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Computer modelling of heat strain responses of exercising personnel in tropical climate.

Comput Biol Med 2021 May 29;134:104530. Epub 2021 May 29.

Department of Mechanical Engineering, National University of Singapore, 9 Engineering Drive 1, 117575, Singapore.

Physiologically based thermoregulatory models are useful for deriving predictions of heat strain for pragmatic applications such as planning of continuous exercise/work-rest protocols. The SCENARIO model is an example of a thermoregulatory model that predicts heat strain including body core temperature (Tc) from individual characteristics, physical activity, clothing properties and environmental conditions. This paper presents work to optimize and enhance the SCENARIO model for prediction of Tc during high intensity load carriage tasks under predominantly tropical climate conditions. Read More

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Automated detection of artefacts in neonatal EEG with residual neural networks.

Comput Methods Programs Biomed 2021 May 24;208:106194. Epub 2021 May 24.

Brain Modelling Group, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia; BaBA center, Department of Children's Clinical Neurophysiology, Children's hospital, HUS Medical Imaging center, Helsinki University Central Hospital and University of Helsinki, Finland. Electronic address:

Background And Objective: To develop a computational algorithm that detects and identifies different artefact types in neonatal electroencephalography (EEG) signals.

Methods: As part of a larger algorithm, we trained a Residual Deep Neural Network on expert human annotations of EEG recordings from 79 term infants recorded in a neonatal intensive care unit (112 h of 18-channel recording). The network was trained using 10 fold cross validation in Matlab. Read More

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Enhanced immune reconstitution of γδ T cells after allograft overcomes negative impact of pre-transplant MRD positive status in AML patients.: γδ T cells and MRD+ AML.

Transplant Cell Ther 2021 Jun 9. Epub 2021 Jun 9.

Department of Stem Cell Transplantation, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. Electronic address:

Background: Minimal residual disease (MRD) prior to allogeneic stem cell transplantation (allo-SCT) in AML is a poor risk factor for outcome. The γδ T cells represents a unique minority lymphocyte population which is preferentially located in peripheral tissues, can recognize antigens in non-MHC restricted manner and plays a "bridging" role between innate and adaptive immune system.

Objectives: In this study, we investigated a potential graft-vs-leukaemia effect of γδ T cells reconstitution post-transplant in AML patients with pre-transplant positive minimal/measurable disease status (MRD+). Read More

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Root cause determination of intraperitoneal catheter obstructions: Insulin amyloid aggregates vs foreign body reaction.

J Control Release 2021 Jun 9. Epub 2021 Jun 9.

Department of Pharmaceutical Sciences, University of Connecticut, 69 N Eagleville Road U3092, Storrs, CT 06269, USA. Electronic address:

Continuous intraperitoneal insulin infusion, from an implanted insulin pump connected to a catheter that delivers insulin directly to the peritoneal cavity has many clinical advantages for patients with Type 1 diabetes. However, the ongoing incidence of catheter obstructions remains a barrier to the widespread use of this therapy. To date, the root cause of these obstructions remains unknown. Read More

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Appendicular skeletal muscle mass and quality estimated by bioelectrical impedance analysis in the assessment of frailty syndrome risk in older individuals.

Aging Clin Exp Res 2021 Jun 12. Epub 2021 Jun 12.

Department of Biostructure, University School of Physical Education in Wroclaw, Al. I. J. Paderewskiego 35, 51-612, Wroclaw, Poland.

Background And Aim: The rising aging index of many populations necessitates the continuous evolution of geriatric assessment methods, especially the ones used to identify frailty and the risk of frailty. An appropriately early diagnosis of adverse changes in skeletal muscles can reduce the risk of functional limitations in elderly persons. The aim of this study was to assess the correlation between the appendicular skeletal muscle mass and quality, estimated by the bioelectrical impedance analysis method, and the risk of prevalence of the pre-frailty state in elderly persons. Read More

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Characterizing variations in dissolved organic matter (DOM) properties in Nansi Lake: a typical macrophytes-derived lake in northern China.

Environ Sci Pollut Res Int 2021 Jun 12. Epub 2021 Jun 12.

School of Environment and Planning, Liaocheng University, Road 1, Liaocheng, 252000, Hunan, China.

