492,376 results match your criteria analysis approach

Biomarker-Based Determination of Equiseti herba Contamination by Equisetum palustre Using HPLC-MS/MS.

Planta Med 2021 Jul 22. Epub 2021 Jul 22.

Institute of Pharmaceutical Biology, Technische Universität Braunschweig, Braunschweig, Germany.

Equiseti herba has been traditionally indicated in bacterial diseases of the efferent urinary tract or bad healing wounds in many regions worldwide. Most of the plant material used for medical purposes comes from collections of wild growing plants. The European Pharmacopoeia requires that Equiseti herba should consist of a minimum of 95% and a maximum of 5% foreign ingredients. Read More

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Effect of Sustained Interventions from Infancy to Toddlerhood in Children with Cleft Lip and Palate for Preventing Early Childhood Caries.

Caries Res 2021 Jul 22:1-9. Epub 2021 Jul 22.

Department of Pediatric and Preventive Dentistry, Pushpagiri College of Dental Sciences, Thiruvalla, India.

The study aimed to evaluate the effectiveness of sustained interventions in children with cleft lip and palate (CLP) for preventing early childhood caries (ECC). This prospective, nonrandomized interventional cohort study was conducted in infants aged 0-12 months with congenital CLP. Interventions were given to parents/primary caregivers in the form of combined oral health-care measures (sterile wet gauze piece, finger brush, toothbrush, and toothpaste) by a motivational interviewing approach. Read More

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Deep neural network-based approach to improving radiomics analysis reproducibility in liver cancer: effect on image resampling.

Phys Med Biol 2021 Jul 22. Epub 2021 Jul 22.

Nuclear & Radiological Engineering and Medical Physics Programs, Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA, USA, Atlanta, Georgia, UNITED STATES.

Objectives: To test the effect of traditional up-sampling slice thickness (ST) methods on the reproducibility of CT radiomics features of liver tumors and investigate the improvement using a deep neural network (DNN) scheme.

Methods: CT images with ≤ 1 mm ST in the public dataset were converted to low resolution (3 mm, 5 mm) CT images. A DNN model was trained for the conversion from 3 mm-ST and 5 mm-ST to 1 mm-ST and compared with conventional interpolation-based methods (cubic, linear, nearest) using structural similarity (SSIM) and peak-signal-to-noise-ratio (PSNR). Read More

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Improvement of exhausted cerebral autoregulation in patients with idiopathic intracranial hypertension benefit of venous sinus stenting.

Physiol Meas 2021 Jul 22. Epub 2021 Jul 22.

Neurology, Beijing Tiantan Hospital, Beijing, CHINA.

Objective: Utilizing transfer function analysis to assess the cerebral autoregulation in patients with idiopathic intracranial hypertension (IIH), and to explore its improvement after venous sinus stenting.

Approach: In total, 15 consecutive IIH patients with venous sinus stenosis and 15 controls were recruited. All the patients underwent digital subtraction angiography and venous manometry. Read More

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Mapping groundwater-dependent ecosystems in arid Central Asia: Implications for controlling regional land degradation.

Sci Total Environ 2021 Jul 14;797:149027. Epub 2021 Jul 14.

Eurasia Institute of Earth Sciences, Istanbul Technical University, Maslak, Istanbul 34469, Turkey.

Groundwater-dependent ecosystems (GDEs) exist all over the world, especially in water-limited regions. To achieve better water management, it is necessary to map and identify GDEs. Central Asia (CA) is one of the most arid regions in the mid-latitudes and one of the major regions with shallow groundwater tables. Read More

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Evaluation of an inertial measurement unit-based approach for determining centre-of-mass movement during non-seated cycling.

J Biomech 2021 Apr 19;126:110441. Epub 2021 Apr 19.

Centre for Sensorimotor Performance School of Human Movement and Nutrition Sciences, The University of Queensland, St Lucia, Queensland, Australia.

Instantaneous crank power does not equal total joint power if a rider's centre of mass (CoM) gains and loses mechanical energy. Thus, estimating CoM motion and the associated energy changes can provide valuable information about the mechanics of cycling. To date, an accurate and precise method for tracking CoM motion during outdoor cycling has not been validated. Read More

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Hierarchical BiMoO microsphere photocatalysts modified with polypyrrole conjugated polymer for efficient decontamination of organic pollutants.

