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Effect of Posterior Tibial Slope Change on Postoperative Range of Motion and Clinical Outcomes after Posterior Cruciate-Substituting Total Knee Arthroplasty.

J Knee Surg 2021 May 15. Epub 2021 May 15.

Department of Orthopedic Surgery, Seoul National University Hospital, Seoul, Korea (the Republic of).

The posterior tibial slope (PTS) is usually adjusted by less than 5 degrees, without considering its individual difference, during posterior cruciate-substituting (PS) total knee arthroplasty (TKA). The effect of these individual changes of PTS would be important because clinical results depending on postoperative PTS were reported conflictingly. We investigated the effect of the change in PTS on the postoperative range of motion (ROM) and clinical scores after PS TKA. Read More

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Impact of Preoperative Opioid Use on Patient-Reported Outcomes after Revision Total Knee Arthroplasty: A Propensity Matched Analysis.

J Knee Surg 2021 May 15. Epub 2021 May 15.

Department of Orthopaedic Surgery, Bioengineering Laboratory, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.

This is a retrospective study. Prior studies have characterized the deleterious effects of narcotic use in patients undergoing primary total knee arthroplasty (TKA). While there is an increasing revision arthroplasty burden, data on the effect of narcotic use in the revision surgery setting remain limited. Read More

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Bimanual Coordination in a Whole-Body Dynamic Balance Sport, Slacklining: A Comparison of Novice and Expert.

Motor Control 2021 May 13:1-13. Epub 2021 May 13.

Waseda University.

As previous studies have suggested that bimanual coordination is important for slacklining, the authors questioned whether this important skill plays a role in the performance of a fundamental task of slacklining. To address this question, the authors compared single-leg standing on the slackline between novices and experts in terms of bimanual coordination dynamics within a dynamical systems framework using relative phase and recurrence quantification analysis measures. Five novices and five experts participated in the experiment. Read More

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Restoring Walking Complexity in Older Adults Through Arm-in-Arm Walking: Were Almurad et al.'s (2018) Results an Artifact?

Motor Control 2021 May 13:1-16. Epub 2021 May 13.

University of Montpellier.

The analysis of stride series revealed a loss of complexity in older people, which correlated with the falling propensity. A recent experiment evidenced an increase of walking complexity in older participants when they walked in close synchrony with a younger companion. Moreover, a prolonged experience of such synchronized walking yielded a persistent restoration of complexity. Read More

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How Common Is the Exponential Decay Pattern of Motor Skill Acquisition? A Brief Investigation.

Motor Control 2021 May 13:1-11. Epub 2021 May 13.

University of Utah.

Motor performance is classically described as improving nonlinearly with practice, demonstrating rapid improvements early in practice with stabilization later, which is commonly modeled by exponential decay functions. However, retrospective analyses of our previously collected data challenge this theoretical model of motor skill acquisition, suggesting that a majority of individual learners actually demonstrate patterns of motor improvement different from this classical model. A convenience sample of young adults, older adults, and people with Parkinson disease trained on the same functional upper-extremity task. Read More

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Co-treatment of electroplating sludge, copper slag, and spent cathode carbon for recovering and solidifying heavy metals.

J Hazard Mater 2021 May 5;417:126020. Epub 2021 May 5.

Engineering Research Center of Metallurgical Energy Conservation and Emission Reduction, Ministry of Education, Kunming University of Science and Technology, Kunming, China; National Local Joint Engineering Research Center of Energy Saving and Environmental Protection Technology in Metallurgy and Chemical Engineering Industry, Kunming University of Science and Technology, Kunming, China; State Key Laboratory of Complex Nonferrous Metal Resources Clean Utilization, Kunming University of Science and Technology, Kunming, China; Faculty of Metallurgical and Energy Engineering, Kunming University of Science and Technology, Kunming, China.

