36,441 results match your criteria analysis highlighted

Pyrolysis of de-oiled yeast biomass of Rhodotorula mucilaginosa IIPL32: Kinetics and thermodynamic parameters using thermogravimetric analysis.

Bioresour Technol 2021 Jul 22;340:125534. Epub 2021 Jul 22.

Material Resource Efficiency Division (MRED), CSIR-Indian Institute of Petroleum, Mohkampur Haridwar Road, Dehradun 248005, Uttarakhand, India; Academy of Scientific and Innovative Research (AcSIR), CSIR-HRDC Campus, Sector 19 Kamla Nagar, Ghaziabad 210002, India. Electronic address:

The increasing demand for natural resources has highlighted the need to search for unutilized carbon resource that satisfy the demand and pose a minor threat to the environment. Yeast is a microbe with large industrial applications, and the biomass leftover after fermentation needs utilization for achieving increased efficiency. De-oiled yeast biomass (DYB), the residue after yeast lipid extraction, has not yet been evaluated for its potential application in the pyrolysis process. Read More

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Reproducibility challenges in the search for antibacterial compounds from nature.

PLoS One 2021 29;16(7):e0255437. Epub 2021 Jul 29.

Institute of Pharmacy and Food Chemistry, University of Wuerzburg, Wuerzburg, Germany.

Background: Reproducibility of reported antibacterial activities of plant extracts has long remained questionable. Although plant-related factors should be well considered in serious pharmacognostic research, they are often not addressed in many research papers. Here we highlight the challenges in reproducing antibacterial activities of plant extracts. Read More

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Unravelling the genetic causes of multiple malformation syndromes: A whole exome sequencing study of the Cypriot population.

PLoS One 2021 29;16(7):e0253562. Epub 2021 Jul 29.

Department of Cytogenetics and Genomics, The Cyprus Institute of Neurology and Genetics, Nicosia, Cyprus.

Multiple malformation syndromes (MMS) belong to a group of genetic disorders characterised by neurodevelopmental anomalies and congenital malformations. Here we explore for the first time the genetic aetiology of MMS using whole-exome sequencing (WES) in undiagnosed patients from the Greek-Cypriot population after prior extensive diagnostics workup including karyotype and array-CGH. A total of 100 individuals (37 affected), from 32 families were recruited and family-based WES was applied to detect causative single-nucleotide variants (SNVs) and indels. Read More

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Predicting the catalytic activity of azolium-based halogen bond donors: an experimentally-verified theoretical study.

Org Biomol Chem 2021 Jul 29. Epub 2021 Jul 29.

Institute of Chemistry, Saint Petersburg State University, Universitetskaya Nab. 7/9, Saint Petersburg, 199034, Russian Federation.

This report demonstrates the successful application of electrostatic surface potential distribution analysis for evaluating the relative catalytic activity of a series of azolium-based halogen bond donors. A strong correlation (R2 > 0.97) was observed between the positive electrostatic potential of the σ-hole on the halogen atom and the Gibbs free energy of activation of the model reactions (i. Read More

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Predicting biochar cation exchange capacity using Fourier transform infrared spectroscopy combined with partial least square regression.

Sci Total Environ 2021 Jun 29;794:148762. Epub 2021 Jun 29.

Department of Soil Science, School of Agricultural Sciences, Federal University of Lavras, Lavras, Minas Gerais 37200-900, Brazil.

Determination of cation exchange capacity (CEC) in biochar by applying traditional wet methods is laborious, time-consuming, and generates chemical wastes. In this study, models were developed based on partial least square regression (PLSR) to predict CECs of biochars produced from a wide variety of feedstocks using Fourier transform infrared spectroscopy (FTIR). PLSR models used to predict CEC of biochars on weight (CEC-W) and carbon (CEC-C) basis were obtained from twenty-four biochars derived from several origins of feedstock, as well as compositions and mixtures, including four reference biochar samples. Read More

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Microplastics in the environment: Sampling, pretreatment, analysis and occurrence based on current and newly-exploited chromatographic approaches.

Sci Total Environ 2021 Jun 29;794:148725. Epub 2021 Jun 29.