Chemosphere 2021 Jul 15;286(Pt 1):131541. Epub 2021 Jul 15.

College of Textiles & Clothing, Qingdao University, Qingdao, 266071, PR China; Collaborative Innovation Center for Eco-Textiles of Shandong Province, Qingdao, 266071, PR China.

To effectively degrade organic pollutants in wastewater, visible-light-driven BiMoO/PPy hierarchical heterogeneous photocatalysts were prepared through a solvothermal method and the following in-situ chemical oxidation polymerization. Compared with pristine BiMoO photocatalyst, the composite photocatalysts exhibited dramatically improved photocatalytic activity and photostability towards the degradation of methylene blue dye and tetracycline antibiotic. BiMoO/PPy-80 sample achieved the highest photocatalytic degradation rates for methylene blue dye (93. Read More

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Leveraging unsupervised image registration for discovery of landmark shape descriptor.

Med Image Anal 2021 Jul 9;73:102157. Epub 2021 Jul 9.

Scientific Computing and Imaging Institute, 72 Central Campus Dr, University of Utah, Salt Lake City, Utah-84112, USA; School of Computing, 50 Central Campus Dr, University of Utah, Salt Lake City, Utah-84112, USA.

In current biological and medical research, statistical shape modeling (SSM) provides an essential framework for the characterization of anatomy/morphology. Such analysis is often driven by the identification of a relatively small number of geometrically consistent features found across the samples of a population. These features can subsequently provide information about the population shape variation. Read More

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Teen reactions to a self-representational avatar: A qualitative exploration.

J Sport Health Sci 2021 Jul 19. Epub 2021 Jul 19.

United States Department of Agriculture Agricultural Research Center Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA. Electronic address:

Purpose: This research presents findings from a qualitative exploration of the reactions of adolescents (12-14 years old) to navigating an exergame with an avatar created from multiple scans of the player (referred to as a self-representational avatar).

Methods: Post-gameplay interviews were conducted with adolescents following participation in a 20-min laboratory session (21.2 ± 0. Read More

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Meta-computational techniques' for managing spare data: An application in off-pump heart surgery.

Comput Methods Programs Biomed 2021 Jul 5;208:106267. Epub 2021 Jul 5.

Department of Mathematics, College of Science Al-Zulfi, Majmaah University, PO Box 66, Al-Majmaah 11952, Saudi Arabia. Electronic address:

Background And Objectives: This research looked at the key considerations to remember when selecting a model for working with sparse data. In the presence of sparse evidence, it proposes ideal conditions for conducting meta-analysis.

Methods: Monte Carlo simulations were used to produce study results, and three forms of continuity correction were used in the research. Read More

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A More Universal Approach to Comprehensive Analysis of ThalaSsemia Alleles (CATSA).

J Mol Diagn 2021 Jul 19. Epub 2021 Jul 19.

Hunan Jiahui Genetics Hospital, Changsha, Hunan 410078, China; Center for Medical Genetics and Hunan Key Laboratory of Medical Genetics, School of Life Sciences, Central South University, Changsha, Hunan 410078, China. Electronic address:

The aim of the study was to assess the clinical utility of a third generation sequencing (TGS) approach termed Comprehensive Analysis of ThalaSsemia Alleles (CATSA) for identifying both alpha and beta thalassemia genetic carrier status. Prospective blood samples (n = 1759) with abnormal hemoglobin parameters were screened for pathogenic thalassemia variants by CATSA on the PacBio TGS platform. In 1159 individuals, a total of 1317 pathogenic thalassemia variants were identified and confirmed by independent PCR based tests. Read More

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An integrated approach to uncover anti-tumor active materials of Curcumae Rhizoma-Sparganii Rhizoma based on spectrum-effect relationship, molecular docking, and ADME evaluation.

J Ethnopharmacol 2021 Jul 19:114439. Epub 2021 Jul 19.