Electroplating sludge, a hazardous solid waste product of the electroplating industry, presents a serious environmental pollution risk. In this study, an environmentally friendly process for solidifying and recovering heavy metals from electroplating sludge using copper slag and spent cathode carbon is proposed. Combining the results of toxicity characteristic leaching procedure tests, thermodynamic analysis, chemical analysis, X-ray diffraction analysis, and electron probe microanalysis, the Cr, Ni, Cu, Fe, and F transformation mechanisms were first probed during vitrification. Read More

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2D confinement freestanding graphene oxide composite membranes with enriched oxygen vacancies for enhanced organic contaminants removal via peroxymonosulfate activation.

J Hazard Mater 2021 May 8;417:126028. Epub 2021 May 8.

Institute of Green Chemistry and Chemical Technology, Advanced Chemical Engineering Laboratory of Green Materials and Energy of Jiangsu Province, School of Chemistry and Chemical Engineering, Jiangsu University, Zhenjiang 212013, China. Electronic address:

Introducing membrane filtration into advanced oxidation processes to decrease energy and cost consumption has been considered as a promising direction in environmental remediation. In this work, we firstly developed a kind of novel lawn-like FeO@CoFe@nitrogen-doped reduced graphene oxide@carbon nanotube composites (FeCo@GCTs) through in-situ pyrolysis of self-assembly of Prussian blue analogues and GO, followed through a vacuum-assisted filtration strategy to fabricate 2D confinement freestanding GO composite membrane. Electrochemical analysis and H-TPR revealed the superiority of FeCo@GCTs as ideal electron acceptor, and this unique lawn-like structure concentrated active sites with a confined space and enriched oxygen vacancies that realized 98. Read More

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Production of medium-chain fatty acid caproate from Chinese liquor distillers' grain using pit mud as the fermentation microbes.

J Hazard Mater 2021 May 5;417:126037. Epub 2021 May 5.

Co-Innovation Center of Efficient Processing and Utilization of Forestry Resources, College of Materials Science and Engineering, Nanjing Forestry University, Nanjing, Jiangsu 210037, China; Higher Institution Centre of Excellence (HICoE), Institute of Tropical Aquaculture and Fisheries (AKUATROP), Universiti Malaysia Terengganu, 21030 Kuala Nerus, Terengganu, Malaysia; Henan Province Engineering Research Center for Biomass Value-added Products, School of Forestry, Henan Agricultural University, Zhengzhou 450002, China. Electronic address:

Chinese liquor distillers' grain (CLDG) is an abundant industrial organic waste showing high potential as feedstock for biofuel conversion. In this study, CLDG was used as substrate by microbial community in pit mud to produce medium-chain fatty acids (especially caproate). Simulated and real fermentation were used to evaluate the effect of ethanol and lactic acid being the electronic donors (EDs) during the anaerobic chain elongation (CE). Read More

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Zein based-nanoparticles loaded botanical pesticides in pest control: An enzyme stimuli-responsive approach aiming sustainable agriculture.

J Hazard Mater 2021 May 7;417:126004. Epub 2021 May 7.

Laboratory of Bioactivity Assessment and Toxicology of Nanomaterials (LABiToN), University of Sorocaba (UNISO), Sorocaba, São Paulo 18023-000, Brazil. Electronic address:

Nanoencapsulation of biopesticides is an important strategy to increase the efficiency of these compounds, reducing losses and adverse effects on non-target organisms. This study describes the preparation and characterisation of zein nanoparticles containing the botanical compounds limonene and carvacrol, responsive to proteolytic enzymes present in the insects guts. The spherical nanoparticles, prepared by the anti-solvent precipitation method, presented in the nanoparticle tracking analysis (NTA) a concentration of 4. Read More

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Assessment of the Cytoprotective Effects of High-Dose Valproic Acid Compared to a Clinically Used Lower Dose.

J Surg Res 2021 May 11;266:125-141. Epub 2021 May 11.

Department of Surgery, University of Michigan Health System, Ann Arbor, Michigan; Department of Surgery, Feinberg School of Medicine/Northwestern University, Chicago, Illinois. Electronic address:

Objective: Valproic acid (VPA) treatment improves survival in animal models of injuries on doses higher than those allowed by Food and Drug Administration (FDA). We investigated the proteomic alterations induced by a single high-dose (140mg/kg) of VPA (VPA140) compared to the FDA-approved dose of 30mg/kg (VPA30) in healthy humans. We also describe the proteomic and transcriptomic changes induced by VPA140 in an injured patient. Read More

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Trait dissociation as a predictor of induced dissociation by ketamine or esketamine in treatment-resistant depression: Secondary analysis from a randomized controlled trial.