Laboratory of Environmental Pollution Control, Department of Chemistry, Aristotle University of Thessaloniki, GR-541 24 Thessaloniki, Greece; Center for Interdisciplinary Research and Innovation (CIRI-AUTH), Balkan Center, Thessaloniki GR-57001, Greece. Electronic address:

The omnipresent character of microplastics (MPs) in environmental matrices, organisms and products has recently posed the need of their qualitative as well as quantitative analysis imperative, in order to provide data about their abundance and specification of polymer types in several substrates. In this framework, current and emerging approaches based on the chromatographic separation are of increased relevance in the field of MPs analysis and possess a large number of merits, since most of them are applicable in various complex matrices, sensitive and ideal for the detection of small-sized particles, whereas the common absence of any special pre-treatment step before analysis should also be highlighted. Αnalytical pyrolysis coupled with gas chromatography mass spectrometry (GC-MS) has recently gained ground as a powerful means to deliver information on MPs composition and degradation after their release into environment. Read More

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Development of a gene signature associated with iron metabolism in lung adenocarcinoma.

Bioengineered 2021 Dec;12(1):4556-4568

Department of Thoracic and Cardiovascular Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, P. R. China.

There are few studies on the role of iron metabolism genes in predicting the prognosis of lung adenocarcinoma (LUAD). Therefore, our research aims to screen key genes and to establish a prognostic signature that can predict the overall survival rate of lung adenocarcinoma patients. RNA-Seq data and corresponding clinical materials of 594 adenocarcinoma patients from The Cancer Genome Atlas(TCGA) were downloaded. Read More

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December 2021

Professionals' understanding of their responsibilities in the collaboration with family caregivers of older persons with mental health problems in Norway.

Health Soc Care Community 2021 Jul 29. Epub 2021 Jul 29.

Faculty of Health and Social Sciences, Western Norway University of Applied Sciences, Førde, Norway.

Research has highlighted the importance of health and social care professionals' collaboration with family caregivers. In the field of mental healthcare, involvement of family members is perceived as beneficial to the recovery process of the care recipient. Furthermore, family care-giving is an essential part of elderly care. Read More

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Current Evidence for the Effectiveness of Psychosocial Interventions for Children Undergoing Medical Procedures.

Child Care Health Dev 2021 Jul 28. Epub 2021 Jul 28.

Stanford Children's Health, Lucile Packard Children's Hospital Stanford, Palo Alto, CA.

Background: Because more than three million children are hospitalized every year in the United States, psychosocial and emotional impacts of hospitalization on children cannot be overlooked. As such, a variety of psychosocial support services are offered in pediatric facilities to reduce the negative effects often associated with hospitalization. This review examines current evidence for the effectiveness of common psychosocial interventions for children and youth undergoing medical procedures. Read More

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Real world evidence in effectiveness, safety, and cost savings of generic levothyroxine: a systematic review.

Endocrine 2021 Jul 28. Epub 2021 Jul 28.

Auburn University Harrison School of Pharmacy, Auburn, AL, 36849, USA.

Purpose: Generic levothyroxine, approved through Abbreviated New Drug Application (ANDA), is available for generic substitution. But ANDA does not require nonclinical or clinical data to establish safety and efficacy. Post-marketing evidence in generic equivalence for marketed levothyroxine products is limited. Read More

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A novel multi-stage distributed authentication scheme for smart meter communication.

PeerJ Comput Sci 2021 15;7:e643. Epub 2021 Jul 15.

School of IT, Centre for Cyber Security Research and Innovation (CSRI), Deakin University, Geelong, VIC, Australia.

Smart meters have ensured effective end-user energy consumption data management and helping the power companies towards network operation efficiency. However, recent studies highlighted that cyber adversaries may launch attacks on smart meters that can cause data availability, integrity, and confidentiality issues both at the consumer side or at a network operator's end. Therefore, research on smart meter data security has been attributed as one of the top priorities to ensure the safety and reliability of the critical energy system infrastructure. Read More

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Sociodemographic and psychosocial correlates of substance abuse among street children: A cross-sectional survey in the streets of Kolkata, West Bengal.

J Family Med Prim Care 2021 Jun 2;10(6):2259-2264. Epub 2021 Jul 2.

Department of Community Medicine, College of Medicine and JNM Hospital, West Bengal University of Health Sciences, Kolkata, West Bengal, India.

Context: India is now witnessing steady increase of substance abuse in younger age group. Street life is a major reason in addition to curiosity, unawareness of harm, migration, peer pressure.

Aims: To assess the prevalence, pattern and related factors of substance use and stress among the street living children. Read More

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Shared Decision Making in Primary Care Based Depression Treatment: Communication and Decision-Making Preferences Among an Underserved Patient Population.