Nansi Lake is the largest lake along the eastern route of China's South-to-North Water Diversion Project (SNWDP). It is divided into the upper lake and the lower lake by a dam. By using UV-Vis spectroscopy, synchronous fluorescence (SF) spectroscopy, excitation-emission matrix and parallel factor analysis (EEM-PARAFAC), spatial, and temporal differences in the properties of dissolved organic matter (DOM) were found in the 2 areas of Nansi Lake under different hydrological conditions. Read More

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Sorption of Se(IV) from aqueous solution by wheat bran-hydroxyapatite (HA) composite.

Environ Sci Pollut Res Int 2021 Jun 12. Epub 2021 Jun 12.

College of Bioengineering, Henan University of Technology, Zhengzhou, 450001, China.

Natural biocompatible material is promising candidate for selenite sorption from water since it allows to reuse selenium while dispose of waste materials. In this study, innovative wheat bran-hydroxyapatite (HA) composite was prepared by in situ precipitation method. Scanning electronic microscopy (SEM) and X-ray diffraction (XRD) revealed that the hydroxyapatite aggregated in the fiber matrix of the wheat bran. Read More

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Prevalence, recent infection and predictors of HIV infection in fishing community along the shore of Lake Victoria in Tanzania.

J Public Health (Oxf) 2021 Jun 12. Epub 2021 Jun 12.

Tanzania Field Epidemiology and Laboratory Training Program, Dar es Salaam 9083, Tanzania.

Background: Fishing communities are a subpopulation burdened by human immunodeficiency virus (HIV), mainly due to their mobility and cash income access. Strategies to mitigate the spread of HIV in fishing communities have varying outcomes. We conducted a study to determine the prevalence of HIV, recent infection and associated factors among fishing communities at Lake Victoria in Tanzania. Read More

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Coronary revascularization in patients with chronic kidney disease and end-stage renal disease: a meta-analysis.

Int J Clin Pract 2021 Jun 12:e14506. Epub 2021 Jun 12.

Department of Cardiac Surgery, Peking University First Hospital, Beijing, China.

To compare coronary artery bypass grafting (CABG) and percutaneous coronary intervention (PCI) for revascularizing coronary arteries in patients with chronic kidney disease (CKD) and end-stage renal disease (ESRD). CKD is described as a continuous decrease in the glomerular filtration rate or abnormalities in kidney structure or function. PubMed, Cochrane Library, and Embase databases were searched for studies on the revascularization of coronary arteries in patients with CKD and ESRD. Read More

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Predoctoral substance use disorders curricula: A survey analysis and experiential pedagogy.

J Dent Educ 2021 Jun 11. Epub 2021 Jun 11.

New York State Psychiatric Institute, Columbia University, New York, New York.

Substance Use Disorders (SUD) are chronic health conditions with heritability characteristics, environmental influences, long-term management considerations and they cooccur. The US opioid epidemic is a crisis of both prescription and nonprescription opioid use. Clinicians now have access to evidence-based practices but the evolving trends require continuous attention including curriculum initiatives for dental schools. Read More

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Non-infectious uveitis affecting the posterior segment treated with fluocinolone acetonide intravitreal implant: 3-year fellow eye analysis.

Eye (Lond) 2021 Jun 11. Epub 2021 Jun 11.

Department of Ophthalmology, St. Franziskus Hospital Muenster, Muenster, Germany.

Background: Prevention of non-infectious uveitis of the posterior segment (NIU-PS) recurrence using 0.2 μg/day fluocinolone acetonide implant (FAi) was assessed over 3 years (NCT01694186). Outcomes for FAi-treated and fellow eyes with NIU-PS were compared, to evaluate FAi versus conventional treatment strategies. Read More

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Spectral collapse in anisotropic two-photon Rabi model.

Authors:
C F Lo

Sci Rep 2021 Jun 11;11(1):12401. Epub 2021 Jun 11.

Institute of Theoretical Physics and Department of Physics, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong.

In this communication, based upon a squeezed-state trial wave function, we have performed a simple variational study of the spectral collapse in the anisotropic two-photon Rabi model. Our analysis indicates that the light-matter interaction and the spin-flipping (together with the anisotropy) effectively constitute two competing impacts upon the radiation mode. Whilst the former tries to decrease the radiation mode frequency, the latter may counteract or reinforce it. Read More

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Long-term effect of apomorphine infusion in advanced Parkinson's disease: a real-life study.