J Psychiatr Res 2021 May 8;138:576-583. Epub 2021 May 8.

Laboratório de Neuropsicofarmacologia, Serviço de Psiquiatria do Hospital Universitário Professor Edgard Santos, Universidade Federal da Bahia, Salvador, Brazil; Programa de Pós-Graduação em Medicina e Saúde, Faculdade de Medicina da Bahia, Universidade Federal da Bahia, Salvador, Brazil; Departamento de Neurociências e Saúde Mental, Faculdade de Medicina da Bahia, Universidade Federal da Bahia, Salvador, Brazil. Electronic address:

Dissociative symptoms are common, possibly severe, side effects associated with the use of ketamine and esketamine in depression. We investigated the relationship between trait dissociation and dissociation induced by ketamine and esketamine used as augmentation therapy in treatment-resistant depression (TRD). Adults with TRD were randomly assigned to receive a single intravenous infusion, with a duration of 40 min, of either esketamine 0. Read More

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Impaired global efficiency in boys with conduct disorder and high callous unemotional traits.

J Psychiatr Res 2021 Apr 29;138:560-568. Epub 2021 Apr 29.

Medical Psychological Center, The Second Xiangya Hospital, Central South University, Changsha, China; National Clinical Research Center on Psychiatry and Psychology, Changsha, China; Medical Psychological Institute of Central South University, Changsha, China; National Clinical Research Center for Mental Disorders, Changsha, China. Electronic address:

Callous unemotional (CU) traits differentiate subtypes of conduct disorder (CD). It has been suggested that CU traits may be related to topographical irregularities that hinder information integration. To date, there is limited evidence of whether CU traits may be associated with abnormal brain topology. Read More

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Sodium fluoride causes oxidative damage to silkworm (Bombyx mori) testis by affecting the oxidative phosphorylation pathway.

Ecotoxicol Environ Saf 2021 May 11;218:112229. Epub 2021 May 11.

School of Biotechnology, Southwest University, Chongqing, China. Electronic address:

Bombyx mori was used to study the molecular mechanism of fluoride induced reproductive toxicity. In our previous study, we confirmed the physiological and biochemical effects of NaF on reproductive toxicity, and we found that the molecular mechanism of NaF induced reproductive damage may be associated with the oxidative phosphorylation pathway. To further study the function of NaF exposure on the oxidative phosphorylation pathway in the testis in Bombyx mori, and the relationship between oxidative phosphorylation and oxidative stress, we measured the changes in the main ROS (O and HO) in the testis, the activity of the main electron transport chain complex enzymes in the oxidative phosphorylation pathway and the transcription levels of the corresponding genes; we additionally performed pathological observations of the silkworm testis after exposure to 200 mg/L NaF solution for different times. Read More

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Can phthalates move into the eggs of the loggerhead sea turtle Caretta caretta? The case of the nests on the Linosa Island in the Mediterranean Sea.

Mar Pollut Bull 2021 May 12;168:112395. Epub 2021 May 12.

Dipartimento di Scienze e Tecnologie Biologiche, Chimiche e Farmaceutiche (STEBICEF), Università degli Studi di Palermo, 90100 Palermo, Italy. Electronic address:

During the monitoring of Caretta caretta nests on the island of Linosa, 30 unhatched eggs from four nests were collected to study the presence of phthalates in their three components (shell, yolk, and albumen). Four phthalates, namely diethyl (DEP), dibutyl (DBP), di-(2-ethylhexyl) (DEHP), and dioctyl (DOTP) phthalic acid esters (PAE), which are widely used as additives in plastics, were detected in all egg components. The most frequently found phthalate was DBP, followed by DEHP in eggshell and yolk. Read More

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Evidence of microplastic ingestion by cultured European sea bass (Dicentrarchus labrax).