School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing, 102488, PR China; Beijing Key Laboratory for Quality Evaluation of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, 102488, PR China. Electronic address:

Ethnopharmacological Relevance: Curcumae Rhizoma-Sparganii Rhizoma (CR-SR), an ancient and classical herbal couple, has been extensively used for tumor treatment in clinic of traditional Chinese medicines (TCMs).

Aim Of The Study: The study aimed to uncover the anti-tumor active materials of CR-SR water decoction (CR:SR = 1:1) via an integrated approach of spectrum-effect relationship, molecular docking, and ADME evaluation.

Materials And Methods: The anti-tumor activities toward A549, HepG2, Hela, BGC-823, and MCF-7 cells of the different polar elution fractions (DPEFs) of CR, SR, and CR-SR were determined by Cell Counting Kit-8 (CCK-8) assay. Read More

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Revealing new therapeutic opportunities in hypertension through network-driven integrative genetic analysis and drug target prediction approach.

Gene 2021 Jul 19:145856. Epub 2021 Jul 19.

Translational Research Lab, Department of Biotechnology, Jamia Millia Islamia, New Delhi 110025, India. Electronic address:

Epidemiological studies have established that untreated hypertension (HTN) is a major independent risk factor for developing cardiovascular diseases (CVD), stroke, renal failure, and other conditions. Several important studies have been published to prevent and manage HTN; however, antihypertensive agents' optimal choice remains controversial. Therefore, the present study is undertaken to update our knowledge in the primary treatment of HTN, specifically in the setting of other three important diseases. Read More

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Personalized 0D-1D multiscale hemodynamic modeling and wave dynamics analysis of cerebral circulation for an elderly patient with dementia.

Int J Numer Method Biomed Eng 2021 Jul 22:e3510. Epub 2021 Jul 22.

Graduate School of Engineering, Chiba University, Chiba, Japan.

Senile dementia is associated with pronounced alterations in cerebral circulation. A fundamental understanding of intracranial hemodynamics and wave dynamics is essential for assessing dementia risk. Recent findings suggest that higher carotid artery wave intensity (WI) can predict future cognitive impairments in the elderly. Read More

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Interacting Quantum Atoms Analysis of the Reaction Force: a tool to analyse driving and retarding forces in chemical reactions.

Chemphyschem 2021 Jul 22. Epub 2021 Jul 22.

Universidad de Oviedo Facultad de Quimica, Departamento de Química y Física Analítica, SPAIN.

The analysis of the reaction force and its topology has provided a wide range of fruitful concepts in the theory of chemical reactivity over the years, allowing to identify chemically relevant regions along a reaction profile. The reaction force (RF), a projection of the Hellmann-Feynman forces acting on the nuclei of a molecular system onto a suitable reaction coordinate, is partitioned using the interacting quantum atoms approach (IQA). The exact IQA molecular energy decomposition is now shown to open a unique window to identify and quantify the chemical entities that drive or retard a chemical reaction. Read More

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Parotid saliva H-NMR analysis for colon cancer metabolomics: A case report.

Spec Care Dentist 2021 Jul 22. Epub 2021 Jul 22.

Dental Physical Sciences Unit, Centre for Oral Bioengineering, Institute of Dentistry, Queen Mary University of London, London, UK.

Background: A key priority in colon cancer research is the identification of molecular biomarkers to improve early diagnosis, guide prognosis, and the design of new therapeutic approaches. Saliva is a powerful diagnostic biofluid that can be used to detect systemic alterations. This study aimed to investigate the parotid saliva (PS) metabolic Proton Nuclear Magnetic Resonance ( H-NMR) profile of a patient diagnosed with colon cancer, and the subsequent changes 1 year after the end of chemotherapy. Read More

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Measuring Postprandial Metabolic Flexibility To Assess Metabolic Health and Disease.

J Nutr 2021 Jul 22. Epub 2021 Jul 22.

Hubert Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, Georgia, USA.

Metabolic abnormalities substantially increase the risk of noncommunicable diseases, which are among the leading causes of mortality globally. Mitigating and preventing these adverse consequences remains challenging due to a limited understanding of metabolic health. Metabolic flexibility, a key tenet of metabolic health, encompasses the responsiveness of interrelated pathways to maintain energy homeostasis throughout daily physiologic challenges, such as the response to meal challenges. Read More

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DoE-Based Analytical-FMCEA for Enhanced AQbD Approach to MEER-RP-HPLC Method for Synchronous Estimation of Fifteen Antihypertensive Pharmaceutical Dosage Forms.