NPJ Parkinsons Dis 2021 Jun 11;7(1):50. Epub 2021 Jun 11.

Neurology Department, Pitié-Salpêtrière Hospital, AP-HP, Paris, France.

Long-term effects of continuous subcutaneous apomorphine infusion (CSAI) on health-related quality of life (HRQoL) and predictors of CSAI discontinuation are poorly known. Data from consecutive advanced Parkinson's disease patients treated in routine care were retrospectively collected over 24 months after CSAI initiation, with a focus on the 39-item Parkinson's disease questionnaire (PDQ-39). We determined predictors of CSAI discontinuation and HRQoL improvement using multiple regression analysis. Read More

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Effect of Genetic Polymorphism of the CYP2D6 Gene on the Efficacy and Safety of Fluvoxamine in Major Depressive Disorder.

Am J Ther 2021 Jun 2. Epub 2021 Jun 2.

Moscow Research and Practical Centre on Addictions of the Moscow Department of Healthcare, Moscow, Russia; Russian Medical Academy of Continuous Professional Education of the Ministry of Health of the Russian Federation, Moscow, Russian Federation; I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University), Moscow, Russia; and NRC Institute of Immunology FMBA of Russia, Moscow, Russia.

Background: Previous studies have shown that cytochrome P450 2D6 (CYP2D6) is involved in the metabolism of fluvoxamine, the activity of which is highly dependent, inter alia, on the polymorphism of the gene encoding it. The objective of our study was to investigate the effect of 1846G>A polymorphism of the CYP2D6 gene on the efficacy and safety of fluvoxamine, using findings on CYP2D6 enzymatic activity and on CYP2D6 expression level in patients with depressive disorders comorbid with alcohol use disorder.

Study Question: Efficacy and safety of fluvoxamine depend on the polymorphism of CYP2D6 gene in patients with major depressive disorder. Read More

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The emotional experience of nurses in the Home Hospitalization Unit in palliative care: A qualitative exploratory study.

Enferm Clin (Engl Ed) 2021 Jun 8. Epub 2021 Jun 8.

Departamento de Psicología Evolutiva, Educativa, Social y Metodología, Universitat Jaume I, Castellón de la Plana, Castellón, Spain. Electronic address:

Objective: To explore the emotions experienced by the nurses of a Home Hospitalization Unitas a result of their work role.

Method: A qualitative exploratory study was carried out with a phenomenology approach toexplore people's experiences and inner-life experiences. The participants were 9 nurses workingin the home hospitalization unit. Read More

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Improving the experience of facility-based delivery for vulnerable women through obstetric care navigation: a qualitative evaluation.

BMC Pregnancy Childbirth 2021 Jun 11;21(1):425. Epub 2021 Jun 11.

Wuqu' Kawoq | Maya Health Alliance, 2da Avenida 3-48 Zona 3, Barrio Patacabaj, Tecpán, Chimaltenango, Guatemala.

Background: Global disparities in maternal mortality could be reduced by universal facility delivery. Yet, deficiencies in the quality of care prevent some mothers from seeking facility-based obstetric care. Obstetric care navigators (OCNs) are a new form of lay health workers that combine elements of continuous labor support and care navigation to promote obstetric referrals. Read More

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Obstructive sleep apnea prediction from electrocardiogram scalograms and spectrograms using convolutional neural networks.

Physiol Meas 2021 Jun 11. Epub 2021 Jun 11.

Biomedical Engineering, TOBB Ekonomi ve Teknoloji Universitesi, Sogutozu Cad. No:43, Cankaya, 06560, TURKEY.

Objective: In this study, we conducted a comparative analysis of deep convolutional neural network (CNN) models in predicting Obstructive Sleep Apnea (OSA) using electrocardiograms. Unlike other studies in the literature, this study automatically extracts time-frequency features by using CNNs instead of manual feature extraction from ECG recordings.

Approach: The proposed model generates scalogram and spectrogram representations by transforming preprocessed 30-sec ECG segments from time domain to the frequency domain using Continuous Wavelet Transform (CWT) and Short Time Fourier transform (STFT), respectively. Read More

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Navigating in the dark: Meta-synthesis of subjective experiences of gender dysphoria amongst transgender and gender non-conforming youth.