Mar Pollut Bull 2021 May 12;168:112450. Epub 2021 May 12.

Marine Ecophysiology Group (EOMAR), Iu-ECOAQUA, Universidad de Las Palmas de Gran Canaria, 35017 Campus Universitario de Tafira, Canary Islands, Spain. Electronic address:

The presence of microplastics (MPs) in the marine environment is a concerning topic due to the ecotoxicological effects and possible seafood contamination. Data is needed to evaluate human exposure and assess risks, in the context of a healthy and beneficial seafood consumption. While microplastic ingestion by wild fish has been reported since the early 70's, farmed fish are rarely investigated. Read More

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Poaching of endangered species in Mediterranean Sea: Alopias vulpinus.

Mar Pollut Bull 2021 May 12;168:112456. Epub 2021 May 12.

Istituto Zooprofilattico Sperimentale della Puglia e della Basilicata, Centro di Referenza Nazionale Radioattività, via Manfredonia 20, 71121 Foggia, ITALY.

A thresher shark poached by fishermen in the stretch of sea between the island of Ponza and the coast of Terracina (Lazio, Central Italy, Mediterranean Sea) and confiscated by the Italian health authorities was evaluated for the presence of chemical contaminants. Hg mean concentration of 2.1 mg kg was found in muscle; speciation analysis confirmed it was almost in the toxic organic form of MeHg (2. Read More

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Marine litter: A review of educative interventions.

Mar Pollut Bull 2021 May 12;168:112446. Epub 2021 May 12.

Department of Science and Technology, Portuguese Distance Learning University, Lisbon, Portugal; CENSE - Center for Environmental and Sustainability Research, School of Science and Technology, NOVA University of Lisbon, Lisbon, Portugal.

Marine litter is claimed to be one of the most meaningful environmental crises of the century. Education that supports behavior change is a tool to tackle this problem. However, there is a lack of research linking educational initiatives and marine litter issues. Read More

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Dual-energy CT of the liver: True noncontrast vs. virtual noncontrast images derived from multiple phases for the diagnosis of fatty liver.

Eur J Radiol 2021 Apr 29;140:109741. Epub 2021 Apr 29.

Siemens Healthineers Ltd., 23 Chungjeong-ro, Seoul, 03737, Republic of Korea.

Purpose: To evaluate the difference in liver density and to compare the performance to diagnose fatty liver between true noncontrast (TNC) images and virtual noncontrast (VNC) images generated from dual-energy CT (DECT).

Materials And Methods: Patients who underwent liver dynamic DECT and MRI were included (n = 49). Two observers measured the liver and spleen densities on TNC images and three VNC images from the arterial, portal and delayed phases of DECT (VNCa, VNCp and VNCd, respectively). Read More

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Intraprocedural cone-beam CT with parenchymal blood volume assessment for transarterial chemoembolization guidance: Impact on the effectiveness of the individual TACE sessions compared to DSA guidance alone.

Eur J Radiol 2021 May 8;140:109768. Epub 2021 May 8.

Department of Diagnostic and Interventional Radiology, Eberhard Karls University, Hoppe-Seyler-Strasse 3, 72076, Tübingen, Germany. Electronic address:

Purpose: The objective of this retrospective single centre study was to evaluate the impact of intraprocedural cone-beam CT with parenchymal blood volume assessment (PBV-CBCT) for guidance of transarterial chemoembolization with drug-eluting beads (DEB-TACE) in HCC patients on the effectiveness (local tumour response, survival and number of individual TACE sessions) compared to guidance solely by digital subtraction angiography (DSA).

Method: n = 179 HCC patients (mean age, 77.4 y) undergoing DEB-TACE, with (n = 28) and without (n = 151) PBV-CBCT, using 100-300 μm microspheres loaded with epirubicin were retrospectively analysed. Read More

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The perception of training and professional development according to nursing students as health workers during COVID-19: A qualitative study.

Nurse Educ Pract 2021 May 3;53:103072. Epub 2021 May 3.