J AOAC Int 2021 Jul 22. Epub 2021 Jul 22.

Department of Quality Assurance, Maliba Pharmacy College, Uka Tarsadia University, Bardoli-Mahuva Road, Tarsadi, Mahuva, Surat-394 350, Gujarat, India.

Background: In the recent scenario of green chemistry, the usage of organic solvent should be minimized in the development of the analytical method for the safety of the environment and analysts.

Objective: Hence, the RP-HPLC method has been developed as an economical and eco-friendly alternative to published RP-HPLC methods for the analysis of FDC of anti-hypertensive drugs to save time, resources, cost and organic solvent.

Method: The method has been developed by the implementation of an enhanced AQbD approach based on DoE-based AFMCEA. Read More

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Cuba-U.S. scientific collaboration: Beyond the embargo.

PLoS One 2021 22;16(7):e0255106. Epub 2021 Jul 22.

Coordinación General de Desarrollo Estratégico y Calidad, Universidad Católica del Norte, Antofagasta, Chile.

Cuba and the U.S. have the oldest Academies of Sciences outside Europe. Read More

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Radiative analysis of luminescence in photoreactive systems: Application to photosensitizers for solar fuel production.

PLoS One 2021 22;16(7):e0255002. Epub 2021 Jul 22.

Université Clermont Auvergne, Clermont Auvergne INP, CNRS, Institut Pascal, F-63000 Clermont-Ferrand, France.

Most chemical reactions promoted by light and using a photosensitizer (a dye) are subject to the phenomenon of luminescence. Redistribution of light in all directions (isotropic luminescence emission) and in a new spectral range (luminescence emission spectrum) makes experimental and theoretical studies much more complex compared to a situation with a purely absorbing reaction volume. This has a significant impact on the engineering of photoreactors for industrial applications. Read More

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Network-based repurposing identifies anti-alarmins as drug candidates to control severe lung inflammation in COVID-19.

PLoS One 2021 22;16(7):e0254374. Epub 2021 Jul 22.

Servier, Research and Development, Suresnes Cedex, France.

While establishing worldwide collective immunity with anti SARS-CoV-2 vaccines, COVID-19 remains a major health issue with dramatic ensuing economic consequences. In the transition, repurposing existing drugs remains the fastest cost-effective approach to alleviate the burden on health services, most particularly by reducing the incidence of the acute respiratory distress syndrome associated with severe COVID-19. We undertook a computational repurposing approach to identify candidate therapeutic drugs to control progression towards severe airways inflammation during COVID-19. Read More

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Renovation priorities for old residential districts based on resident satisfaction: An application of asymmetric impact-performance analysis in Xi'an, China.

PLoS One 2021 22;16(7):e0254372. Epub 2021 Jul 22.

School of Management, Xi'an University of Architecture and Technology, Xi'an, China.

China is currently designing a regional economic layout for high-quality urban development, shifting its focus from the primary stage of beautifying cities to the next stage of profound urbanization aiming at strengthening industry. This is of high importance given that the urbanization rate of permanent residents by the end of 2019 was 60.60%, according to the National Bureau of Statistics of China. Read More

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Design and psychometric evaluation of schools' resilience tool in Emergencies and disasters: A mixed-method.

PLoS One 2021 22;16(7):e0253906. Epub 2021 Jul 22.

Department of Anesthesiology and Critical Care, Shahid Rahnemoun Hospital, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.

Background: In addition to their educational role, resilient schools have a good capacity in response to disasters. Due to the large student population, the schools can be a safe and secure environment during disasters, in addition to maintaining their performance after. Given the role and importance of the schools, the impact of culture and environment on resilience, without any indigenous and comprehensive tool for measuring the resilience in Iran, the study aimed to design and psychometrically evaluate the measurement tools. Read More

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Estimating the net value of treating hepatitis C virus using sofosbuvir-velpatasvir in India.

