relationship between hospital Magnet status recognition and postoperative outcomes following complex cancer surgery remains ill-defined. We sought to characterize Textbook Outcome (TO) rates among patients undergoing (HP) surgery for cancer in Magnet versus non-Magnet centers.

Methods: Medicare beneficiaries undergoing HP surgery between 2015 and 2017 were identified. Read More

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Mitral Surgery after Transcatheter Edge-to-Edge Repair: Society of Thoracic Surgeons Database Analysis.

J Am Coll Cardiol 2021 Apr 27. Epub 2021 Apr 27.

Department of Cardiovascular Surgery, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Background: Transcatheter edge-to-edge (TEER) mitral repair may be complicated by residual or recurrent mitral regurgitation. Increasing need for surgical reintervention has been reported but operative outcomes are ill-defined.

Objectives: This study evaluated national outcomes of mitral surgery after TEER. Read More

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CT Simplified Radiomic Approach to Assess the Metastatic Ductal Adenocarcinoma of the Pancreas.

Cancers (Basel) 2021 Apr 13;13(8). Epub 2021 Apr 13.

Unit of General and Pancreatic Surgery, The Pancreas Institute, Policlinico GB Rossi, University of Verona, 37129 Verona, Italy.

The aim of this study was to perform a simplified radiomic analysis of pancreatic ductal adenocarcinoma based on qualitative and quantitative tumor features and to compare the results between metastatic and non-metastatic patients. A search of our radiological, surgical, and pathological databases identified 1218 patients with a newly diagnosed pancreatic ductal adenocarcinoma who were referred to our Institution between January 2014 and December 2018. Computed Tomography (CT) examinations were reviewed analyzing qualitative and quantitative features. Read More

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CT for lymph node staging of Colon cancer: not only size but also location and number of lymph node count.

Abdom Radiol (NY) 2021 Apr 27. Epub 2021 Apr 27.

Department of Radiology, Netherlands Cancer Institute, Amsterdam, The Netherlands.

Purpose: To evaluate the diagnostic accuracy of imaging features to predict lymph node status of colon cancer using CT.

Methods: This was a retrospective study from 2 tertiary hospitals in South Korea and Netherlands. 317 Colon cancer patients who underwent primary surgical treatment were included. Read More

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Investigating genetic drivers of juvenile dermatomyositis pathogenesis using bioinformatics methods.

J Dermatol 2021 Apr 23. Epub 2021 Apr 23.

Department of Rheumatology, The Affiliated Huaian No. 1 People's Hospital of Nanjing Medical University, Huaian, China.

Juvenile dermatomyositis (JDM) is a chronic autoimmune disease. The pathogenic mechanisms remain ill-defined. The purpose of this study was to identify key genes related to JDM. Read More

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Recent Trends in Cardiovascular Mortality in Rio de Janeiro State Health Regions and Capital.

Arq Bras Cardiol 2021 04;116(4):763-771

Universidade Federal Fluminense - Departamento de Medicina Clínica, Niterói, RJ - Brasil.

Background: Cardiovascular disease (CVD) mortality, after several decades of decrease, has shown a tendency towards the stabilization in some countries, including Brazil and Rio de Janeiro state. This new tendency was not further analyzed by gender, age group and region of the Rio de Janeiro state.

Objective: To analyze the trends of premature and late mortality from CVD, ischemic heart disease (IHD) and cerebrovascular disease (CBVD) by gender in the city of Rio de Janeiro (capital) and the health regions of Rio de Janeiro state (from 1996 to 2016. Read More

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Profound dysregulation of T cell homeostasisand function in patients with severe COVID-19.

Allergy 2021 Apr 21. Epub 2021 Apr 21.

Department of Immunology, University Hospital Zurich (USZ), Zurich, Switzerland.

Background: Coronavirus disease 2019 (COVID-19) is caused by infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and shows a broad clinical presentation ranging from asymptomatic infection to fatal disease. A very prominentfeature associated with severe COVID-19 is T cell lymphopenia. However, homeostatic and functional properties of T cells are ill-defined in COVID-19. Read More

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Assessment of morphological CT imaging features for the prediction of risk stratification, mutations, and prognosis of gastrointestinal stromal tumors.

Eur Radiol 2021 Apr 21. Epub 2021 Apr 21.

Department of Biomedicine, Neuroscience and Advanced Diagnostics (BiND), University of Palermo, Via del Vespro 129, 90127, Palermo, Italy.

Objectives: To investigate the correlation between CT imaging features and risk stratification of gastrointestinal stromal tumors (GISTs), prediction of mutation status, and prognosis.

Methods: This retrospective dual-institution study included patients with pathologically proven GISTs meeting the following criteria: (i) preoperative contrast-enhanced CT performed between 2008 and 2019; (ii) no treatments before imaging; (iii) available pathological analysis. Tumor risk stratification was determined according to the National Institutes of Health (NIH) 2008 criteria. Read More

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Predictive effect of salt intake on patient and kidney survival in non-dialysis CKD: competing risk analysis in older versus younger patients under nephrology care.

Nephrol Dial Transplant 2020 Dec 1. Epub 2020 Dec 1.

Nefrology Unit, University of Campania "Luigi Vanvitelli", Naples, Italy.