Department of Nursing and Physiotherapy, University of Lleida, 2 Montserrat Roig, St., 25198 Lleida, Spain; Health Care Research Group (GRECS), Biomedical Research Institute of Lleida, 80 Alcalde Rovira Roure, St., 25198 Lleida, Spain.

Aim: To explore the perception of education and professional development of final-year nursing students who carried out health relief tasks during the COVID-19 pandemic.

Background: The COVID-19 pandemic has led to a global health emergency. This situation has exacerbated the need for additional healthcare employees, forcing the Spanish government to incorporate volunteer nursing students as auxiliary health staff. Read More

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G-triplex: A new type of CRISPR-Cas12a reporter enabling highly sensitive nucleic acid detection.

Biosens Bioelectron 2021 May 9;187:113292. Epub 2021 May 9.

State Key Laboratory of Magnetic Resonance and Atomic Molecular Physics, Wuhan National Laboratory for Optoelectronics, National Centre for Magnetic Resonance in Wuhan, Wuhan Institute of Physics and Mathematics, Innovation Academy for Precision Measurement Science and Technology, Chinese Academy of Sciences - Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology, Wuhan, 430071, China; University of Chinese Academy of Sciences, Beijing, 10049, China. Electronic address:

CRISPR-Cas12a (Cpf1) trans-cleaves ssDNA and this feature has been widely harnessed for nucleic acid detection. Herein, we introduce a new type of Cas12a reporter, G-triplex (G3), and a highly sensitive biosensor termed G-CRISPR. We proved that Cas12a trans-cleaves G3 structures in about 10 min and G3 can serve as an excellent reporter based on the cleavage-induced high-order structure disruption. Read More

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The guidelines and policies that influence the conduct of Animal-Assisted Activities in Residential Aged-Care Facilities: A systematic integrative review.

Complement Ther Clin Pract 2021 May 3;44:101395. Epub 2021 May 3.

School of Health, Medical and Applied Science, Central Queensland University, Central Queensland University, 6 University Drive, Branyan Queensland, 4670, Australia. Electronic address:

Introduction: For some time, Residential Aged Care Facilities (RACF) have incorporated animals into their environment to relieve loneliness and isolation for aged-care residents. However, research examining this practice is not as developed. This paper aims to identify the policies and practices influencing the conduct of Animal-Assisted Activities (AAA) in RACF focusing on the Australian context. Read More

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Development of a new nano arginase HPLC capillary column for the fast screening of arginase inhibitors and evaluation of their binding affinity.

J Chromatogr B Analyt Technol Biomed Life Sci 2021 May 1;1175:122751. Epub 2021 May 1.

Univ Franche - Comté, F-25000 Besançon, France; EA481 Neurosciences Intégratives et Cliniques/Pôle Chimie Analytique Bioanalytique et Physique (PCABP), F-25000 Besançon, France; CHRU Besançon, Pôle Pharmaceutique, F-25000 Besançon, France. Electronic address:

A simple and rapid Nano LC method has been developed for the screening of arginase inhibitors. The method is based on the immobilization of biotinylated arginase on a neutravidin functionalized nano HPLC capillary column. The arginase immobilization step performed by frontal analysis is very fast and only takes a few minutes. Read More

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Simultaneous and rapid determination of 12 tyrosine kinase inhibitors by LC-MS/MS in human plasma: Application to therapeutic drug monitoring in patients with non-small cell lung cancer.

J Chromatogr B Analyt Technol Biomed Life Sci 2021 May 1;1175:122752. Epub 2021 May 1.

Department of Clinical Pharmacy, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200080, PR China. Electronic address:

In recent years, more than 50 tyrosine kinase inhibitors (TKIs) was indicated against numerous cancers, especially outstanding advantages in the treatment of non-small cell lung cancer (NSCLC), and several studies have shown that therapeutic drug monitoring (TDM) of TKIs can improve treatment efficacy and safety. The present study aimed to develop and validate a LC-MS/MS method for the TDM of 12 TKIs (gefitinib, erlotinib, afatinib, dacomitinib, icotinib, osimertinib, crizotinib, ceritinib, alectinib, dabrafenib, trametinib, anlotinib) in patients with NSCLC. The analytes of interest and internal standard were extracted from human plasma. Read More

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Optimisation of high-speed lipidome analysis by nanoflow ultrahigh-performance liquid chromatography-tandem mass spectrometry: Application to identify candidate biomarkers for four different cancers.