PLoS One 2021 22;16(7):e0252764. Epub 2021 Jul 22.

Stanford Graduate School of Business, Stanford, California, United States of America.

Recently developed direct-acting antiviral (DAA) treatments for hepatitis C virus (HCV) have been groundbreaking for their high efficacy across disease genotypes and lack of severe side effects. This study uses a cost-of-illness (COI) approach to estimate the net value conferred by this class of drugs using the cost and efficacy of one of these novel drug combinations, sofosbuvir and velpatasvir (SOF/VEL), recently licensed for generic manufacture in India. This study considers COI of lifetime earnings lost by patients and potential secondarily infected individuals due to disability and premature death from HCV infection. Read More

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Persistent homology as a new method of the assessment of heart rate variability.

PLoS One 2021 22;16(7):e0253851. Epub 2021 Jul 22.

Department of Hypertension and Diabetology, Medical University of Gdańsk, Gdańsk, Poland.

Heart rate variability (hrv) is a physiological phenomenon of the variation in the length of the time interval between consecutive heartbeats. In many cases it could be an indicator of the development of pathological states. The classical approach to the analysis of hrv includes time domain methods and frequency domain methods. Read More

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Prioritization of neglected tropical zoonotic diseases: A one health perspective from Tigray region, Northern Ethiopia.

PLoS One 2021 22;16(7):e0254071. Epub 2021 Jul 22.

Department of Basic and Diagnostic Sciences, College of Veterinary Sciences, Mekelle University, Mekelle, Tigray, Ethiopia.

Neglected tropical zoonotic diseases (NTZDs) continue to have a major effect on the health of humans and animals. In this study, a one health approach was used to prioritize and rank neglected tropical zoonotic diseases at the regional and zonal levels in Tigray National Regional State, Ethiopia. For prioritization of NTZDs a cross-sectional study through a structured questionnaire was administered to 313 health experts from human and animal health sectors. Read More

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Introduction to network meta-analysis for evidence synthesis.

Medwave 2021 Jul 15;21(6):e8315. Epub 2021 Jul 15.

Centro Interdisciplinario de Estudios en Salud (CIESAL), Universidad de Valparaíso, Viña del Mar, Chile; Centro Asociado Universidad de Valparaíso, Cochrane Chile, Viña del Mar, Chile. Address:Angamos 655 Edificio R2 Oficina 1107 Reñaca, Viña del Mar, Chile. Email: ORCID: 0000-0001-9505-0358.

This article belongs to a collaborative methodological series of narrative reviews about biostatistics and clinical epidemiology. The goal is to present basics concepts concerning the systematics reviews of multiple treatments comparisons with network meta-analysis. For clinical ques-tions with several therapeutic alternatives to be compared, the central question is how to classify or rank their effectiveness (benefit and harm) to choose the best option. Read More

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Evaluating the impact of COVID-19 on the adoption of virtual care in general practice in 20 countries (inSIGHT): rationale and study protocol.

JMIR Res Protoc 2021 Jul 19. Epub 2021 Jul 19.

Institute of Global Health Innovation, Department of Surgery & Cancer, Faculty of Medicine, Imperial College London, Institute of Global Health Innovation, Room 1035/7, QEQM Wing, St Mary's Hospital Campus, London, GB.

Background: In recent decades, virtual care has emerged as a promising option to support primary care delivery. However, despite the potential, adoption rates remained low. With the outbreak of COVID-19, it has suddenly been pushed to the forefront of care delivery. Read More

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Online Search Trends Influencing Anti-Coagulation in COVID-19: An Observational Study.

JMIR Form Res 2021 Apr 11. Epub 2021 Apr 11.

Department of Infectious Diseases, Beaumont Hospital, Beaumont Road, Dublin, IE.

Background: Background: Early evidence of Coronavirus Disease (COVID-19) associated coagulopathy disseminated rapidly online during the first months of 2020, followed by clinical debate about how best to manage thrombotic risks in these patients. The rapid online spread of case reports was followed by online interim guidelines, discussions and worldwide online searches for further information. The impact of the global online search trends and online discussion on local approach to coagulopathy in COVID-19 patients has not been studied. Read More

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