Soc Sci Med 2021 Jun 2;281:114094. Epub 2021 Jun 2.

University of Oslo, Department of Psychology, Norway. Electronic address:

Objective: We conducted a meta-synthesis of qualitative research on subjective experiences of gender dysphoria (GD) amongst transgender and gender non-conforming (TGNC) youth in order to improve clinical encounters, complement existing knowledge and potentially influence future research.

Methods: We systematically searched for qualitative studies on GD in English, German, Spanish and Scandinavian languages in seven databases. Starting with 2000 articles, we finally included 12 papers in the meta-synthesis, following Noblit and Hare's (1988) seven steps for qualitative meta-synthesis research. Read More

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Preparation of a novel monoclonal antibody against Avian leukosis virus subgroup J Gp85 protein and identification of its epitope.

Poult Sci 2021 Mar 12;100(7):101108. Epub 2021 Mar 12.

School of Animal Science, Yangtze University, Jingzhou 434025, China. Electronic address:

Avian leukosis virus subgroup J (ALV-J) is an avian oncogenic retrovirus that has caused huge economic losses in the poultry industry due to its great pathogenicity and transmission ability. However, the continuous emergence of new strains would bring challenges to diagnosis and control of ALV-J. . Read More

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Cassava starch-processing residue utilization for packaging development.

Int J Biol Macromol 2021 Jun 8. Epub 2021 Jun 8.

Laboratory of Packaging Technology and Membrane Development, LATEM, Department of Chemical Engineering, Universidade Federal do Rio Grande do Sul (UFRGS), Street Ramiro Barcellos, 2777 Anexo I, ZC: 90035-007 Porto Alegre, RS, Brazil.

The starch-based film development has been extensively studied since, in general, it is possible to obtain transparent, non-toxic, odorless, good gas barrier, biodegradable, and tasteless samples. However, world hunger-related problems are a reality and the use of starches, a recognized carbohydrate source, in the packaging industry should be avoided. Thus, the use of different residual starchy can minimize the costs of production, promoting the development of innovative biomaterials, eliminating the competition with the food chain. Read More

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Experiences with implementation of continuous positive airway pressure for neonates and infants in low-resource settings: A scoping review.

PLoS One 2021 11;16(6):e0252718. Epub 2021 Jun 11.

Vayu Global Health Foundation Boston, Boston, Massachusetts, United States of America.

Background: Continuous positive airway pressure (CPAP) is the gold standard of care in providing non-invasive positive pressure support to neonates in respiratory distress in high-resource settings. While safety has been demonstrated in low-resource settings, there is a lack of knowledge on the barriers and facilitators to proper implementation.

Objective: To identify and describe the barriers, facilitators, and priorities for future implementation of CPAP for neonates and infants in low-resource settings. Read More

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Inclusion of maintenance energy improves the intracellular flux predictions of CHO.

PLoS Comput Biol 2021 Jun 11;17(6):e1009022. Epub 2021 Jun 11.

Centro de Engenharia Biológica, Universidade do Minho, Braga, Portugal.

Chinese hamster ovary (CHO) cells are the leading platform for the production of biopharmaceuticals with human-like glycosylation. The standard practice for cell line generation relies on trial and error approaches such as adaptive evolution and high-throughput screening, which typically take several months. Metabolic modeling could aid in designing better producer cell lines and thus shorten development times. Read More

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Roxadustat for the treatment of anemia in patients with chronic kidney diseases: a meta-analysis.

Aging (Albany NY) 2021 Jun 11;13. Epub 2021 Jun 11.

Department of Thyroid Surgery, The First Hospital of Jilin University, Jilin Province, China.

Background: Anemia is a common complication of chronic kidney disease (CKD). Treating renal anemia with erythropoiesis-stimulating agents (ESAs) or erythropoietin analogs is effective but has side effects. Therefore, we performed a meta-analysis to assess the efficacy and safety of roxadustat in treating CKD-induced anemia. Read More

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Arterial Spin Labeling Reveals Elevated Cerebral Blood Flow with Distinct Clusters of Hypo- and Hyperperfusion after Traumatic Brain Injury.