J Chromatogr B Analyt Technol Biomed Life Sci 2021 May 1;1175:122739. Epub 2021 May 1.

Department of Chemistry, Yonsei University, 50 Yonsei-ro, Seoul 03722, South Korea. Electronic address:

Lipid analysis is a powerful tool that can elucidate the pathogenic roles of lipids in metabolic diseases, and facilitate the development of potential biomarkers. Lipid analysis by large-scale lipidomics requires a high-speed and high-throughput analytical platform. In the present study, a high-speed analytical method for lipid analysis using nanoflow ultrahigh-performance liquid chromatography-electrospray ionisation-tandem mass spectrometry (nUHPLC-ESI-MS/MS) was optimised by investigating the effects of column flow rate, pump flow rate, dwell time, initial binary mobile phase composition, and gradient duration on the separation efficiency of standard lipid mixtures. Read More

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Multimorbidity patterns and their related characteristics in European older adults: A longitudinal perspective.

Arch Gerontol Geriatr 2021 May 4;95:104428. Epub 2021 May 4.

Research Group on Aging, Disability and Health, Girona Biomedical Research Institute (IDIBGI), Catalonia, Spain; Institut d'Assistència Sanitària, Catalonia, Spain; Department of Medical Sciences, School of Medicine, University of Girona, Catalonia, Spain.

Background: The concurrence of several chronic conditions is a rising concern that poses a serious burden on ageing populations. Analysing how these conditions appear together and how they change through time may provide useful information to design successful multimorbidity-management programs.

Objective: To identify multimorbidity patterns and their related characteristics from a longitudinal perspective. Read More

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Clinicopathological profile and its association with peritoneal disease among gastric cancer patients.

Surg Oncol 2021 May 5;38:101595. Epub 2021 May 5.

Department of Surgical Oncology, JIPMER, Puducherry, 6050006, India.

Background: There are no clinicopathological criteria or test to predict peritoneal metastasis either in primary or recurrent gastric cancer. The early prediction will help in altering or adding other adjuvant potential therapy modalities like HIPEC and maintenance chemotherapy.

Methods: Paraffin based blocks of 110 gastric tumor specimens were subjected to IHC staining to assess VEGF, Her 2 neu, E cadherin, bcl 2 and p 53 expression and its association with peritoneal disease evaluated. Read More

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Associations between malignancy and cardiovascular complications following emergency laparotomy - A retrospective cohort study.

Surg Oncol 2021 May 5;38:101591. Epub 2021 May 5.

Center for Surgical Science, Department of Surgery, Zealand University Hospital, Denmark; Department of Clinical Medicine, University of Copenhagen, Denmark.

Background: Systemic inflammation in patients with malignant disease has been associated with increased risk of cardiovascular events. The pro-inflammatory perturbations following surgical trauma may further promote adverse perioperative cardiovascular events and increase the risk of patients with cancer undergoing major surgery. Our objective was to estimate the association between malignant disease and postoperative cardiovascular complications. Read More

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Direct and indirect effects of fenoxycarb on freshwater systems dominated by Neocaridina palmata (Decapoda: Atyidae) and macrophyte Ceratophyllum demersum.

Ecotoxicol Environ Saf 2021 May 12;219:112304. Epub 2021 May 12.

Institute of Pesticide and Environmental Toxicology, Ministry of Agriculture Key Lab of Molecular Biology of Crop Pathogens and Insects, Zhejiang University, Hangzhou 310058, PR China.

Few studies have been conducted with regard to the effects of insecticides on population dynamics of shrimps and associated groups such as macrophytes, phytoplankton, microorganisms etc. In the present study, effects of a single application of fenoxycarb were tested using indoor freshwater systems dominated by Neocaridina palmata and Ceratophyllum demersum (Dicotyledons: Ceratophyllales). The no observed effect concentration (NOEC) and lowest observed effect concentration (LOEC) for the N. Read More

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