Background: The optimal level of salt intake remains ill-defined in non-dialysis chronic kidney disease (CKD) patients under regular nephrology care. This unanswered question becomes critical in older patients who are exposed to higher risk of worsening of cardiorenal disease due to volemic changes.

Methods: In this pooled analysis of four prospective studies in CKD, we compared the risk of all-cause mortality and end-stage kidney disease (ESKD) between patients ≤65 and >65 years of age stratified by salt intake level (<6, 6-8 and >8 g/day) estimated from two measurements of 24-h urinary sodium. Read More

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December 2020

How Can We Differentiate Local Recurrence From Heterotopic Ossification After Resection and Implantation of an Oncologic Knee Prosthesis in Patients with a Bone Sarcoma?

Clin Orthop Relat Res 2021 05;479(5):1134-1143

K. Jamshidi, A. Bagherifard, A. Mirzaei, Bone and Joint Reconstruction Research Center, Shafa Orthopedic Hospital, Iran University of Medical Sciences, Tehran, Iran.

Background: Heterotopic ossification (HO) is common after total joint arthroplasty and usually does not cause diagnostic problems. However, the occurrence of HO after oncologic prostheses implantation can be troublesome as it may mimic a locally recurrent tumor. Because this distinction could have a profound impact on the surgeon and patient, it is important to distinguish the two entities; to our knowledge, no study has evaluated this after oncologic endoprosthetic reconstruction around the knee after tumor resection. Read More

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Effects of interleukin-1 antagonism and corticosteroids on fibroblast growth factor-21 in patients with metabolic syndrome.

Sci Rep 2021 Apr 12;11(1):7911. Epub 2021 Apr 12.

Division of Endocrinology, Diabetes, and Metabolism, University Hospital Basel, Basel, Switzerland.

Fibroblast growth factor-21 (FGF21) is elevated in patients with the metabolic syndrome. Although the exact underlying mechanisms remain ill-defined, chronic low-grade inflammation with increased Interleukin-(IL)-1β expression may be responsible. The aim of this study was to investigate effects of two different anti-inflammatory treatments (IL-1 antagonism or high-dose corticosteroids) on FGF21 in patients with the metabolic syndrome. Read More

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Utility of multiparametric pre-operative magnetic resonance imaging in differentiation of chordoid meningioma from the other histopathological subtypes of meningioma-a retrospective study.

Neuroradiology 2021 Apr 10. Epub 2021 Apr 10.

Department of Neuropathology, National Institute of Mental Health and Neurosciences, Bengaluru, Karnataka, 560029, India.

Purpose: To determine the magnetic resonance imaging (MRI) features which could pre-operatively differentiate chordoid meningioma (CM) from other histopathological subtypes of meningioma.

Methods: Retrospective analysis of pre-operative MRI of cases with histopathologically confirmed diagnosis of meningioma during the last 5 years at our institute was done. T1W, T2W, FLAIR sequences, and post-contrast enhancement were evaluated on a qualitative scale. Read More

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Prevalence of thyroid carcinoma in nodules with thy 3 cytology: the role of preoperative ultrasonography and strain elastography.

Thyroid Res 2021 Apr 9;14(1). Epub 2021 Apr 9.

European University Cyprus, 6 Diogenes Street, Engomi, 2404, Nicosia, Cyprus.

Background: Fine needle aspiration (FNA) cytology, the gold standard in assessing thyroid nodules, is limited by its inability to determine the true risk of malignancy in Thy 3 nodules. Most patients with Thy3 cytology undergo surgery to establish a histologic diagnosis. The aims of this study were to evaluate the prevalence of malignancy in Thy3 nodules, to examine the ultrasound (US) characteristics that are associated with a high cancer risk and to assess the role of real-time strain elastography. Read More

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Value of Contrast-Enhanced Ultrasound in the Differential Diagnosis of Focal Splenic Lesions.

Cancer Manag Res 2021 1;13:2947-2958. Epub 2021 Apr 1.

Laboratory of Ultrasound Imaging, West China Hospital of Sichuan University, Chengdu, Sichuan, People's Republic of China.

Purpose: To identify and validate contrast-enhanced ultrasound (CEUS) features for differentiating malignant from benign splenic lesions.

Patients And Methods: Splenic lesions in 123 patients who underwent conventional ultrasound (B-mode US) and CEUS were included in this study. Two radiologists evaluated the sonograms of B-mode and CEUS. Read More

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Brainstem phaeohyphomycosis due to Curvularia lunata (Cochliobolus lunatus) in a cat.

Aust Vet J 2021 Apr 8. Epub 2021 Apr 8.

Diagnostic Laboratory, School of Veterinary Medicine, Aristotle University of Thessaloniki, Thessaloniki, 546 27, Greece.

A 13-year-old female neutered domestic short-hair cat was presented with chronic progressive vestibular ataxia, lethargy and anorexia. Clinical examination revealed bilateral mucopurulent nasal discharge. Neurological examination revealed obtundation, a right head tilt, ambulatory tetraparesis, generalised vestibular ataxia, decreased postural reactions in all limbs, right Horner's syndrome, spontaneous conjugate jerk rotatory nystagmus and right positional ventral strabismus. Read More

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