J Neurotrauma 2021 Jun 10. Epub 2021 Jun 10.

The University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.

Imaging detection of brain perfusion alterations after traumatic brain injury (TBI) may provide prognostic insights. In this study, we used arterial spin labeling (ASL) to quantify cross-sectional and longitudinal changes in cerebral blood flow (CBF) after TBI and correlated changes with clinical outcome. We analyzed magnetic resonance imaging scans from adult participants with TBI requiring hospitalization in the acute (2 weeks post-injury,  = 33) and chronic (6 months post-injury,  = 16) phases, with 13 participants scanned longitudinally at both time points. Read More

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Limited added value of negative pressure wound therapy compared to calcium alginate dressings for second intention healing in a non-contaminated and contaminated equine distal limb wound model.

Equine Vet J 2021 Jun 11. Epub 2021 Jun 11.

Department of Surgery and Anaesthesiology of Domestic Animals, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820, Merelbeke, Belgium.

Background: Distal limb wounds in horses often show aberrant healing due to a slow inflammatory response. In human medicine, negative pressure wound therapy (NPWT) is used for treatment of chronic wounds with a similar inflammatory response.

Objectives: To compare the effect of NPWT to calcium alginate dressings on the healing of (non-) contaminated equine distal limb wounds. Read More

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Systematic review and meta-analyses of cholecystectomy as a treatment of biliary hyperkinesia.

Clin J Gastroenterol 2021 Jun 11. Epub 2021 Jun 11.

Consultant Upper GI Surgeon, North Cumbria University Hospitals NHS Trust, Carlisle, UK.

Biliary hyperkinesia is typically diagnosed in patients with biliary-like pain and no evidence of gall stones on imaging modalities but who have had biliary scintigraphy scan (HIDA) that shows ejection fraction ≥ 80%. This study aims to identify whether the removal of the gall bladder can alleviate the symptoms associated with biliary hyperkinesia. Systematic search following PRISMA guidelines was done from inception to January 2020 using PubMed/Medline, OVID, Embase, Cochrane database of systemic reviews, Cochrane central register of controlled trials, The Database of Abstracts of Reviews of Effects (DARE) and Cochrane library databases. Read More

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Acupuncture treatment for emotional problems in infertile women: A protocol for systematic review and meta-analysis.

Medicine (Baltimore) 2021 Jun;100(23):e26306

Department of Korean Medicine Obstetrics and Gynecology, Pusan National University Korean Medicine Hospital.

Background: Infertility causes emotional and psychological problems, including anxiety, depression, low self-efficacy, and chronic mental stress in women. These emotional problems can negatively affect fertility treatment. Numerous studies have reported the clinical therapeutic effects of acupuncture on emotional problems; however, the efficacy and safety of acupuncture treatment for emotional problems in infertile women remain unclear. Read More

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Shaofu Zhuyu decoction for primary dysmenorrhea: A protocol for systematic review and meta-analysis.

Medicine (Baltimore) 2021 Jun;100(23):e26226

College of Basic Medicine, Guizhou University of Traditional Chinese Medicine, Guiyang, Guizhou, China.

Background: Primary dysmenorrhea (PD), one of the common gynecological diseases, is more common in adolescent women. According to epidemiological investigation, the incidence of PD accounts for about 60% of all patients with dysmenorrhea, and its symptoms seriously affect the normal working life of women, so it is important to find a more safe and effective treatment. In recent years, traditional Chinese medicine has made a lot of achievements in the treatment of female PD, among which a number of clinical studies have shown that Shaofu Zhuyu decoction (SFZY) can significantly improve the symptoms of dysmenorrhea and improve the therapeutic effect. Read More

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Contactless Sleep Monitoring for Early Detection of Health Deteriorations in Community-Dwelling Older Adults: Exploratory Study.

JMIR Mhealth Uhealth 2021 Jun 11;9(6):e24666. Epub 2021 Jun 11.

Gerontechnology and Rehabilitation Group, ARTORG Center for Biomedical Engineering Research, University of Bern, Bern, Switzerland.

Background: Population aging is posing multiple social and economic challenges to society. One such challenge is the social and economic burden related to increased health care expenditure caused by early institutionalizations. The use of modern pervasive computing technology makes it possible to continuously monitor the health status of community-dwelling older adults at home. Read More

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