Front Psychiatry 2021 12;12:681165. Epub 2021 Jul 12.

College of Public Health, Temple University, Philadelphia, PA, United States.

Although depression is a significant public health issue, many individuals experiencing depressive symptoms are not effectively linked to treatment by their primary care provider, with underserved populations have disproportionately lower rates of engagement in depression care. Shared decision making (SDM) is an evidence-based health communication framework that can improve collaboration and optimize treatment for patients, but there is much unknown about how to translate SDM into primary care depression treatment among underserved communities. This study seeks to explore patients' experiences of SDM, and articulate communication and decision-making preferences among an underserved patient population receiving depression treatment in an urban, safety net primary care clinic. Read More

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Copy number aberration analysis to predict response to neoadjuvant anti-HER2 therapy: results from the NeoALTTO phase III clinical trial.

Clin Cancer Res 2021 Jul 28. Epub 2021 Jul 28.

Breast Cancer Research Laboratory, Jules Bordet Institute

Purpose: The heterogeneity of response to anti-HER2 agents represents a major challenge in patients with HER2-positive breast cancer. To better understand the sensitivity and resistance to trastuzumab and lapatinib, we investigated the role of copy number aberrations (CNAs) in predicting pathological complete response (pCR) and survival outcomes in the NeoALTTO trial.

Experimental Design: The neoadjuvant phase III NeoALTTO trial enrolled 455 HER2-positive early-stage breast cancer patients. Read More

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Characterizing dedifferentiation of thyroid cancer by integrated analysis.

Sci Adv 2021 Jul 28;7(31). Epub 2021 Jul 28.

School of Life Sciences, Gwangju Institute of Science and Technology (GIST), Gwangju, Republic of Korea.

Understanding of dedifferentiation, an indicator of poo prognosis for patients with thyroid cancer, has been hampered by imprecise and incomplete characterization of its heterogeneity and its attributes. Using single-cell RNA sequencing, we explored the landscape of thyroid cancer at single-cell resolution with 46,205 cells and delineated its dedifferentiation process and suppressive immune microenvironment. The developmental trajectory indicated that anaplastic thyroid cancer (ATC) cells were derived from a small subset of papillary thyroid cancer (PTC) cells. Read More

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Experience of nutritional counselling in a nutritional programme in HIV care in the Tigray region of Ethiopia using the socio-ecological model.

J Health Popul Nutr 2021 Jul 28;40(1):34. Epub 2021 Jul 28.

School of Public Health, Mekelle University, Mekelle, Ethiopia.

Background: In many resource-poor settings, nutritional counselling is one of the key components of nutrition support programmes aiming to improve nutritional and health outcomes amongst people living with HIV. Counselling methods, contents and recommendations that are culturally appropriate, locally tailored and economically affordable are essential to ensure desired health and nutritional outcomes are achieved. However, there is little evidence showing the effectiveness of counselling in nutritional programmes in HIV care, and the extent to which counselling policies and guidelines are translated into practice and utilised by people with HIV suffering from undernutrition. Read More

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Distinct signatures of codon and codon pair usage in 32 primary tumor types in the novel database CancerCoCoPUTs for cancer-specific codon usage.

Genome Med 2021 Jul 28;13(1):122. Epub 2021 Jul 28.

Hemostasis Branch, Division of Plasma Protein Therapeutics, Office of Tissues and Advanced Therapies, Center for Biologics Evaluation & Research, US Food and Drug Administration, Silver Spring, MD, USA.

Background: Gene expression is highly variable across tissues of multi-cellular organisms, influencing the codon usage of the tissue-specific transcriptome. Cancer disrupts the gene expression pattern of healthy tissue resulting in altered codon usage preferences. The topic of codon usage changes as they relate to codon demand, and tRNA supply in cancer is of growing interest. Read More

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Mothers' quality of life delivering kangaroo mother care at Malawian hospitals: a qualitative study.

Health Qual Life Outcomes 2021 Jul 28;19(1):186. Epub 2021 Jul 28.

Department of Pediatrics and Child Health, College of Medicine, University of Malawi, Blantyre, Malawi.

Introduction: Kangaroo mother care is known to help save the lives of preterm and low birthweight infants, particularly in resource-limited health settings, yet barriers to implementation have been documented. Mothers and their families are very involved in the process of providing kangaroo mother care and the impact on their well-being has not been well explored. The objective of this research was to investigate the perspectives and experiences of a mother's quality of life while delivering facility-based kangaroo mother care. Read More

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Equity across the cancer care continuum for culturally and linguistically diverse migrants living in Australia: a scoping review.

Global Health 2021 Jul 28;17(1):87. Epub 2021 Jul 28.

Queensland University of Technology, 149 Victoria Park Road, QLD, 4059, Kelvin Grove, Australia.

International evidence suggests migrants experience inequitable access, outcomes and treatment quality across the cancer care continuum. There is currently limited research assessing equity across the cancer care continuum for culturally and linguistically diverse migrants living in Australia. A detailed protocol and search strategy were developed and used to identify all relevant literature, utilising the Joanna Briggs Institute Reviewer's Manual. Read More

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Health workers' perceptions on where and how to integrate tobacco use cessation services into tuberculosis treatment; a qualitative exploratory study in Uganda.

BMC Public Health 2021 Jul 28;21(1):1464. Epub 2021 Jul 28.

College of Public Health, East Tennessee State University, Johnson City, USA.

Background: Tobacco use is associated with exacerbation of tuberculosis (TB) and poor TB treatment outcomes. Integrating tobacco use cessation within TB treatment could improve healing among TB patients. The aim was to explore perceptions of health workers on where and how to integrate tobacco use cessation services into TB treatment programs in Uganda. Read More

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Bioconversion of Food Waste to produce Industrial-scale Sophorolipid Syrup and Crystals: dynamic Life Cycle Assessment (dLCA) of Emerging Biotechnologies.

Bioresour Technol 2021 Oct 27;337:125474. Epub 2021 Jun 27.

School of Energy and Environment, City University of Hong Kong, Kowloon, Hong Kong. Electronic address:

Bioconversion of food waste into sophorolipid-based biosurfactants is a promising emerging technology. It is important to evaluate the environmental impacts associated with the latest advancements in sophorolipid production as it matures to maximize sustainability on scale-up. This study takes a dynamic Life Cycle Assessment (dLCA) approach to address the inherent uncertainties and evaluate the environmental performances. Read More

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October 2021

Semliki Forest virus chimeras with functional replicase modules from related alphaviruses survive by adaptive mutations in functionally important hotspots.

J Virol 2021 Jul 28:JVI0097321. Epub 2021 Jul 28.

Institute of Technology, University of Tartu, Nooruse 1, 50411 Tartu, Estonia.

Alphaviruses (family ) include both human pathogens such as chikungunya virus (CHIKV) and Sindbis virus (SINV) and model viruses such as Semliki Forest virus (SFV). The alphavirus positive-strand RNA genome is translated into nonstructural (ns) polyprotein(s) that are precursors for four nonstructural proteins (nsPs). The three-dimensional structures of nsP2 and the N-terminal 2/3 of nsP3 reveal that these proteins consist of several domains. Read More

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Comparative transcriptomic analysis of ovaries from high and low egg-laying Lingyun black-bone chickens.

Vet Med Sci 2021 Jul 28. Epub 2021 Jul 28.

College of Animal Science and Technology, Guangxi University, Nanning Guangxi, P. R. China.

Egg-laying rate is mainly determined by ovarian function and regulated by the hypothalamic-pituitary-gonadal axis; however, the mechanism by which the ovary regulates the egg-laying rate is still poorly understood. The purpose of this study was to compare the differences in the transcriptomes of the ovary of Lingyun black-bone chickens with relatively high and low egg-laying rates and screen candidate genes related to the egg-laying rate. RNA-sequencing (RNA-Seq) was conducted to explore the chicken transcriptome from the ovarian tissue of six Lingyun black-bone chickens with high (group G, n = 3) and low (group D, n = 3) egg-laying rates. Read More

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Provider Perspectives on Barriers and Facilitators to Postpartum Care for Low-Income Individuals.

Womens Health Rep (New Rochelle) 2021 16;2(1):254-262. Epub 2021 Jul 16.

Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.

Recent paradigm shifts in postpartum care have conceptualized the "fourth trimester" as a critical transitional period requiring tailored, ongoing health care. However, this concept presents challenges for providers, especially in low-resource settings. Our objective was to understand providers' perspectives on challenges in postpartum care to highlight strategies for optimizing care. Read More

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Establishing a baseline of science communication skills in an undergraduate environmental science course.

Int J STEM Educ 2021 23;8(1):47. Epub 2021 Jul 23.

Department of Biological Sciences, College of Liberal Arts and Sciences, Northern Illinois University, 447 Montgomery Hall, DeKalb, IL 60115 USA.

Background: Seminal reports, based on recommendations by educators, scientists, and in collaboration with students, have called for undergraduate curricula to engage students in some of the same practices as scientists-one of which is communicating science with a general, non-scientific audience (SciComm). Unfortunately, very little research has focused on helping students develop these skills. An important early step in creating effective and efficient curricula is understanding what baseline skills students have prior to instruction. Read More

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Surgical Results of Selective Dorsal Rhizotomy for the Treatment of Spastic Cerebral Palsy.

J Pediatr Neurosci 2021 Jan-Mar;16(1):24-29. Epub 2021 Jun 25.

Division of Pediatric Neurosurgery, University of São Paulo, Ribeirão Preto, São Paulo, Brazil.

Background: Selective dorsal rhizotomy (SDR) is one of the surgical alternatives for treating spasticity, especially in children with spastic diplegia secondary to cerebral palsy (CP). It is becoming increasingly used, and the results of this operation need to be further highlighted.

Aim: The main objective of this article was to present the results of such surgical procedure in a cohort of a specialized center, with a particular focus on a quantitative analysis (goniometry). Read More

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Recent Advances in (Bio)Chemical Sensors for Food Safety and Quality Based on Silver Nanomaterials.

Food Technol Biotechnol 2021 Jun;59(2):216-237

Faculty of Chemical Engineering and Technology, University of Zagreb, Marulićev trg 19, 10000 Zagreb, Croatia.

There is a continuing need for tools and devices which can simplify, quicken and reduce the cost of analyses of food safety and quality. Chemical sensors and biosensors are increasingly being developed for this purpose, reaping from the opportunities provided by nanotechnology. Due to the distinct electrical and optical properties of silver nanoparticles (AgNPs), this material plays a vital role in (bio)sensor development. Read More

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Insulin signaling, androgen receptor and PSMA immunohistochemical analysis by semi-automated tissue microarray in prostate cancer with diabetes (DIAMOND study).

Transl Res 2021 Jul 24. Epub 2021 Jul 24.

Urology Section, Department of Surgery, University of Catania, Catania, Italy. Electronic address:

In the last years, many studies have highlighted the hypothesis that diabetes and hyperglycemia could be relevant for prostate cancer (PC) development and progression. We aimed to identify the prognostic value of tissue expression of androgen receptor (AR), Prostate-Specific Membrane Antigen (PSMA), Ki-67, insulin receptors (IR)  α and β, insulin growth factor-1 (IGF-1) receptor, in patients with PC and to evaluate their association with diabetes. We retrospectively collected data from 360 patients who underwent radical prostatectomy for PC or surgery for benign prostatic hyperplasia (BPH), between 2010 and 2020. Read More

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Baseline serum hepatitis B core antibody level predicts HBeAg seroconversion in patients with HBeAg-positive chronic hepatitis B after antiviral treatment.

Antiviral Res 2021 Jul 24:105146. Epub 2021 Jul 24.

Department of Infectious Diseases, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, Jiangsu, China. Electronic address:

Antibody to hepatitis B core antigen (anti-HBc) is one of the most classical serological markers of HBV infection. This study aimed to investigate the association of serum anti-HBc and HBeAg seroconversion in patients with HBeAg-positive chronic hepatitis B (CHB) after antiviral treatment. Two hundred and seventeen HBeAg-positive CHB patients treated with entecavir (ETV) or tenofovir disoproxil fumarate (TDF) for 48 weeks were retrospectively enrolled. Read More

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Comparative transcriptome analysis of unripe and ripe banana (cv. Nendran) unraveling genes involved in ripening and other related processes.

PLoS One 2021 27;16(7):e0254709. Epub 2021 Jul 27.

Department of Biotechnology, Plant Tissue Culture and Genetic Engineering Lab, National Agri-Food Biotechnology Institute (NABI), Ministry of Science and Technology (Government of India), Mohali, Punjab, India.

Banana is one of the most important fruit crops consumed globally owing to its high nutritional value. Previously, we demonstrated that the ripe pulp of the banana cultivar (cv.) Nendran (AAB) contained a high amount of pro-vitamin A carotenoids. Read More

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